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R. Charles Coombes
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Journal Articles

Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer

Carolina Gemma, Chun-Fui Lai, Anup K. Singh, Antonino Belfiore, Neil Portman, Heloisa Z. Milioli, Manikandan Periyasamy, Sara Raafat, Alyssa J. Nicholls, Claire M. Davies, Naina R. Patel, Georgia M. Simmons, Hailing Fan, Van T.M. Nguyen, Luca Magnani, Emad Rakha, Lesley-Ann Martin, Elgene Lim, R. Charles Coombes, Giancarlo Pruneri, Laki Buluwela, Simak Ali
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4283–4297.
https://doi.org/10.1158/0008-5472.CAN-24-0013
Published: 16 December 2024
View article titled, Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 459: Lipidomic analysis of extracellular vesicles and its potential for the identification of body fluid-based biomarkers for breast cancer diagnosis

Erika Dorado, M Luisa Doria, Anika Nagelkerke, James S McKenzie, Stefania Maneta-Stavrakaki, Charlotte Ion, Thomas Whittaker, Jeremy Nicholson, Molly M Stevens, R Charles Coombes, Zoltan Takats
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 459.
https://doi.org/10.1158/1538-7445.AM2021-459
Published: 01 July 2021
View article titled, Abstract 459: Lipidomic analysis of extracellular vesicles and its potential for the identification of body fluid-based biomarkers for breast cancer diagnosis
Journal Articles

Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy.

Hetal Patel, Silvia Ottaviani, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B Kroll, Sean Delaney, Zahida Zahoor, Matthew J. Fuchter, Anthony G.M Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 694.
https://doi.org/10.1158/1538-7445.AM2013-694
Published: 15 April 2013
View article titled, Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy.
Journal Articles

Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.

Silvia Ottaviani, Sean Delaney, Hetal Patel, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B. Kroll, Matthew J. Fuchter, Anthony G.M. Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 700.
https://doi.org/10.1158/1538-7445.AM2013-700
Published: 15 April 2013
View article titled, Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.
Journal Articles

Abstract 3311: Role of nicastrin in the maintenance of breast cancer stem cells and invasion

Ylenia Lombardo, Aleksandra Filipovic, Gemma Molyneux, R Charles Coombes
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3311.
https://doi.org/10.1158/1538-7445.AM2012-3311
Published: 15 April 2012
View article titled, Abstract 3311: Role of nicastrin in the maintenance of breast cancer stem cells and invasion
Journal Articles

The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity

Simak Ali, Dean A. Heathcote, Sebastian H.B. Kroll, Ashutosh S. Jogalekar, Bodo Scheiper, Hetal Patel, Jan Brackow, Alekasandra Siwicka, Matthew J. Fuchter, Manikandan Periyasamy, Robert S. Tolhurst, Seshu K. Kanneganti, James P. Snyder, Dennis C. Liotta, Eric O. Aboagye, Anthony G.M. Barrett, R. Charles Coombes
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6208–6215.
https://doi.org/10.1158/0008-5472.CAN-09-0301
Published: 29 July 2009
View article titled, The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
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Includes: Supplementary data
Journal Articles

Paclitaxel-Induced Nuclear Translocation of FOXO3a in Breast Cancer Cells Is Mediated by c-Jun NH2-Terminal Kinase and Akt

Andrew Sunters, Patricia A. Madureira, Karen M. Pomeranz, Muriel Aubert, Jan J. Brosens, Simon J. Cook, Boudewijn M.T. Burgering, R. Charles Coombes, Eric W.-F. Lam
Journal: Cancer Research
Cancer Res (2006) 66 (1): 212–220.
https://doi.org/10.1158/0008-5472.CAN-05-1997
Published: 05 January 2006
View article titled, Paclitaxel-Induced Nuclear Translocation of FOXO3a in Breast Cancer Cells Is Mediated by c-Jun NH<sub>2</sub>-Terminal Kinase and Akt
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Journal Articles

Quantification of Cellular Proliferation in Tumor and Normal Tissues of Patients with Breast Cancer by [18F]Fluorothymidine-Positron Emission Tomography Imaging: Evaluation of Analytical Methods

