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Ralph J. DeBerardinis
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Journal Articles

The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models

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Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J. DeBerardinis, George K. Acquaah-Mensah, Vassilis Aidinis, Jennifer E. Beane, Shyam Biswal, Ting Chen, Carla P. Concepcion-Crisol, Barbara M. Grüner, Deshui Jia, Robert A. Jones, Jonathan M. Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David MacPherson, Rosanna Martinelli, Pawel K. Mazur, Sarah A. Mazzilli, Shinji Mii, Herwig P. Moll, Roger A. Moorehead, Edward E. Morrisey, Sheng Rong Ng, Matthew G. Oser, Arun R. Pandiri, Charles A. Powell, Giorgio Ramadori, Mirentxu Santos, Eric L. Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T. Tran, Yifeng Xia, J. Edward van Veen, Monte M. Winslow, Guanghua Xiao, Charles M. Rudin, Trudy G. Oliver, Yang Xie, John D. Minna
Journal: Cancer Research
Cancer Res (2025) 85 (10): 1769–1783.
https://doi.org/10.1158/0008-5472.CAN-24-1607
Published: 15 May 2025
View articletitled, The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Open the PDF for The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models in another window
Includes: Supplementary data
Journal Articles

Abstract 1793: Transmembrane serine protease TMPRSS11B promotes tumorigenesis in lung squamous cell carcinoma through enhanced lactate export and modulation of the tumor microenvironment

Free
Hari Shankar Sunil, Barrett L. Updegraff, Jingfei Zhu, Lisa Thomas, Bret M. Evers, Jean R. Clemenceau, Isabel Barnfather, John D. Minna, Ralph J. Deberardinis, Trudy G. Oliver, Tae Hyun Hwang, Kathryn A. O'Donnell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1793.
https://doi.org/10.1158/1538-7445.AM2024-1793
Published: 22 March 2024
View articletitled, Abstract 1793: Transmembrane serine protease TMPRSS11B promotes tumorigenesis in lung squamous cell carcinoma through enhanced lactate export and modulation of the tumor microenvironment
Journal Articles

Abstract 4450: MYC upregulates MCT4 expression and promotes metabolic reprogramming and enhanced lactate utilization in LKB1-deficient NSCLC

Free
Yu Qian, David Molkentine, Yifan Kong, Qian Huang, Chendong Yang, Alissa Poteete, Alvaro P. Guimaraes, Peixin Jiang, Ferdinandos Skoulidis, Alexandre Reuben, John D. Minna, Ralph J. DeBerardinis, John V. Heymach
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4450.
https://doi.org/10.1158/1538-7445.AM2024-4450
Published: 22 March 2024
View articletitled, Abstract 4450: MYC upregulates MCT4 expression and promotes metabolic reprogramming and enhanced lactate utilization in LKB1-deficient NSCLC
Journal Articles

Abstract IA016: Metabolic reprogramming and cancer progression in patients

Free
Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): IA016.
https://doi.org/10.1158/1538-7445.BRAIN23-IA016
Published: 04 March 2024
View articletitled, Abstract IA016: Metabolic reprogramming and cancer progression in patients
Journal Articles

Abstract IA017: Metabolic reprogramming and kidney cancer progression

Free
Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): IA017.
https://doi.org/10.1158/1538-7445.KIDNEY23-IA017
Published: 15 August 2023
View articletitled, Abstract IA017: Metabolic reprogramming and kidney cancer progression
Journal Articles

Abstract 3685: Targeting a novel cell surface serine protease TMPRSS11B for lung cancer therapy

Free
Hari Shankar Sunil, Barrett Updegraff, Jingfei Zhu, Bret M. Evers, John D. Minna, Ralph J. Deberardinis, Trudy G. Oliver, Kathryn A. O'Donnell
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3685.
https://doi.org/10.1158/1538-7445.AM2023-3685
Published: 04 April 2023
View articletitled, Abstract 3685: Targeting a novel cell surface serine protease TMPRSS11B for lung cancer therapy
Journal Articles

Abstract 271: MYC mediates enhanced lactate reutilization and resistance to anti-angiogenesis therapy in preclinical models of LKB1-deficient NSCLC

Free
Yu Qian, David Molkentine, Chendong Yang, Ana Galan Cobo, Irene Guijarro, Minghao Dang, Alissa Poteete, Peixin Jiang, Ferdinandos Skoulidis, Linghua Wang, Alexandre Reuben, John D. Minna, Ralph J. DeBerardinis, John V. Heymach
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 271.
https://doi.org/10.1158/1538-7445.AM2023-271
Published: 04 April 2023
View articletitled, Abstract 271: MYC mediates enhanced lactate reutilization and resistance to anti-angiogenesis therapy in preclinical models of LKB1-deficient NSCLC
Journal Articles

