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Abstract 719: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention

Kanchan Singh, Vidhi Chandra, Lincoln Ballew, Tingting Mills, Erika Y. Faraoni, Trent Clark, Lana A. Vornik, Michelle I. Savage, Holger K. Eltzschig, Altaf Mohammed, Shizuko Sei, Powel H. Brown, Florencia McAllister, Jennifer Bailey-Lundberg

Cancer Res (2022) 82 (12_Supplement): 719.

DOI: https://doi.org/10.1158/1538-7445.AM2022-719

Published: 15 June 2022

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Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells

William M Tahaney, Jing Qian, Reid Powell, Cassandra L Moyer, Yanxia Ma, Nghi Nguyen, Jamal Hill, Clifford Stephan, Abhijit Mazumdar, Peter JA Davies, Powel H Brown

Cancer Res (2022) 82 (4_Supplement): GS1-09.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS1-09

Published: 15 February 2022

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Abstract 2411: CEACAM1 is a Critical SOX9-regulated gene that suppresses TNBC growth

Yanxia Ma, William M. Tahaney, Ganiraju C. Manyam, Wenyi Wang, Abhijit Mazumdar, Powel H. Brown

Cancer Res (2021) 81 (13_Supplement): 2411.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2411

Published: 01 July 2021

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Journal Articles

Abstract PS8-12: Interim analysis of a phase I dose escalation study of topical bexarotene in women at high risk for breast cancer

Parijatham S Thomas, Anisha B Patel, Diane Liu, J. Jack Lee, Seema Khan, Miguel Muzzio, Alejandro Contreras, Lana Vornik, Eileen P Dimond, Marjorie Perloff, Brandy Heckman-Stoddard, Powel H Brown

Cancer Res (2021) 81 (4_Supplement): PS8-12.

DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS8-12

Published: 15 February 2021

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Journal Articles

Abstract 19: Examination of HJC0152, a putative modulator of glucose and energy metabolism, for mammary cancer prevention

Hyejin Kim, Xi Liu, Yefei Wen, Jia Zhou, Romaine Fernando, Shizuko Sei, Powel H. Brown, Qiang Shen

Cancer Res (2020) 80 (16_Supplement): 19.

DOI: https://doi.org/10.1158/1538-7445.AM2020-19

Published: 15 August 2020

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Abstract 1303: PRTN3, RGCC and SLCO4C1 are critical SOX9-regulated genes that control TNBC growth

Yanxia Ma, William M. Tahaney, Jing Qian, Jamal Hill, Yun Zhan, Abhijit Mazumdar, Powel H. Brown

Cancer Res (2020) 80 (16_Supplement): 1303.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1303

Published: 15 August 2020

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Journal Articles

Abstract 21: Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention

Praveen Rajendran, Ahmetmursel Ulusan, Wan-Mohaiza Dashwood, Sabeeta Kapoor, Altaf Mohammed, Shizuko Sei, Asif Rashid, Powel H. Brown, Eduardo Vilar-Sanchez, Roderick H. Dashwood

Cancer Res (2020) 80 (16_Supplement): 21.

DOI: https://doi.org/10.1158/1538-7445.AM2020-21

Published: 15 August 2020

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Journal Articles

Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer

William Miska Tahaney, Reid Powell, Nghi Nguyen, Lakshmi Reddy Bollu, Jing Qian, Abhijit Mazumdar, Clifford Stephan, Peter JA Davies, Powel H Brown

Cancer Res (2020) 80 (4_Supplement): P3-03-08.

DOI: https://doi.org/10.1158/1538-7445.SABCS19-P3-03-08

Published: 15 February 2020

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Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

Ahmetmursel Ulusan, Praveen Rajendran, Wan-Mohaiza Dashwood, Altaf Mohammed, Shizuko Sei, Powel H. Brown, Eduardo Vilar-Sanchez, Roderick H. Dashwood

Cancer Res (2019) 79 (13_Supplement): 5074.

DOI: https://doi.org/10.1158/1538-7445.AM2019-5074

Published: 01 July 2019

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Abstract 2618: SOX9 controls TNBC growth and metastasis via regulating the expression of apoptosis and EMT genes

Yanxia Ma, Lakshmi Bollu, Jamal Hill, Yun Zhang, William M. Tahaney, Abhijit Mazumdar, Powel H. Brown

Cancer Res (2019) 79 (13_Supplement): 2618.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2618

Published: 01 July 2019

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Abstract CT065: A phase Ib biomarker trial of naproxen in patients at risk for DNA mismatch repair deficient colorectal cancer

Laura Reyes Uribe, Ramona Lin, Elena M. Stoffel, N. Jewel Samadder, Patrick Lynch, Priyanka Kanth, Ginger Milne, Lawrence J. Marnett, Valerie Sepeda, Diane D Liu, Y. Nancy You, Lana A. Vornik, J. Jack Lee, Ellen Richmond, Asad Umar, Marjorie Perloff, Steven M. Lipkin, Powel H. Brown, Eduardo Vilar-Sanchez

Cancer Res (2018) 78 (13_Supplement): CT065.

