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Journal Articles

Abstract CT265: KRAS^G12Dtargeting using engineered exosomes in pancreatic cancer: Results from the iEXPLORE phase 1 trial

Valerie S. LeBleu, Brandon Smaglo, Krishnan Mahadevan, Michelle Kirtley, Kathleen M. McAndrews, Mayela Mendt, Sujuan Yang, Shubam Pant, Elizabeth Shpall, Anirban Maitra, Raghu Kalluri

Cancer Res (2025) 85 (8_Supplement_2): CT265.

https://doi.org/10.1158/1538-7445.AM2025-CT265

Published: 25 April 2025

View articletitled, Abstract CT265: KRASG12Dtargeting using engineered exosomes in pancreatic cancer: Results from the iEXPLORE phase 1 trial

Journal Articles

Abstract B064: Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

Krishnan K Mahadevan, Allison M. Dyevoich, Yang Chen, Bingrui Li, Hikaru Sugimoto, Amari Sockwell, Kathleen McAndrews, Huamin Wang, Shabnam Shalapour, Stephanie Watowich, Raghu Kalluri

Cancer Res (2024) 84 (17_Supplement_2): B064.

https://doi.org/10.1158/1538-7445.PANCREATIC24-B064

Published: 15 September 2024

View articletitled, Abstract B064: Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

Journal Articles

Abstract B092: CDK8 and CXCL2 remodel the tumor microenvironment to contribute to KRAS^G12D small molecule inhibition resistance in pancreatic ductal adenocarcinoma

Cancer Res (2024) 84 (2_Supplement): B092.

https://doi.org/10.1158/1538-7445.PANCA2023-B092

Published: 16 January 2024

View articletitled, Abstract B092: CDK8 and CXCL2 remodel the tumor microenvironment to contribute to KRASG12D small molecule inhibition resistance in pancreatic ductal adenocarcinoma

Journal Articles

Abstract C084: iExplore: A phase I study of mesenchymal stem cell derived exosomes with Kras^G12D siRNA for metastatic pancreas cancer patients harboring the Kras^G12D mutation

Cancer Res (2024) 84 (2_Supplement): C084.

https://doi.org/10.1158/1538-7445.PANCA2023-C084

Published: 16 January 2024

View articletitled, Abstract C084: iExplore: A phase I study of mesenchymal stem cell derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring the KrasG12D mutation

Journal Articles

Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8⁺ T cells

Valerie S. LeBleu, Krishnan K. Mahadevan, Elena V. Ramirez, Yang Chen, Bingrui Li, Amari M. Sockwell, Mihai Gagea, Hikaru Sugimoto, Desiree Tampe, Michael Zeisberg, Haoqiang Ying, Abhinav K. Jain, Ronald A. DePinho, Aniban Maitra, Kathleen M. McAndrews, Raghu Kalluri

Cancer Res (2024) 84 (2_Supplement): B082.

https://doi.org/10.1158/1538-7445.PANCA2023-B082

Published: 16 January 2024

View articletitled, Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells

Journal Articles

Abstract 1073: PRMT5 inhibition synergizes with a natural small molecule compound to kill MTAP-deleted cells and suppress tumor growth

Yasaman Barekatain, Kyle LaBella, Hikaru Sugimoto, Kristen Harris, Sunada Khadka, Florian Muller, Raghu Kalluri

Cancer Res (2023) 83 (7_Supplement): 1073.

https://doi.org/10.1158/1538-7445.AM2023-1073

Published: 04 April 2023

View articletitled, Abstract 1073: PRMT5 inhibition synergizes with a natural small molecule compound to kill MTAP-deleted cells and suppress tumor growth

Journal Articles

Abstract 2395: Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

Yasaman Barekatain, Jeffrey Ackroyd, Victoria Yan, Sunada Khadka, Ko-Chien Chen, Raghu Kalluri, John de Groot, Jason Huse, Florian muller

Cancer Res (2022) 82 (12_Supplement): 2395.

https://doi.org/10.1158/1538-7445.AM2022-2395

Published: 15 June 2022

View articletitled, Abstract 2395: Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

Journal Articles

Abstract PO-059: Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis

Julienne L. Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M. McAndrews, Arvind Rao, Jared K. Burks, Andrew D. Rhim, Raghu Kalluri

Cancer Res (2021) 81 (22_Supplement): PO-059.

