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Piotr Rychahou
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Journal Articles

Abstract 3872: Fatty acid synthase inhibition to prevent metastatic colonization by pancreatic neuroendocrine tumor cells

Piotr Rychahou, Benjamin M. Evers, Yekateriza Zaytseva, Courtney M. Townsend, B. Mark Evers
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3872.
https://doi.org/10.1158/1538-7445.AM2025-3872
Published: 21 April 2025
View articletitled, Abstract 3872: Fatty acid synthase inhibition to prevent metastatic colonization by pancreatic neuroendocrine tumor cells
Journal Articles

Abstract 4187: Enhancing doxorubicin DNA-damaging therapy in neuroendocrine cancer via DNA-PK inhibition

Subin Kim, Allisa Pack, Nathan L. Vanderford, Courtney M. Townsend, B. Mark Evers, Piotr Rychahou
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4187.
https://doi.org/10.1158/1538-7445.AM2025-4187
Published: 21 April 2025
View articletitled, Abstract 4187: Enhancing doxorubicin DNA-damaging therapy in neuroendocrine cancer via DNA-PK inhibition
Journal Articles

Abstract 1489: Targeting the DNA double-strand break repair pathways in MYCN-amplified neuroblastoma increases tumor sensitivity to chemotherapy

Mahnaz Norouzi, Subin Kim, B. Mark Evers, Eric J. Rellinger, Piotr Rychahou
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1489.
https://doi.org/10.1158/1538-7445.AM2025-1489
Published: 21 April 2025
View articletitled, Abstract 1489: Targeting the DNA double-strand break repair pathways in MYCN-amplified neuroblastoma increases tumor sensitivity to chemotherapy
Journal Articles

Abstract CT194: ETCTN 10388: a first in human phase I trial of triapine and lutetium Lu 177 DOTATATE in well-differentiated somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Aman Chauhan, Susanne Arnold, Jill Kolesar, William Carson, Heidi Weiss, Rani Jayswal, Donglin Yan, Riham El Khouli, Aman Khurana, Jan Beumer, Heloisa Soares, Mary Mulcahy, Thorvardur Halfdanarson, Daneng Li, Heather Jacene, Percy Ivy, Elise Kohn, John Wright, Larry Rubinstein, Zeta Chow, Piotr Rychahou, Mark B. Evers, Charles Kunos, Lowell Anthony, Bhavana Konda
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT194.
https://doi.org/10.1158/1538-7445.AM2023-CT194
Published: 14 April 2023
View articletitled, Abstract CT194: ETCTN 10388: a first in human phase I trial of triapine and lutetium Lu 177 DOTATATE in well-differentiated somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs)
Journal Articles

Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy

Zhuangzhuang Zhang, Lijun Cheng, Jie Li, Qi Qiao, Anju Karki, Derek B. Allison, Nuha Shaker, Kunyu Li, Sagar M. Utturkar, Nadia M. Atallah Lanman, Xiongjian Rao, Piotr Rychahou, Daheng He, Stephen F. Konieczny, Chi Wang, Qing Shao, B. Mark Evers, Xiaoqi Liu
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3532–3548.
https://doi.org/10.1158/0008-5472.CAN-22-0018
Published: 04 October 2022
View articletitled, Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy
Open the PDF for Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 5430: Inhibition of de novo and salvage pathways for dNTP synthesis enhances sensitivity to ionizing radiation in pancreatic neuroendocrine tumor cells

Jennifer Castle, J. Robert McCorkle, Jeremy Johnson, Aman Chauhan, Percy Ivy, Susanne Arnold, William Carson, B. Mark Evers, Piotr Rychahou, Jill Kolesar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5430.
https://doi.org/10.1158/1538-7445.AM2022-5430
Published: 15 June 2022
View articletitled, Abstract 5430: Inhibition of de novo and salvage pathways for dNTP synthesis enhances sensitivity to ionizing radiation in pancreatic neuroendocrine tumor cells
Journal Articles

Abstract 2308: Inhibition of fatty acid synthesis and concurrent lipid deprivation decreases neuroendocrine cancer cell proliferation and colony formation

