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Journal Articles

Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer

Ling Zhang, Clara I. Troccoli, Beatriz Mateo-Victoriano, Laura Misiara Lincheta, Erin Jackson, Ping Shu, Trisha Plastini, Wensi Tao, Deukwoo Kwon, Xi Steven Chen, Janaki Sharma, Merce Jorda, Surinder Kumar, David B. Lombard, James L. Gulley, Marijo Bilusic, Albert C. Lockhart, Annie Beuve, Priyamvada Rai

Cancer Res (2025) 85 (1): 134–153.

https://doi.org/10.1158/0008-5472.CAN-24-0133

Published: 02 January 2025

View article titled, Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer

Includes: Supplementary data

Journal Articles

Abstract 2967: The mammalian 8-oxo-dGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Beatriz Mateo-Victoriano, Ling Zhang, Jaya Samaranayake, Z McGaughey, Cassie Due, Clara Troccoli, Michael G. Mohsen, Nagaraj Nagathihalli, Oliver G. McDonald, Michael VanSaun, Eric T. Kool, Priyamvada Rai

Cancer Res (2024) 84 (6_Supplement): 2967.

https://doi.org/10.1158/1538-7445.AM2024-2967

Published: 22 March 2024

View article titled, Abstract 2967: The mammalian 8-oxo-dGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Journal Articles

Abstract B091: The mammalian 8-oxodGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Beatriz Mateo-Victoriano, Ling Zhang, Govindi J. Samaranayake, Vanessa Mcgaughey, Cassie Due, Clara Troccoli, Michael G. Mohsen, Nagaraj S. Nagathihalli, Oliver G. McDonald, Michael VanSaun, Eric T. Kool, Priyamvada Rai

Cancer Res (2024) 84 (2_Supplement): B091.

https://doi.org/10.1158/1538-7445.PANCA2023-B091

Published: 16 January 2024

View article titled, Abstract B091: The mammalian 8-oxodGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Journal Articles

Abstract 4790: Oxidation in the nucleotide pool as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Beatriz Mateo-Victoriano, Ling Zhang, Govindi J. Samaranayake, Cassie Due, Clara Troccoli, Julia Zaias, Nagaraj Nagathihalli, Michael VanSaun, Michael G. Mohsen, Eric T. Kool, Priyamvada Rai

Cancer Res (2023) 83 (7_Supplement): 4790.

https://doi.org/10.1158/1538-7445.AM2023-4790

Published: 04 April 2023

View article titled, Abstract 4790: Oxidation in the nucleotide pool as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Journal Articles

Abstract 4335: Repurposing metformin in early-stage high risk prostate cancer to avoid ADT-induced cardiovascular toxicity

Philip Gregory, Beatriz Mateo-Victoriano, Ling Zhang, Cassie Due, Marijo Bilusic, Priyamvada Rai

Cancer Res (2023) 83 (7_Supplement): 4335.

https://doi.org/10.1158/1538-7445.AM2023-4335

Published: 04 April 2023

View article titled, Abstract 4335: Repurposing metformin in early-stage high risk prostate cancer to avoid ADT-induced cardiovascular toxicity

Journal Articles

Abstract 2076: Low OGG1 protects against the DNA damage induced by MTH1 inhibition

Laura Misiara Lincheta, Ling Zhang, Govindi Samaranayake, Nisha Sharma, Dao Nguyen, Yu-Ki Tahara, Eric Kool, Priyamvada Rai

Cancer Res (2021) 81 (13_Supplement): 2076.

https://doi.org/10.1158/1538-7445.AM2021-2076

Published: 01 July 2021

View article titled, Abstract 2076: Low OGG1 protects against the DNA damage induced by MTH1 inhibition

Journal Articles

Abstract 888: Exploring the signaling and activity interactome between oncogenic RAS and the nucleotide pool-detoxifying enzyme MTH1

Govindi J. Samaranayake, Clara I. Troccoli, Christina Jayaraj, Brittany C. Durden, Nagaraj Nagathihalli, Nipun Merchant, Priyamvada Rai

Cancer Res (2019) 79 (13_Supplement): 888.

https://doi.org/10.1158/1538-7445.AM2019-888

Published: 01 July 2019

View article titled, Abstract 888: Exploring the signaling and activity interactome between oncogenic RAS and the nucleotide pool-detoxifying enzyme MTH1

Journal Articles

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Nagaraj S. Nagathihalli, Jason A. Castellanos, Purushottam Lamichhane, Fanuel Messaggio, Chanjuan Shi, Xizi Dai, Priyamvada Rai, Xi Chen, Michael N. VanSaun, Nipun B. Merchant

Cancer Res (2018) 78 (21): 6235–6246.

https://doi.org/10.1158/0008-5472.CAN-18-0634

Published: 01 November 2018

View article titled, Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Journal Articles

Abstract B032: Inappropriate AR reactivation-induced redox stress as a novel therapeutic target in castration-resistant prostate cancer

Govindi J. Samaranayake, Clara I. Troccoli, Mai Q. Huynh, Rolando D.Z. Lyles, Deukwoo Kwon, Yuguang Ban, Steven Xi Chen, Merce Jorda, Kerry Burnstein, Priyamvada Rai

Cancer Res (2018) 78 (16_Supplement): B032.

https://doi.org/10.1158/1538-7445.PRCA2017-B032

Published: 14 August 2018

View article titled, Abstract B032: Inappropriate AR reactivation-induced redox stress as a novel therapeutic target in castration-resistant prostate cancer

Journal Articles

Abstract 5479: Redox stress as a therapeutic Achilles heel in castration-resistant prostate cancer

Clara I. Troccoli, Govindi J. Samaranayake, Mai Q. Huynh, Karen Kage, Deukwoo Kwon, Yuguang Ban, Xi S. Chen, Enrique R. Zarco, Merce Jorda, Kerry L. Burnstein, Priyamvada Rai

Cancer Res (2017) 77 (13_Supplement): 5479.

https://doi.org/10.1158/1538-7445.AM2017-5479

Published: 01 July 2017

View article titled, Abstract 5479: Redox stress as a therapeutic Achilles heel in castration-resistant prostate cancer

Journal Articles

Abstract 5473: Towards a better understanding of MTH1 as a therapeutic target in RAS-driven cancer

Govindi J. Samaranayake, Clara I. Troccoli, Mai Q. Huynh, Andrew Win, Debin Ji, Eric T. Kool, Priyamvada Rai

Cancer Res (2017) 77 (13_Supplement): 5473.

https://doi.org/10.1158/1538-7445.AM2017-5473

Published: 01 July 2017

View article titled, Abstract 5473: Towards a better understanding of MTH1 as a therapeutic target in RAS-driven cancer

NARROW

Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer

Abstract 2967: The mammalian 8-oxo-dGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Abstract B091: The mammalian 8-oxodGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Abstract 4790: Oxidation in the nucleotide pool as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Abstract 4335: Repurposing metformin in early-stage high risk prostate cancer to avoid ADT-induced cardiovascular toxicity

Abstract 2076: Low OGG1 protects against the DNA damage induced by MTH1 inhibition

Abstract 888: Exploring the signaling and activity interactome between oncogenic RAS and the nucleotide pool-detoxifying enzyme MTH1

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Abstract B032: Inappropriate AR reactivation-induced redox stress as a novel therapeutic target in castration-resistant prostate cancer

Abstract 5479: Redox stress as a therapeutic Achilles heel in castration-resistant prostate cancer

Abstract 5473: Towards a better understanding of MTH1 as a therapeutic target in RAS-driven cancer

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