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Abstract 1186: Inhibition of topoisomerase 2β sensitizes acute myeloid leukemia cells to ATRA induced apoptosis independent of the MAPK/ERK pathway

Eric J. Norris, Amy Dorszynski, Aaron Lucander, Darla Destephanis, Ram Ganapathi, Mahrukh Ganapathi

Cancer Res (2016) 76 (14_Supplement): 1186.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1186

Published: 15 July 2016

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Journal Articles

Abstract 4828: Enhanced cytotoxicity following sequential treatment with filanesib and melphalan in human myeloma cell lines

Darla Destephanis, Eric J. Norris, Brian Turnquist, Saad Usmani, Mahrukh Ganapathi, Ram Ganapathi

Cancer Res (2016) 76 (14_Supplement): 4828.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4828

Published: 15 July 2016

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Journal Articles

Abstract 5431: Histone deacetylase inhibitor (HDAC) panobinostat (LBH589) enhances the antiproliferative effect of a topoisomerase II (topo II) inhibitor in doxorubicin-resistant HL-60 cells, despite high MDR expression

Anna K. Brady, Anjali S. Advani, Dale Grabowski, Ram Ganapathi, Mahrukh K. Ganapathi

Cancer Res (2010) 70 (8_Supplement): 5431.

DOI: https://doi.org/10.1158/1538-7445.AM10-5431

Published: 15 April 2010

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Abstract 1626: Tyrosine phosphorylation of RIN1 modulates the anti-proliferative effects of sorafenib and sunitinib in renal cell carcinoma (RCC)

Adrian G. Grozav, Belinda Willard, Susan A. Vaziri, Eric R. Koegle, Toshiuki Kozuki, Dale R. Grabowski, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ram Ganapathi

Cancer Res (2010) 70 (8_Supplement): 1626.

DOI: https://doi.org/10.1158/1538-7445.AM10-1626

Published: 15 April 2010

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Abstract LB-51: Correlation of expression of MDR-associated genes with outcome in primary ovarian serous carcinoma

Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Ben Davidson, Mari Bunkholt Elstrand, Ram Ganapathi, Anil K. Sood, Suresh V. Ambudkar, Michael V. Seiden, Bo R. Rueda, Michael M. Gottesman

Cancer Res (2010) 70 (8_Supplement): LB-51.

DOI: https://doi.org/10.1158/1538-7445.AM10-LB-51

Published: 15 April 2010

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Journal Articles

Abstract #LB-274: Role of ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1) in cell adhesion, secondary homing and recurrence in presence of lysophosphatidic acid and paclitaxel.

Chunyang Wang, Chad Michener, Jerome Belinson, Susan Vaziri, Ram Ganapathi, Saubhik Sengupta

Cancer Res (2009) 69 (9_Supplement): LB-274.

Published: 01 May 2009

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Journal Articles

Abstract #2950: Over-expression of cisplatin resistance-associated overexpressed protein (CROP) is correlated with platinum resistance in ovarian cancer.

Toshiyuki Kozuki, Eric Koegle, Dale Grabowski, Ram Ganapathi, Mahrukh Ganapathi

Cancer Res (2009) 69 (9_Supplement): 2950.

Published: 01 May 2009

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Journal Articles

Abstract #4567: Sensitivity to suberoylanilide hydroxamic acid varies with differential expression of topoisomerase II isoforms

Anna Brady, Anjali Advani, Andrew Porter, Mahrukh Ganapathi, Ram Ganapathi

Cancer Res (2009) 69 (9_Supplement): 4567.

Published: 01 May 2009

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Polymorphism -2518 A/A in the CCL2 gene is associated with decreased IL-1β response and chemoresistance in ovarian cancer cells

Nabila Rasool, Amanda Nickles Fader, Peter Faber, Toshiyuki Kozuki, Susan Vaziri, Charles Biscotti, Jerome Belinson, Peter Rose, Chad Michener, Ram Ganapathi, Mahrukh Ganapathi

Cancer Res (2008) 68 (9_Supplement): 2988A.

Published: 01 May 2008

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Journal Articles

Expression of topoisomerase II isozymes α or β differentially affect anti-proliferative and apoptotic effects of suberoylanilide hydroxamic acid (SAHA) in human leukemia cells

Ram Ganapathi, Toshiyuki Kozuki, Dale Grabowski, Nicole Davis, Adrian Grozav, Ronald Bukowski, Mahrukh Ganapathi

Cancer Res (2008) 68 (9_Supplement): 778.

Published: 01 May 2008

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Journal Articles

Phosphorylation of tyrosine 656 in topoisomerase IIβ is required for enzymatic activity and anti-tumor drug sensitivity

Kenichi Chikamori, Toshiyuki Kozuki, Adrian Grozav, Dale Grabowski, Jianrong Wang, Andrew Yen, Ronald Bukowski, Anni Andersen, Ram Ganapathi, Mahrukh Ganapathi

Cancer Res (2007) 67 (9_Supplement): 3144.

Published: 01 May 2007

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Journal Articles

Truncation of the C-terminus domain of topoisomerase IIα enhances enzymatic activity and reduces drug sensitivity

Kenichi Chikamori, Anni H. Andersen, Ronald M. Bukowski, Ram Ganapathi, Mahrukh K. Ganapathi

Cancer Res (2006) 66 (8_Supplement): 456–457.

Published: 15 April 2006

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Casein kinase I δ /ε isoforms phosphorylate serine 1106 in the catalytic domain of human topoisomerase IIα

Adrian G. Grozav, Kenichi Chikamori, Dale R. Grabowski, Yan xu, Michael Kinter, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ram Ganapathi

Cancer Res (2006) 66 (8_Supplement): 1005.

