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Journal Articles

Abstract 1727: Cytoplasmic EZH2 and the DLC1 tumor suppressor are regulated by the CRM1 nuclear export protein and by specific complex formation between mutant KRAS and RAN-GAP

Brajendra Tripathi, Nicole Hirsh, David Hansen, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Ashley Lim, Alex G. Papageorge, Suresh S. Ramalingham, Adam I. Marcus, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1727.
https://doi.org/10.1158/1538-7445.AM2023-1727
Published: 04 April 2023
View article titled, Abstract 1727: Cytoplasmic EZH2 and the DLC1 tumor suppressor are regulated by the CRM1 nuclear export protein and by specific complex formation between mutant KRAS and RAN-GAP
Journal Articles

Abstract 3912: cProSite: A web based interactive platform for on-line proteomics and phosphoproteomics data analysis

Dunrui Wang, Xiaolan Qian, Yi-Chieh Nancy Du, Beatriz Sanchez-Solana, Kailing Chen, Brian Park, Ben Chen, Lisa Jenkins, Jason Luo, Brajendra K. Tripathi, Marian E. Durkin, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3912.
https://doi.org/10.1158/1538-7445.AM2022-3912
Published: 15 June 2022
View article titled, Abstract 3912: cProSite: A web based interactive platform for on-line proteomics and phosphoproteomics data analysis
Journal Articles

Abstract 5848: Inhibition of the CRM1 nuclear export protein can treat mutant KRAS tumors through stabilizing the DLC1 tumor suppressor protein

Brajendra K. Tripathi, Nicole Hirsh, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Fernando J. de Miguel, Katerina Politi, James H. Doroshow, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5848.
https://doi.org/10.1158/1538-7445.AM2022-5848
Published: 15 June 2022
View article titled, Abstract 5848: Inhibition of the CRM1 nuclear export protein can treat mutant <em>KRAS</em> tumors through stabilizing the DLC1 tumor suppressor protein
Journal Articles

Abstract 2508: Targeting mutant KRAS tumors by inhibiting cytoplasmic EZH2, which directly methylates and destabilizes the DLC1 tumor suppressor protein

Brajendra K. Tripathi, Disha Bhargava, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Fernando J. de Miguel, Katerina Politi, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2508.
https://doi.org/10.1158/1538-7445.AM2021-2508
Published: 01 July 2021
View article titled, Abstract 2508: Targeting mutant <em>KRAS</em> tumors by inhibiting cytoplasmic EZH2, which directly methylates and destabilizes the DLC1 tumor suppressor protein
Journal Articles

Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function

Dunrui Wang, Xiaolan Qian, Beatriz Sanchez-Solana, Brajendra K. Tripathi, Marian E. Durkin, Douglas R. Lowy
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (17): 3568–3579.
https://doi.org/10.1158/0008-5472.CAN-19-3984
Published: 02 September 2020
View article titled, Cancer-Associated Point Mutations in the <em>DLC1</em> Tumor Suppressor and Other <em>Rho-GAPs</em> Occur Frequently and Are Associated with Decreased Function
Open the PDF for Cancer-Associated Point Mutations in the <em>DLC1</em> Tumor Suppressor and Other <em>Rho-GAPs</em> Occur Frequently and Are Associated with Decreased Function in another window
Includes: Supplementary data
Journal Articles

Abstract 2586: Identification of cancer-associated RhoA mutants and analogous K-Ras mutants that induce gain-of function despite low GTP binding

Xiaolan Qian, Alex Papageorge, Dunrui Wang, Brajendra Tripathi, Yucheng Gao, Marian Durkin, Beatriz Sanchez-Solana, Dominic Esposito, Timothy Waybright, Andrew Stephen, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2586.
https://doi.org/10.1158/1538-7445.AM2020-2586
Published: 15 August 2020
View article titled, Abstract 2586: Identification of cancer-associated RhoA mutants and analogous K-Ras mutants that induce gain-of function despite low GTP binding
Journal Articles

Abstract 3431: Epigenetic reactivation of the DLC1 tumor suppressor protein is a new approach for cancer treatment

