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Rajarshi Guha
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Journal Articles

Abstract B018: A high-throughput screen identifies HSP90 inhibitors as potent therapeutics across multiple clinically representative organoid models of advanced prostate cancer

Keith H. Jansson, John B. Tucker, Lauren E. Stahl, John K. Simmons, Caitlyn Fuller, Michael L. Beshiri, Supreet Agarwal, Yasmine Abbey, Lei Fang, Paul G. Hynes, Alilin Aian Neil, Jacob Cawley, Ross Lake, Crystal Tran, Caitlin M. Tice, JuanJuan Yin, Xiahu Zhang, Rajarshi Guha, Shelley Hoover, R. Mark Simpson, Holly Nguyen, Eva Corey, Craig J. Thomas, David Proia, Kathleen Kelly
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B018.
https://doi.org/10.1158/1538-7445.PRCA2017-B018
Published: 14 August 2018
View article titled, Abstract B018: A high-throughput screen identifies HSP90 inhibitors as potent therapeutics across multiple clinically representative organoid models of advanced prostate cancer
Journal Articles

Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein

Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Min Shen, Lu Chen, Rajarshi Guha, Bethelihem Tebase, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-066.
https://doi.org/10.1158/1538-7445.AM2018-LB-066
Published: 01 July 2018
View article titled, Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein
Journal Articles

Abstract 1629: Targeting resistance mechanisms to CDK4/6 inhibitors in Ewing sarcoma with an IGF1R inhibitor drug combination strategy

Lillian M. Guenther, Neekesh V. Dharia, Linda Ross, Amy S. Conway, Amanda L. Robichaud, Alanna J. Church, Rajarshi Guha, Mindy I. Davis, Gabriela Alexe, Jaume Mora, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1629.
https://doi.org/10.1158/1538-7445.AM2018-1629
Published: 01 July 2018
View article titled, Abstract 1629: Targeting resistance mechanisms to CDK4/6 inhibitors in Ewing sarcoma with an IGF1R inhibitor drug combination strategy
Journal Articles

Abstract 1169: Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutics

Darmood Wei, Youfeng Yang, Christopher J. Ricketts, Cathy D. Vocke, Mark W. Ball, Carole Sourbier, Darawalee Wangsa, Danny Wangsa, Rajarshi Guha, Xiaohu Zhang, Paul Meltzer, Thomas Reid, Craig J. Thomas, Maria J. Merino, W. Marston Linehan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1169.
https://doi.org/10.1158/1538-7445.AM2018-1169
Published: 01 July 2018
View article titled, Abstract 1169: Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutics
Journal Articles

Abstract 1930: Evaluating the effect of PARP inhibitors in combination with nicotinamide phosphoribosyltransferase inhibitors in Ewing sarcoma

Joshua T. Baumgart, Christine Heske, Mindy I. Davis, Kelli Wilson, Xiaoha Zhang, Rajarshi Guha, Marc Ferrer, Arnulfo Mendoza, Craig J. Thomas, Lee J. Helman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1930.
https://doi.org/10.1158/1538-7445.AM2017-1930
Published: 01 July 2017
View article titled, Abstract 1930: Evaluating the effect of PARP inhibitors in combination with nicotinamide phosphoribosyltransferase inhibitors in Ewing sarcoma
Journal Articles

Abstract 1943: High-throughput chemical screening identifies Focal Adhesion Kinase and Aurora Kinase B inhibition as a synergistic treatment combination in Ewing sarcoma

Brian Crompton, Sarah Wang, Elizabeth Hwang, Rajarshi Guha, Matthew Boxer, Crystal McKnight, Min Shen, Nicole Melong, Chansey Veinotte, Amy Conway, Jason Berman, Matthew Hall, Mindy Davis, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1943.
https://doi.org/10.1158/1538-7445.AM2017-1943
Published: 01 July 2017
View article titled, Abstract 1943: High-throughput chemical screening identifies Focal Adhesion Kinase and Aurora Kinase B inhibition as a synergistic treatment combination in Ewing sarcoma
Journal Articles

Abstract 3065: High-throughput screen identifies HSP90 as a potential therapeutic target in models of advanced CRPC

Keith H. Jansson, John Tucker, Lauren Stahl, Caitlyn Fuller, Michael Beshiri, John K. Simmons, Supreet Agarwal, Lei Fang, Aian Neil Alilin, Ross Lake, Crystal Tran, Paul G. Hynes, Jacob Cawley, JuanJuan Yin, Xiaohu Zhang, Rajarshi Guha, Shelley Hoover, R. Mark Simpson, Holly Nguyen, Eva Corey, Craig Thomas, David Proia, Kathleen Kelly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3065.
https://doi.org/10.1158/1538-7445.AM2017-3065
Published: 01 July 2017
View article titled, Abstract 3065: High-throughput screen identifies HSP90 as a potential therapeutic target in models of advanced CRPC
Journal Articles

