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Prafulla C. Gokhale
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Journal Articles

The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination–Deficient Tumors

Louise Cadzow, Jehrod Brenneman, Erica Tobin, Pamela Sullivan, Sumeet Nayak, Janid A. Ali, Sol Shenker, Jim Griffith, Michael McGuire, Paula Grasberger, Yuji Mishina, Morgan Murray, Anne E. Dodson, Hugh Gannon, Elsa Krall, Jeff Hixon, Edmond Chipumuro, Kerstin Sinkevicius, Prafulla C. Gokhale, Suthakar Ganapathy, Ursula A. Matulonis, Joyce F. Liu, Andrew Olaharski, Dipen Sangurdekar, Hanlan Liu, Jeremy Wilt, Michael Schlabach, Frank Stegmeier, Andrew A. Wylie
Journal: Cancer Research
Cancer Res (2024) 84 (20): 3419–3434.
https://doi.org/10.1158/0008-5472.CAN-24-0293
Published: 15 October 2024
View article titled, The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination–Deficient Tumors
Open the PDF for The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination–Deficient Tumors in another window
Includes: Supplementary data
Journal Articles

EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V. Anekal, Paula D.L.M. Montero Llopis, Clement N. David, Jeffery L. Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A. Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E. Hawkins, Christopher Ponne, Quan Le, Geoffrey I. Shapiro, Madeleine E. Lemieux, Kyle P. Eagen, Christopher A. French
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3956–3973.
https://doi.org/10.1158/0008-5472.CAN-23-1475
Published: 01 December 2023
View article titled, EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
Open the PDF for EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes in another window
Includes: Supplementary data
Journal Articles

The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma

R. Taylor Durall, Julianna Huang, Luke Wojenski, Yeying Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Joshua O. Nash, Pedro L. Ballester, Scott Davidson, Adam Shlien, Emmanuel Sotirakis, Fabien Bertaux, Vincent Dubus, Jia Luo, Catherine J. Wu, Derin B. Keskin, Kyle P. Eagen, Geoffrey I. Shapiro, Christopher A. French
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3846–3860.
https://doi.org/10.1158/0008-5472.CAN-23-2545
Published: 01 December 2023
View article titled, The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma
Open the PDF for The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma in another window
Includes: Supplementary data
Journal Articles

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

Ryohei Yoshida, Maria Saigi, Tetsuo Tani, Benjamin F. Springer, Hirofumi Shibata, Shunsuke Kitajima, Navin R. Mahadevan, Marco Campisi, William Kim, Yoshihisa Kobayashi, Tran C. Thai, Koji Haratani, Yurie Yamamoto, Shriram K. Sundararaman, Erik H. Knelson, Amir Vajdi, Israel Canadas, Ravindra Uppaluri, Cloud P. Paweletz, Juan J. Miret, Patrick H. Lizotte, Prafulla C. Gokhale, Pasi A. Jänne, David A. Barbie
Journal: Cancer Research
Cancer Res (2022) 82 (21): 4079–4092.
https://doi.org/10.1158/0008-5472.CAN-22-0770
Published: 02 November 2022
View article titled, MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract 6377: Developing combination therapy with SHP2 inhibition for CIN-type gastroesophageal adenocarcinoma with KRAS amplification

Osamu Kikuchi, Tianxia Li, Jin Zhou, Yichen Wang, Klavdija Bastl, Prafulla C. Gokhale, Aine Knott, Yanxi Zhang, John G. Doench, Zandra Ho, Daniel V. Catenacci, Adam J. Bass
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6377.
https://doi.org/10.1158/1538-7445.AM2022-6377
Published: 15 June 2022
View article titled, Abstract 6377: Developing combination therapy with SHP2 inhibition for CIN-type gastroesophageal adenocarcinoma with <em>KRAS</em> amplification
Journal Articles

Abstract 3065: Establishment and characterization of a platform of endometrial cancer organoids

Aisha L. Saldanha, Ha V. Vo, Kevin Vasquez, Kenneth Ngo, Shrabasti Roychoudhury, Carina Feeney, Courtney H. Qi, Swati Narayan, Jennifer D. Curtis, Prafulla C. Gokhale, Dipanjan Chowdhury, Cloud P. Paweletz, Marisa R. Nucci, Ursula A. Matulonis, Elena Ivanova, Joyce F. Liu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3065.
https://doi.org/10.1158/1538-7445.AM2022-3065
Published: 15 June 2022
View article titled, Abstract 3065: Establishment and characterization of a platform of endometrial cancer organoids
Journal Articles

