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Purushottam Lamichhane
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Journal Articles

Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

Vanessa Tonin Garrido, Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Purushottam Lamichhane, Siddharth Mehra, Samara P. Singh, Austin R. Dosch, Oliver Umland, Michael n N. VanSaun, Peter J. Hosein, Nagaraj Nagathihalli, Nipun Merchant
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4187.
https://doi.org/10.1158/1538-7445.AM2022-4187
Published: 15 June 2022
View article titled, Abstract 4187: Combined MEK and STAT3 inhibition reprograms the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer
Journal Articles

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Nagaraj S. Nagathihalli, Jason A. Castellanos, Purushottam Lamichhane, Fanuel Messaggio, Chanjuan Shi, Xizi Dai, Priyamvada Rai, Xi Chen, Michael N. VanSaun, Nipun B. Merchant
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6235–6246.
https://doi.org/10.1158/0008-5472.CAN-18-0634
Published: 01 November 2018
View article titled, Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
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Journal Articles

Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Supriya Srinivasan, Tulasigeri Totiger, Chanjuan Shi, Jason Castellanos, Purushottam Lamichhane, Austin R. Dosch, Fanuel Messaggio, Nilesh Kashikar, Kumaraswamy Honnenahally, Yuguang Ban, Nipun B. Merchant, Michael VanSaun, Nagaraj S. Nagathihalli
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6146–6158.
https://doi.org/10.1158/0008-5472.CAN-18-0579
Published: 01 November 2018
View article titled, Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Open the PDF for Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer

Purushottam Lamichhane, Lavakumar Karyampudi, Barath Shreeder, James Krempski, Deborah Bahr, Joshua Daum, Kimberly R. Kalli, Ellen L. Goode, Matthew S. Block, Martin J. Cannon, Keith L. Knutson
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6667–6678.
https://doi.org/10.1158/0008-5472.CAN-17-0740
Published: 30 November 2017
View article titled, IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Abstract B75: Targeting the immune-microenvironment with combined inhibition of MEK and STAT3 in a mouse model of pancreatic cancer

Casey Roberts, Michael N. VanSaun, Purushottam Lamichhane, Fanuel Messaggio, Krisztina Kovacs, Supriya Srinivasan, Xizi Dai, Jennifer Barretta, Nagaraj Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B75.
https://doi.org/10.1158/1538-7445.PANCA16-B75
Published: 14 December 2016
View article titled, Abstract B75: Targeting the immune-microenvironment with combined inhibition of MEK and STAT3 in a mouse model of pancreatic cancer
Journal Articles

PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB

Lavakumar Karyampudi, Purushottam Lamichhane, James Krempski, Kimberly R. Kalli, Marshall D. Behrens, Doris M. Vargas, Lynn C. Hartmann, Jo Marie T. Janco, Haidong Dong, Karen E. Hedin, Allan B. Dietz, Ellen L. Goode, Keith L. Knutson
Journal: Cancer Research
Cancer Res (2016) 76 (2): 239–250.
https://doi.org/10.1158/0008-5472.CAN-15-0748
Published: 14 January 2016
View article titled, PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB
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Includes: Supplementary data
Journal Articles

Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody

Lavakumar Karyampudi, Purushottam Lamichhane, Adam D. Scheid, Kimberly R. Kalli, Barath Shreeder, James W. Krempski, Marshall D. Behrens, Keith L. Knutson
Journal: Cancer Research
Cancer Res (2014) 74 (11): 2974–2985.
https://doi.org/10.1158/0008-5472.CAN-13-2564
Published: 29 May 2014
View article titled, Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody
Open the PDF for Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody in another window
Includes: Supplementary data