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β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages

Cancer Res CAN-22-0507.

DOI: https://doi.org/10.1158/0008-5472.CAN-22-0507

Published: 15 July 2022

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Includes: Supplementary data

Journal Articles

Abstract 2899: Targeting regulatory T cells with HFB101110, a novel anti-human CCR8 antibody for the treatment of solid tumors

Roshan M. Kumar, Julie Prigent, Hombline Poullain, Ayrin Kok, Carine George, Sami Ellouze, Yun-Yueh Lu, Rebecca Silver, Clarisse Monchecourt, Ross B. Fulton, Qian Zhang, Nicola Beltraminelli, Bernhard Moser, Francisco Adrian, Liang Schweizer

Cancer Res (2022) 82 (12_Supplement): 2899.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2899

Published: 15 June 2022

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Journal Articles

Abstract 4248: HFB200603, a novel anti-BTLA monoclonal antibody that provides therapeutic potential for immune escape and synergizes with anti-PD-1 treatment

Juying Li, Qian Zhang, Bingqing Shen, Manan Shah, Mingjie Chen, Sharon Li, Ling Dong, Francisco Adrian, Liang Schweizer

Cancer Res (2022) 82 (12_Supplement): 4248.

DOI: https://doi.org/10.1158/1538-7445.AM2022-4248

Published: 15 June 2022

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Journal Articles

Abstract 5560: KIR-based CAR design showed durable antitumor efficacy by altered internalization kinetics following persistent antigenic stimulation

Qian Zhang, Eric Nigel, Alvin Yu, Morgan Hresko, Nicholas Minutolo, Daniel Powell, Michael C. Milone

Cancer Res (2022) 82 (12_Supplement): 5560.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5560

Published: 15 June 2022

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Journal Articles

Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer

Cancer Res (2021) 81 (13_Supplement): 1883.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1883

Published: 01 July 2021

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Journal Articles

Abstract 1843: Dicovery and characterization of a novel anti-human CXCR5 antibody for the treatment of B cell lymphomas

Ayrin Kok, Germain Margallducos, Stephanie Beq, Clarisse Monchecourt, Hombline Poullain, Muriel David, Carine George, Sami Ellouze, Mingjie Chen, Yun-Yueh Lu, Juying Li, Qian Zhang, Jean Wang, Francisco Adrian, Liang Schweizer, Nicola Beltraminelli

Cancer Res (2021) 81 (13_Supplement): 1843.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1843

Published: 01 July 2021

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Journal Articles

NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation

Jan M. Pawlicki, David L. Cookmeyer, Damian Maseda, John K. Everett, Fang Wei, Hong Kong, Qian Zhang, Hong Y. Wang, John W. Tobias, David M. Walter, Kelly M. Zullo, Sarah Javaid, Amanda Watkins, Mariusz A. Wasik, Frederic D. Bushman, James L. Riley

Cancer Res (2021) 81 (12): 3241–3254.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-2297

Published: 15 June 2021

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Includes: Supplementary data

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Abstract 2285: HFB10-1E1, a novel OX-40 agonistic antibody with a unique pharmacological profile and biomarker strategy

Cancer Res (2020) 80 (16_Supplement): 2285.

DOI: https://doi.org/10.1158/1538-7445.AM2020-2285

Published: 15 August 2020

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Journal Articles

Abstract 4143: Identification of molecular targets for conservative management of early stage, low-grade endometrial cancer through compartment-specific transcriptome profiling

Qian Zhang, Xiaoping Su, Joseph Celestino, Ying Yuan, Samuel C. Mok, Karen H. Lu, Melinda S. Yates

Cancer Res (2020) 80 (16_Supplement): 4143.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4143

Published: 15 August 2020

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Journal Articles

Abstract 2282: Discovery and characterization of novel TNFR2 antibodies to modulate T cell activities in immunosuppressive environment

Shuo Wei, Guang Yang, Juying Li, Qian Zhang, Matthieu Delince, Greg Rose, Charina Ortega, Pascaline Mary, He Zhou, Dean Lee, Roshan Kumar, Stephanie Beq, Nicola Beltraminelli, Francisco Adrian, Liang Schweizer

Cancer Res (2020) 80 (16_Supplement): 2282.

DOI: https://doi.org/10.1158/1538-7445.AM2020-2282

Published: 15 August 2020

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Journal Articles

mTORC2 Suppresses GSK3-Dependent Snail Degradation to Positively Regulate Cancer Cell Invasion and Metastasis

Shuo Zhang, Guoqing Qian, Qian-Qian Zhang, Yuying Yao, Dongsheng Wang, Zhuo G. Chen, Li-Jing Wang, Mingwei Chen, Shi-Yong Sun

Cancer Res (2019) 79 (14): 3725–3736.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-0180

Published: 15 July 2019

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Includes: Supplementary data

Journal Articles

Abstract 4598: mTORC2 suppresses GSK3-dependent, but b-TrCP-independent, Snail degradation, contributing to positive regulation of cancer cell invasion and metastasis

Shuo Zhang, Guoqing Qian, Qian-Qian Zhang, Yuying Yao, DongSheng Wang, Zhuo G. Chen, Lijing Wang, Mingwei Chen, Shi-Yong Sun

Cancer Res (2019) 79 (13_Supplement): 4598.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4598

Published: 01 July 2019

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Journal Articles

Abstract 1324: TRPM2 promotes leukemia proliferation and survival through modulation of ROS and autophagy

Shu-Jen Chen, Lei Bao, Kerry Keefer, Longgui Chen, JuFang Wang, Xue-Qian Zhang, Santhanam Shanmughapriya, Iwona Hirschler-Laszkiewicz, Muniswamy Madesh, Joseph Y. Cheung, Hong-Gang Wang, Barbara A. Miller