Abstract B36: Preclinical development of a multikinase targeting molecule with activity against the cancer stem cell phenotype in pancreatic adenocarcinoma

Taylor Aiken, Yansong Bian, Yaroslav Teper, Lesley Mathews Griner, Rajarshi Guha, Paul Shinn, Hong-Wu Xin, Holger Pflicke, Jian-kang Jiang, Paresma Patel, Steven Rogers, Jeffery Aube, Marc Ferrer, Craig J. Thomas, Udo Rudloff
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B36.
https://doi.org/10.1158/1538-7445.PANCA16-B36
Published: 14 December 2016
View article titled, Abstract B36: Preclinical development of a multikinase targeting molecule with activity against the cancer stem cell phenotype in pancreatic adenocarcinoma
Journal Articles

Abstract 278: No cell left behind: Residual ovarian spheroids drive recurrence and are sensitive to the pro-oxidant elesclomol

Ian S. Goldlust, Kelli Wilson, Ludmila Szabova, Xiaohu Zhang, Lesley Mathews-Griner, Maria Vias, Anna Piskorz, Rory Stark, Lee Mendil, Monica Kasbekar, John Braisted, Rajarshi Guha, Crystal McKnight, Paul Shinn, Donna Michelle-Smith, Zoe Weaver Ohler, Mindy Davis, Udo Rudloff, Sam Michael, Madhu Lal-Nag, Scott Martin, Christina Annunziata, Marc Ferrer, James D. Brenton, Craig Thomas
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 278.
https://doi.org/10.1158/1538-7445.AM2016-278
Published: 15 July 2016
View article titled, Abstract 278: No cell left behind: Residual ovarian spheroids drive recurrence and are sensitive to the pro-oxidant elesclomol
Journal Articles

Abstract 1352: High-throughput matrix screening reveals synergistic chemotherapeutic combinations with blockade of CD47 to enhance cytotoxicity in breast cancer

David D. Roberts, Ashley Smith, John M. Sipes, Adam Wilson, Lesley Mathews-Griner, Rajarshi Guha, Craig J. Thomas, Marc Ferrer, David R. Soto-Pantoja
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1352.
https://doi.org/10.1158/1538-7445.AM2016-1352
Published: 15 July 2016
View article titled, Abstract 1352: High-throughput matrix screening reveals synergistic chemotherapeutic combinations with blockade of CD47 to enhance cytotoxicity in breast cancer
Journal Articles

Abstract 3758: Quantitative high-throughput screening as a tool to identify novel therapies in bladder cancer: lessons from flavopiridol

Reema Railkar, Achuth Nair, Keidren Lewi, Spencer Krane, Rajarshi Guha, Marc Ferrer, Craig Thomas, Piyush K. Agarwal
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3758.
https://doi.org/10.1158/1538-7445.AM2016-3758
Published: 15 July 2016
View article titled, Abstract 3758: Quantitative high-throughput screening as a tool to identify novel therapies in bladder cancer: lessons from flavopiridol
Journal Articles

Abstract LB-281: Elucidating potential therapeutic targets in a model of Pten/Tp53 null prostate cancer using high-throughput screening technology

Keith H. Jansson, John K. Simmons, Caitlyn Fuller, Supreet Agarwal, Paul G. Hynes, Lei Fang, Ross Lake, Jacob Cawley, Lauren Stahl, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Kathleen Kelly
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-281.
https://doi.org/10.1158/1538-7445.AM2016-LB-281
Published: 15 July 2016
View article titled, Abstract LB-281: Elucidating potential therapeutic targets in a model of Pten/Tp53 null prostate cancer using high-throughput screening technology
Journal Articles

Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma

Dominik Bogen, Jun S. Wei, David O. Azorsa, Pinar Ormanoglu, Eugen Buehler, Rajarshi Guha, Jonathan M. Keller, Lesley A. Mathews Griner, Marc Ferrer, Young K. Song, Hongling Liao, Arnulfo Mendoza, Berkley E. Gryder, Sivasish Sindri, Jianbin He, Xinyu Wen, Xinyu Wen, Shile Zhang, John F. Shern, Marielle E. Yohe, Sabine Taschner-Mandl, Jason Shohet, Craig J. Thomas, Scott E. Martin, Peter F. Ambros, Javed Khan
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B31.
https://doi.org/10.1158/1538-7445.PEDCA15-B31
Published: 04 April 2016
View article titled, Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma
Journal Articles

