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Ramon Alemany
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Journal Articles

Abstract 3562: LOAd732 - a novel oncolytic adenovirus with enhanced immunostimulatory properties and resistance to immunosuppression

Jessica Wenthe, Emma Eriksson, Tanja Lövgren, Rafael Moreno, Ramon Alemany, Angelica Loskog
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3562.
https://doi.org/10.1158/1538-7445.AM2022-3562
Published: 15 June 2022
View article titled, Abstract 3562: LOAd732 - a novel oncolytic adenovirus with enhanced immunostimulatory properties and resistance to immunosuppression
Journal Articles

Abstract 3559: Redirection of anti-virus immunity towards anti-tumor immunity using nanoparticle-induced immune tolerance for oncolytic adenovirus therapy

Dong Ho Shin, Hong Jiang, Debora Kim, Teresa T. Nguyen, Sagar Sohoni, Xuejun Fan, Yanhua Yi, Arie C. Van Wieren, Gheath Al-Atrash, Chantale Bernatchez, Ramon Alemany, Marta Alonso, Frederick Lang, Candelaria Gomez-Manzano, Bulent Ozpolat, Juan Fueyo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3559.
https://doi.org/10.1158/1538-7445.AM2022-3559
Published: 15 June 2022
View article titled, Abstract 3559: Redirection of anti-virus immunity towards anti-tumor immunity using nanoparticle-induced immune tolerance for oncolytic adenovirus therapy
Journal Articles

Abstract 915: Abscopal effect using intratumoral oncolytic virotherapy (LOAd703) is enhanced by anti-PD-1 or anti-PD-L1

Jessica Wenthe, Sedigheh Naseri, Ann-Charlotte Hellström, Rafael Moreno, Gustav Ullenhag, Ramon Alemany, Tanja Lövgren, Emma Eriksson, Angelica Loskog
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 915.
https://doi.org/10.1158/1538-7445.AM2020-915
Published: 15 August 2020
View article titled, Abstract 915: Abscopal effect using intratumoral oncolytic virotherapy (LOAd703) is enhanced by anti-PD-1 or anti-PD-L1
Journal Articles

Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Teresa Cejalvo, Ana Judith Perisé-Barrios, Isabel del Portillo, Eduardo Laborda, Miguel A. Rodriguez-Milla, Isabel Cubillo, Fernando Vázquez, David Sardón, Manuel Ramirez, Ramon Alemany, Noemí del Castillo, Javier García-Castro
Journal: Cancer Research
Cancer Res (2018) 78 (17): 4891–4901.
https://doi.org/10.1158/0008-5472.CAN-17-3754
Published: 04 September 2018
View article titled, Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy
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Includes: Supplementary data
Journal Articles

Abstract 3662: Activation of CD40 while inhibiting IL6/STAT3 using oncolytic viruses induces mature DCs with high cytokine production but blocks PDL1 expression

Emma Eriksson, Ioanna Milenova, Jessica Wenthe, Anna Dimberg, Rafael Moreno, Gustav Ullenhag, Ramon Alemany, Angelica Loskog
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3662.
https://doi.org/10.1158/1538-7445.AM2017-3662
Published: 01 July 2017
View article titled, Abstract 3662: Activation of CD40 while inhibiting IL6/STAT3 using oncolytic viruses induces mature DCs with high cytokine production but blocks PDL1 expression
Journal Articles

Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy

Carlos Alberto Fajardo, Sonia Guedan, Luis Alfonso Rojas, Rafael Moreno, Marcel Arias-Badia, Jana de Sostoa, Carl H. June, Ramon Alemany
Journal: Cancer Research
Cancer Res (2017) 77 (8): 2052–2063.
https://doi.org/10.1158/0008-5472.CAN-16-1708
Published: 13 April 2017
View article titled, Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy
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Includes: Supplementary data
Journal Articles

Abstract 1474: A novel oncolytic adenovirus expressing tumor microenvironment modulators that activates myeloid cells, lymphocytes and endothelial cells