Laura M. Kenny, David M. Vigushin, Adil Al-Nahhas, Safiye Osman, Sajinder K. Luthra, Sami Shousha, R. Charles Coombes, Eric O. Aboagye
Journal: Cancer Research
Cancer Res (2005) 65 (21): 10104–10112.
https://doi.org/10.1158/0008-5472.CAN-04-4297
Published: 01 November 2005
View article titled, Quantification of Cellular Proliferation in Tumor and Normal Tissues of Patients with Breast Cancer by [<sup>18</sup>F]Fluorothymidine-Positron Emission Tomography Imaging: Evaluation of Analytical Methods
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Journal Articles

Results of a Phase I/II clinical trial with OncoVEXGM-CSF, a second generation oncolytic herpes simplex virus

Jennifer C. Hu, Robert S. Coffin, Ceri J. Davis, Nicola J. Graham, Natasha Groves, Peter J. Guest, Kevin J. Harrington, Nicholas D. James, Colin A. Love, Iain McNeish, Louise C. Medley, Agnieszka Michael, Christopher M. Nutting, Hardev S. Pandha, Claire A. Shorrock, Julie Simpson, Jan Steiner, Neil M. Steven, R. Charles Coombes
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1251.
Published: 01 May 2005
View article titled, Results of a Phase I/II clinical trial with OncoVEX<sub>GM-CSF</sub>, a second generation oncolytic herpes simplex virus
Journal Articles

Ubiquitin dependent degradation of cyclin D1 occurs via distinct nuclear and cytoplasmic pathways in MCF-7 breast cancer cells treated with the histone deacetylase inhibitor trichostatin A

John Patrick Alao, Alexandra V. Stavropoulou, Eric W.-F. Lam, R. Charles Coombes, David M. Vigushin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 534.
Published: 01 May 2005
View article titled, Ubiquitin dependent degradation of cyclin D1 occurs via distinct nuclear and cytoplasmic pathways in MCF-7 breast cancer cells treated with the histone deacetylase inhibitor trichostatin A
Journal Articles

Estrogen receptor dependent and independent mechanisms of cyclin D1 downregulation by the histone deacetylase inhibitor trichostatin A.

John P. Alao, Eric W. Lam, Simak Ali, Walter Bordogna, Peter Lockey, R. Charles Coombes, David M. Vigushin
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 565–566.
Published: 01 April 2004
View article titled, Estrogen receptor dependent and independent mechanisms of cyclin D1 downregulation by the histone deacetylase inhibitor trichostatin A.
Journal Articles

T:G mismatch-specific thymine DNA glycosylase interacts with SRC1 and potentiates estrogen receptor activity, in the absence of ligand

Marie J. Lucey, Dongsheng Chen, Fladia Phoenix, Jorge Lopez-Garcia, Roger White, Regine Losson, Lakjaya Buluwela, R. Charles Coombes, Pierre Chambon, Malcolm G. Parker, Primo Schar, Simak Ali
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 608.
Published: 01 April 2004
View article titled, T:G mismatch-specific thymine DNA glycosylase interacts with SRC1 and potentiates estrogen receptor activity, in the absence of ligand
Journal Articles

Inhibitory Effects of Activin on the Growth and Morphogenesis of Primary and Transformed Mammary Epithelial Cells

Qiu Yan Liu, Birunthi Niranjan, Peter Gomes, Jennifer J. Gomm, Derek Davies, R. Charles Coombes, Lakjaya Buluwela
Journal: Cancer Research
Cancer Res (1996) 56 (5): 1155–1163.
Published: 01 March 1996
View article titled, Inhibitory Effects of Activin on the Growth and Morphogenesis of Primary and Transformed Mammary Epithelial Cells
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Journal Articles

Idoxifene: Report of a Phase I Study in Patients with Metastatic Breast Cancer

R. Charles Coombes, Ben P. Haynes, Mitchell Dowsett, Mary Quigley, Jacqueline English, Ian R. Judson, Lesley J. Griggs, Gerry A. Potter, Ray McCague, Michael Jarman
Journal: Cancer Research
Cancer Res (1995) 55 (5): 1070–1074.
Published: 01 March 1995
View article titled, Idoxifene: Report of a Phase I Study in Patients with Metastatic Breast Cancer
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Journal Articles