Abstract PR16: Targeting the chromatin architecture established by PAX3-FOXO1 in rhabdomyosarcoma

Berkley E. Gryder, Marielle E. Yohe, Jack Shern, Hsien-Chao Chou, Young Song, Rajesh Patidar, Sam Li, Sivasish Sindiri, Abigail Cleveland, Hongling Liao, Xinyu Wen, Xiaohu Zhang, Lesley Mathews-Griner, Rajarshi Guha, Paul Shinn, Marc Ferrer, Scott Martin, Madhu Lal, Craig Thomas, Javed Khan
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): PR16.
https://doi.org/10.1158/1538-7445.PEDCA15-PR16
Published: 04 April 2016
View article titled, Abstract PR16: Targeting the chromatin architecture established by PAX3-FOXO1 in rhabdomyosarcoma
Journal Articles

Abstract LB-254: High-throughput drug matrix screen with SMAC (second mitochondria-derived activator of caspases)-mimetic birinapant in high-grade serous ovarian cancer cell lines identifies synergism

Kristen Bunch, Ian Goldlust, Craig Thomas, Lidia Hernandez, Rajarshi Guha, Christina Annunziata
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-254.
https://doi.org/10.1158/1538-7445.AM2015-LB-254
Published: 01 August 2015
View article titled, Abstract LB-254: High-throughput drug matrix screen with SMAC (second mitochondria-derived activator of caspases)-mimetic birinapant in high-grade serous ovarian cancer cell lines identifies synergism
Journal Articles

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas D. Pfister, Philip M. Reaper, Christopher S. Barnes, Julie Jones, Peter Charlton, John R. Pollard, Joel Morris, James H. Doroshow, Yves Pommier
Journal: Cancer Research
Cancer Res (2014) 74 (23): 6968–6979.
https://doi.org/10.1158/0008-5472.CAN-13-3369
Published: 30 November 2014
View article titled, ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Open the PDF for ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses in another window
Includes: Supplementary data
Journal Articles

Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies

Antonella Antignani, Matteo Pasetto, Chris Choo, Evan Angelus, Lesley Mathews, Rajarshi Guha, Paul Shinn, Marc Ferrer, Craig J. Thomas, Ira Pastan, David J. Fitzgerald
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2907.
https://doi.org/10.1158/1538-7445.AM2014-2907
Published: 01 October 2014
View article titled, Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies
Journal Articles

Abstract 794: The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation

Rozenn Jossé, Scott E. Martin, Rajarshi Guha, Pinar Ormanoglu, Thomas Pfister, Joel Morris, James H. Doroshow, Yves Pommier
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 794.
https://doi.org/10.1158/1538-7445.AM2014-794
Published: 01 October 2014
View article titled, Abstract 794: The ATR inhibitor VE-821 in combination with the novel topoisomerase I inhibitor LMP-400 selectively kills cancer cells by disabling DNA replication initiation and fork elongation
Journal Articles

Abstract 4543: High-throughput combination screening identifies novel drug-drug pairings for a Bruton's tyrosine kinase inhibitor against the ABC subtype of diffuse large B-cell lymphomas.

Lesley A. Mathews, Rajarshi Guha, Paul Shinn, Ryan M. Young, Kian-Huat Lim, Jonathan Keller, Dongbo Liu, Adam Yasgar, Crystal McKnight, Matthew B. Boxer, Damien Y. Duveau, Jian-kang Jiang, Sam Michael, Bryan T. Mott, Paresma R. Patel, William Leister, David J. Maloney, Christopher A. LeClair, Ganesha Rai, Ajit Jadhav, Brian D. Peyser, Christopher P. Austin, Scott Martin, Anton Simeonov, Marc Ferrer, Louis Staudt, Craig J. Thomas
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4543.
https://doi.org/10.1158/1538-7445.AM2013-4543
Published: 15 April 2013
View article titled, Abstract 4543: High-throughput combination screening identifies novel drug-drug pairings for a Bruton's tyrosine kinase inhibitor against the ABC subtype of diffuse large B-cell lymphomas.
Journal Articles

Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family

Lynn M. Pouliot, Yu-Chi Chen, Jennifer Bai, Rajarshi Guha, Scott E. Martin, Michael M. Gottesman, Matthew D. Hall
Journal: Cancer Research
Cancer Res (2012) 72 (22): 5945–5955.
https://doi.org/10.1158/0008-5472.CAN-12-1400
Published: 14 November 2012
View article titled, Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family
Open the PDF for Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family in another window
Includes: Supplementary data