https://doi.org/10.1158/1538-7445.PANCA21-PO-059

Published: 15 November 2021

View articletitled, Abstract PO-059: Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis

Journal Articles

Abstract 2010: Pancreatic cancer stem cell exosomes drive a hierarchical intratumor communication network that fuels disease progression through hippo pathway inhibition

Carolina F. Ruivo, Nuno Bastos, Ines Batista, Barbara Adem, Cecilia Duraes, Carlos A. Melo, Francisco J. Campos‐Laborie, Pedro Moutinho-Ribeiro, Barbara Mourão, Marília Cravo, Guilherme Macedo, Fátima Carneiro, Tony Kouzarides, Raghu Kalluri, Jose C. Machado, Sonia Melo

Cancer Res (2021) 81 (13_Supplement): 2010.

https://doi.org/10.1158/1538-7445.AM2021-2010

Published: 01 July 2021

View articletitled, Abstract 2010: Pancreatic cancer stem cell exosomes drive a hierarchical intratumor communication network that fuels disease progression through hippo pathway inhibition

Journal Articles

Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells

Xunian Zhou, Fei Xiao, Hikaru Sugimoto, Bingrui Li, Kathleen M. McAndrews, Raghu Kalluri

Cancer Res (2021) 81 (10): 2690–2702.

https://doi.org/10.1158/0008-5472.CAN-20-2930

Published: 15 May 2021

View articletitled, Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells

Includes: Supplementary data

Journal Articles

Abstract PR08: Intratumoral T-cell distribution in murine and patient pancreatic cancer correlates with tissue heterogeneity and survival

Julienne L. Carstens, Pedro Correa de Sampaio, Soutik Barua, Huamin Wang, Jared K. Burks, Arvind Rao, Valerie S. LeBleu, Raghu Kalluri

Cancer Res (2019) 79 (24_Supplement): PR08.

https://doi.org/10.1158/1538-7445.PANCA19-PR08

Published: 13 December 2019

View articletitled, Abstract PR08: Intratumoral T-cell distribution in murine and patient pancreatic cancer correlates with tissue heterogeneity and survival

Journal Articles

Nischarin Regulates Secretion of Exosomes and Cancer Progression

Kathleen M. McAndrews, Raghu Kalluri

Cancer Res (2019) 79 (9): 2099–2101.

https://doi.org/10.1158/0008-5472.CAN-19-0387

Published: 01 May 2019

View articletitled, Nischarin Regulates Secretion of Exosomes and Cancer Progression

Journal Articles

Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587

Javier Figueroa, Lynette M. Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J. Bean, George A. Calin, Juan Fueyo, Edgar T. Walters, Raghu Kalluri, Roel G. Verhaak, Frederick F. Lang

Cancer Res (2017) 77 (21): 5808–5819.

https://doi.org/10.1158/0008-5472.CAN-16-2524

Published: 31 October 2017

View articletitled, Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587

Includes: Supplementary data

Journal Articles

Abstract IA15: Functional diversity of the pancreas tumor stroma

Cancer Res (2016) 76 (3_Supplement): IA15.

https://doi.org/10.1158/1538-7445.FBCR15-IA15

Published: 07 April 2016

View articletitled, Abstract IA15: Functional diversity of the pancreas tumor stroma

Journal Articles

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24⁺ Progenitor Cells

Jing Zhang, Jingjing Jiao, Silvia Cermelli, Kyle Muir, Kwang Hwa Jung, Ruhai Zou, Asif Rashid, Mihai Gagea, Sonya Zabludoff, Raghu Kalluri, Laura Beretta

Cancer Res (2015) 75 (9): 1859–1867.

https://doi.org/10.1158/0008-5472.CAN-14-1254

Published: 30 April 2015

View articletitled, miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells

Includes: Supplementary data

Journal Articles

Abstract B22: Oncogene activation of K‐ras in resident myofibroblasts leads to development of spontaneous bronchioalveolar carcinoma in mice

Sylvia Vong, Hikaru Sugimoto, Yingqi Teng, Liang Xie, Rajan Dewar, Raghu Kalluri

Cancer Res (2009) 69 (23_Supplement): B22.

https://doi.org/10.1158/0008-5472.FBCR09-B22

Published: 28 October 2014

View articletitled, Abstract B22: Oncogene activation of K‐ras in resident myofibroblasts leads to development of spontaneous bronchioalveolar carcinoma in mice