DOI: https://doi.org/10.1158/1538-7445.AM2018-CT065

Published: 01 July 2018

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Journal Articles

Abstract 3218: Maternal embryonic leucine zipper kinase (MELK) confers radioresistance in triple-negative breast cancers (TNBC) through a nonhomologous end joining (NHEJ)-mediated pathway

Shyam Nyati, Ben Chandler, Eric Olsen, Leah Moubadder, Meilan Liu, Meleah Cameron, Kari Wilder-Romans, Theodore S. Lawrence, Powel H. Brown, Fellix Y. Fang, Lori J. Pierce, Corey Speers

Cancer Res (2018) 78 (13_Supplement): 3218.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3218

Published: 01 July 2018

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Abstract 2532: Wild-type p53 represses MELK expression by blocking the recruitment of FOXM1 to MELK promoter

Lakshmi Reddy Bollu, Jonathan Shepherd, Dekuang Zhao, Yanxia Ma, Abhijit Mazumdar, Powel H. Brown

Cancer Res (2018) 78 (13_Supplement): 2532.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2532

Published: 01 July 2018

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Journal Articles

Abstract 3347: SOX9 is a critical regulator of triple-negative breast cancer growth and invasion

Yanxia Ma, Jonathan Shepherd, Dekuang Zhao, Lakshmi Bollu, Jamal Hill, Yun Zhang, Abhijit Mazumdar, Powel H. Brown

Cancer Res (2018) 78 (13_Supplement): 3347.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3347

Published: 01 July 2018

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Journal Articles

Abstract 3526: The expression of MELK, a growth regulator of triple-negative breast cancer, is regulated by p53

Lakshmi Reddy Bollu, Powel H. Brown, Abhijit Mazumdar, Dekuang Zhao, Yanxia Ma

Cancer Res (2017) 77 (13_Supplement): 3526.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3526

Published: 01 July 2017

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Journal Articles

Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice

Emily L. Rossi, Sarah M. Dunlap, Laura W. Bowers, Subreen A. Khatib, Steven S. Doerstling, Laura A. Smith, Nikki A. Ford, Darcy Holley, Powel H. Brown, Marcos R. Estecio, Donna F. Kusewitt, Linda A. deGraffenried, Scott J. Bultman, Stephen D. Hursting

Cancer Res (2017) 77 (9): 2500–2511.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2795

Published: 30 April 2017

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Includes: Supplementary data

Journal Articles

Abstract LB-010: Maternal embryonic leucine zipper kinase (MELK): A novel target for radiosensitization that is independently prognostic in triple-negative breast cancers

Corey Speers, Alyssa Santola, Shuang G. Zhao, Meilan Liu, Vishal Kothari, Kari Wilder-Romans, Theodore S. Lawrence, Powel H. Brown, Lori J. Pierce, Felix Y. Fang

Cancer Res (2016) 76 (14_Supplement): LB-010.

DOI: https://doi.org/10.1158/1538-7445.AM2016-LB-010

Published: 15 July 2016

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Journal Articles

Abstract 2913: The SOX11 transcription factor is critical for basal-like breast cancer growth and migration and is associated with poor survival

Jonathan Shepherd, Abhijit Mazumdar, Anna Tsimelzon, Susan G. Hilsenbeck, Powel H. Brown

Cancer Res (2016) 76 (14_Supplement): 2913.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2913

Published: 15 July 2016

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Journal Articles

Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

Petra den Hollander, Kathryn Rawls, Anna Tsimelzon, Jonathan Shepherd, Abhijit Mazumdar, Jamal Hill, Suzanne A.W. Fuqua, Jenny C. Chang, C. Kent Osborne, Susan G. Hilsenbeck, Gordon B. Mills, Powel H. Brown

Cancer Res (2016) 76 (7): 1942–1953.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-0673

Published: 31 March 2016

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Includes: Supplementary data

Journal Articles

Abstract 2804: The thiazolidinedione pioglitazone enhances the cancer preventive activity of the rexinoid LG100268 in Her2/neu induced breast cancer

Iván P. Uray, Jennifer M. Rodenberg, Yun Zhang, Jamal L. Hill, Powel H. Brown

Cancer Res (2015) 75 (15_Supplement): 2804.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2804

Published: 01 August 2015

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NARROW

Abstract 719: Preclinical testing of CD73 inhibitors for pancreatic cancer immunoprevention

Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells

Abstract 2411: CEACAM1 is a Critical SOX9-regulated gene that suppresses TNBC growth

Abstract PS8-12: Interim analysis of a phase I dose escalation study of topical bexarotene in women at high risk for breast cancer

Abstract 19: Examination of HJC0152, a putative modulator of glucose and energy metabolism, for mammary cancer prevention

Abstract 1303: PRTN3, RGCC and SLCO4C1 are critical SOX9-regulated genes that control TNBC growth

Abstract 21: Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention

Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer

Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

Abstract 2618: SOX9 controls TNBC growth and metastasis via regulating the expression of apoptosis and EMT genes

Abstract CT065: A phase Ib biomarker trial of naproxen in patients at risk for DNA mismatch repair deficient colorectal cancer

Abstract 3218: Maternal embryonic leucine zipper kinase (MELK) confers radioresistance in triple-negative breast cancers (TNBC) through a nonhomologous end joining (NHEJ)-mediated pathway

Abstract 2532: Wild-type p53 represses MELK expression by blocking the recruitment of FOXM1 to MELK promoter

Abstract 3347: SOX9 is a critical regulator of triple-negative breast cancer growth and invasion

Abstract 3526: The expression of MELK, a growth regulator of triple-negative breast cancer, is regulated by p53

Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice

Abstract LB-010: Maternal embryonic leucine zipper kinase (MELK): A novel target for radiosensitization that is independently prognostic in triple-negative breast cancers

Abstract 2913: The SOX11 transcription factor is critical for basal-like breast cancer growth and migration and is associated with poor survival

Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

Abstract 2804: The thiazolidinedione pioglitazone enhances the cancer preventive activity of the rexinoid LG100268 in Her2/neu induced breast cancer

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