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Journal Articles

Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma

Bo Zhang, Hui Peng, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E. Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo Hatanpaa, John A. Copland, Ralph J. DeBerardinis, Yingfei Wang, Weibo Luo

Cancer Res canres.3868.2021.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3868

Published: 02 May 2022

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Includes: Supplementary data

Journal Articles

Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers

Cherise R Glodowski, Chengheng Liao, Cheng Fan, Juan Liu, Kevin R Mott, Akash Kaushik, Hieu Vu, Jason W Locasale, Samuel K McBrayer, Ralph J DeBerardinis, Charles M Perou, Qing Zhang

Cancer Res (2022) 82 (4_Supplement): P5-05-01.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P5-05-01

Published: 15 February 2022

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Journal Articles

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R. Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis, Charles M. Perou, Qing Zhang

Cancer Res (2022) 82 (4): 665–680.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2745

Published: 15 December 2021

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Includes: Supplementary data

Journal Articles

Abstract 871: KYNU expression is a prognostic factor in KEAP1/STK11 co-mutated lung adenocarcinoma

Ling Cai, Thomas J. Rogers, Huiyu Li, Jiyeon Kim, Yang Xie, Guanghua Xiao, John Minna, Ralph J. DeBerardinis

Cancer Res (2021) 81 (13_Supplement): 871.

DOI: https://doi.org/10.1158/1538-7445.AM2021-871

Published: 01 July 2021

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Journal Articles

Abstract IA21: Metabolic phenotypes and liabilities in human cancer

Ralph J. DeBerardinis

Cancer Res (2020) 80 (23_Supplement): IA21.

DOI: https://doi.org/10.1158/1538-7445.EPIMETAB20-IA21

Published: 02 December 2020

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Journal Articles

Abstract 245: Glutamine fuels the TCA cycle in VHL and FH mutant renal cell carcinoma

Akash K. Kaushik, Cissy Yong, Mukundan Ragavan, Christina Stevens, Layton Woolford, Aparna Rao, Brandon Faubert, Panayotis Pachnis, Lauren Zacharias, Hieu Vu, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis

Cancer Res (2020) 80 (16_Supplement): 245.

DOI: https://doi.org/10.1158/1538-7445.AM2020-245

Published: 15 August 2020

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Journal Articles

Abstract SY21-01: Analyzing tumor metabolism in patients

Ralph J. Deberardinis

Cancer Res (2019) 79 (13_Supplement): SY21-01.

DOI: https://doi.org/10.1158/1538-7445.AM2019-SY21-01

Published: 01 July 2019

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Journal Articles

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

Ana Galan-Cobo, Piyada Sitthideatphaiboon, Xiao Qu, Alissa Poteete, Marlese A. Pisegna, Pan Tong, Pei-Hsuan Chen, Lindsey K. Boroughs, Mirna L.M. Rodriguez, Winter Zhang, Francesco Parlati, Jing Wang, Varsha Gandhi, Ferdinandos Skoulidis, Ralph J. DeBerardinis, John D. Minna, John V. Heymach

Cancer Res (2019) 79 (13): 3251–3267.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-3527

Published: 01 July 2019

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Includes: Supplementary data

Journal Articles

Abstract IA23: Metabolic complexity in cancer cells and tumors

Ralph J. DeBerardinis

Cancer Res (2018) 78 (19_Supplement): IA23.

DOI: https://doi.org/10.1158/1538-7445.PEDCA17-IA23

Published: 01 October 2018

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Journal Articles

Abstract SY02-01: Understanding metabolic phenotypes in human tumors

Ralph J. Deberardinis

Cancer Res (2017) 77 (13_Supplement): SY02-01.

DOI: https://doi.org/10.1158/1538-7445.AM2017-SY02-01

Published: 01 July 2017

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Journal Articles

Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma

Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Christine Chio, John M. Asara, John D. Minna, David A. Tuveson, Ralph J. DeBerardinis, Lewis C. Cantley

Cancer Res (2016) 76 (24_Supplement): B04.

DOI: https://doi.org/10.1158/1538-7445.PANCA16-B04

Published: 14 December 2016

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Journal Articles

Abstract 53: Epigenetic silencing of krebs cycle metabolism in kidney cancer

Eun-Young Kho, Carolina B. Livi, Phillip Buckhaults, Francesca Carobbio, Hye-Young Nam, Richard Kirkman, David Crossman, Praveen K. Vayalil, Shi Wei, Ralph J. DeBerardinis, Sunil Sudarshan

Cancer Res (2016) 76 (14_Supplement): 53.