Journal Articles

Abstract B23: Distinct roles for cancer‐associated fibroblasts in breast cancer progression and metastasis

Joyce C. Tse, Hikaru Sugimoto, Vesselina G. Cooke, Brian A. MacDonald, Ankit I. Mehta, Eric G. Neilson, Michael Zeisberg, Raghu Kalluri

Cancer Res (2009) 69 (23_Supplement): B23.

https://doi.org/10.1158/0008-5472.FBCR09-B23

Published: 28 October 2014

View articletitled, Abstract B23: Distinct roles for cancer‐associated fibroblasts in breast cancer progression and metastasis

Journal Articles

Abstract LB-143: Interplay between tissue tension and inflammation in pancreatic tumor progression

Hanane Laklai, Yekaterina Miroshnikova, Jon lakins, Novitskiy Sergey, Agnes Gorska, Lidiya Korets, Raghu Kalluri, Harold Moses, Valerie Weaver

Cancer Res (2014) 74 (19_Supplement): LB-143.

https://doi.org/10.1158/1538-7445.AM2014-LB-143

Published: 01 October 2014

View articletitled, Abstract LB-143: Interplay between tissue tension and inflammation in pancreatic tumor progression

Journal Articles

Abstract A47: Reciprocal dialogue between cellular and extracellular matrix tension and tissue inflammation in pancreatic tumor progression.

Hanane Laklai, Raghu Kalluri, Harold Moses, Valerie Weaver, Hideaki Ijichi, Jonathan Lakins, Yekaterina Miroshnikova, Irene Acerbi, Jose Lopez, Elena Kassianidou, Agnieszka Gorska, Sergey Novitskiy

Cancer Res (2012) 72 (14_Supplement): A47.

https://doi.org/10.1158/1538-7445.PANCA2012-A47

Published: 03 April 2014

View articletitled, Abstract A47: Reciprocal dialogue between cellular and extracellular matrix tension and tissue inflammation in pancreatic tumor progression.

Journal Articles

VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation

Sung-Hee Chang, Keizo Kanasaki, Vasilena Gocheva, Galia Blum, Jay Harper, Marsha A. Moses, Shou-Ching Shih, Janice A. Nagy, Johanna Joyce, Matthew Bogyo, Raghu Kalluri, Harold F. Dvorak

Cancer Res (2009) 69 (10): 4537–4544.

https://doi.org/10.1158/0008-5472.CAN-08-4539

Published: 15 May 2009

View articletitled, VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation

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Abstract CT265: KRAS^G12Dtargeting using engineered exosomes in pancreatic cancer: Results from the iEXPLORE phase 1 trial

Abstract B064: Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

Abstract B092: CDK8 and CXCL2 remodel the tumor microenvironment to contribute to KRAS^G12D small molecule inhibition resistance in pancreatic ductal adenocarcinoma

Abstract C084: iExplore: A phase I study of mesenchymal stem cell derived exosomes with Kras^G12D siRNA for metastatic pancreas cancer patients harboring the Kras^G12D mutation

Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8⁺ T cells

Abstract 1073: PRMT5 inhibition synergizes with a natural small molecule compound to kill MTAP-deleted cells and suppress tumor growth

Abstract 2395: Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine

Abstract PO-059: Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis

Abstract 2010: Pancreatic cancer stem cell exosomes drive a hierarchical intratumor communication network that fuels disease progression through hippo pathway inhibition

Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells

Abstract PR08: Intratumoral T-cell distribution in murine and patient pancreatic cancer correlates with tissue heterogeneity and survival

Nischarin Regulates Secretion of Exosomes and Cancer Progression

Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587

Abstract IA15: Functional diversity of the pancreas tumor stroma

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24⁺ Progenitor Cells

Abstract B22: Oncogene activation of K‐ras in resident myofibroblasts leads to development of spontaneous bronchioalveolar carcinoma in mice

Abstract B23: Distinct roles for cancer‐associated fibroblasts in breast cancer progression and metastasis

Abstract LB-143: Interplay between tissue tension and inflammation in pancreatic tumor progression

Abstract A47: Reciprocal dialogue between cellular and extracellular matrix tension and tissue inflammation in pancreatic tumor progression.

VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation

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