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Journal Articles

Abstract CT056: Development of a novel next-generation RET inhibitor

Jun Zhong, Ruxue Xiao, Wenya Xie, Minchun Chen, Xiaohu Chen, Hao Wang, Yongbo Liu, Qin Gao, Xiupeng Wang, Zongbao Wang, Qian Chen, Jing Yang, Yizhe Ji, Yuxun Wang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT056.
https://doi.org/10.1158/1538-7445.AM2024-CT056
Published: 05 April 2024
View article titled, Abstract CT056: Development of a novel next-generation RET inhibitor
Journal Articles

Abstract CT117: A phase 1 study of D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, as monotherapy in patients with KRAS G12C-mutated solid tumors

Byoung Chul Cho, Shun Lu, Myung Ah Lee, Zhengbo Song, John Park, Sun Min Lim, Ziming Li, Jun Zhao, Gary Richardson, Yanqiao Zhang, Jun Zhang, Anwen Liu, Cheng Chen, Jia Wang, Jingtao Lu, Haopeng Rui, Qian Chen, Hui Wang, Jing Zhang, Zhi Jian Chen, Tony Mok
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT117.
https://doi.org/10.1158/1538-7445.AM2024-CT117
Published: 05 April 2024
View article titled, Abstract CT117: A phase 1 study of D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, as monotherapy in patients with KRAS G12C-mutated solid tumors
Journal Articles

Abstract 7668: Novel pretreatment nomograms based on pan-Immune-inflammation value for predicting clinical outcome in patients with head and neck squamous cell carcinoma

Qian Chen, Xiang Li, Yanxia Bai, Yue Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7668.
https://doi.org/10.1158/1538-7445.AM2024-7668
Published: 22 March 2024
View article titled, Abstract 7668: Novel pretreatment nomograms based on pan-Immune-inflammation value for predicting clinical outcome in patients with head and neck squamous cell carcinoma
Journal Articles

Abstract 2729: Discovery and characterization of LILRB2XPD-L1 bispecific antibody SPX-303

Anthony Haight, Qian Chen, Brandon William, Dinh-Duc Nguyen, Robert Cai, Jichun Ma, Michael White, Jindong Jin, Jadon Shen, Martin Siekierzycki, Victoria Hall, Hua Jin, Roland Meier, Justin Moser
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2729.
https://doi.org/10.1158/1538-7445.AM2024-2729
Published: 22 March 2024
View article titled, Abstract 2729: Discovery and characterization of LILRB2XPD-L1 bispecific antibody SPX-303
Journal Articles

Abstract ND10: Discovery of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for MYC-driven cancers

Owen B. Wallace, Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Maciej Cabanski, Lisa Cantagallo, Agustin Chicas, Qian Chen, Anna Diesslin, Christopher King, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Dave Peck, Carolina Perdomo Ortiz, Martin Schillo, Ambika Singh, Ralph Tiedt, Simone Tortoioli, Silvia Buonamici, Markus Warmuth, Filip Janku, Bernhard Fasching
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): ND10.
https://doi.org/10.1158/1538-7445.AM2023-ND10
Published: 29 May 2023
View article titled, Abstract ND10: Discovery of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for MYC-driven cancers
Journal Articles

Abstract 5663: Discovery and characterization of anti-LILRB2 antibody SPX-104

Anthony Haight, Qian Chen, Ernesto Rodriguez, Martin Siekierzycki, Victoria Hall, Brandon Williams, Jun Shi, Dinh-Duc Nguyen, Robert Cai, Jichun Ma, Michael White, Jingdong Qin, Jadon Shen, Chuanke Zhao, Zhuona Rong, Lin Meng, Chengchao Shou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5663.
https://doi.org/10.1158/1538-7445.AM2023-5663
Published: 04 April 2023
View article titled, Abstract 5663: Discovery and characterization of anti-LILRB2 antibody SPX-104
Journal Articles

