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Journal Articles

Abstract 811: Pharmacologic ascorbate opens a therapeutic window for ATM inhibition and radiotherapy in colorectal cancer

Cameron M. Callaghan, Ibrahim M. Abukhiran, Richard V. Van Rheeden, Amanda L. Kalen, Samuel N. Rodman, Michael S. Petronek, Kranti A. Mapuskar, Sarah L. Mott, Mitchell C. Coleman, Prabhat C. Goswami, John M. Buatti, Bryan G. Allen, Douglas R. Spitz, Joseph M. Caster

Cancer Res (2022) 82 (12_Supplement): 811.

https://doi.org/10.1158/1538-7445.AM2022-811

Published: 15 June 2022

View article titled, Abstract 811: Pharmacologic ascorbate opens a therapeutic window for ATM inhibition and radiotherapy in colorectal cancer

Journal Articles

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

Adrienne R. Gibson, Brianne R. O'Leary, Juan Du, Ehab H. Sarsour, Amanda L. Kalen, Brett A. Wagner, Jeffrey M. Stolwijk, Kelly C. Falls-Hubert, Matthew S. Alexander, Rory S. Carroll, Douglas R. Spitz, Garry R. Buettner, Prabhat C. Goswami, Joseph J. Cullen

Cancer Res (2020) 80 (7): 1401–1413.

https://doi.org/10.1158/0008-5472.CAN-19-3094

Published: 02 April 2020

View article titled, Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

Includes: Supplementary data

Journal Articles

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy

Kranti A. Mapuskar, Kyle H. Flippo, Joshua D. Schoenfeld, Dennis P. Riley, Stefan Strack, Taher Abu Hejleh, Muhammad Furqan, Varun Monga, Frederick E. Domann, John M. Buatti, Prabhat C. Goswami, Douglas R. Spitz, Bryan G. Allen

Cancer Res (2017) 77 (18): 5054–5067.

https://doi.org/10.1158/0008-5472.CAN-17-0106

Published: 14 September 2017

View article titled, Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy

Includes: Supplementary data

Journal Articles

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

Juan Du, John A. Cieslak, III, Jessemae L. Welsh, Zita A. Sibenaller, Bryan G. Allen, Brett A. Wagner, Amanda L. Kalen, Claire M. Doskey, Robert K. Strother, Anna M. Button, Sarah L. Mott, Brian Smith, Susan Tsai, James Mezhir, Prabhat C. Goswami, Douglas R. Spitz, Garry R. Buettner, Joseph J. Cullen

Cancer Res (2015) 75 (16): 3314–3326.

https://doi.org/10.1158/0008-5472.CAN-14-1707

Published: 13 August 2015

View article titled, Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

Includes: Supplementary data

Journal Articles

Manganese Superoxide Dismutase Regulates a Metabolic Switch during the Mammalian Cell Cycle

Ehab H. Sarsour, Amanda L. Kalen, Zhen Xiao, Timothy D. Veenstra, Leena Chaudhuri, Sujatha Venkataraman, Philip Reigan, Garry R. Buettner, Prabhat C. Goswami

Cancer Res (2012) 72 (15): 3807–3816.

https://doi.org/10.1158/0008-5472.CAN-11-1063

Published: 31 July 2012

View article titled, Manganese Superoxide Dismutase Regulates a Metabolic Switch during the Mammalian Cell Cycle

Includes: Supplementary data

Journal Articles

Superoxide Signaling Mediates N-acetyl-l-cysteine–Induced G₁ Arrest: Regulatory Role of Cyclin D1 and Manganese Superoxide Dismutase

Sarita G. Menon, Ehab H. Sarsour, Amanda L. Kalen, Sujatha Venkataraman, Michael J. Hitchler, Frederick E. Domann, Larry W. Oberley, Prabhat C. Goswami

Cancer Res (2007) 67 (13): 6392–6399.

https://doi.org/10.1158/0008-5472.CAN-07-0225

Published: 06 July 2007

View article titled, Superoxide Signaling Mediates N-acetyl-<sc>l</sc>-cysteine–Induced G1 Arrest: Regulatory Role of Cyclin D1 and Manganese Superoxide Dismutase

Includes: Supplementary data

Journal Articles

Celecoxib Toxicity Is Cell Cycle Phase Specific

Jonathan M. Bock, Sarita G. Menon, Lori L. Sinclair, Nichole S. Bedford, Prabhat C. Goswami, Frederick E. Domann, Douglas K. Trask