Phase I and Endocrine Study of Exemestane (FCE 24304), a New Aromatase Inhibitor, in Postmenopausal Women

T. R. Jeffry Evans, Enrico Di Salle, Giorgio Ornati, Mercedes Lassus, Margherita Strollin Benedetti, Elio Pianezzola, R. Charles Coombes
Journal: Cancer Research
Cancer Res (1992) 52 (21): 5933–5939.
Published: 01 November 1992
View article titled, Phase I and Endocrine Study of Exemestane (FCE 24304), a New Aromatase Inhibitor, in Postmenopausal Women
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Journal Articles

Localization of Basic Fibroblast Growth Factor and Transforming Growth Factor β1 in the Human Mammary Gland

Jennifer J. Gomm, Janet Smith, Glenys K. Ryall, Robin Baillie, Lesley Turnbull, R. Charles Coombes
Journal: Cancer Research
Cancer Res (1991) 51 (17): 4685–4692.
Published: 01 September 1991
View article titled, Localization of Basic Fibroblast Growth Factor and Transforming Growth Factor β<sub>1</sub> in the Human Mammary Gland
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Journal Articles

Immunocytochemical Determination of Estrogen Receptor, Progesterone Receptor, and 1,25-Dihydroxyvitamin D3 Receptor in Breast Cancer and Relationship to Prognosis

Uta Berger, Richard A. McClelland, Patricia Wilson, Geoffrey L. Greene, Mark R. Haussler, J. W. Pike, Kay Colston, Douglas Easton, R. Charles Coombes
Journal: Cancer Research
Cancer Res (1991) 51 (1): 239–244.
Published: 01 January 1991
View article titled, Immunocytochemical Determination of Estrogen Receptor, Progesterone Receptor, and 1,25-Dihydroxyvitamin D<sub>3</sub> Receptor in Breast Cancer and Relationship to Prognosis
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Journal Articles

Preliminary Study of the Treatment of Advanced Breast Cancer in Postmenopausal Women with the Aromatase Inhibitor CGS 16949A

Robert C. Stein, Mitchell Dowsett, Joanna Davenport, Anthea Hedley, Hubert T. Ford, Jean-Claude Gazet, R. Charles Coombes
Journal: Cancer Research
Cancer Res (1990) 50 (5): 1381–1384.
Published: 01 March 1990
View article titled, Preliminary Study of the Treatment of Advanced Breast Cancer in Postmenopausal Women with the Aromatase Inhibitor CGS 16949A
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Journal Articles

Immunohistochemical Study of β- and κ-Casein in the Human Breast and Breast Carcinomas, Using Monoclonal Antibodies

Helena M. Earl, R. A. Jeffrey McIlhinney, Patricia Wilson, Barry A. Gusterson, R. Charles Coombes
Journal: Cancer Research
Cancer Res (1989) 49 (21): 6070–6076.
Published: 01 November 1989
View article titled, Immunohistochemical Study of β- and κ-Casein in the Human Breast and Breast Carcinomas, Using Monoclonal Antibodies
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Journal Articles

Comparison of an Immunocytochemical Assay for Progesterone Receptor with a Biochemical Method of Measurement and Immunocytochemical Examination of the Relationship between Progesterone and Estrogen Receptors

Uta Berger, Pat Wilson, Suki Thethi, Richard A. McClelland, Geoffrey L. Greene, R. Charles Coombes
Journal: Cancer Research
Cancer Res (1989) 49 (18): 5176–5179.
Published: 01 September 1989
View article titled, Comparison of an Immunocytochemical Assay for Progesterone Receptor with a Biochemical Method of Measurement and Immunocytochemical Examination of the Relationship between Progesterone and Estrogen Receptors
Open the PDF for Comparison of an Immunocytochemical Assay for Progesterone Receptor with a Biochemical Method of Measurement and Immunocytochemical Examination of the Relationship between Progesterone and Estrogen Receptors in another window