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Powel H. Brown
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Journal Articles

Abstract 6427: Nous-209 off-the-shelf neoantigen immunotherapy induces robust neoantigen T cell response with the potential to intercept cancer in Lynch syndrome carriers

Jason Willis, Anna Morena D'Alise, Michael J. Hall, Marcia Cruz-Correa, Gregory E. Idos, Selvi Thirumurthi, Veroushka Ballester, Guido Leoni, Irene Garzia, Laura Antonucci, Lorenzo De Marco, Elisa Micarelli, Sven Gogov, Wenli Dong, J. Jack Lee, Lana A. Vornik, Araceli Garcia-Gonzalez, Laura Reyes-Uribe, Ellen Richmond, Asad Umar, Powel H. Brown, Luz Maria Rodriguez, Elisa Scarselli, Eduardo Vilar
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6427.
https://doi.org/10.1158/1538-7445.AM2025-6427
Published: 21 April 2025
View articletitled, Abstract 6427: Nous-209 off-the-shelf neoantigen immunotherapy induces robust neoantigen T cell response with the potential to intercept cancer in Lynch syndrome carriers
Journal Articles

Abstract 5276: Immunomodulatory activity of intermittent low-dose erlotinib plus sulindac: Implications for hereditary and sporadic colorectal cancer

Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5276.
https://doi.org/10.1158/1538-7445.AM2024-5276
Published: 22 March 2024
View articletitled, Abstract 5276: Immunomodulatory activity of intermittent low-dose erlotinib plus sulindac: Implications for hereditary and sporadic colorectal cancer
Journal Articles

Abstract 778: Atorvastatin modulates serum biomarkers in women at increased risk for breast cancer

Amanda L. Lanier, Johannes Fahrmann, Fatma N. Mustafayev, Angelica Gutierrez Barrera, Powel H. Brown, Banu Arun
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 778.
https://doi.org/10.1158/1538-7445.AM2024-778
Published: 22 March 2024
View articletitled, Abstract 778: Atorvastatin modulates serum biomarkers in women at increased risk for breast cancer
Journal Articles

Abstract 522: TP53mutations promote death of breast cancer cells following Kif11 inhibition

Amanda L. Lanier, William Tahaney, Jing Qian, Cassandra Moyer, Yanxia Ma, Banu Arun, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 522.
https://doi.org/10.1158/1538-7445.AM2024-522
Published: 22 March 2024
View articletitled, Abstract 522: TP53mutations promote death of breast cancer cells following Kif11 inhibition
Journal Articles

Abstract 5258: Preclinical testing of CD73 inhibitor AB680 for pancreatic cancer immunoprevention

Lincoln N. Strickland, Erika Y. Faraoni, Nicolette R. Mardik, Lana Vornik, Michelle I. Savage, Shizuko Sei, Mark S. Miller, Holger K. Eltzschig, Powel H. Brown, Florencia McAllister, Jennifer M. Bailey-Lundberg
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5258.
https://doi.org/10.1158/1538-7445.AM2023-5258
Published: 04 April 2023
View articletitled, Abstract 5258: Preclinical testing of CD73 inhibitor AB680 for pancreatic cancer immunoprevention
Journal Articles

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer

Erika Y. Faraoni, Kanchan Singh, Vidhi Chandra, Olivereen Le Roux, Yulin Dai, Ismet Sahin, Baylee J. O'Brien, Lincoln N. Strickland, Le Li, Emily Vucic, Amanda N. Warner, Melissa Pruski, Trent Clark, George Van Buren, Nirav C. Thosani, John S. Bynon, Curtis J. Wray, Dafna Bar-Sagi, Kyle L. Poulsen, Lana A. Vornik, Michelle I. Savage, Shizuko Sei, Altaf Mohammed, Zhongming Zhao, Powel H. Brown, Tingting Mills, Holger K. Eltzschig, Florencia McAllister, Jennifer M. Bailey-Lundberg
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1111–1127.
https://doi.org/10.1158/0008-5472.CAN-22-2553
Published: 04 April 2023
View articletitled, CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Open the PDF for CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3966: Targeting S100A10, a SOX9 binding protein, for the treatment of triple negative breast cancer

Yanxia Ma, Jing Qian, Cassandra Moyer, Amanda Lanier, Jamal Hill, Darian Coleman, David H. Hawke, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3966.
https://doi.org/10.1158/1538-7445.AM2023-3966
Published: 04 April 2023
View articletitled, Abstract 3966: Targeting S100A10, a SOX9 binding protein, for the treatment of triple negative breast cancer
Journal Articles

Abstract 719: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention

Kanchan Singh, Vidhi Chandra, Lincoln Ballew, Tingting Mills, Erika Y. Faraoni, Trent Clark, Lana A. Vornik, Michelle I. Savage, Holger K. Eltzschig, Altaf Mohammed, Shizuko Sei, Powel H. Brown, Florencia McAllister, Jennifer Bailey-Lundberg
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 719.
https://doi.org/10.1158/1538-7445.AM2022-719
Published: 15 June 2022
View articletitled, Abstract 719: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention
Journal Articles

Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells

William M Tahaney, Jing Qian, Reid Powell, Cassandra L Moyer, Yanxia Ma, Nghi Nguyen, Jamal Hill, Clifford Stephan, Abhijit Mazumdar, Peter JA Davies, Powel H Brown
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS1-09.
https://doi.org/10.1158/1538-7445.SABCS21-GS1-09
Published: 15 February 2022
View articletitled, Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells
Journal Articles

Abstract 2411: CEACAM1 is a Critical SOX9-regulated gene that suppresses TNBC growth

