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Journal Articles

Abstract 4087: Co-expression of membrane bound IL-15 enhanced anti-tumor response of CAR-T

Cuiqing Yang, Fuwei Jiang, Yifang Wang, Tingting Liu, Chao Wang, Qingyang Wang, Qin Wang, Gang Ye, Renhong Tang, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4087.
https://doi.org/10.1158/1538-7445.AM2023-4087
Published: 04 April 2023
View article titled, Abstract 4087: Co-expression of membrane bound IL-15 enhanced anti-tumor response of CAR-T
Journal Articles

Abstract 4078: Optimized chimeric antigen receptors (CARs) for CAR-NK cell therapies

Cuiqing Yang, Yifang Wang, Tingting Liu, Fuwei Jiang, Qingyang Wang, Qin Wang, Gang Ye, Renhong Tang, Zhouxiao Cao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4078.
https://doi.org/10.1158/1538-7445.AM2023-4078
Published: 04 April 2023
View article titled, Abstract 4078: Optimized chimeric antigen receptors (CARs) for CAR-NK cell therapies
Journal Articles

Abstract 4077: Dual-targeted CAR-NK cell therapy: optimized CAR design to prevent antigen escape and elicit a deep and durable response in multiple myeloma

Cuiqing Yang, Yifang Wang, Tingting Liu, Chao Wang, Huanyu Wang, Qingyang Wang, Qin Wang, Gang Ye, Renhong Tang, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4077.
https://doi.org/10.1158/1538-7445.AM2023-4077
Published: 04 April 2023
View article titled, Abstract 4077: Dual-targeted CAR-NK cell therapy: optimized CAR design to prevent antigen escape and elicit a deep and durable response in multiple myeloma
Journal Articles

Abstract 2900: To develop a next generation NK therapy with deep and durable response by engineered CD16 enhancing NK cytotoxicity

Cuiqing Yang, Fuwei Jiang, Yifang Wang, Tingting Liu, Qingyang Wang, Qin Wang, Gang Ye, Renhong Tang, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2900.
https://doi.org/10.1158/1538-7445.AM2023-2900
Published: 04 April 2023
View article titled, Abstract 2900: To develop a next generation NK therapy with deep and durable response by engineered CD16 enhancing NK cytotoxicity
Journal Articles

Abstract 2899: Small molecule inhibitor of ubiquitin ligase CBL-B enhanced anti-tumor response of CAR-T and CAR-NK cell therapies

Cuiqing Yang, Yifang Wang, Tingting Liu, Fuwei Jiang, Chao Wang, Qingyang Wang, Qin Wang, Zhengtao Li, Wansun Mai, Gang Ye, Renhong Tang, Zhuoxiao Cao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2899.
https://doi.org/10.1158/1538-7445.AM2023-2899
Published: 04 April 2023
View article titled, Abstract 2899: Small molecule inhibitor of ubiquitin ligase CBL-B enhanced anti-tumor response of CAR-T and CAR-NK cell therapies
Journal Articles

USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer

Yidan Ren, Maoxiao Feng, Xiaodong Hao, Xiaoyan Liu, Juan Li, Peilong Li, Jie Gao, Qiuchen Qi, Lutao Du, Chuanxin Wang, Qin Wang, Yunshan Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1074–1093.
https://doi.org/10.1158/0008-5472.CAN-22-1812
Published: 04 April 2023
View article titled, USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Open the PDF for USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5541: BGB-15025, a potent and selective HPK1 inhibitor, is efficacious as a single agent or in combination with PD-1 antibody in multiple tumor models

Ye Liu, Jing Li, Zhuo Li, Qin Wang, Xing Zhou, Xiaoxin Liu, Bo Zhang, Xitao Wang, Sanjia Xu, Hanzi Sun, Xiaomin Song, Xi Yuan, Zhiwei Wang, Xuesong Liu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5541.
https://doi.org/10.1158/1538-7445.AM2022-5541
Published: 15 June 2022
View article titled, Abstract 5541: BGB-15025, a potent and selective HPK1 inhibitor, is efficacious as a single agent or in combination with PD-1 antibody in multiple tumor models
Journal Articles

Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment

Hui Qin Wang, Iain J. Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, Gina Trabucco, David S. Quinn, Tyler A. Longmire, Nidhi Patel, Roshani Patil, Matthew D. Shirley, Yan Chen, Hao Wang, David A. Ruddy, Claire Fabre, Juliet A. Williams, Peter S. Hammerman, Jennifer Mataraza, Barbara Platzer, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3079–3091.
https://doi.org/10.1158/0008-5472.CAN-20-0189
Published: 01 June 2021
View article titled, Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
Open the PDF for Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment in another window
Includes: Supplementary data
Journal Articles

HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

Lei Bi, Yidan Ren, Maoxiao Feng, Peng Meng, Qin Wang, Weiping Chen, Qinlian Jiao, Yuli Wang, Lutao Du, Fuqiong Zhou, Yucui Jiang, Feiyan Chen, Chuanxin Wang, Bo Tang, Yunshan Wang
Journal: Cancer Research
Cancer Res (2021) 81 (8): 2015–2028.
https://doi.org/10.1158/0008-5472.CAN-20-3044
Published: 15 April 2021
View article titled, HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness
Open the PDF for HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract 4006: Effect of Prior Cancer on Trial Eligibility and Treatment Outcomes in Nasopharyngeal Carcinoma: Implications for Clinical Trial Accrual

Ya-Qin Wang, Jia-Wei Lv, Ling-Long Tang, Xiao-Jing Du, Lei Chen, Wen-Fei Li, Xu Liu, Ying Guo, Ai-Hua Lin, Yan-Ping Mao, Ying Sun, Yu-Pei Chen, Jun Ma
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4006.
https://doi.org/10.1158/1538-7445.AM2019-4006
Published: 01 July 2019
View article titled, Abstract 4006: Effect of Prior Cancer on Trial Eligibility and Treatment Outcomes in Nasopharyngeal Carcinoma: Implications for Clinical Trial Accrual
Journal Articles

Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability

Jian Zhang, Ying-Qin Li, Rui Guo, Ya-Qin Wang, Pan-Pan Zhang, Xin-Ran Tang, Xin Wen, Xiao-Hong Hong, Yuan Lei, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Jun Ma, Na Liu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (4): 747–759.
https://doi.org/10.1158/0008-5472.CAN-18-1754
Published: 15 February 2019
View article titled, Hypermethylation of <em>SHISA3</em> Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability
Open the PDF for Hypermethylation of <em>SHISA3</em> Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability in another window
Includes: Supplementary data
Journal Articles

Abstract 3222: Evaluation of associations between circulating proteins and breast cancer risk using genetic variants

Xiang Shu, Jiandong Bao, Lang Wu, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Jacques Simard, Douglas F. Easton
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3222.
https://doi.org/10.1158/1538-7445.AM2018-3222
Published: 01 July 2018
View article titled, Abstract 3222: Evaluation of associations between circulating proteins and breast cancer risk using genetic variants
Journal Articles

Abstract 5314: DNA methylation quantitative trait loci and breast cancer risk: Data from nearly 230,000 women of European descent

Yaohua Yang, Qiuyin Cai, Xiang Shu, Lang Wu, Bingshan Li, Xingyi Guo, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Jacques Simard, Douglas F. Easton, Wei Zheng, Jirong Long, Breast Cancer Association Consortium (BCAC)
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5314.
https://doi.org/10.1158/1538-7445.AM2018-5314
Published: 01 July 2018
View article titled, Abstract 5314: DNA methylation quantitative trait loci and breast cancer risk: Data from nearly 230,000 women of European descent
Journal Articles

Abstract 5560: PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancers

Hui Qin Wang, Jinsheng Liang, Iain Mulford, Fiona Sharp, Swann Gaulis, Yan Chen, Gina Trabucco, David Quinn, Joseph D. Growney, Matthew J. Meyer, Juliet Williams, Peter Hammerman, Francesco Hofmann, Glenn Dranoff, Jeffrey Engelman, Jennifer Mataraza, Ensar Halilovic
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5560.
https://doi.org/10.1158/1538-7445.AM2018-5560
Published: 01 July 2018
View article titled, Abstract 5560: PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancers
Journal Articles

Abstract 3099: pH-regulated hydrophilicity/hydrophobicity-, surface charge-reversible and redox sensitive nanogels for anticancer drug delivery

Hao Yang, Qin Wang, Fuying Li, Yanhong Zhu, Lu Gan, Xiangliang Yang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3099.
https://doi.org/10.1158/1538-7445.AM2017-3099
Published: 01 July 2017
View article titled, Abstract 3099: pH-regulated hydrophilicity/hydrophobicity-, surface charge-reversible and redox sensitive nanogels for anticancer drug delivery
Journal Articles

Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)