Angelica Loskog, Emma Eriksson, Ioanna Milenova, Rafael Moreno, Ramon Alemany
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1474.
https://doi.org/10.1158/1538-7445.AM2016-1474
Published: 15 July 2016
View article titled, Abstract 1474: A novel oncolytic adenovirus expressing tumor microenvironment modulators that activates myeloid cells, lymphocytes and endothelial cells
Journal Articles

Abstract 297: Immunotherapy with a CD40L/4-1BBL double-armed oncolytic adenovirus drives Th1 immunity and control tumor progression in a pancreas cancer model

Emma Svensson, Ioanna Milenova, Rafael Moreno, Ramon Alemany, Angelica Loskog
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 297.
https://doi.org/10.1158/1538-7445.AM2015-297
Published: 01 August 2015
View article titled, Abstract 297: Immunotherapy with a CD40L/4-1BBL double-armed oncolytic adenovirus drives Th1 immunity and control tumor progression in a pancreas cancer model
Journal Articles

Bioselection of a Gain of Function Mutation that Enhances Adenovirus 5 Release and Improves Its Antitumoral Potency

Alena Gros, Jordi Martínez-Quintanilla, Cristina Puig, Sonia Guedan, David G. Molleví, Ramon Alemany, Manel Cascallo
Journal: Cancer Research
Cancer Res (2008) 68 (21): 8928–8937.
https://doi.org/10.1158/0008-5472.CAN-08-1145
Published: 30 October 2008
View article titled, Bioselection of a Gain of Function Mutation that Enhances Adenovirus 5 Release and Improves Its Antitumoral Potency
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Includes: Supplementary data
Journal Articles

ICOVIR-5 Shows E2F1 Addiction and Potent Antiglioma Effect In vivo

Marta M. Alonso, Manel Cascallo, Candelaria Gomez-Manzano, Hong Jiang, B. Nebiyou Bekele, Anna Perez-Gimenez, Frederick F. Lang, Yuji Piao, Ramon Alemany, Juan Fueyo
Journal: Cancer Research
Cancer Res (2007) 67 (17): 8255–8263.
https://doi.org/10.1158/0008-5472.CAN-06-4675
Published: 05 September 2007
View article titled, ICOVIR-5 Shows E2F1 Addiction and Potent Antiglioma Effect <em>In vivo</em>
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Journal Articles

New alliance against gliomas: Treatment with oncolytic adenovirus ICOVIR-5 in combination with TMZ or RAD001 significantly improves survival in glioma xenografts

Marta M. Alonso, Ramon Alemany, Candelaria Gomez-Manzao, Manel Cascallo, Frederick F. Lang, Jing Xu, Verlene Henry, Alfred W. K. Yung, Alfred W. K. Yung, Juan Fueyo
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 946.
Published: 15 April 2006
View article titled, New alliance against gliomas: Treatment with oncolytic adenovirus ICOVIR-5 in combination with TMZ or RAD001 significantly improves survival in glioma xenografts
Journal Articles

Conditionally replicative adenovirus expressing mutant p53 resistant to degradation by HPV E6 protein, exhibits potent and selective lytic replication on cervical cancer cells

Daniëlle Heideman, Renske Steenbergen, Jaco Van der Torre, Martin Scheffner, Ramon Alemany, Winald Gerritsen, Chris Meijer, Peter Snijders, Victor Van Beusechem
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 316.
Published: 01 May 2005
View article titled, Conditionally replicative adenovirus expressing mutant p53 resistant to degradation by HPV E6 protein, exhibits potent and selective lytic replication on cervical cancer cells
Journal Articles

Oncolytic adenovirus Icovir-2 shows improved therapeutic index than D24-RGD for glioma

Marta M. Alonso, Ramon Alemany, Candelaria Gomez-Manzano, W. K. Alfred Yung, Hong Jiang, Juan Fueyo
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 312–313.
Published: 01 May 2005
View article titled, Oncolytic adenovirus Icovir-2 shows improved therapeutic index than D24-RGD for glioma
Journal Articles

Downmodulation of E1A protein expression as a novel strategy to design cancer selective adenoviruses

