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Journal Articles

Abstract 6594: 4-1BB: A double-edged sword for T cells

Liping Yang, Timothy P. Sheets, Yang Feng, Kuo-Sheng Hsu, Guojun Yu, Steven Seaman, Pradip Bajgain, Daeho So, Jaewon Lee, Raj Chari, Brad St. Croix
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6594.
https://doi.org/10.1158/1538-7445.AM2024-6594
Published: 22 March 2024
View article titled, Abstract 6594: 4-1BB: A double-edged sword for T cells
Journal Articles

Abstract 1089: Endogenous HiBiT-tagging of PAX3-FOXO1 reveals downregulation of the fusion oncogene by CDK inhibitors and has synergy with vincristine

Yong Yean Kim, Katrina Jia, Mehal Churiwal, Teresa Hawley, Silvia Pomella, Christine Evans, Raj Chari, David Milewski, Ranuka Sinniah, Young Song, Hsien-Chao Chou, Xinyu Wen, Craig Thomas, Michele Ceribelli, Jun Wei, Robert Hawley, Javed Khan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1089.
https://doi.org/10.1158/1538-7445.AM2024-1089
Published: 22 March 2024
View article titled, Abstract 1089: Endogenous HiBiT-tagging of PAX3-FOXO1 reveals downregulation of the fusion oncogene by CDK inhibitors and has synergy with vincristine
Journal Articles

Abstract 1644: Exploring the role of a TERT intronic tandem repeat in regulating cell proliferative responses to environmental factors and cancer risk

Michelle Ho, Oscar Florez-Vargas, Maxwell Hogshead, Brenen Papenberg, Chia Han Lee, Chi Zhang, Kaitlin Forsythe, Wusheng Yan, Raj Chari, Ludmila Prokunina-Olsson
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1644.
https://doi.org/10.1158/1538-7445.AM2024-1644
Published: 22 March 2024
View article titled, Abstract 1644: Exploring the role of a <em>TERT</em> intronic tandem repeat in regulating cell proliferative responses to environmental factors and cancer risk
Journal Articles

Abstract IA016: Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms

Raphael Pavani, Veenu Tripathi, Dali Zong, Elsa Callen, Ajith Pankajam, Andre Nussenzweig, Wei Wu, Kyle Vrtis, Raj Chari, Johannes C Walter
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): IA016.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-IA016
Published: 09 January 2024
View article titled, Abstract IA016: Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms
Journal Articles

Abstract 3538: Endogenous HiBiT-tagging of PAX3-FOXO1 identifies potent suppressors of PAX3-FOXO1 protein levels by high-throughput screening

Yong Yean Kim, Robert G. Hawley, Mehal Churiwal, Teresa S. Hawley, Christine N. Evans, Raj Chari, David Milewski, Ranuka Sinniah, Young K. Song, Hsien-Chao Chou, Xinyu Wen, Ying Pang, Jing Wu, Craig J. Thomas, Jun S. Wei, Michele Ceribelli, Javed Khan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3538.
https://doi.org/10.1158/1538-7445.AM2023-3538
Published: 04 April 2023
View article titled, Abstract 3538: Endogenous HiBiT-tagging of PAX3-FOXO1 identifies potent suppressors of PAX3-FOXO1 protein levels by high-throughput screening
Journal Articles

Abstract 1469: Visualization of endogenous EWSR1 in Ewing sarcoma cells reveals a regular nucleoplasmic organization that includes concentration at regions of active transcription

Soumya Sundara Rajan, Vernon Ebegboni, Tamara L. Jones, Patrick Pichling, Katelyn R. Ludwig, Raj Chari, Michael Kruhlak, Jadranka Loncarek, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1469.
https://doi.org/10.1158/1538-7445.AM2023-1469
Published: 04 April 2023
View article titled, Abstract 1469: Visualization of endogenous EWSR1 in Ewing sarcoma cells reveals a regular nucleoplasmic organization that includes concentration at regions of active transcription
Journal Articles

Abstract 5239: Integrative analysis of 3D chromatin organization at GWAS loci identifies RAPGEF1 as a melanoma susceptibility gene

Rohit Thakur, Mai Xu, Alexandra Thornock, Hayley Sowards, Epring Long, Thomas Rheling, Karen Funderburk, Jinhu Yin, Rebecca Hennessey, Raj Chari, Tongwu Zhang, Lea Jessop, Timothy Myers, Matthew E. Johnson, Andrew D. Wells, Alessandra Chesi, Struan F. Grant, Mark I. Iles, Maria T. Landi, Matthew Law, Melanoma Meta-Analysis Consortium, Mitchell Machiela, Jiyeon Choi, Leonard I. Zon, Kevin M. Brown
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5239.
https://doi.org/10.1158/1538-7445.AM2023-5239
Published: 04 April 2023
View article titled, Abstract 5239: Integrative analysis of 3D chromatin organization at GWAS loci identifies <em>RAPGEF1</em> as a melanoma susceptibility gene
Journal Articles

Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

Poonam Tewary, Alan D. Brooks, Ya-Ming Xu, E.M. Kithsiri Wijeratne, Ashley L. Babyak, Timothy C. Back, Raj Chari, Christine N. Evans, Curtis J. Henrich, Thomas J. Meyer, Elijah F. Edmondson, Maria T. Prudente de Aquino, Thanigaivelan Kanagasabai, Anil Shanker, A.A. Leslie Gunatilaka, Thomas J. Sayers
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3374–3386.
https://doi.org/10.1158/0008-5472.CAN-20-2634
Published: 15 June 2021
View article titled, Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins
Open the PDF for Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins in another window
Includes: Supplementary data
Journal Articles