Leila Dardaei, Hui Qin Wang, Paul Fordjour, Manrose Singh, Grainne Kerr, Satoshi Yoda, Jinsheng Liang, Yichen Cao, Yan Chen, Justin F. Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T. Myers, Emma Labrot, David Ruddy, Melissa Parks, Dana Lee, Richard H. DiCecca, Susan Moody, Huaixiang Hao, Morvarid Mohseni, Matthew LaMarche, Juliet Williams, Keith Hoffmaster, Giordano Caponigro, Cyril H. Benes, Alice T. Shaw, Aaron N. Hata, Fang Li, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1007.
https://doi.org/10.1158/1538-7445.AM2017-1007
Published: 01 July 2017
View article titled, Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)
Journal Articles

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Hermela Shimelis, Romy L.S. Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne M.G.R. Calléja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M. Aalfs, Kristiina Aittomäki, Irene Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W. Beckmann, Javier Benitez, Natalia V. Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dörk, Isabel dos-Santos-Silva, Alison M. Dunning, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G. Giles, Gord Glendon, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B. Hogervorst, Antoinette Hollestelle, John L. Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L. Milne, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Janet E. Olson, Curtis Olswold, Jan J.C. Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Katri Pylkäs, Paolo Radice, Muhammad Usman Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K. Schmidt, Minouk J. Schoemaker, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Martha Shrubsole, Xiao-Ou Shu, Susan Slager, Melissa C. Southey, Daniel O. Stram, Anthony Swerdlow, Soo H. Teo, Ian Tomlinson, Diana Torres, Thérèse Truong, Christi J. van Asperen, Lizet E. van der Kolk, Qin Wang, Robert Winqvist, Anna H. Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan Walker, Lenka Foretova, Florentia Fostira, Kathleen B.M. Claes, Liliana Varesco, Setareh Moghadasi, Douglas F. Easton, Amanda Spurdle, Peter Devilee, Harry Vrieling, Alvaro N.A. Monteiro, David E. Goldgar, Aura Carreira, Maaike P.G. Vreeswijk, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2017) 77 (11): 2789–2799.
https://doi.org/10.1158/0008-5472.CAN-16-2568
Published: 31 May 2017
View article titled, <em>BRCA2</em> Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Open the PDF for <em>BRCA2</em> Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2780: Evaluation of genetic variants in high and moderate-penetrance breast cancer susceptibility genes in East Asians

Mi-Ryung Han, Xiao-Ou Shu, Qiuyin Cai, Yu-Tang Gao, Ying Zheng, Kyriaki Michailidou, Joe Dennis, Manjeet K. Bolla, Qin Wang, Ji-Yeob Choi, Mikael Hartman, Daehee Kang, Artitaya Lophatananon, Hui Miao, Keitaro Matsuo, Kenneth Muir, Sulee Sangrajrang, Chen-Yang Shen, Soo Hwang Teo, Anna H Wu, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Wei Zheng, Jirong Long
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2780.
https://doi.org/10.1158/1538-7445.AM2015-2780
Published: 01 August 2015
View article titled, Abstract 2780: Evaluation of genetic variants in high and moderate-penetrance breast cancer susceptibility genes in East Asians
Journal Articles

Abstract 5570: Heterogeneity of luminal breast cancer characterized by immunohistochemical expression of basal markers

Hyuna Sung, Jenny Chang-Claude, Jonine Figueroa, Heli Nevanlinna, Graham G. Giles, Angelia Cox, Simon S. Cross, Melissa C. Southey, Catriona McLean, Manjeet K. Bolla, Mitul Shah, Alison M. Dunning, Joe Dennis, Qin Wang, Kyriaki Michailidou, Douglas F. Easton, Paul D. P. Pharoah, Mark E. Sherman, Montserrat Garcia-Closas, Xiaohong R. Yang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5570.
https://doi.org/10.1158/1538-7445.AM2015-5570
Published: 01 August 2015
View article titled, Abstract 5570: Heterogeneity of luminal breast cancer characterized by immunohistochemical expression of basal markers
Journal Articles

Abstract 782: Modulation of receptor tyrosine kinase signaling by cMET inhibitor, INC280, in cMETmut/amp gastric carcinoma cell line Hs746.T

Maria C. Pinzon-Ortiz, Xianhui Rong, Jinsheng Liang, Hui Qin Wang, Alan Huang, Robert Schlegel, Z. Alexander Cao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 782.
https://doi.org/10.1158/1538-7445.AM2015-782
Published: 01 August 2015
View article titled, Abstract 782: Modulation of receptor tyrosine kinase signaling by cMET inhibitor, INC280, in cMET<sup>mut/amp g</sup>astric carcinoma cell line Hs746.T