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Histone deacetylase inhibitors deplete Ezh2 and associated Polycomb Repressive Complex 2/3 proteins resulting in downregulation of HOXA9 and MEIS1 expression in human acute leukemia cells

Warren Fiskus, Michael Pranpat, Purva Bali, Maria Balasis, Sandhya Kumaraswamy, Sandhya Boyapalle, Kathy Rocha, Peter Atadja, Kapil Bhalla

Cancer Res (2006) 66 (8_Supplement): 1089.

Published: 15 April 2006

View articletitled, Histone deacetylase inhibitors deplete Ezh2 and associated Polycomb Repressive Complex 2/3 proteins resulting in downregulation of HOXA9 and MEIS1 expression in human acute leukemia cells

Journal Articles

Inhibition of histone deacetylase 6 sensitizes human leukemia and breast cancer cells to inhibitor of heat shock protein 90 and/or bortezomib

Purva Bali, Maria Balasis, Warren Fiskus, Michael Pranpat, Kathy Rocha, Sandhya Kumaraswamy, Sandhya Boyapalle, Peter Atadja, Kapil Bhalla

Cancer Res (2006) 66 (8_Supplement): 576.

Published: 15 April 2006

View articletitled, Inhibition of histone deacetylase 6 sensitizes human leukemia and breast cancer cells to inhibitor of heat shock protein 90 and/or bortezomib

Journal Articles

Levels and activity of nerve growth factor (NGF) receptor tyrosine kinase TrkA, a heat shock protein (hsp) 90 chaperoned client protein, are abrogated in human acute leukemia cells by hsp90 inhibitor17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG).

Sandhya Kumaraswamy, Que T. Lambert, Kathy Rocha, Purva Bali, Warren Fiskus, Maria Balasis, Michael Pranpat, Sandhya Boyapalle, Alison Hannah, Gary W. Reuther, Kapil Bhalla

Cancer Res (2006) 66 (8_Supplement): 1296.

Published: 15 April 2006

View articletitled, Levels and activity of nerve growth factor (NGF) receptor tyrosine kinase TrkA, a heat shock protein (hsp) 90 chaperoned client protein, are abrogated in human acute leukemia cells by hsp90 inhibitor17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG).

Journal Articles

Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin

Fei Guo, Kathy Rocha, Purva Bali, Michael Pranpat, Warren Fiskus, Sandhya Boyapalle, Sandhya Kumaraswamy, Maria Balasis, Benjamin Greedy, E. Simon M. Armitage, Nicholas Lawrence, Kapil Bhalla

Cancer Res (2005) 65 (22): 10536–10544.

https://doi.org/10.1158/0008-5472.CAN-05-1799

Published: 15 November 2005

View articletitled, Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin

Journal Articles

Chemical ablation of androgen receptor in prostate cancer cells with the histone deacetylase inhibitor LAQ824

Liwei Chen, Songshu Meng, Purva Bali, Peter Atadja, Kapil Bhalla, Jie Wu

Cancer Res (2005) 65 (9_Supplement): 1449.

Published: 01 May 2005

View articletitled, Chemical ablation of androgen receptor in prostate cancer cells with the histone deacetylase inhibitor LAQ824

Journal Articles

Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Fei Guo, Celia Sigua, Purva Bali, Michael Pranpat, Warren Fiskus, Nicholas Lawrence, Kapil Bhalla

Cancer Res (2005) 65 (9_Supplement): 771.

Published: 01 May 2005

View articletitled, Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Journal Articles

Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Purva Bali, Fei Guo, Warren Fiskus, Michael Pranpat, Celia Sigua, Kapil Bhalla

Cancer Res (2005) 65 (9_Supplement): 769–770.

Published: 01 May 2005

View articletitled, Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Journal Articles

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Prince George, Purva Bali, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Warren Fiskus, Anna Scuto, Srinivas Annavarapu, Lynn Moscinski, Kapil Bhalla

Cancer Res (2004) 64 (10): 3645–3652.

https://doi.org/10.1158/0008-5472.CAN-04-0006

Published: 17 May 2004

View articletitled, Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Journal Articles

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Fei Guo, Celia Sigua, Jianguo Tao, Purva Bali, Prince George, Yunqing Li, Sylvie Wittmann, Lynn Moscinski, Peter Atadja, Kapil Bhalla

Cancer Res (2004) 64 (7): 2580–2589.

https://doi.org/10.1158/0008-5472.CAN-03-2629

Published: 01 April 2004

View articletitled, Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Journal Articles

Molecular mechanisms underlying the superior activity of sequential treatment with Docetaxel followed by Flavopiridol in human breast cancer cells

Purva Bali, Yunqing Li, Kapil N. Bhalla

Cancer Res (2004) 64 (7_Supplement): 136–137.

Published: 01 April 2004

View articletitled, Molecular mechanisms underlying the superior activity of sequential treatment with Docetaxel followed by Flavopiridol in human breast cancer cells

Journal Articles

Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-x_L and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Fei Guo, Celia Sigua, Purva Bali, Prince George, Ravi Gutti, Yunqing Li, Kapil N. Bhalla

Cancer Res (2004) 64 (7_Supplement): 135–136.

Published: 01 April 2004

View articletitled, Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-xL and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

Journal Articles

A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Ravi Gutti, Prince George, Purva Bali, Jianguo Tao, Fei Guo, Celia Sigua, Yunqing Li, Lynn Moscinski, Peter Atadja, Kapil N. Bhalla

Cancer Res (2004) 64 (7_Supplement): 699.