Abstract 3264: Ex vivo treatment in high grade serous ovarian cancer demonstrates the benefit of EZH2 inhibition in combination with standard therapy

Ha V. Vo, Qing Zeng, David A. Barbie, Prafulla C. Gokhale, Elizabeth Adams, Cloud P. Paweletz, Elena Ivanova
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3264.
https://doi.org/10.1158/1538-7445.AM2022-3264
Published: 15 June 2022
View article titled, Abstract 3264: <em>Ex vivo</em> treatment in high grade serous ovarian cancer demonstrates the benefit of EZH2 inhibition in combination with standard therapy
Journal Articles

Abstract 333: Activity of the erythropoietin-producing hepatocellular A2 receptor (EphA2) targeting Bicycle® Toxin Conjugate (BTC™) BCY6033 in EGFR inhibitor resistant non-small lung cancer (NSCLC) patient derived xenografts

Kenneth Ngo, Elena V. Ivanova, Tyler J. Teceno, Carly Campbell, Johanna Lahdenranta, Stephen J. Blakemore, Gavin Bennett, Pasi A. Jänne, Cloud P. Paweletz, Prafulla C. Gokhale
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 333.
https://doi.org/10.1158/1538-7445.AM2022-333
Published: 15 June 2022
View article titled, Abstract 333: Activity of the erythropoietin-producing hepatocellular A2 receptor (EphA2) targeting Bicycle® Toxin Conjugate (BTC™) BCY6033 in EGFR inhibitor resistant non-small lung cancer (NSCLC) patient derived xenografts
Journal Articles

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

Jieun Son, Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa Verano, Mika Lin, John M. Hatcher, Nicholas P. Kwiatkowski, Pinar Ö. Eser, Michael J. Poitras, Stephen Wang, Man Xu, Prafulla C. Gokhale, Michael D. Cameron, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1633–1645.
https://doi.org/10.1158/0008-5472.CAN-21-2693
Published: 15 April 2022
View article titled, A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Heidi M. Haikala, Timothy Lopez, Jens Köhler, Pinar O. Eser, Man Xu, Qing Zeng, Tyler J. Teceno, Kenneth Ngo, Yutong Zhao, Elena V. Ivanova, Arrien A. Bertram, Brittaney A. Leeper, Emily S. Chambers, Anika E. Adeni, Luke J. Taus, Mari Kuraguchi, Paul T. Kirschmeier, Channing Yu, Yoshinobu Shiose, Yasuki Kamai, Yang Qiu, Cloud P. Paweletz, Prafulla C. Gokhale, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2022) 82 (1): 130–141.
https://doi.org/10.1158/0008-5472.CAN-21-2426
Published: 04 January 2022
View article titled, EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd
Open the PDF for EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd in another window
Includes: Supplementary data
Journal Articles

Abstract 5543: TAK1 deficiency in tumor cells enhances sensitivity to CTL-mediated killing via TNF-α

Juan J. Miret, Troy A. Luster, Patrick Lizotte, Min Wu, Sarah Nzikoba, Luke Taus J. Taus, Prafulla C. Gokhale, Paul Kirschmeier, David Barbie, Cloud P. Paweletz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5543.
https://doi.org/10.1158/1538-7445.AM2020-5543
Published: 15 August 2020
View article titled, Abstract 5543: TAK1 deficiency in tumor cells enhances sensitivity to CTL-mediated killing via TNF-α
Journal Articles

Abstract 4515: The anti-CD47 antibody SRF231 increases anti-tumor activity of standard of care chemotherapy in platinum-resistant PDX models of ovarian cancer

Joyce F. Liu, Kshama A. Doshi, Benjamin H. Lee, Marisa O. Peluso, Li Zhang, Shan Zhou, Qing Zeng, Stephen Wang, Paul T. Kirschmeier, Cam A. Tran, Cloud Paweletz, Matthew Rausch, Alison M. Paterson, Prafulla C. Gokhale, Ursula A. Matulonis
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4515.
https://doi.org/10.1158/1538-7445.AM2020-4515
Published: 15 August 2020
View article titled, Abstract 4515: The anti-CD47 antibody SRF231 increases anti-tumor activity of standard of care chemotherapy in platinum-resistant PDX models of ovarian cancer
Journal Articles

Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors

Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W. Roberts
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2867.
https://doi.org/10.1158/1538-7445.AM2019-2867
Published: 01 July 2019
View article titled, Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors
Journal Articles

Abstract 1732: Switch to MET oncogene dependence as a novel mechanism of drug resistance in EGFR-mutant lung cancer