Cancer Res (2018) 78 (13_Supplement): 1324.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1324

Published: 01 July 2018

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Journal Articles

Abstract 1458: TRPM2 modulates neuroblastoma cell survival through Pyk2, CREB and MCU activation

Iwona Malgorzata Hirschler-Laszkiewicz, Shu-jen Chen, Lei Bao, JuFang Wang, Xue-Qian Zhang, Santhanam Shanmughapriya, Kerry Keefer, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller

Cancer Res (2018) 78 (13_Supplement): 1458.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1458

Published: 01 July 2018

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Journal Articles

Abstract 4480: SerRS is a key inhibitor of VEGFA through both transcriptional and translational controls

Ze Liu, Yi Shi, Qian Zhang, Xianglei Yang

Cancer Res (2017) 77 (13_Supplement): 4480.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4480

Published: 01 July 2017

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Journal Articles

Abstract 1214: Development of anti-5T4 antibody-drug conjugates, ZV05-ADCs for targeted cancer therapy in different type of cancers

Zhaohui Li, Zhangming Xie, Qian Zhang, Jie Fang, Liqin Wu, Hedi Fang, Hong Zhang, Tong Zhu, Gang Chen, David Miao, Sheldon Cao

Cancer Res (2016) 76 (14_Supplement): 1214.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1214

Published: 15 July 2016

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Journal Articles

miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14

Yiyi Li, Cem Kuscu, Anna Banach, Qian Zhang, Ashleigh Pulkoski-Gross, Deborah Kim, Jingxuan Liu, Eric Roth, Ellen Li, Kenneth R. Shroyer, Paula I. Denoya, Xiaoxia Zhu, Longhua Chen, Jian Cao

Cancer Res (2015) 75 (13): 2674–2685.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-2875

Published: 30 June 2015

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Includes: Supplementary data

Journal Articles

Abstract PR7: An oncolytic vaccinia virus encoding the human sodium iodide symporter facilitates long-term deep-tissue image monitoring of virotherapy and targeted radiotherapy of pancreatic cancer

Dana Haddad, Aladar A. Szalay, Yuman Fong, Pat B. Zanzonico, Sean Carlin, Chun-Hao Chen, Nanhai G. Chen, Qian Zhang, Yong A. Yu, Valerie Longo, Kelly Mojica

Cancer Res (2011) 71 (18_Supplement): PR7.

DOI: https://doi.org/10.1158/1538-7445.FBCR11-PR7

Published: 28 October 2014

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Journal Articles

Abstract C58: Heterotetramers of ERBB2 and ERBB3 generate qualitatively distinct signals from heterodimers and provide most of the neuregulin-induced phosphorylation of ERBB2

Qian Zhang, Eisun Park, Kian Kani, Ralf Landgraf

Cancer Res (2011) 71 (18_Supplement): C58.

DOI: https://doi.org/10.1158/1538-7445.FBCR11-C58

Published: 28 October 2014

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Journal Articles

Abstract 4102: p27 as a biomarker and determinant of risk for endometrial carcinoma arising in the setting of obesity

Adrienne S. McCampbell, Megan L. Mittlestedt, Ruhee Dere, Lijun Zhou, Bojana Djordjevic, Pamela T. Soliman, Qian Zhang, Caimiao Wei, Stephen D. Hursting, Karen H. Lu, Cheryl L. Walker, Russell R. Broaddus

Cancer Res (2014) 74 (19_Supplement): 4102.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4102

Published: 01 October 2014

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NARROW

β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages

Abstract 2899: Targeting regulatory T cells with HFB101110, a novel anti-human CCR8 antibody for the treatment of solid tumors

Abstract 4248: HFB200603, a novel anti-BTLA monoclonal antibody that provides therapeutic potential for immune escape and synergizes with anti-PD-1 treatment

Abstract 5560: KIR-based CAR design showed durable antitumor efficacy by altered internalization kinetics following persistent antigenic stimulation

Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer

Abstract 1843: Dicovery and characterization of a novel anti-human CXCR5 antibody for the treatment of B cell lymphomas

NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation

Abstract 2285: HFB10-1E1, a novel OX-40 agonistic antibody with a unique pharmacological profile and biomarker strategy

Abstract 4143: Identification of molecular targets for conservative management of early stage, low-grade endometrial cancer through compartment-specific transcriptome profiling

Abstract 2282: Discovery and characterization of novel TNFR2 antibodies to modulate T cell activities in immunosuppressive environment

mTORC2 Suppresses GSK3-Dependent Snail Degradation to Positively Regulate Cancer Cell Invasion and Metastasis

Abstract 4598: mTORC2 suppresses GSK3-dependent, but b-TrCP-independent, Snail degradation, contributing to positive regulation of cancer cell invasion and metastasis

Abstract 1324: TRPM2 promotes leukemia proliferation and survival through modulation of ROS and autophagy

Abstract 1458: TRPM2 modulates neuroblastoma cell survival through Pyk2, CREB and MCU activation

Abstract 4480: SerRS is a key inhibitor of VEGFA through both transcriptional and translational controls

Abstract 1214: Development of anti-5T4 antibody-drug conjugates, ZV05-ADCs for targeted cancer therapy in different type of cancers

miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14

Abstract PR7: An oncolytic vaccinia virus encoding the human sodium iodide symporter facilitates long-term deep-tissue image monitoring of virotherapy and targeted radiotherapy of pancreatic cancer

Abstract C58: Heterotetramers of ERBB2 and ERBB3 generate qualitatively distinct signals from heterodimers and provide most of the neuregulin-induced phosphorylation of ERBB2

Abstract 4102: p27 as a biomarker and determinant of risk for endometrial carcinoma arising in the setting of obesity

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