DOI: https://doi.org/10.1158/1538-7445.AM2016-53

Published: 15 July 2016

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Journal Articles

Abstract IA07: Metabolic heterogeneity in cancer cells and tumors

Ralph J. DeBerardinis

Cancer Res (2016) 76 (3_Supplement): IA07.

DOI: https://doi.org/10.1158/1538-7445.FBCR15-IA07

Published: 07 April 2016

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Journal Articles

Abstract 4710: Evaluation of the glutaminase inhibitor CB-839 in non-small cell lung cancer

Lindsey K. Boroughs, Pei-Hsuan Chen, Ling Cai, Mirna Rodriguez, Winter Zhang, Kenneth E. Huffman, Lauren A. Byers, Luc Girard, Adi F. Gazdar, John V. Heymach, Michael A. White, John D. Minna, Ethan Emberley, Alison Pan, Frank Parlati, Ralph J. DeBerardinis

Cancer Res (2015) 75 (15_Supplement): 4710.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4710

Published: 01 August 2015

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Journal Articles

Abstract 4708: Mammalian glutamine metabolism controls circadian rhythm through regulation of reactive oxygen species

Brian J. Altman, Zachary E. Stine, Annie L. Hsieh, Ralph J. Deberardinis, Chi V. Dang

Cancer Res (2015) 75 (15_Supplement): 4708.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4708

Published: 01 August 2015

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Journal Articles

Abstract SY10-01: Understanding metabolic heterogeneity in cancer

Ralph J. DeBerardinis

Cancer Res (2014) 74 (19_Supplement): SY10-01.

DOI: https://doi.org/10.1158/1538-7445.AM2014-SY10-01

Published: 01 October 2014

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Journal Articles

Abstract 965: An oncogenic metabolic switch mediates resistance to NOTCH1 inhibition in T-ALL

Daniel Herranz, Alberto Ambesi-Impiombato1, Jessica Sudderth, Marta Sánchez-Martín, Valeria Tosello, Luyao Xu, Mireia Castillo, Carlos Cordon-Cardo, Andrew L. Kung, Ralph J. DeBerardinis, Adolfo Ferrando

Cancer Res (2014) 74 (19_Supplement): 965.

DOI: https://doi.org/10.1158/1538-7445.AM2014-965

Published: 01 October 2014

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Journal Articles

Abstract C16: Mapping synthetic vulnerabilities in non-small cell lung cancer

Cancer Res (2013) 73 (19_Supplement): C16.

DOI: https://doi.org/10.1158/1538-7445.FBCR13-C16

Published: 15 May 2014

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Journal Articles

A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography

Timothy H. Witney, Laurence Carroll, Israt S. Alam, Anil Chandrashekran, Quang-Dé Nguyen, Roberta Sala, Robert Harris, Ralph J. DeBerardinis, Roshan Agarwal, Eric O. Aboagye

Cancer Res (2014) 74 (5): 1319–1328.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-2768

Published: 02 March 2014

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Includes: Supplementary data

Journal Articles

Abstract 1248: Enhanced glutamine metabolism contributes to docetaxel resistance in DU145 prostate cancer cells

Kartik N. Rajagopalan, Calin O. Marian, Jerry W. Shay, Ralph J. DeBerardinis

Cancer Res (2011) 71 (8_Supplement): 1248.

DOI: https://doi.org/10.1158/1538-7445.AM2011-1248

Published: 15 April 2011

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NARROW

Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma

Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Abstract 871: KYNU expression is a prognostic factor in KEAP1/STK11 co-mutated lung adenocarcinoma

Abstract IA21: Metabolic phenotypes and liabilities in human cancer

Abstract 245: Glutamine fuels the TCA cycle in VHL and FH mutant renal cell carcinoma

Abstract SY21-01: Analyzing tumor metabolism in patients

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

Abstract IA23: Metabolic complexity in cancer cells and tumors

Abstract SY02-01: Understanding metabolic phenotypes in human tumors

Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma

Abstract 53: Epigenetic silencing of krebs cycle metabolism in kidney cancer

Abstract IA07: Metabolic heterogeneity in cancer cells and tumors

Abstract 4710: Evaluation of the glutaminase inhibitor CB-839 in non-small cell lung cancer

Abstract 4708: Mammalian glutamine metabolism controls circadian rhythm through regulation of reactive oxygen species

Abstract SY10-01: Understanding metabolic heterogeneity in cancer

Abstract 965: An oncogenic metabolic switch mediates resistance to NOTCH1 inhibition in T-ALL

Abstract C16: Mapping synthetic vulnerabilities in non-small cell lung cancer

A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography

Abstract 1248: Enhanced glutamine metabolism contributes to docetaxel resistance in DU145 prostate cancer cells

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