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Pomila Singh
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Journal Articles

Abstract 902: Cancer-stem-cell (CSC) marker, DCLK1-S, enhances invasive potential of cancer cells by phosphorylating/activating NFATc2: role of COL3A1 and SPARC in mediating metastatic effects of DCLK1-S/NFATc2

Malaney O. Connell, Shubhashish Sarkar, Heidi Spratt, Steven Widen, Thomas G. Wood, Pomila Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 902.
https://doi.org/10.1158/1538-7445.AM2017-902
Published: 01 July 2017
View articletitled, Abstract 902: Cancer-stem-cell (CSC) marker, DCLK1-S, enhances invasive potential of cancer cells by phosphorylating/activating NFATc2: role of COL3A1 and SPARC in mediating metastatic effects of DCLK1-S/NFATc2
Journal Articles

Abstract 729: A novel cancer-stem-cell biomarker, DCLK1-S, traffics to nuclei of colon cancer cells: potential use as a biomarker for assessing colon cancer risk after screening colonoscopy

Shubhashish Sarkar, Vsevolod L. L. Popov, Malany O'Connell, Heather L. Stevenson, Brian S. Lee, Robert A. Obeid, Pomila Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 729.
https://doi.org/10.1158/1538-7445.AM2017-729
Published: 01 July 2017
View articletitled, Abstract 729: A novel cancer-stem-cell biomarker, DCLK1-S, traffics to nuclei of colon cancer cells: potential use as a biomarker for assessing colon cancer risk after screening colonoscopy
Journal Articles

Abstract 2957: Generation of a novel, mono-specific, antibody against short Isoform of DCLK1 (DCLK1-S): a novel biomarker of colon carcinogenesis in patients

Shubhashish Sarkar, Malaney O. Connell, Vsevolod L. Popov, Gurinder Luthra, Pomila Singh
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2957.
https://doi.org/10.1158/1538-7445.AM2016-2957
Published: 15 July 2016
View articletitled, Abstract 2957: Generation of a novel, mono-specific, antibody against short Isoform of DCLK1 (DCLK1-S): a novel biomarker of colon carcinogenesis in patients
Journal Articles

Abstract 5242: Differential, dose-dependent, effects of curcumin/analogs, on long (L) versus short (S) isoforms of a cancer stem cell marker, DCLK1, in colon and pancreatic cancer cells: biological impact

Shubhashish Sarkar, Malaney O. Connell, Pomila Singh
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5242.
https://doi.org/10.1158/1538-7445.AM2016-5242
Published: 15 July 2016
View articletitled, Abstract 5242: Differential, dose-dependent, effects of curcumin/analogs, on long (L) versus short (S) isoforms of a cancer stem cell marker, DCLK1, in colon and pancreatic cancer cells: biological impact
Journal Articles

Abstract 2892: FOXD3 is a novel repressor of the expression of short isoform of DCLK1 (DCLK1-S) from IntronV(β)-promoter of hDCLK1-gene, and is epigenetically silenced in hCRCs: prognostic/diagnostic implications of FOXD3/DCLK1-S expression in hCRCs

Malaney R. O’Connell, Shubhashish Sarkar, Gurinder Luthra, Yoshinaga Okugawa, Yuji Toiyama, Denise Ward, Ajay Goel, Pomila Singh
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2892.
https://doi.org/10.1158/1538-7445.AM2016-2892
Published: 15 July 2016
View articletitled, Abstract 2892: FOXD3 is a novel repressor of the expression of short isoform of DCLK1 (DCLK1-S) from IntronV(β)-promoter of hDCLK1-gene, and is epigenetically silenced in hCRCs: prognostic/diagnostic implications of FOXD3/DCLK1-S expression in hCRCs
Journal Articles

Abstract 2817: Dietary chemopreventive agent (curcumin), hypomethylates 5′ promoter of DCLK1 gene in human colon cancer cells and restores expression of long isoform of DCLK1

Shubhashish Sarkar, Malaney O'Connell, Pomila singh
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2817.
https://doi.org/10.1158/1538-7445.AM2015-2817
Published: 01 August 2015
View articletitled, Abstract 2817: Dietary chemopreventive agent (curcumin), hypomethylates 5′ promoter of DCLK1 gene in human colon cancer cells and restores expression of long isoform of DCLK1
Journal Articles