Abstract 3449: Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction

Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Maciej Cabanski, Lisa Cantagallo, Agustin Chicas, Qian Chen, Anna Diesslin, Christopher King, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Dave Peck, Carolina Perdomo Ortiz, Martin Schillo, Ambika Singh, Ralph Tiedt, Simone Tortoioli, Silvia Buonamici, Filip Janku, Owen Wallace, Bernhard Fasching
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3449.
https://doi.org/10.1158/1538-7445.AM2023-3449
Published: 04 April 2023
View article titled, Abstract 3449: Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction
Journal Articles

Abstract 5720: Niraparib enhances radiosensitivity of glioblastoma cells with proficient BRCA1/2 through proliferation-related nucleolar protein DDX21

Jia Luo, He Xiao, Qian Chen, Yanlan Li, Chuan Chen, Mingying Geng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5720.
https://doi.org/10.1158/1538-7445.AM2022-5720
Published: 15 June 2022
View article titled, Abstract 5720: Niraparib enhances radiosensitivity of glioblastoma cells with proficient BRCA1/2 through proliferation-related nucleolar protein DDX21
Journal Articles

Abstract 2193: Subsets of cancer cells expressing CX3CR1 are endowed with metastasis-initiating properties and resistance to chemotherapy

Jieyi Zhang, Anthony DiNatale, Ramanpreet Kaur, Qian Chen, Michael Marchioli, Darin Ipe, Maria Castelli, Christopher McNair, Gaurav Kumar, Olimpia Meucci, Alessandro Fatatis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2193.
https://doi.org/10.1158/1538-7445.AM2022-2193
Published: 15 June 2022
View article titled, Abstract 2193: Subsets of cancer cells expressing CX3CR1 are endowed with metastasis-initiating properties and resistance to chemotherapy
Journal Articles

Abstract 6383: HTBPI inhibits liver tumorigenesis by combined inhibition of Akt

Haiyang Yu, Hongwei Liu, Qian Chen, Xu Pang, Shuangshuang Yin, Kailong Wang, Rui Wang, Tao Wang, Yuling Qiu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6383.
https://doi.org/10.1158/1538-7445.AM2020-6383
Published: 15 August 2020
View article titled, Abstract 6383: HTBPI inhibits liver tumorigenesis by combined inhibition of Akt
Journal Articles

CD317 Activates EGFR by Regulating Its Association with Lipid Rafts

Guizhong Zhang, Xin Li, Qian Chen, Junxin Li, Qingguo Ruan, Youhai H. Chen, Xiaolu Yang, Xiaochun Wan
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2220–2231.
https://doi.org/10.1158/0008-5472.CAN-18-2603
Published: 01 May 2019
View article titled, CD317 Activates EGFR by Regulating Its Association with Lipid Rafts
Open the PDF for CD317 Activates EGFR by Regulating Its Association with Lipid Rafts in another window
Includes: Supplementary data
Journal Articles

Abstract CT041: The clinical study on CD19-directed chimeric antigen receptor-modified T cells in patient with Richter Syndrome

Leiming Xia, Qian Chen, Qiao Li, Tan Li, Yi Wang, Yangyi Bao
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT041.
https://doi.org/10.1158/1538-7445.AM2017-CT041
Published: 01 July 2017
View article titled, Abstract CT041: The clinical study on CD19-directed chimeric antigen receptor-modified T cells in patient with Richter Syndrome
Journal Articles

Abstract 2820: Use of a genetically engineered mouse model and RNA sequencing to identify genes that are aberrantly regulated by mutant p53 in prostate cells following irradiation

Ruth L. Vinall, Qian Chen, George Talbott, Neil Hubbard, Clifford Tepper, Alexander Borowsky
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2820.
https://doi.org/10.1158/1538-7445.AM2017-2820
Published: 01 July 2017
View article titled, Abstract 2820: Use of a genetically engineered mouse model and RNA sequencing to identify genes that are aberrantly regulated by mutant p53 in prostate cells following irradiation
Journal Articles

Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer

Mo Li, Qian Chen, Xiaochun Yu
Journal: Cancer Research
Cancer Res (2017) 77 (2): 448–458.
https://doi.org/10.1158/0008-5472.CAN-16-2350
Published: 16 January 2017
View article titled, Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer
Open the PDF for Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage

