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Journal Articles

A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma

Jing Shi, Tao Jiao, Qian Guo, Weining Weng, Linjie Ma, Qing Zhang, Lijun Wang, Jianjian Zhang, Caiwei Chen, Yaling Huang, Mingqiao Wang, Rong Pan, Yanfang Tang, Wenhao Hu, Tao Meng, Shu-Hui Liu, Jun Guo, Yan Kong, Xun Meng
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3783–3795.
https://doi.org/10.1158/0008-5472.CAN-23-1356
Published: 15 November 2023
View article titled, A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
Open the PDF for A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract A003: Kinome-wide siRNA screening identifies DCLK2 as a TBK1 activator and therapeutic target for ccRCC

Lianxin Hu, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): A003.
https://doi.org/10.1158/1538-7445.KIDNEY23-A003
Published: 15 August 2023
View article titled, Abstract A003: Kinome-wide siRNA screening identifies DCLK2 as a TBK1 activator and therapeutic target for ccRCC
Journal Articles

Abstract PR007: Von Hippel Lindau (VHL) tumor suppressor regulates m6A-dependent gene expression involved in renal tumorigenesis

Cheng Zhang, Zhao Zhang, Austin Hepperla, Miaomiao Yu, Jin Zhou, Lianxin Hu, Jun Fang, Qian Liang, Kexin Xu, Liwei Jia, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): PR007.
https://doi.org/10.1158/1538-7445.KIDNEY23-PR007
Published: 15 August 2023
View article titled, Abstract PR007: Von Hippel Lindau (VHL) tumor suppressor regulates m6A-dependent gene expression involved in renal tumorigenesis
Journal Articles

Abstract IA004: Identification of potential new therapeutic targets in kidney cancer

Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): IA004.
https://doi.org/10.1158/1538-7445.KIDNEY23-IA004
Published: 15 August 2023
View article titled, Abstract IA004: Identification of potential new therapeutic targets in kidney cancer
Journal Articles

Abstract B033: Targeting acquired resistance to HIF2α inhibition in kidney cancer

Fangzhou Zhao, Jeremy Simon, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): B033.
https://doi.org/10.1158/1538-7445.KIDNEY23-B033
Published: 15 August 2023
View article titled, Abstract B033: Targeting acquired resistance to HIF2α inhibition in kidney cancer
Journal Articles

Abstract 2600: BBOX1 is a novel tumor suppressor in kidney cancer

Chengheng Liao, Liwei Jia, Hua Zhong, Lianxin Hu, Payal Kapur, James Brugarolas, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2600.
https://doi.org/10.1158/1538-7445.AM2023-2600
Published: 04 April 2023
View article titled, Abstract 2600: BBOX1 is a novel tumor suppressor in kidney cancer
Journal Articles

Abstract P4-08-23: ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

Chengheng Liao, Wentong Fang, Rachel Shi, Jeremy Simon, Travis Ptacek, Giada Zurlo, Youqiong Ye, Leng Han, Cheng Fan, Lei Bao, Christopher Llynard Ortiz, Hong-Rui Lin, Ujjawal Manocha, Weibo Luo, Yan Peng, William Y Kim, Lee-Wei Yang, Qing Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-23.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-23
Published: 01 March 2023
View article titled, Abstract P4-08-23: ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer
Journal Articles

Abstract 5668: DNA damage response gene mutations and their association with PD-L1 expression in sarcoma and bone tumor

Fanfei Meng, Qing Zhang, Fei Pang, Xiaoliang Shi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5668.
https://doi.org/10.1158/1538-7445.AM2022-5668
Published: 15 June 2022
View article titled, Abstract 5668: DNA damage response gene mutations and their association with PD-L1 expression in sarcoma and bone tumor
Journal Articles

Abstract 1764: Development of an alphalex™-auristatin low pH targeting conjugate for the treatment of solid tumors

Sophia Gayle, Robert Aiello, Jane Bechtold, Patricia Bourassa, Johanna Csengery, Connor Hagen, Katia Howard, Kelli Jones, Lori Lopresti-Morrow, Robert Maguire, Timothy Paradis, Theresa Pasqualini, Joseph Tweed, Laurie Tylaska, Qing Zhang, Vishwas Paralkar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1764.
https://doi.org/10.1158/1538-7445.AM2022-1764
Published: 15 June 2022
View article titled, Abstract 1764: Development of an alphalex™-auristatin low pH targeting conjugate for the treatment of solid tumors
Journal Articles

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Xinchao Zhang, Shuyan Li, Jing He, Yunjie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun-Ying Lei, Jing Zhang, Qing Zhang, Yanping Xu, Lei Lv
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2097–2109.
https://doi.org/10.1158/0008-5472.CAN-21-3013
Published: 06 June 2022
View article titled, TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling
Open the PDF for TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling in another window
Includes: Supplementary data
Journal Articles

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R. Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis, Charles M. Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4): 665–680.
https://doi.org/10.1158/0008-5472.CAN-21-2745
Published: 15 February 2022
View article titled, Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
Open the PDF for Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers

Cherise R Glodowski, Chengheng Liao, Cheng Fan, Juan Liu, Kevin R Mott, Akash Kaushik, Hieu Vu, Jason W Locasale, Samuel K McBrayer, Ralph J DeBerardinis, Charles M Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-05-01.
https://doi.org/10.1158/1538-7445.SABCS21-P5-05-01
Published: 15 February 2022
View article titled, Abstract P5-05-01: Metabolite profiling and RNA-seq identifies novel metabolomic-genomic biomarker and therapeutic options for rapidly proliferating breast cancers
Journal Articles

