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Ralph H. Hruban
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Journal Articles

Abstract 1206: Three-dimensional immune atlas of pancreatic cancer precursor lesions reveals large inter- and intra-lesion heterogeneity

Ashley L. Kiemen, Cristina Almagro-Pérez, Valentina Matos-Romero, Alicia M. Braxton, Jaanvi Mahesh-Babu, Elizabeth D. Thompson, Toby C. Cornish, PeiHsun Wu, Laura D. Wood, Arrate Muñoz-Barrutia, Ralph H. Hruban, Denis Wirtz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1206.
https://doi.org/10.1158/1538-7445.AM2024-1206
Published: 22 March 2024
View article titled, Abstract 1206: Three-dimensional immune atlas of pancreatic cancer precursor lesions reveals large inter- and intra-lesion heterogeneity
Journal Articles

Abstract 7243: CRISPR-cas9 genetic targeting of metastatic pancreatic cancer

Kirsten Bowland, Jiaying Lai, Selina Shiqing K. Teh, Alexis Bennett, Alyza Skaist, Yan Zhang, Elizabeth Thompson, Ralph H. Hruban, Nicholas J. Roberts, Rachel Karchin, Christine A. Iacobuzio-Donahue, James R. Eshleman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7243.
https://doi.org/10.1158/1538-7445.AM2024-7243
Published: 22 March 2024
View article titled, Abstract 7243: CRISPR-cas9 genetic targeting of metastatic pancreatic cancer
Journal Articles

Abstract 6092: Three-dimensional multi-omic analysis of early invasion of human pancreatic ductal adenocarcinoma from IPMN

Shalini Datta, Sarah M. Shin, Jessie Kanacharoen, Michael Johannes Pflüger, Katsuya Hirose, André Forjaz, Sarah Graham, Pei-Hsun Wu, Ralph H. Hruban, Denis Wirtz, Won Jin Ho, Ashley L. Kiemen, Laura D. Wood
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6092.
https://doi.org/10.1158/1538-7445.AM2024-6092
Published: 22 March 2024
View article titled, Abstract 6092: Three-dimensional multi-omic analysis of early invasion of human pancreatic ductal adenocarcinoma from IPMN
Journal Articles

Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis

Emily K.W. Lo, Brian M. Mears, H. Carlo Maurer, Adrian Idrizi, Kasper D. Hansen, Elizabeth D. Thompson, Ralph H. Hruban, Kenneth P. Olive, Andrew P. Feinberg
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1905–1916.
https://doi.org/10.1158/0008-5472.CAN-22-4052
Published: 02 June 2023
View article titled, Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Open the PDF for Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis in another window
Includes: Supplementary data
Journal Articles

Abstract LB357: CRISPR-Cas9 targeting of somatic mutations selectively kills cancer cells

Kirsten Bowland, Selina Shiqing K. Teh, Alyza Skaist, Ralph H. Hruban, Nicholas J. Roberts, Chrisine Iacobuzio-Donahue, James R. Eshleman
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB357.
https://doi.org/10.1158/1538-7445.AM2023-LB357
Published: 14 April 2023
View article titled, Abstract LB357: CRISPR-Cas9 targeting of somatic mutations selectively kills cancer cells
Journal Articles

Abstract B027: Three-dimensional genomic analysis of human pancreatic intraepithelial neoplasia (PanIN) reveals striking multifocality and genetic heterogeneity

Alicia M. Braxton, Ashley Kiemen, Rachel Karchin, Yuchen Jiao, Pei-Hsun Wu, Ralph H Hruban, Denis Wirtz, Laura D. Wood
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B027.
https://doi.org/10.1158/1538-7445.PANCA22-B027
Published: 15 November 2022
View article titled, Abstract B027: Three-dimensional genomic analysis of human pancreatic intraepithelial neoplasia (PanIN) reveals striking multifocality and genetic heterogeneity
Journal Articles

Abstract PR007: Three-dimensional genomic analysis of human pancreatic intraepithelial neoplasia (PanIN) reveals striking multifocality and genetic heterogeneity