Lintao Wang, Qian Chen, Haixia Qi, Chunming Wang, Cheng Wang, Junfeng Zhang, Lei Dong
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (22): 6631–6642.
https://doi.org/10.1158/0008-5472.CAN-15-3034
Published: 14 November 2016
View article titled, Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage
Open the PDF for Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage in another window
Includes: Supplementary data
Journal Articles

Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study

Jennifer Schmitz, Julian Schwab, Johannes Schwenck, Qian Chen, Leticia Quintanilla-Martinez, Markus Hahn, Beate Wietek, Nina Schwenzer, Annette Staebler, Ursula Kohlhofer, Olulanu H. Aina, Neil E. Hubbard, Gerald Reischl, Alexander D. Borowsky, Sara Brucker, Konstantin Nikolaou, Christian la Fougère, Robert D. Cardiff, Bernd J. Pichler, Andreas M. Schmid
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5512–5522.
https://doi.org/10.1158/0008-5472.CAN-15-0642
Published: 15 September 2016
View article titled, Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric <em>In Vivo</em> Imaging: A Translational Study
Open the PDF for Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric <em>In Vivo</em> Imaging: A Translational Study in another window
Includes: Supplementary data
Journal Articles

Combined Treatment with Epigenetic, Differentiating, and Chemotherapeutic Agents Cooperatively Targets Tumor-Initiating Cells in Triple-Negative Breast Cancer

Vanessa F. Merino, Nguyen Nguyen, Kideok Jin, Helen Sadik, Soonweng Cho, Preethi Korangath, Liangfeng Han, Yolanda M.N. Foster, Xian C. Zhou, Zhe Zhang, Roisin M. Connolly, Vered Stearns, Syed Z. Ali, Christina Adams, Qian Chen, Duojia Pan, David L. Huso, Peter Ordentlich, Angela Brodie, Saraswati Sukumar
Journal: Cancer Research
Cancer Res (2016) 76 (7): 2013–2024.
https://doi.org/10.1158/0008-5472.CAN-15-1619
Published: 31 March 2016
View article titled, Combined Treatment with Epigenetic, Differentiating, and Chemotherapeutic Agents Cooperatively Targets Tumor-Initiating Cells in Triple-Negative Breast Cancer
Open the PDF for Combined Treatment with Epigenetic, Differentiating, and Chemotherapeutic Agents Cooperatively Targets Tumor-Initiating Cells in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4231: Combination of epigenetic, differentiation and DNA damaging agents induce tumor cell death and stem cell depletion in breast cancer

Vanessa F. Merino, Nguyen Nguyen, Helen Sadik, Soonweng Cho, Leslie Cope, Xian C. Zhou, Zhe Zhang, Qian Chen, Duojia Pan, David L. Huso, Syed Ali, Christina Adams, Balázs Győrffy, Saraswati Sukumar
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4231.
https://doi.org/10.1158/1538-7445.AM2015-4231
Published: 01 August 2015
View article titled, Abstract 4231: Combination of epigenetic, differentiation and DNA damaging agents induce tumor cell death and stem cell depletion in breast cancer
Journal Articles

Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs

Diana I. Albu, Zichun Wang, Jiayi Wu, Kuan-chun Huang, Wei Li, Diana Liu, Galina Kuznetsov, Qian Chen, Xingfeng Bao, Mary Woodall-Jappe
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 275.
https://doi.org/10.1158/1538-7445.AM2015-275
Published: 01 August 2015
View article titled, Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs
Journal Articles

Abstract 3726: Combinations of HDAC inhibitor, chemotherapeutic agent and retinoic acid induce growth arrest, differentiation and tumor regression in preclinical models of breast cancer.

Vanessa F. Merino, Nguyen Nguyen, Helen Sadik, Sean Cho, Xian Chong Zhou, Qian Chen, Duojia Pan, Saraswati Sukumar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3726.
https://doi.org/10.1158/1538-7445.AM2013-3726
Published: 15 April 2013
View article titled, Abstract 3726: Combinations of HDAC inhibitor, chemotherapeutic agent and retinoic acid induce growth arrest, differentiation and tumor regression in preclinical models of breast cancer.