Abstract 660: Real-world prevalence of metastasis and overall survival (OS) in patients with advanced non-small cell lung cancer (aNSCLC) with KRAS G12C and with or without STK11 or KEAP1 mutations

Cristina Julian, Navdeep Pal, Anda Gershon, Maria Evangelista, Hans Purkey, Peter Lambert, Zhen Shi, Qing Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 660.
https://doi.org/10.1158/1538-7445.AM2021-660
Published: 01 July 2021
View article titled, Abstract 660: Real-world prevalence of metastasis and overall survival (OS) in patients with advanced non-small cell lung cancer (aNSCLC) with <em>KRAS G12C</em> and with or without <em>STK11</em> or <em>KEAP1</em> mutations
Journal Articles

Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer

Chengheng Liao, Yang Zhang, Cheng Fan, Laura E. Herring, Juan Liu, Jason W. Locasale, Mamoru Takada, Jin Zhou, Giada Zurlo, Lianxin Hu, Jeremy M. Simon, Travis S. Ptacek, Victor G. Andrianov, Einars Loza, Yan Peng, Huanghe Yang, Charles M. Perou, Qing Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD15-10.
https://doi.org/10.1158/1538-7445.SABCS20-PD15-10
Published: 15 February 2021
View article titled, Abstract PD15-10: Identification of BBOX1 as a therapeutic target in triple-negative breast cancer
Journal Articles

Abstract 5869: Characterization and therapeutic implications of SMARCA4 mutations in cancer

Tharu M. Fernando, Robert Piskol, Russell Bainer, Ethan Sokol, Sally Trabucco, Qing Zhang, Huong Trinh, Sophia Maund, Marc Kschonsak, Subhra Chaudhuri, Tom Januario, Zora Modrusan, Robert L. Yauch
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5869.
https://doi.org/10.1158/1538-7445.AM2020-5869
Published: 15 August 2020
View article titled, Abstract 5869: Characterization and therapeutic implications of SMARCA4 mutations in cancer
Journal Articles

Abstract 6242: Development of alphalex™-toxin low pH targeting conjugates for the treatment of solid tumors

Sophia Gayle, Robert Aiello, Jane Bechtold, Patricia Bourassa, Johanna Csengery, Ketaki Deshpande, Kelli Jones, Lori Lopresti-Morrow, Robert Maguire, Dan Marshall, Hunter Moore, Timothy Paradis, Laurie Tylaska, Qing Zhang, Robert Volkmann, Ranjit S. Bindra, Peter M. Glazer, Vishwas Paralkar
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6242.
https://doi.org/10.1158/1538-7445.AM2020-6242
Published: 15 August 2020
View article titled, Abstract 6242: Development of alphalex™-toxin low pH targeting conjugates for the treatment of solid tumors
Journal Articles

Abstract 6249: CBX-12: A low pH targeting alphalex™-exatecan conjugate for the treatment of solid tumors

Robert J. Aiello, Sophia Gayle, Jane Bechtold, Patricia Bourassa, Johanna Csengery, Ketaki Deshpande, Kelli Jones, Lori Lopresti-Morrow, Robert Maguire, Dan Marshall, Hunter Moore, Timothy Paradis, Laurie Tylaska, Qing Zhang, Robert Volkmann, Ranjit S. Bindra, Peter M. Glazer, Vishwas Paralkar
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6249.
https://doi.org/10.1158/1538-7445.AM2020-6249
Published: 15 August 2020
View article titled, Abstract 6249: CBX-12: A low pH targeting alphalex™-exatecan conjugate for the treatment of solid tumors
Journal Articles

Abstract 3639: Fusion-associated neoantigen burden and predicted immunogenicity of CDK12 biallelic loss-of-function tumors vary substantially across cancer types

Andrew Elliott, Phillip Stafford, Jian Zhang, Qing Zhang, Jeff Swensen, Daniel Martin, Joanne Xiu, Zoran Gatalica, Daniel Vaena, Elisabeth Heath, W. Michael Korn
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3639.
https://doi.org/10.1158/1538-7445.AM2020-3639
Published: 15 August 2020
View article titled, Abstract 3639: Fusion-associated neoantigen burden and predicted immunogenicity of CDK12 biallelic loss-of-function tumors vary substantially across cancer types
Journal Articles

Abstract 1296: Arylsulfonamide KCN1 suppresses primary and metastatic growth of uveal melanoma through anti-angiogenic and anti-invasion mechanisms

Stefan Kaluz, Qing Zhang, Hua Yang, Satoru Osuka, Jiyoung Mun, Narra S. Devi, Mark Goodman, Hans E. Grossniklaus, Erwin G. Van Meir
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1296.
https://doi.org/10.1158/1538-7445.AM2019-1296
Published: 01 July 2019
View article titled, Abstract 1296: Arylsulfonamide KCN1 suppresses primary and metastatic growth of uveal melanoma through anti-angiogenic and anti-invasion mechanisms
Journal Articles

Abstract 2981: Targeting solid tumor acidic microenvironment with an alphalex PARP inhibitor

Vishwas Paralkar, Robert J. Aiello, Dan Marshall, Johanna Csengery, Patricia Bourassa, Qing Zhang, Brett S. Robinson, Lori Lopresti-Morrow, Jane Bechtold, Laurie Tylaska, Timothy Paradis, Gregory Slaybaugh, Hanna Visca, Anna Moshnikova, Dhammika Weerakkody, Oleg Andreev, Yana K. Reshetnyak, Donald Engelman, Ranjit Bindra, Peter Glazer, Per Hellsund
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2981.
https://doi.org/10.1158/1538-7445.AM2019-2981
Published: 01 July 2019
View article titled, Abstract 2981: Targeting solid tumor acidic microenvironment with an alphalex PARP inhibitor