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Journal Articles

Abstract 3095: A high-throughput phenotypic screen to identify small molecule inhibitors of Werner helicase

Christine A. Moomau, Yipin Lu, Xiaobin Zhang, Xiang Zhai, Lina Gu, Qing Sheng, Fang Li, Yaoyu Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3095.
https://doi.org/10.1158/1538-7445.AM2024-3095
Published: 22 March 2024
View article titled, Abstract 3095: A high-throughput phenotypic screen to identify small molecule inhibitors of Werner helicase
Journal Articles

Abstract 1590: The role of mucosal associated invariant T (MAIT) cells in pancreatic cancer liver metastasis

Jugmohit Toor, Peter Dimitrion, Rachel Krevh, Kalpana Subedi, Bobby Zuniga, Jie Wang, Li Zhou, Qing-Sheng Mi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1590.
https://doi.org/10.1158/1538-7445.AM2024-1590
Published: 22 March 2024
View article titled, Abstract 1590: The role of mucosal associated invariant T (MAIT) cells in pancreatic cancer liver metastasis
Journal Articles

Abstract 142: HDAC3 is required for pathognomonic features of Langerhans cell histiocytes

Peter Dimitrion, Jugmohit Toor, James Ge, Qiyan Wang, Carl Allen, Li Zhou, Qing-Sheng Mi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 142.
https://doi.org/10.1158/1538-7445.AM2024-142
Published: 22 March 2024
View article titled, Abstract 142: HDAC3 is required for pathognomonic features of Langerhans cell histiocytes
Journal Articles

Abstract 2568: ARTS-021 is a potent and selective CDK2 inhibitor that demonstrates anti-cancer activity in preclinical cancer models with CCNE1 amplification

jiaqi Liang, Dai Cheng, Yali Guo, xiaobin zhang, Xipan Liu, Jia Fu, Qiang Ding, Wen Xiong, Fang Li, Yaoyu Chen, Qing Sheng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2568.
https://doi.org/10.1158/1538-7445.AM2022-2568
Published: 15 June 2022
View article titled, Abstract 2568: ARTS-021 is a potent and selective CDK2 inhibitor that demonstrates anti-cancer activity in preclinical cancer models with CCNE1 amplification
Journal Articles

Abstract 2108: ScRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic tumor liver metastasis

Jie Wang, Qijun Yi, Tingting Liu, Yi Yao, Ian Loveless, Kalpana Subedi, Indra Adrianto, Howard Crawford, Li Zhou, Qing-Sheng Mi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2108.
https://doi.org/10.1158/1538-7445.AM2022-2108
Published: 15 June 2022
View article titled, Abstract 2108: ScRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic tumor liver metastasis
Journal Articles

Abstract 2920: A Diversity outbred (DO) mouse model reveals regulators of HER2-driven tumorigenesis

Jennifer Jacob, Kuang Wei, Joyce D. Reyes, Cong-Cong Yin, Elizabeth Rondini, Qing-Sheng Mi, James Granneman, Prahlad Parajuli, K Wagner, Wei-Zen Wei
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2920.
https://doi.org/10.1158/1538-7445.AM2021-2920
Published: 01 July 2021
View article titled, Abstract 2920: A Diversity outbred (DO) mouse model reveals regulators of HER2-driven tumorigenesis
Journal Articles

Abstract P4-10-07: Tumor ER protein modulation, molecular characterization and monitoring of cfDNA in phase 1 study of LSZ102 and LSZ102 + ribociclib in patients with ER+ MBC

Komal Jhaveri, Dejan Juric, Sara Cresta, Yoon-Sim Yap, Francois P. Duhoux, Catherine Terret, Rachel Layman, Alejandro Balbin, Qing Sheng, Serena Liao, Adam Crystal, Giuseppe Curigliano
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-10-07.
https://doi.org/10.1158/1538-7445.SABCS19-P4-10-07
Published: 15 February 2020
View article titled, Abstract P4-10-07: Tumor ER protein modulation, molecular characterization and monitoring of cfDNA in phase 1 study of LSZ102 and LSZ102 + ribociclib in patients with ER+ MBC
Journal Articles