Hong Jiang, Diana R. Medrano, Candelaria Gomez-Manzano, Michael G. Lemoine, Ramon Alemany, Melissa V. Olson, Marta M. Alonso, Charles C. Conrad, W. K. A. Yung, Juan Fueyo
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 312.
Published: 01 May 2005
View article titled, Downmodulation of E1A protein expression as a novel strategy to design cancer selective adenoviruses
Journal Articles

Conditionally Replicating Adenoviruses Expressing Short Hairpin RNAs Silence the Expression of a Target Gene in Cancer Cells

Jan E. Carette, Renée M. Overmeer, Frederik H. E. Schagen, Ramon Alemany, Oleg A. Barski, Winald R. Gerritsen, Victor W. van Beusechem
Journal: Cancer Research
Cancer Res (2004) 64 (8): 2663–2667.
https://doi.org/10.1158/0008-5472.CAN-03-3530
Published: 15 April 2004
View article titled, Conditionally Replicating Adenoviruses Expressing Short Hairpin RNAs Silence the Expression of a Target Gene in Cancer Cells
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Journal Articles

The level of E1A as a factor for tumor selectivity in oncolytic adenoviruses

Hong Jiang, Candelaria Gomez-Manzano, Diana Medrano, Andrea Cass, Marta M. Alonso, Ramon Alemany, Alfred Yung, Juan Fueyo
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 275.
Published: 01 April 2004
View article titled, The level of E1A as a factor for tumor selectivity in oncolytic adenoviruses
Journal Articles

Ras-dependent Oncolysis with an Adenovirus VAI Mutant

Manel Cascalló, Gabriel Capellà, Adela Mazo, Ramon Alemany
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5544–5550.
Published: 18 September 2003
View article titled, Ras-dependent Oncolysis with an Adenovirus VAI Mutant
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Journal Articles

Potential of the Conditionally Replicative Adenovirus Ad5-Δ24RGD in the Treatment of Malignant Gliomas and Its Enhanced Effect with Radiotherapy

Martine L. M. Lamfers, Jacques Grill, Clemens M. F. Dirven, Victor W. van Beusechem, Birgit Geoerger, Jaap van den Berg, Ramon Alemany, Juan Fueyo, David T. Curiel, Gilles Vassal, Herbert M. Pinedo, W. Peter Vandertop, Winald R. Gerritsen
Journal: Cancer Research
Cancer Res (2002) 62 (20): 5736–5742.
Published: 15 October 2002
View article titled, Potential of the Conditionally Replicative Adenovirus Ad5-Δ24RGD in the Treatment of Malignant Gliomas and Its Enhanced Effect with Radiotherapy
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Journal Articles

Novel Oncolytic Adenoviruses Targeted to Melanoma: Specific Viral Replication and Cytolysis by Expression of E1A Mutants from the Tyrosinase Enhancer/Promoter

Dirk M. Nettelbeck, Angel A. Rivera, Cristina Balagué, Ramon Alemany, David T. Curiel
Journal: Cancer Research
Cancer Res (2002) 62 (16): 4663–4670.
Published: 15 August 2002
View article titled, Novel Oncolytic Adenoviruses Targeted to Melanoma: <subtitle>Specific Viral Replication and Cytolysis by Expression of E1A Mutants from the Tyrosinase Enhancer/Promoter</subtitle>
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Journal Articles

Treatment of Ovarian Cancer with a Tropism Modified Oncolytic Adenovirus

Gerd J. Bauerschmitz, John T. Lam, Anna Kanerva, Kaori Suzuki, Dirk M. Nettelbeck, Igor Dmitriev, Victor Krasnykh, Galina V. Mikheeva, Mack N. Barnes, Ronald D. Alvarez, Peter Dall, Ramon Alemany, David T. Curiel, Akseli Hemminki
Journal: Cancer Research
Cancer Res (2002) 62 (5): 1266–1270.
Published: 01 March 2002
View article titled, Treatment of Ovarian Cancer with a Tropism Modified Oncolytic Adenovirus
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