Abstract 543: A short isoform of DCLK1, transcribed from an alternate promoter in human colon cancers, represents a novel biomarker and target for diagnostic and treatment purposes

Malaney R. O'Connell, Shubhashish Sarkar, Gurinder Luthra, Yoshinaga Okugawa, Yuji Toiyama, Ajay Goel, Aakash Gajjar, Suimin Qiu, Lawrence Sowers, Pomila Singh
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 543.
https://doi.org/10.1158/1538-7445.AM2015-543
Published: 01 August 2015
View articletitled, Abstract 543: A short isoform of DCLK1, transcribed from an alternate promoter in human colon cancers, represents a novel biomarker and target for diagnostic and treatment purposes
Journal Articles

Abstract 3903: A sub-set of DCLK1+ve colon cancer stem cells (CSCs) survive curcumin induced autophagy, while co-treatment with curcumin +DCLK1-siRNA eliminates CSCs: Role of long and short isofoms of DCLK1

Shubhashish Sarkar, Malaney O'Connell, Carla Kantara, Pomila Singh
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3903.
https://doi.org/10.1158/1538-7445.AM2014-3903
Published: 01 October 2014
View articletitled, Abstract 3903: A sub-set of DCLK1+ve colon cancer stem cells (CSCs) survive curcumin induced autophagy, while co-treatment with curcumin +DCLK1-siRNA eliminates CSCs: Role of long and short isofoms of DCLK1
Journal Articles

Abstract 1940: Short (S) isoform of cancer-stem-cell marker, DCLK1, is critically required to maintain proliferative/tumorigenic potential of colon cancer cells: identification of associated molecular pathways

Malaney R. O'Connell, Shubhashish Sarkar, Pomila Singh
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1940.
https://doi.org/10.1158/1538-7445.AM2014-1940
Published: 01 October 2014
View articletitled, Abstract 1940: Short (S) isoform of cancer-stem-cell marker, DCLK1, is critically required to maintain proliferative/tumorigenic potential of colon cancer cells: identification of associated molecular pathways
Journal Articles

Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA

Carla Kantara, Malaney O'Connell, Shubhashish Sarkar, Stephanie Moya, Robert Ullrich, Pomila Singh
Journal: Cancer Research
Cancer Res (2014) 74 (9): 2487–2498.
https://doi.org/10.1158/0008-5472.CAN-13-3536
Published: 30 April 2014
View articletitled, Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
Open the PDF for Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA in another window
Includes: Supplementary data
Journal Articles

Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence of coloncancer disease: Role of autocrine/endocrine progastrin.

Malaney R. O'Connell, Shubhashish Sarkar, Gurinder Luthra, Suimin Qui, Aakash Gajjar, Carrie Maxwell, Pomila Singh
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4891.
https://doi.org/10.1158/1538-7445.AM2013-4891
Published: 15 April 2013
View articletitled, Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence of coloncancer disease: Role of autocrine/endocrine progastrin.
Journal Articles

Abstract 3738: Knockdown of Annexin A2 by liposomal formulation of Annexin A2 small hairpin RNA induces apoptosis and inhibits angiogenesis in lung cancer stem cells.

Terrick A. Andey, Srujan Marepally, Pomila Singh, Mandip S. Sachdeva
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3738.
https://doi.org/10.1158/1538-7445.AM2013-3738
Published: 15 April 2013
View articletitled, Abstract 3738: Knockdown of Annexin A2 by liposomal formulation of Annexin A2 small hairpin RNA induces apoptosis and inhibits angiogenesis in lung cancer stem cells.
Journal Articles

Abstract 2574: Curcumin either stimulates or inhibits expression of short isoform of stem-cell-marker DCLK1 (DCLK1-S) in non-transformed vs transformed cells, resulting in stabilization/inhibition of growth, respectively.