Published: 01 April 2004

View articletitled, A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Journal Articles

Arsenic Trioxide Inhibits Translation of mRNA of bcr-abl , Resulting in Attenuation of Bcr-Abl Levels and Apoptosis of Human Leukemia Cells

Ramadevi Nimmanapalli, Purva Bali, Erica O’Bryan, Lianne Fuino, Fei Guo, Jie Wu, Peter Houghton, Kapil Bhalla

Cancer Res (2003) 63 (22): 7950–7958.

Published: 21 November 2003

View articletitled, Arsenic Trioxide Inhibits Translation of mRNA of bcr-abl , Resulting in Attenuation of Bcr-Abl Levels and Apoptosis of Human Leukemia Cells

Journal Articles

Histone Deacetylase Inhibitor LAQ824 Both Lowers Expression and Promotes Proteasomal Degradation of Bcr-Abl and Induces Apoptosis of Imatinib Mesylate-sensitive or -refractory Chronic Myelogenous Leukemia-Blast Crisis Cells

Ramadevi Nimmanapalli, Lianne Fuino, Purva Bali, Maura Gasparetto, Michele Glozak, Jianguo Tao, Lynn Moscinski, Clayton Smith, Jie Wu, Richard Jove, Peter Atadja, Kapil Bhalla

Cancer Res (2003) 63 (16): 5126–5135.

Published: 26 August 2003

View articletitled, Histone Deacetylase Inhibitor LAQ824 Both Lowers Expression and Promotes Proteasomal Degradation of Bcr-Abl and Induces Apoptosis of Imatinib Mesylate-sensitive or -refractory Chronic Myelogenous Leukemia-Blast Crisis Cells

Journal Articles

Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis

Sylvie Wittmann, Purva Bali, Sreenivasa Donapaty, Ramadevi Nimmanapalli, Fei Guo, Hirohito Yamaguchi, Mei Huang, Richard Jove, Hong Gang Wang, Kapil Bhalla

Cancer Res (2003) 63 (1): 93–99.

Published: 01 January 2003

View articletitled, Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis

Journal Articles

Molecular Characterization and Sensitivity of STI-571 (Imatinib Mesylate, Gleevec)-resistant, Bcr-Abl-positive, Human Acute Leukemia Cells to SRC Kinase Inhibitor PD180970 and 17-Allylamino-17-demethoxygeldanamycin

Ramadevi Nimmanapalli, Erica O’Bryan, Mei Huang, Purva Bali, Pearlie Kay Burnette, Thomas Loughran, James Tepperberg, Richard Jove, Kapil Bhalla

Cancer Res (2002) 62 (20): 5761–5769.

Published: 15 October 2002

View articletitled, Molecular Characterization and Sensitivity of STI-571 (Imatinib Mesylate, Gleevec)-resistant, Bcr-Abl-positive, Human Acute Leukemia Cells to SRC Kinase Inhibitor PD180970 and 17-Allylamino-17-demethoxygeldanamycin

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Histone deacetylase inhibitors deplete Ezh2 and associated Polycomb Repressive Complex 2/3 proteins resulting in downregulation of HOXA9 and MEIS1 expression in human acute leukemia cells

Inhibition of histone deacetylase 6 sensitizes human leukemia and breast cancer cells to inhibitor of heat shock protein 90 and/or bortezomib

Levels and activity of nerve growth factor (NGF) receptor tyrosine kinase TrkA, a heat shock protein (hsp) 90 chaperoned client protein, are abrogated in human acute leukemia cells by hsp90 inhibitor17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG).

Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin

Chemical ablation of androgen receptor in prostate cancer cells with the histone deacetylase inhibitor LAQ824

Abrogation of hsp70 induction: A strategy to enhance the antileukemia effects of hsp90 inhibitor 17-allylamino-demethoxy geldanamycin (17-AAG)

Mechanisms underlying hydroxamic acid analogue (HA) histone deacetylase (HDAC) inhibitors (HDIs)-induced apoptosis: New role of HDAC6 inhibition, acetylation and inhibition of hsp90 and depletion of pro-growth and pro-survival oncoproteins

Cotreatment with 17-Allylamino-Demethoxygeldanamycin and FLT-3 Kinase Inhibitor PKC412 Is Highly Effective against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Molecular mechanisms underlying the superior activity of sequential treatment with Docetaxel followed by Flavopiridol in human breast cancer cells

Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-x_L and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells

A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase.

Arsenic Trioxide Inhibits Translation of mRNA of bcr-abl , Resulting in Attenuation of Bcr-Abl Levels and Apoptosis of Human Leukemia Cells

Histone Deacetylase Inhibitor LAQ824 Both Lowers Expression and Promotes Proteasomal Degradation of Bcr-Abl and Induces Apoptosis of Imatinib Mesylate-sensitive or -refractory Chronic Myelogenous Leukemia-Blast Crisis Cells

Flavopiridol Down-Regulates Antiapoptotic Proteins and Sensitizes Human Breast Cancer Cells to Epothilone B-induced Apoptosis

Molecular Characterization and Sensitivity of STI-571 (Imatinib Mesylate, Gleevec)-resistant, Bcr-Abl-positive, Human Acute Leukemia Cells to SRC Kinase Inhibitor PD180970 and 17-Allylamino-17-demethoxygeldanamycin

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