Brajendra K. Tripathi, Luciarita Boccuzzi, Meghan Anderman, Xiaolan Qian, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3431.
https://doi.org/10.1158/1538-7445.AM2020-3431
Published: 15 August 2020
View article titled, Abstract 3431: Epigenetic reactivation of the DLC1 tumor suppressor protein is a new approach for cancer treatment
Journal Articles

Abstract 5563: Harnessing pre-existing viral immunity for development of a broadly applicable tumor immunotherapy

Nicolas Cuburu, Lukas Bialkowski, Sergio M. Pontejo, Alexander Bell, Rina Kim, Cynthia D. Thompson, Douglas R. Lowy, John T. Schiller
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5563.
https://doi.org/10.1158/1538-7445.AM2020-5563
Published: 15 August 2020
View article titled, Abstract 5563: Harnessing pre-existing viral immunity for development of a broadly applicable tumor immunotherapy
Journal Articles

Abstract 1762: The START domain of the DLC1 tumor suppressor binds phosphatidylserine and two proteins, PLCD1 and Caveolin-1

Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Alex Papageorge, Parthibane Velayoudame, Jairaj Acharya, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1762.
https://doi.org/10.1158/1538-7445.AM2019-1762
Published: 01 July 2019
View article titled, Abstract 1762: The START domain of the DLC1 tumor suppressor binds phosphatidylserine and two proteins, PLCD1 and Caveolin-1
Journal Articles

Abstract 4513: Targeting the DLC1 Rho-GAP tumor suppressor protein to treat solid tumors

Brajendra K. Tripathi, Meghan F. Anderman, James H. Doroshow, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4513.
https://doi.org/10.1158/1538-7445.AM2019-4513
Published: 01 July 2019
View article titled, Abstract 4513: Targeting the DLC1 Rho-GAP tumor suppressor protein to treat solid tumors
Journal Articles

Abstract 4235: Phosphorylation of Serine 861 in the ECT2 guanine nucleotide exchange factor activates Rho family GTPases and is a biomarker for several tumor types

Dunrui Wang, Xiaolan Qian, Sarah Eng, Shivani Nellore, Alex G. Papageorge, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4235.
https://doi.org/10.1158/1538-7445.AM2019-4235
Published: 01 July 2019
View article titled, Abstract 4235: Phosphorylation of Serine 861 in the ECT2 guanine nucleotide exchange factor activates Rho family GTPases and is a biomarker for several tumor types
Journal Articles

Abstract 5522: Cancer-associated point mutant in the START domain of DLC1 encodes a protein attenuated for tumor suppressor activity and for binding both Caveolin-1 and PLCD1 but not for Rho-GAP activity

Beatriz Sanchez-Solana, Xiaolan Qian, Dunrui Wang, Marian Durkin, Brajendra Tripathi, Alex Papageorge, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5522.
https://doi.org/10.1158/1538-7445.AM2018-5522
Published: 01 July 2018
View article titled, Abstract 5522: Cancer-associated point mutant in the START domain of DLC1 encodes a protein attenuated for tumor suppressor activity and for binding both Caveolin-1 and PLCD1 but not for Rho-GAP activity
Journal Articles

Abstract 4359: Several cancer types are associated with increased expression and activity of the ECT2 RhoGEF and decreased expression and activity of the DLC1 RhoGAP, leading to increased RhoA activity

Dunrui Wang, Xiaolan Qian, Marian E. Durkin, Alexander G. Papageorge, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4359.
https://doi.org/10.1158/1538-7445.AM2018-4359
Published: 01 July 2018
View article titled, Abstract 4359: Several cancer types are associated with increased expression and activity of the ECT2 RhoGEF and decreased expression and activity of the DLC1 RhoGAP, leading to increased RhoA activity
Journal Articles

Abstract 3957: SRC inhibitors dephosphorylate and reactivate the DLC1 tumor suppressor: A new biomarker of clinical response