Yanxia Ma, William M. Tahaney, Ganiraju C. Manyam, Wenyi Wang, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2411.
https://doi.org/10.1158/1538-7445.AM2021-2411
Published: 01 July 2021
View articletitled, Abstract 2411: CEACAM1 is a Critical SOX9-regulated gene that suppresses TNBC growth
Journal Articles

Abstract PS8-12: Interim analysis of a phase I dose escalation study of topical bexarotene in women at high risk for breast cancer

Parijatham S Thomas, Anisha B Patel, Diane Liu, J. Jack Lee, Seema Khan, Miguel Muzzio, Alejandro Contreras, Lana Vornik, Eileen P Dimond, Marjorie Perloff, Brandy Heckman-Stoddard, Powel H Brown
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS8-12.
https://doi.org/10.1158/1538-7445.SABCS20-PS8-12
Published: 15 February 2021
View articletitled, Abstract PS8-12: Interim analysis of a phase I dose escalation study of topical bexarotene in women at high risk for breast cancer
Journal Articles

Abstract 1303: PRTN3, RGCC and SLCO4C1 are critical SOX9-regulated genes that control TNBC growth

Yanxia Ma, William M. Tahaney, Jing Qian, Jamal Hill, Yun Zhan, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1303.
https://doi.org/10.1158/1538-7445.AM2020-1303
Published: 15 August 2020
View articletitled, Abstract 1303: PRTN3, RGCC and SLCO4C1 are critical SOX9-regulated genes that control TNBC growth
Journal Articles

Abstract 19: Examination of HJC0152, a putative modulator of glucose and energy metabolism, for mammary cancer prevention

Hyejin Kim, Xi Liu, Yefei Wen, Jia Zhou, Romaine Fernando, Shizuko Sei, Powel H. Brown, Qiang Shen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 19.
https://doi.org/10.1158/1538-7445.AM2020-19
Published: 15 August 2020
View articletitled, Abstract 19: Examination of HJC0152, a putative modulator of glucose and energy metabolism, for mammary cancer prevention
Journal Articles

Abstract 21: Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention

Praveen Rajendran, Ahmetmursel Ulusan, Wan-Mohaiza Dashwood, Sabeeta Kapoor, Altaf Mohammed, Shizuko Sei, Asif Rashid, Powel H. Brown, Eduardo Vilar-Sanchez, Roderick H. Dashwood
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 21.
https://doi.org/10.1158/1538-7445.AM2020-21
Published: 15 August 2020
View articletitled, Abstract 21: Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention
Journal Articles

Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer

William Miska Tahaney, Reid Powell, Nghi Nguyen, Lakshmi Reddy Bollu, Jing Qian, Abhijit Mazumdar, Clifford Stephan, Peter JA Davies, Powel H Brown
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-03-08.
https://doi.org/10.1158/1538-7445.SABCS19-P3-03-08
Published: 15 February 2020
View articletitled, Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer
Journal Articles

Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

Ahmetmursel Ulusan, Praveen Rajendran, Wan-Mohaiza Dashwood, Altaf Mohammed, Shizuko Sei, Powel H. Brown, Eduardo Vilar-Sanchez, Roderick H. Dashwood
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5074.
https://doi.org/10.1158/1538-7445.AM2019-5074
Published: 01 July 2019
View articletitled, Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP
Journal Articles

Abstract 2618: SOX9 controls TNBC growth and metastasis via regulating the expression of apoptosis and EMT genes

Yanxia Ma, Lakshmi Bollu, Jamal Hill, Yun Zhang, William M. Tahaney, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2618.
https://doi.org/10.1158/1538-7445.AM2019-2618
Published: 01 July 2019
View articletitled, Abstract 2618: SOX9 controls TNBC growth and metastasis via regulating the expression of apoptosis and EMT genes
Journal Articles

Abstract CT065: A phase Ib biomarker trial of naproxen in patients at risk for DNA mismatch repair deficient colorectal cancer

Laura Reyes Uribe, Ramona Lin, Elena M. Stoffel, N. Jewel Samadder, Patrick Lynch, Priyanka Kanth, Ginger Milne, Lawrence J. Marnett, Valerie Sepeda, Diane D Liu, Y. Nancy You, Lana A. Vornik, J. Jack Lee, Ellen Richmond, Asad Umar, Marjorie Perloff, Steven M. Lipkin, Powel H. Brown, Eduardo Vilar-Sanchez
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT065.
https://doi.org/10.1158/1538-7445.AM2018-CT065
Published: 01 July 2018
View articletitled, Abstract CT065: A phase Ib biomarker trial of naproxen in patients at risk for DNA mismatch repair deficient colorectal cancer
Journal Articles

Abstract 3347: SOX9 is a critical regulator of triple-negative breast cancer growth and invasion

Yanxia Ma, Jonathan Shepherd, Dekuang Zhao, Lakshmi Bollu, Jamal Hill, Yun Zhang, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3347.
https://doi.org/10.1158/1538-7445.AM2018-3347
Published: 01 July 2018
View articletitled, Abstract 3347: SOX9 is a critical regulator of triple-negative breast cancer growth and invasion
Journal Articles

Abstract 2532: Wild-type p53 represses MELK expression by blocking the recruitment of FOXM1 to MELK promoter

Lakshmi Reddy Bollu, Jonathan Shepherd, Dekuang Zhao, Yanxia Ma, Abhijit Mazumdar, Powel H. Brown
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2532.
https://doi.org/10.1158/1538-7445.AM2018-2532
Published: 01 July 2018
View articletitled, Abstract 2532: Wild-type p53 represses MELK expression by blocking the recruitment of FOXM1 to MELK promoter