Published: 15 April 2006

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Journal Articles

Apoptotic pathways induced by ixabepilone in paclitaxel-refractory ovarian carcinoma cells

Luis A. Rojas-Espaillat, Denise Uyar, Dale Grabowski, Jerome L. Belinson, Francis Lee, Renzo Canetta, Ronald Bukowski, Mahrukh Ganapathi, Ram Ganapathi

Cancer Res (2005) 65 (9_Supplement): 1257.

Published: 01 May 2005

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Journal Articles

Targeted si-RNA mediated down-regulation of topoisomerase II α or β isozymes defines selectivity to inhibitors of the enzyme

Kenichi Chikamori, Jason E. Hill, Adrian G. Grozav, Dale R. Grabowski, Susan A. J. Vaziri, Andrei V. Gudkov, Ronald M. Bukowski, Ram Ganapathi, Mahrukh K. Ganapathi

Cancer Res (2005) 65 (9_Supplement): 563.

Published: 01 May 2005

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Journal Articles

In vivo characterization of site-specific phosphorylation in human topoisomerase IIβ

Adrian G. Grozav, Kenichi Chikamori, Dale R. Grabowski, Yan Xu, Michael Kinter, Ram Ganapathi, Mahrukh K. Ganapathi

Cancer Res (2005) 65 (9_Supplement): 564.

Published: 01 May 2005

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Journal Articles

HPC1/RNASEL Mediates Apoptosis of Prostate Cancer Cells Treated with 2′,5′-Oligoadenylates, Topoisomerase I Inhibitors, and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Krishnamurthy Malathi, Jayashree M. Paranjape, Ram Ganapathi, Robert H. Silverman

Cancer Res (2004) 64 (24): 9144–9151.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-2226

Published: 16 December 2004

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Journal Articles

LC–MS/MS with online solid-phase sample extraction –a facile, sensitive and highly selective method for the measurement of docetaxel in human plasma

Adrian Grozav, Thomas E. Hutson, Xiang Zhou, Ronald M. Bukowski, Ram Ganapathi, Yan Xu

Cancer Res (2004) 64 (7_Supplement): 91.

Published: 01 April 2004

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Journal Articles

Targeted down-regulation of topoisomerase IIβ : Effects on growth characteristics and drug sensitivity

Kenichi Chikamori, Jason Hill, Dale R. Grabowski, Adrian Grozav, Andrei V. Gudkov, Ronald M. Bukowski, Ram Ganapathi, Mahrukh K. Ganapathi

Cancer Res (2004) 64 (7_Supplement): 276–277.

Published: 01 April 2004

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Journal Articles

Synergistic enhancement of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is NF-κ B independent and involves down-regulation of survivin

Susan A. Vaziri, Nagio Takigawa, Kenichi Chikamori, Dale R. Grabowski, Tarek Mekhail, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ram Ganapathi

Cancer Res (2004) 64 (7_Supplement): 1125.

Published: 01 April 2004

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NARROW

Abstract 1186: Inhibition of topoisomerase 2β sensitizes acute myeloid leukemia cells to ATRA induced apoptosis independent of the MAPK/ERK pathway

Abstract 4828: Enhanced cytotoxicity following sequential treatment with filanesib and melphalan in human myeloma cell lines

Abstract 5431: Histone deacetylase inhibitor (HDAC) panobinostat (LBH589) enhances the antiproliferative effect of a topoisomerase II (topo II) inhibitor in doxorubicin-resistant HL-60 cells, despite high MDR expression

Abstract 1626: Tyrosine phosphorylation of RIN1 modulates the anti-proliferative effects of sorafenib and sunitinib in renal cell carcinoma (RCC)

Abstract LB-51: Correlation of expression of MDR-associated genes with outcome in primary ovarian serous carcinoma

Abstract #LB-274: Role of ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1) in cell adhesion, secondary homing and recurrence in presence of lysophosphatidic acid and paclitaxel.

Abstract #2950: Over-expression of cisplatin resistance-associated overexpressed protein (CROP) is correlated with platinum resistance in ovarian cancer.

Abstract #4567: Sensitivity to suberoylanilide hydroxamic acid varies with differential expression of topoisomerase II isoforms

Polymorphism -2518 A/A in the CCL2 gene is associated with decreased IL-1β response and chemoresistance in ovarian cancer cells

Expression of topoisomerase II isozymes α or β differentially affect anti-proliferative and apoptotic effects of suberoylanilide hydroxamic acid (SAHA) in human leukemia cells

Phosphorylation of tyrosine 656 in topoisomerase IIβ is required for enzymatic activity and anti-tumor drug sensitivity

Truncation of the C-terminus domain of topoisomerase IIα enhances enzymatic activity and reduces drug sensitivity

Casein kinase I δ /ε isoforms phosphorylate serine 1106 in the catalytic domain of human topoisomerase IIα

Apoptotic pathways induced by ixabepilone in paclitaxel-refractory ovarian carcinoma cells

Targeted si-RNA mediated down-regulation of topoisomerase II α or β isozymes defines selectivity to inhibitors of the enzyme

In vivo characterization of site-specific phosphorylation in human topoisomerase IIβ

HPC1/RNASEL Mediates Apoptosis of Prostate Cancer Cells Treated with 2′,5′-Oligoadenylates, Topoisomerase I Inhibitors, and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

LC–MS/MS with online solid-phase sample extraction –a facile, sensitive and highly selective method for the measurement of docetaxel in human plasma

Targeted down-regulation of topoisomerase IIβ : Effects on growth characteristics and drug sensitivity

Synergistic enhancement of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is NF-κ B independent and involves down-regulation of survivin

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