Brajendra K. Tripathi, Meghan Anderman, Xiaolan Qian, Ming Zhou, Dunrui Wang, Alex G. Papageorge, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3957.
https://doi.org/10.1158/1538-7445.AM2018-3957
Published: 01 July 2018
View article titled, Abstract 3957: SRC inhibitors dephosphorylate and reactivate the DLC1 tumor suppressor: A new biomarker of clinical response
Journal Articles

Abstract 1364: Direct phosphorylation and attenuation of the DLC1 tumor suppressor by SRC kinase: a new mechanism of SRC-dependent activation of Rho with translational implications

Brajendra K. Tripathi, Xiaolan Qian, Ming Zhou, Dunrui Wang, Marian Durkin, Alex G. Papageorge, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1364.
https://doi.org/10.1158/1538-7445.AM2017-1364
Published: 01 July 2017
View article titled, Abstract 1364: Direct phosphorylation and attenuation of the DLC1 tumor suppressor by SRC kinase: a new mechanism of SRC-dependent activation of Rho with translational implications
Journal Articles

Abstract 4377: AKT positively regulates Rho-GTP by attenuating the GAP activity of the DLC1 tumor suppressor: a mechanistic study with translational implications

Brajendra K. Tripathi, Tiera Grant, Philipp Mertins, Xiaolan Qian, Dunrui Wang, Alex G. Papageorge, Steven A. Carr, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4377.
https://doi.org/10.1158/1538-7445.AM2016-4377
Published: 15 July 2016
View article titled, Abstract 4377: AKT positively regulates Rho-GTP by attenuating the GAP activity of the DLC1 tumor suppressor: a mechanistic study with translational implications
Journal Articles

Abstract 888: Inactivation of the DLC1 RhoGAP tumor suppressor by point mutation occurs commonly in human cancer and can result from Rho-dependent or Rho-independent mechanisms

Xiaolan Qian, Dunrui Wang, Beatriz Sanchez-Solana, Brajendra K. Tripathi, Marian E. Durkin, Alex Papageorge, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 888.
https://doi.org/10.1158/1538-7445.AM2016-888
Published: 15 July 2016
View article titled, Abstract 888: Inactivation of the DLC1 RhoGAP tumor suppressor by point mutation occurs commonly in human cancer and can result from Rho-dependent or Rho-independent mechanisms
Journal Articles

Abstract PL02-04: Drastically reducing HPV-associated cancers through etiologically-based primary and secondary prevention

Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): PL02-04.
https://doi.org/10.1158/1538-7445.AM2015-PL02-04
Published: 01 August 2015
View article titled, Abstract PL02-04: Drastically reducing HPV-associated cancers through etiologically-based primary and secondary prevention
Journal Articles

Abstract 4680: Efficacy of the HPV16/18 vaccine against cervical, anal, and oral HPV infection among women with and without previous HPV16/18 exposure

Daniel C. Beachler, Aimee R. Kreimer, Mark Schiffman, Rolando Herrero, Sholom Wacholder, Ana Cecilia Rodriguez, Douglas R. Lowy, Carolina Porras, John T. Schiller, Silvia Jimenez, Linda Struijk, John Schussler, Allan Hildesheim, Paula Gonzalez, Costa Rica Vaccine Trial Group
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4680.
https://doi.org/10.1158/1538-7445.AM2015-4680
Published: 01 August 2015
View article titled, Abstract 4680: Efficacy of the HPV16/18 vaccine against cervical, anal, and oral HPV infection among women with and without previous HPV16/18 exposure
Journal Articles

Abstract 2155: Inactivation of the tumor suppressor DLC1 by the oncogenes SRC and ERK1 in lung adenocarcinoma

Brajendra K. Tripathi, Xiaolan Qian, Tiera Grant, Philipp Mertins, Dunrui Wang, Alex G. Papageorge, Steven A. Carr, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2155.
https://doi.org/10.1158/1538-7445.AM2015-2155
Published: 01 August 2015
View article titled, Abstract 2155: Inactivation of the tumor suppressor DLC1 by the oncogenes SRC and ERK1 in lung adenocarcinoma