Cancer Res (2007) 67 (8): 3801–3808.

https://doi.org/10.1158/0008-5472.CAN-06-3780

Published: 17 April 2007

View article titled, Celecoxib Toxicity Is Cell Cycle Phase Specific

Journal Articles

Mutation of Succinate Dehydrogenase Subunit C Results in Increased O₂^·−, Oxidative Stress, and Genomic Instability

Benjamin G. Slane, Nùkhet Aykin-Burns, Brian J. Smith, Amanda L. Kalen, Prabhat C. Goswami, Frederick E. Domann, Douglas R. Spitz

Cancer Res (2006) 66 (15): 7615–7620.

https://doi.org/10.1158/0008-5472.CAN-06-0833

Published: 02 August 2006

View article titled, Mutation of Succinate Dehydrogenase Subunit C Results in Increased O2·−, Oxidative Stress, and Genomic Instability

Journal Articles

NSAID activity is mediated by cell cycle phase-specific toxicity in squamous cell carcinoma of the head and neck

Jonathan M. Bock, Prabhat C. Goswami, Frederick E. Domann, Douglas K. Trask

Cancer Res (2006) 66 (8_Supplement): 487.

Published: 15 April 2006

View article titled, NSAID activity is mediated by cell cycle phase-specific toxicity in squamous cell carcinoma of the head and neck

Journal Articles

Darglitazone-induced G1-arrest in ALVA-31 human prostate adenocarcinoma cells is associated with increases in p21 and decrease in cyclin D1 protein levels

Joseph O. Nwankwo, Sarita G. Menon, Prabhat C. Goswami, Michael E. Robbins

Cancer Res (2004) 64 (7_Supplement): 194.

Published: 01 April 2004

View article titled, Darglitazone-induced G1-arrest in ALVA-31 human prostate adenocarcinoma cells is associated with increases in p21 and decrease in cyclin D1 protein levels

Journal Articles

Redox Regulation of the G₁ to S Phase Transition in the Mouse Embryo Fibroblast Cell Cycle

Sarita G. Menon, Ehab H. Sarsour, Douglas R. Spitz, Ryuji Higashikubo, Mary Sturm, Hannah Zhang, Prabhat C. Goswami

Cancer Res (2003) 63 (9): 2109–2117.

Published: 01 May 2003

View article titled, Redox Regulation of the G1 to S Phase Transition in the Mouse Embryo Fibroblast Cell Cycle

Journal Articles

Thioredoxin Nuclear Translocation and Interaction with Redox Factor-1 Activates the Activator Protein-1 Transcription Factor in Response to Ionizing Radiation

S. Jack Wei, Ana Botero, Kiichi Hirota, C. Matthew Bradbury, Stephanie Markovina, Andrei Laszlo, Douglas R. Spitz, Prabhat C. Goswami, Junji Yodoi, David Gius

Cancer Res (2000) 60 (23): 6688–6695.

Published: 01 December 2000

View article titled, Thioredoxin Nuclear Translocation and Interaction with Redox Factor-1 Activates the Activator Protein-1 Transcription Factor in Response to Ionizing Radiation

NARROW

Abstract 811: Pharmacologic ascorbate opens a therapeutic window for ATM inhibition and radiotherapy in colorectal cancer

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

Manganese Superoxide Dismutase Regulates a Metabolic Switch during the Mammalian Cell Cycle

Superoxide Signaling Mediates N-acetyl-l-cysteine–Induced G₁ Arrest: Regulatory Role of Cyclin D1 and Manganese Superoxide Dismutase

Celecoxib Toxicity Is Cell Cycle Phase Specific

Mutation of Succinate Dehydrogenase Subunit C Results in Increased O₂^·−, Oxidative Stress, and Genomic Instability

NSAID activity is mediated by cell cycle phase-specific toxicity in squamous cell carcinoma of the head and neck

Darglitazone-induced G1-arrest in ALVA-31 human prostate adenocarcinoma cells is associated with increases in p21 and decrease in cyclin D1 protein levels

Redox Regulation of the G₁ to S Phase Transition in the Mouse Embryo Fibroblast Cell Cycle

Thioredoxin Nuclear Translocation and Interaction with Redox Factor-1 Activates the Activator Protein-1 Transcription Factor in Response to Ionizing Radiation

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