Abstract 922: Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER

L. Alex Gaither, Choi Lai Tiong Yip, Chunrong Wang, Weiyi Toy, Qing Sheng, Jinyun Chen, Yuji Mishina, Rita Das, Stefan Peukert, Alice Loo, Sarat Chandarlapaty, Adam Crystal, Tinya J. Abrams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 922.
https://doi.org/10.1158/1538-7445.AM2019-922
Published: 01 July 2019
View article titled, Abstract 922: Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER
Journal Articles

Abstract 4743: Using genome-wide CRISPR screen to understand resistance mechanisms to PCA062, a P-cadherin targeting antibody-drug conjugate

Angela Tam, Mark Zambrowski, Katherine Seiss, Si-Qi Liu, Tinya Abrams, Giordano Caponigro, William Tschantz, Jennifer Campbell, Tony DAlessio, Qing Sheng
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4743.
https://doi.org/10.1158/1538-7445.AM2019-4743
Published: 01 July 2019
View article titled, Abstract 4743: Using genome-wide CRISPR screen to understand resistance mechanisms to PCA062, a P-cadherin targeting antibody-drug conjugate
Journal Articles

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Weicai Chen, Ye Kuang, Hai-Bo Qiu, Zhifa Cao, Yuqing Tu, Qing Sheng, Grant Eilers, Quan He, Hai-Long Li, Meijun Zhu, Yuexiang Wang, Rongqing Zhang, Yeqing Wu, Fanguo Meng, Jonathan A. Fletcher, Wen-Bin Ou
Journal: Cancer Research
Cancer Res (2017) 77 (18): 5107–5117.
https://doi.org/10.1158/0008-5472.CAN-17-0917
Published: 14 September 2017
View article titled, Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors
Open the PDF for Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 5008: The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Gino B. Ferraro, David P. Kodack, Vasileios Askoxylakis, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Alexander Z. Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Youngchul Song, Carlotta Costa, Kamila Naxerova, Christina Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G. Duda, Ryan C. Miller, Marni B. Siegel, Carey K. Anders, Melinda Sanders, Valeria M. Estrada, Robert Schlegel, Carlos L. Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A. Engelman, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5008.
https://doi.org/10.1158/1538-7445.AM2017-5008
Published: 01 July 2017
View article titled, Abstract 5008: The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Journal Articles

An Essential Role of Maspin in Embryogenesis and Tumor Suppression

Sijana H. Dzinic, M. Margarida Bernardo, Xiaohua Li, Rodrigo Fernandez-Valdivia, Ye-Shih Ho, Qing-Sheng Mi, Sudeshna Bandyopadhyay, Fulvio Lonardo, Semir Vranic, Daniel S.M. Oliveira, R. Daniel Bonfil, Gregory Dyson, Kang Chen, Almasa Omerovic, Xiujie Sheng, Xiang Han, Dinghong Wu, Xinling Bi, Dzenana Cabaravdic, Una Jakupovic, Marian Wahba, Aaron Pang, Deanna Harajli, Wael A. Sakr, Shijie Sheng
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (4): 886–896.
https://doi.org/10.1158/0008-5472.CAN-16-2219
Published: 14 February 2017
View article titled, An Essential Role of <em>Maspin</em> in Embryogenesis and Tumor Suppression
Open the PDF for An Essential Role of <em>Maspin</em> in Embryogenesis and Tumor Suppression in another window
Includes: Supplementary data
Journal Articles

Abstract 5320: Targeting HER3 and EGFR in NRG1 positive and HER3 mutated lung squamous cell carcinoma

Maria C. Pinzon-Ortiz, Xianhui Rong, Richard Versace, Qing Sheng, Z. Alexander Cao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5320.
https://doi.org/10.1158/1538-7445.AM2015-5320
Published: 01 August 2015
View article titled, Abstract 5320: Targeting HER3 and EGFR in NRG1 positive and HER3 mutated lung squamous cell carcinoma
Journal Articles

Abstract LB-237: Targeting HER3 and IGF1R in NRG1 high lung squamous cell carcinoma