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

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Bo Zhang, Hui Peng, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E. Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo J. Hatanpaa, John A. Copland, Ralph J. DeBerardinis, Yingfei Wang, Weibo Luo
Journal: Cancer Research
Cancer Res (2022) 82 (13): 2388–2402.
https://doi.org/10.1158/0008-5472.CAN-21-3868
Published: 05 July 2022
View articletitled, Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
Open the PDF for Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers

Free
Cherise R Glodowski, Chengheng Liao, Cheng Fan, Juan Liu, Kevin R Mott, Akash Kaushik, Hieu Vu, Jason W Locasale, Samuel K McBrayer, Ralph J DeBerardinis, Charles M Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-05-01.
https://doi.org/10.1158/1538-7445.SABCS21-P5-05-01
Published: 15 February 2022
View articletitled, Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers
Journal Articles

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

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Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R. Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis, Charles M. Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4): 665–680.
https://doi.org/10.1158/0008-5472.CAN-21-2745
Published: 15 February 2022
View articletitled, Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
Open the PDF for Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 871: KYNU expression is a prognostic factor in KEAP1/STK11 co-mutated lung adenocarcinoma

Free
Ling Cai, Thomas J. Rogers, Huiyu Li, Jiyeon Kim, Yang Xie, Guanghua Xiao, John Minna, Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 871.
https://doi.org/10.1158/1538-7445.AM2021-871
Published: 01 July 2021
View articletitled, Abstract 871: KYNU expression is a prognostic factor in KEAP1/STK11 co-mutated lung adenocarcinoma
Journal Articles

Abstract IA21: Metabolic phenotypes and liabilities in human cancer

Free
Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): IA21.
https://doi.org/10.1158/1538-7445.EPIMETAB20-IA21
Published: 02 December 2020
View articletitled, Abstract IA21: Metabolic phenotypes and liabilities in human cancer
Journal Articles

Abstract 245: Glutamine fuels the TCA cycle in VHL and FH mutant renal cell carcinoma

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Akash K. Kaushik, Cissy Yong, Mukundan Ragavan, Christina Stevens, Layton Woolford, Aparna Rao, Brandon Faubert, Panayotis Pachnis, Lauren Zacharias, Hieu Vu, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 245.
https://doi.org/10.1158/1538-7445.AM2020-245
Published: 15 August 2020
View articletitled, Abstract 245: Glutamine fuels the TCA cycle in VHL and FH mutant renal cell carcinoma
Journal Articles

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

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Ana Galan-Cobo, Piyada Sitthideatphaiboon, Xiao Qu, Alissa Poteete, Marlese A. Pisegna, Pan Tong, Pei-Hsuan Chen, Lindsey K. Boroughs, Mirna L.M. Rodriguez, Winter Zhang, Francesco Parlati, Jing Wang, Varsha Gandhi, Ferdinandos Skoulidis, Ralph J. DeBerardinis, John D. Minna, John V. Heymach
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3251–3267.
https://doi.org/10.1158/0008-5472.CAN-18-3527
Published: 01 July 2019
View articletitled, LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma
Open the PDF for LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract SY21-01: Analyzing tumor metabolism in patients

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Ralph J. Deberardinis
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY21-01.
https://doi.org/10.1158/1538-7445.AM2019-SY21-01
Published: 01 July 2019
View articletitled, Abstract SY21-01: Analyzing tumor metabolism in patients
Journal Articles

Abstract IA23: Metabolic complexity in cancer cells and tumors

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Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA23.
https://doi.org/10.1158/1538-7445.PEDCA17-IA23
Published: 01 October 2018
View articletitled, Abstract IA23: Metabolic complexity in cancer cells and tumors
Journal Articles

Abstract SY02-01: Understanding metabolic phenotypes in human tumors

Free
Ralph J. Deberardinis
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): SY02-01.
https://doi.org/10.1158/1538-7445.AM2017-SY02-01
Published: 01 July 2017
View articletitled, Abstract SY02-01: Understanding metabolic phenotypes in human tumors
Journal Articles

Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma

Free
Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Christine Chio, John M. Asara, John D. Minna, David A. Tuveson, Ralph J. DeBerardinis, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B04.
https://doi.org/10.1158/1538-7445.PANCA16-B04
Published: 14 December 2016
View articletitled, Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 53: Epigenetic silencing of krebs cycle metabolism in kidney cancer

Free
Eun-Young Kho, Carolina B. Livi, Phillip Buckhaults, Francesca Carobbio, Hye-Young Nam, Richard Kirkman, David Crossman, Praveen K. Vayalil, Shi Wei, Ralph J. DeBerardinis, Sunil Sudarshan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 53.
https://doi.org/10.1158/1538-7445.AM2016-53
Published: 15 July 2016
View articletitled, Abstract 53: Epigenetic silencing of krebs cycle metabolism in kidney cancer
Journal Articles

Abstract IA07: Metabolic heterogeneity in cancer cells and tumors

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Ralph J. DeBerardinis
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): IA07.
https://doi.org/10.1158/1538-7445.FBCR15-IA07
Published: 07 April 2016
View articletitled, Abstract IA07: Metabolic heterogeneity in cancer cells and tumors