Abstract 4794: Mitochondrial matrix protease ClpP agonists inhibit cell growth and cancer stem cell function in breast cancer cells

Yoshimi E. Greer, Lidia Hernandez, Voeller Donna, Raj Chari, Sam Gilbert, Binwu Tang, Christina Annunziata, Lalage Wakefield, Edwin Iwanowicz, Lee M. Graves, Stanley Lipkowitz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4794.
https://doi.org/10.1158/1538-7445.AM2020-4794
Published: 15 August 2020
View article titled, Abstract 4794: Mitochondrial matrix protease ClpP agonists inhibit cell growth and cancer stem cell function in breast cancer cells
Journal Articles

YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway

Larissa A. Pikor, William W. Lockwood, Kelsie L. Thu, Emily A. Vucic, Raj Chari, Adi F. Gazdar, Stephen Lam, Wan L. Lam
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (24): 7301–7312.
https://doi.org/10.1158/0008-5472.CAN-13-1897
Published: 16 December 2013
View article titled, YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway
Open the PDF for YEATS4 Is a Novel Oncogene Amplified in Non–Small Cell Lung Cancer That Regulates the p53 Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract LB-346: A novel lung tumor suppressor implicated in somatic and familial cancers

Ian M. Wilson, Katey S. S. Enfield, Emily A. Vucic, Raj Chari, Yu-An Zhang, Ming You, Calum MacAulay, Stephen Lam, Adi Gazdar, Wan L. Lam
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-346.
https://doi.org/10.1158/1538-7445.AM10-LB-346
Published: 15 April 2010
View article titled, Abstract LB-346: A novel lung tumor suppressor implicated in somatic and familial cancers
Journal Articles

Abstract 1133: Inactivation of BRG1 in non-small cell lung cancer (NSCLC) cell lines

Wei Zhang, Ilse Valencia, Jingsheng Yan, Raj Chari, Luc Girard, Junichi Soh, Kit Tam, Yang Xie, Wan Lam, John Minna, Adi Gazdar
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1133.
https://doi.org/10.1158/1538-7445.AM10-1133
Published: 15 April 2010
View article titled, Abstract 1133: Inactivation of BRG1 in non-small cell lung cancer (NSCLC) cell lines
Journal Articles

A multi-dimensional approach to delineate mechanisms of multidrug resistance in ovarian carcinoma

Emily Vucic, Timon Buys, Raj Chari, Carolyn Brown, Calum MacAulay, Wan Lam
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 39.
Published: 01 May 2008
View article titled, A multi-dimensional approach to delineate mechanisms of multidrug resistance in ovarian carcinoma
Journal Articles

DNA amplification is a common mechanism of oncogene activation in lung cancer

William Lockwood, Jennifer Kennett, Raj Chari, Bradley Coe, Luc Girard, Calum MacAulay, Stephen Lam, Adi Gazdar, John Minna, Wan Lam
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1719.
Published: 01 May 2008
View article titled, DNA amplification is a common mechanism of oncogene activation in lung cancer
Journal Articles

Global DNA methylation and histone H3K9 modifications profiles of the human HCC15 cancer genome

Alice Kuo, Ian Wilson, Bradley Coe, Raj Chari, Wan Lam
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 38.
Published: 01 May 2008
View article titled, Global DNA methylation and histone H3K9 modifications profiles of the human HCC15 cancer genome
Journal Articles

Deciphering the role of gene dosage in lung adenocarcinoma expression networks.

Bradley Coe, Raj Chari, Raymond Ng, Calum MacAulay, Stephen Lam, Wan Lam
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2959.
Published: 01 May 2007
View article titled, Deciphering the role of gene dosage in lung adenocarcinoma expression networks.
Journal Articles

Integrative genomic and gene expression signatures for defining tailored therapeutic targets in lung cancer subtypes

William Lockwood, Raj Chari, Bradley Coe, Timon Buys, Calum MacAulay, Stephen Lam, Wan Lam
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2942.
Published: 01 May 2007
View article titled, Integrative genomic and gene expression signatures for defining tailored therapeutic targets in lung cancer subtypes
Journal Articles

Comprehensive serial analysis of gene expression of the cervical epithelium transcriptome

Ashleen Shadeo, Raj Chari, Calum MacAulay, Wan L Lam
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3715.
Published: 01 May 2007
View article titled, Comprehensive serial analysis of gene expression of the cervical epithelium transcriptome
Journal Articles

Normal large-scale variation in genomic DNA methylation patterns

Jonathan Davies, Ian Wilson, Bradley Coe, Raj Chari, Calum MacAulay, Carolyn Brown, Wan Lam
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4150.
Published: 01 May 2007
View article titled, Normal large-scale variation in genomic DNA methylation patterns
Journal Articles

Array CGH coupled with expression profiling identifies disruption of different pathways between small and non-small cell lung carcinoma cell lines

Bradley P. Coe, William W. Lockwood, Luc Girard, Raj Chari, Calum Macaulay, Stephen Lam, Adi F. Gazdar, John D. Minna, Wan L. Lam
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 38.
Published: 15 April 2006
View article titled, Array CGH coupled with expression profiling identifies disruption of different pathways between small and non-small cell lung carcinoma cell lines