Qing Sheng, Maria Pinzon-Ortiz, Rita Das, Alan Huang, Xianhui Rong, Z. Alexander Cao
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-237.
https://doi.org/10.1158/1538-7445.AM2014-LB-237
Published: 01 October 2014
View article titled, Abstract LB-237: Targeting HER3 and IGF1R in NRG1 high lung squamous cell carcinoma
Journal Articles

Abstract 2612: ljm716, an anti her3 antibody that inhibits her3 dimerization, displays anti-tumor activity in esophageal squamous cell cancer

Qing Sheng, Hui-Qin Wang, rita das, yan chen, jinsheng liang, Fiona Xu, zongyao Wang, Z. Alexander Cao, youzhen Wang, alan huang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2612.
https://doi.org/10.1158/1538-7445.AM2014-2612
Published: 01 October 2014
View article titled, Abstract 2612: ljm716, an anti her3 antibody that inhibits her3 dimerization, displays anti-tumor activity in esophageal squamous cell cancer
Journal Articles

Abstract 5136: HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

Wen-bin Ou, Hailong Li, Li Liu, Shengmei Zhou, Ye Kuang, Ziqin Yan, Zhe Jiang, Si Shi, Fanguo Meng, Qing Sheng, Haimeng Zhou, Jonathan A. Fletcher
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5136.
https://doi.org/10.1158/1538-7445.AM2014-5136
Published: 01 October 2014
View article titled, Abstract 5136: HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status
Journal Articles

Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers

Joan T. Garrett, Cammie R. Sutton, Richard Kurupi, Carl Uli Bialucha, Seth A. Ettenberg, Scott D. Collins, Qing Sheng, Jerry Wallweber, Lisa DeFazio-Eli, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2013) 73 (19): 6013–6023.
https://doi.org/10.1158/0008-5472.CAN-13-1191
Published: 01 October 2013
View article titled, Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers
Open the PDF for Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers in another window
Includes: Supplementary data
Journal Articles

An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin

Andrew P. Garner, Carl U. Bialucha, Elizabeth R. Sprague, Joan T. Garrett, Qing Sheng, Sharon Li, Olga Sineshchekova, Parmita Saxena, Cammie R. Sutton, Dongshu Chen, Yan Chen, Huiqin Wang, Jinsheng Liang, Rita Das, Rebecca Mosher, Jian Gu, Alan Huang, Nicole Haubst, Carolin Zehetmeier, Manuela Haberl, Winfried Elis, Christian Kunz, Analeah B. Heidt, Kara Herlihy, Joshua Murtie, Alwin Schuller, Carlos L. Arteaga, William R. Sellers, Seth A. Ettenberg
Journal: Cancer Research
Cancer Res (2013) 73 (19): 6024–6035.
https://doi.org/10.1158/0008-5472.CAN-13-1198
Published: 01 October 2013
View article titled, An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Open the PDF for An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin in another window
Includes: Supplementary data
Journal Articles

Abstract 4261: Targeting HER3 and PI3K in head and neck squamous cancer cells.

Qing Sheng, HuiQin Wang, Rita Das, Yan Chen, Jinsheng Liang, Alex Cao, Carl Uli Bialucha, Seth Ettenberg, Alan Huang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4261.
https://doi.org/10.1158/1538-7445.AM2013-4261
Published: 15 April 2013
View article titled, Abstract 4261: Targeting HER3 and PI3K in head and neck squamous cancer cells.
Journal Articles

Abstract 2733: LJM716: an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.

Andrew Garner, Qing Sheng, Uli Bialucha, Dongshu Chen, Yan Chen, Rita Das, Winfried Elis, Analeah Heidt, Christian Kunz, Sharon Li, Jinsheng Liang, Joshua Murtie, Parmita Saxena, Alwin Schuller, Olga Sineshchekova, Elizabeth Sprague, Hui Qin Wang, Alan Huang, Seth Ettenberg
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2733.
https://doi.org/10.1158/1538-7445.AM2012-2733
Published: 15 April 2012
View article titled, Abstract 2733: LJM716: an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.