Alicia M. Braxton, Ashley Kiemen, Rachel Karchin, Yuchen Jiao, Pei-Hsun Wu, Ralph H Hruban, Denis Wirtz, Laura D. Wood
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR007.
https://doi.org/10.1158/1538-7445.PANCA22-PR007
Published: 15 November 2022
View article titled, Abstract PR007: Three-dimensional genomic analysis of human pancreatic intraepithelial neoplasia (PanIN) reveals striking multifocality and genetic heterogeneity
Journal Articles

Abstract IA-003: Proteogenomic characterizations of pancreatic ductal adenocarcinoma

Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Alexey I. Nesvizhskii, D.R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana I. Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang, Clinical Proteomic Tumor Analysis Consortium
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): IA-003.
https://doi.org/10.1158/1538-7445.PANCA21-IA-003
Published: 15 November 2021
View article titled, Abstract IA-003: Proteogenomic characterizations of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 2404: Increased mitochondrial DNA copy number occurs during prostate cancer progression and in cancer precursor lesions across multiple organs

Jiayu Chen, Qizhi Zheng, Jessica L. Hicks, Levent Trabzonlu, Emmanuel S. Antonarakis, Mark C. Markowski, Samuel R. Denmeade, Busra Ozbek, Anuj Gupta, Tatianna C. Larman, Ralph H. Hruban, Sarah Wheelan, Srinivasan Yegnasubramanian, Angelo M. De Marzo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2404.
https://doi.org/10.1158/1538-7445.AM2021-2404
Published: 01 July 2021
View article titled, Abstract 2404: Increased mitochondrial DNA copy number occurs during prostate cancer progression and in cancer precursor lesions across multiple organs
Journal Articles

Abstract 17: Proteogenomic characterization of pancreatic ductal adenocarcinoma

Liwei Cao, Chen Huang, Daniel Cui Zhou, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang, Clinical Proteomic Tumor Analysis Consortium Investigators
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 17.
https://doi.org/10.1158/1538-7445.AM2021-17
Published: 01 July 2021
View article titled, Abstract 17: Proteogenomic characterization of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 127: The genomic landscapes of inflammatory bowel disease-associated colorectal cancers

Ana I. Robles, Giovanni Traverso, Ming Zhang, Nicholas Roberts, Mohammed A. Khan, Christine Joseph, Gregory Lauwers, Florin Selaru, Maria Popoli, Xiquan Ke, Ralph H. Hruban, Stephen J. Meltzer, Kenneth W. Kinzler, Bert Vogelstein, Curtis C. Harris, Nickolas Papadopoulos
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 127.
https://doi.org/10.1158/1538-7445.AM2016-127
Published: 15 July 2016
View article titled, Abstract 127: The genomic landscapes of inflammatory bowel disease-associated colorectal cancers
Journal Articles

Abstract 3935: CDKN2A/p16 is inactivated by the combination of inversion and translocation

Alexis L. Norris, Hirohiko Kamiyama, Ralph H. Hruban, James R. Eshleman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3935.
https://doi.org/10.1158/1538-7445.AM2015-3935
Published: 01 August 2015
View article titled, Abstract 3935: CDKN2A/p16 is inactivated by the combination of inversion and translocation
Journal Articles

Abstract IA5: Translating genetic discoveries to patient care

Ralph H. Hruban
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): IA5.
https://doi.org/10.1158/1538-7445.PANCA2014-IA5
Published: 30 June 2015
View article titled, Abstract IA5: Translating genetic discoveries to patient care
Journal Articles

The Early Detection of Pancreatic Cancer: What Will It Take to Diagnose and Treat Curable Pancreatic Neoplasia?