Shubhashish Sarkar, Malaney O’ Connell1, Stephanie M. Moya, Pomila Singh
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2574.
https://doi.org/10.1158/1538-7445.AM2013-2574
Published: 15 April 2013
View articletitled, Abstract 2574: Curcumin either stimulates or inhibits expression of short isoform of stem-cell-marker DCLK1 (DCLK1-S) in non-transformed vs transformed cells, resulting in stabilization/inhibition of growth, respectively.
Journal Articles

Abstract 2378: Detection of circulating tumors cells (CTCs) in mice, using cancer stem cell (CSC) markers and a novel cell surface marker, AnnexinA2

Carla Kantara, Shubhashish Sarkar, Carrie Maxwell, Robert Ullrich, Pomila Singh
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2378.
https://doi.org/10.1158/1538-7445.AM2012-2378
Published: 15 April 2012
View articletitled, Abstract 2378: Detection of circulating tumors cells (CTCs) in mice, using cancer stem cell (CSC) markers and a novel cell surface marker, AnnexinA2
Journal Articles

Abstract 4363: Inhibitory efficacy of curcumin ± stem cell specific RNAi on the growth of tumorospheres in vitro: Assay development and mechanisms of action

Carla Kantara, Shubhashish Sarkar, Rafal Swiercz, Robert Ullrich, Pomila Singh
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4363.
https://doi.org/10.1158/1538-7445.AM2011-4363
Published: 15 April 2011
View articletitled, Abstract 4363: Inhibitory efficacy of curcumin ± stem cell specific RNAi on the growth of tumorospheres in vitro: Assay development and mechanisms of action
Journal Articles

Abstract 4259: Over-expression of autocrine progastrin up-regulates DCAMKL+1/CD44 positive stem/progenitor cells, associated with surprising transformation of HEK-293 cells, in vitro and in vivo

Shubhashish Sarkar, Randal May, Carla Kantara, Courtney Houchen, Umar Shahid, Pomila Singh
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4259.
https://doi.org/10.1158/1538-7445.AM10-4259
Published: 15 April 2010
View articletitled, Abstract 4259: Over-expression of autocrine progastrin up-regulates DCAMKL+1/CD44 positive stem/progenitor cells, associated with surprising transformation of HEK-293 cells, in vitro and in vivo
Journal Articles

Abstract 2585: Targeting extra-cellular Annexin2 on epithelial cancer cells with labeled ligands for diagnosis/treatment of cancers

Pomila Singh, Shubhashish Sarkar
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2585.
https://doi.org/10.1158/1538-7445.AM10-2585
Published: 15 April 2010
View articletitled, Abstract 2585: Targeting extra-cellular Annexin2 on epithelial cancer cells with labeled ligands for diagnosis/treatment of cancers
Journal Articles

Abstract #5275: Novel cross-regulation and activation of NF\#954;Bp65 and \#946;-catenin, in response to over-expression of progastrin, in human embryonic kidney cells (HEK293): role of Annexin II

Shubhashish Sarkar, Pomila Singh
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5275.
Published: 01 May 2009
View articletitled, Abstract #5275: Novel cross-regulation and activation of NF\#954;Bp65 and \#946;-catenin, in response to over-expression of progastrin, in human embryonic kidney cells (HEK293): role of Annexin II
Journal Articles

Abstract #5266: Novel changes in NF-\#954;B activity during progression and regression phases of hyperplasia: Role of ERK1/2 and p38

Yu Wang, Shubhashish Sarkar, Pomila Singh, Shahid Umar
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5266.
Published: 01 May 2009
View articletitled, Abstract #5266: Novel changes in NF-\#954;B activity during progression and regression phases of hyperplasia: Role of ERK1/2 and p38
Journal Articles

Full length progastrin peptide exerts potent growth effects on tumorogenic human embryonic kidney cells (HEK293) via the PG receptor, Annexin-II: activation of NFkB/β catenin and up-regulation of cMYC/iNOS/COX-II/Cyclin D1

Shubhashish Sarkar, Pomila Singh
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3027.
Published: 01 May 2008
View articletitled, Full length progastrin peptide exerts potent growth effects on tumorogenic human embryonic kidney cells (HEK293) via the PG receptor, Annexin-II: activation of NFkB/β catenin and up-regulation of cMYC/iNOS/COX-II/Cyclin D1