Pinar Ö. Eser, Raymond M. Paranal, Michael J. Poitras, Man Xu, Stephen Wang, Atsuko Ogino, Jihyun Choi, Pavlos Missios, Heidi M. Haikala, Jieun Son, Mika Lin, Masahiko Yanagita, Prafulla C. Gokhale, George Q. Daley, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1732.
https://doi.org/10.1158/1538-7445.AM2019-1732
Published: 01 July 2019
View article titled, Abstract 1732: Switch to MET oncogene dependence as a novel mechanism of drug resistance in <em>EGFR-</em>mutant lung cancer
Journal Articles

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong L. Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W.M. Roberts
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2404–2414.
https://doi.org/10.1158/0008-5472.CAN-18-3066
Published: 01 May 2019
View article titled, MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
Open the PDF for MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 5467: Efficacy of the ERK inhibitor LY3214996 and the PI3K/mTOR inhibitor LY3023414 in patient-derived RAS-mutant NSCLC models

Jens Köhler, Prafulla C. Gokhale, Jiaqi Li, Margaret K. Wilkens, Hong Tiv, Shripad V. Bhagwat, Greg Donoho, Patrick Brueck, Ramon V. Tiu, Amanda J. Redig, Emily S. Chambers, Atsuko Ogino, Jihyun Choi, Man Xu, Paul Kirschmeier, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5467.
https://doi.org/10.1158/1538-7445.AM2018-5467
Published: 01 July 2018
View article titled, Abstract 5467: Efficacy of the ERK inhibitor LY3214996 and the PI3K/mTOR inhibitor LY3023414 in patient-derived <em>RAS-</em>mutant NSCLC models
Journal Articles

Abstract 955: Combined inhibition of MEK and mTOR pathways is effective in NRAS Q61K mutant small cell lung cancer

Atsuko Ogino, Mika Lin, Prafulla C. Gokhale, Margaret K. Wilkens, Jihyun Choi, Antonio Calles, Man Xu, Marzia Capelletti, Geoffrey Oxnard, Nathanael S. Gray, Paul Kirschmeier, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 955.
https://doi.org/10.1158/1538-7445.AM2018-955
Published: 01 July 2018
View article titled, Abstract 955: Combined inhibition of MEK and mTOR pathways is effective in <em>NRAS Q61K</em> mutant small cell lung cancer
Journal Articles

Abstract 953: LRRC15 is a novel antigen in sarcoma and the therapeutic target of the antibody-drug conjugate (ADC) ABBV-085

Eytan Ben-Ami, Ying Huang, Prafulla C. Gokhale, Benjamin Eschle, Lisa Durkin, Jonathan Hickson, Mien Sho, Susan Morgan-Lappe, Kurt Gish, Dominic W. Lai, Randy R. Robinson, Diane Hollenbaugh, Eric D. Hsi, Debra T. Chao, George D. Demetri, James W. Purcell
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 953.
https://doi.org/10.1158/1538-7445.AM2018-953
Published: 01 July 2018
View article titled, Abstract 953: LRRC15 is a novel antigen in sarcoma and the therapeutic target of the antibody-drug conjugate (ADC) ABBV-085
Journal Articles

Abstract 1161: Dimethylaminoparthenolide (DMAPT), an oral nuclear factor kappa B inhibitor (NFκB), enhances radiation therapy and enhances epidermal growth factor tyrosine kinase inhibitor (EGFR TKI) activity

Katherine L. Morel, Pamela J. Sykes, Prafulla C. Gokhale, Gwo-Shu Mary Lee, Hong Tiv, Christopher J. Sweeney
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1161.
https://doi.org/10.1158/1538-7445.AM2017-1161
Published: 01 July 2017
View article titled, Abstract 1161: Dimethylaminoparthenolide (DMAPT), an oral nuclear factor kappa B inhibitor (NFκB), enhances radiation therapy and enhances epidermal growth factor tyrosine kinase inhibitor (EGFR TKI) activity
Journal Articles

Abstract 572: Inhibition of IDO1 with epacadostat enhances anti-tumor efficacy of PD-1 blockade in a syngeneic glioblastoma (GBM) model

David A. Reardon, Prafulla C. Gokhale, Sarah R. Klein, Kristen L. Jones, Paul T. Kirschmeier, Maria Speranza, Holly Koblish, Peggy Scherle, Lance Leopold, Robert Newton, Gordon J. Freeman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 572.
https://doi.org/10.1158/1538-7445.AM2017-572
Published: 01 July 2017
View article titled, Abstract 572: Inhibition of IDO1 with epacadostat enhances anti-tumor efficacy of PD-1 blockade in a syngeneic glioblastoma (GBM) model