Anne Marie Lennon, Christopher L. Wolfgang, Marcia Irene Canto, Alison P. Klein, Joseph M. Herman, Michael Goggins, Elliot K. Fishman, Ihab Kamel, Matthew J. Weiss, Luis A. Diaz, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Ralph H. Hruban
Journal: Cancer Research
Cancer Res (2014) 74 (13): 3381–3389.
https://doi.org/10.1158/0008-5472.CAN-14-0734
Published: 30 June 2014
View article titled, The Early Detection of Pancreatic Cancer: What Will It Take to Diagnose and Treat Curable Pancreatic Neoplasia?
Open the PDF for The Early Detection of Pancreatic Cancer: What Will It Take to Diagnose and Treat Curable Pancreatic Neoplasia? in another window
Journal Articles

TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine

Isaac Kinde, Enrico Munari, Sheila F. Faraj, Ralph H. Hruban, Mark Schoenberg, Trinity Bivalacqua, Mohamad Allaf, Simeon Springer, Yuxuan Wang, Luis A. Diaz, Jr., Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos, George J. Netto
Journal: Cancer Research
Cancer Res (2013) 73 (24): 7162–7167.
https://doi.org/10.1158/0008-5472.CAN-13-2498
Published: 16 December 2013
View article titled, <em>TERT</em> Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine
Open the PDF for <em>TERT</em> Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine in another window
Includes: Supplementary data
Journal Articles

Abstract 2735: Inactivation of activin signaling pathway accelerates the development of pancreatic intraductal papillary mucinous neoplasms in vivo.

Wanglong Qiu, Sophia Tang, Sohyae Lee, Andrew T. Turk, Anthony Sireci, Anne Qiu, Ralph H. Hruban, Helen E. Remotti, Gloria H. Su
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2735.
https://doi.org/10.1158/1538-7445.AM2013-2735
Published: 15 April 2013
View article titled, Abstract 2735: Inactivation of activin signaling pathway accelerates the development of pancreatic intraductal papillary mucinous neoplasms in vivo.
Journal Articles

Abstract 2628: Genome-wide sequencing identifies ATM as a pancreatic cancer susceptibility gene

Nicholas J. Roberts, Yuchen Jiao, Jun Yu, Levy Kopelovich, Gloria M. Petersen, Melissa Bondy, Steven Gallinger, Ann G. Schwartz, Sapna Syngal, Michele L. Cote, Jennifer Axilbund, Richard Schulick, Syed Z. Ali, James R. Eshleman, Victor Velculescu, Michael Goggins, Bert Vogelstein, Nikolas Papadopoulous, Ralph H. Hruban, Kenneth W. Kinzler, Alison P. Klein
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2628.
https://doi.org/10.1158/1538-7445.AM2012-2628
Published: 15 April 2012
View article titled, Abstract 2628: Genome-wide sequencing identifies <em>ATM</em> as a pancreatic cancer susceptibility gene
Journal Articles

Abstract LB-191: Loss of the wild-type Kras allele enhances the cellular proliferation and metastasis of pancreatic ductal adenocarcinomas in a conditional P16 and Kras mutant mouse model

Wanglong Qiu, Fikret Sahin, Christine A. Iacobuzio-Donahue, Dario Garcia-Carracedo, Wendy M. Wang, Dan E. Arking, Andrew M. Lowy, Ralph H. Hruban, Helen E. Remotti, Gloria H. Su
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-191.
https://doi.org/10.1158/1538-7445.AM10-LB-191
Published: 15 April 2010
View article titled, Abstract LB-191: Loss of the wild-type <em>Kras</em> allele enhances the cellular proliferation and metastasis of pancreatic ductal adenocarcinomas in a conditional <em>P16</em> and <em>Kras mutant</em> mouse model
Journal Articles

Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer

Amanda Blackford, Giovanni Parmigiani, Thomas W. Kensler, Christopher Wolfgang, Siân Jones, Xiaosong Zhang, D. Willams Parsons, Jimmy Cheng-Ho Lin, Rebecca J. Leary, James R. Eshleman, Michael Goggins, Elizabeth M. Jaffee, Christine A. Iacobuzio-Donahue, Anirban Maitra, Alison Klein, John L. Cameron, Kelly Olino, Richard Schulick, Jordan Winter, Bert Vogelstein, Victor E. Velculescu, Kenneth W. Kinzler, Ralph H. Hruban
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3681–3688.
https://doi.org/10.1158/0008-5472.CAN-09-0015
Published: 15 April 2009
View article titled, Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer
Open the PDF for Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays

Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (16): 7920–7928.
https://doi.org/10.1158/0008-5472.CAN-06-0721
Published: 15 August 2006
View article titled, Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays
Open the PDF for Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays in another window
Includes: Supplementary data