Jeremy Johnson, Yekaterina Y. Zaytseva, Jennifer Castle, B. Mark Evers, Piotr Rychahou
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2308.
https://doi.org/10.1158/1538-7445.AM2022-2308
Published: 15 June 2022
View articletitled, Abstract 2308: Inhibition of fatty acid synthesis and concurrent lipid deprivation decreases neuroendocrine cancer cell proliferation and colony formation
Journal Articles

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1575–1588.
https://doi.org/10.1158/0008-5472.CAN-21-2778
Published: 15 April 2022
View articletitled, Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer
Open the PDF for Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2880: CD36, a fatty acid translocase, promotes metastasis in CRC

James Michael Drury, Piotr Rychahou, Heidi L. Weiss, Yekaterina Y. Zaytseva
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2880.
https://doi.org/10.1158/1538-7445.AM2021-2880
Published: 01 July 2021
View articletitled, Abstract 2880: CD36, a fatty acid translocase, promotes metastasis in CRC
Journal Articles

Abstract 676: Effect of novel mTOR-PI3K dual inhibitors on neuroendocrine tumor cell proliferation and apoptosis

Zeta Chow, Courtney Townsend, B. Mark Evers, Piotr Rychahou
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 676.
https://doi.org/10.1158/1538-7445.AM2020-676
Published: 15 August 2020
View articletitled, Abstract 676: Effect of novel mTOR-PI3K dual inhibitors on neuroendocrine tumor cell proliferation and apoptosis
Journal Articles

Abstract 6269: Effect of 3AP on neuroendocrine tumor cell proliferation, apoptosis and activation of DNA repair pathway

Zeta Chow, Aman Chauhan, Lowell Anthony, Courtney Townsend, B. Mark Evers, Piotr Rychahou
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6269.
https://doi.org/10.1158/1538-7445.AM2020-6269
Published: 15 August 2020
View articletitled, Abstract 6269: Effect of 3AP on neuroendocrine tumor cell proliferation, apoptosis and activation of DNA repair pathway
Journal Articles

Abstract 6402: DNA-PK inhibitor, M3814, as a radiation sensitizer in the treatment of neuroendocrine tumors

Piotr Rychahou, Aman Chauhan, Zeta Chow, Tadahidi Izumi, Quan Chen, Eun Y. Lee, Dana Napier, Lowell B. Anthony, Michael J. Cavnar, Charles Kunos, B. Mark Evers
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6402.
https://doi.org/10.1158/1538-7445.AM2020-6402
Published: 15 August 2020
View articletitled, Abstract 6402: DNA-PK inhibitor, M3814, as a radiation sensitizer in the treatment of neuroendocrine tumors
Journal Articles

Abstract 1119: S100A4 alters mitochondrial metabolism to promote invasion and metastasis of non-small cell lung cancer cells through upregulation of NDUFS2

Lili Liu, Lei Qi, Teresa Knifley, Dava W. Piecoro, Piotr Rychahou, Jinpeng Liu, Mihail I. Mitov, Jeremiah Martin, Chi Wang, Jianrong Wu, Heidi L. Weiss, D. Allan Butterfield, B. Mark Evers, Kathleen L. O'Connor, Min Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1119.
https://doi.org/10.1158/1538-7445.AM2019-1119
Published: 01 July 2019
View articletitled, Abstract 1119: S100A4 alters mitochondrial metabolism to promote invasion and metastasis of non-small cell lung cancer cells through upregulation of NDUFS2
Journal Articles

Abstract 3868: FND 4b decreases proliferation and increases apoptosis of triple negative breast cancer through AMPK activation

Jeremy Johnson, Piotr Rychahou, Vitaliy M. Sviripa, Heidi L. Weiss, David Watt, B. Mark Evers
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3868.
https://doi.org/10.1158/1538-7445.AM2019-3868
Published: 01 July 2019
View articletitled, Abstract 3868: FND 4b decreases proliferation and increases apoptosis of triple negative breast cancer through AMPK activation
Journal Articles

Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth

Qingding Wang, Yuning Zhou, Piotr Rychahou, Jennifer W. Harris, Yekaterina Y. Zaytseva, Jinpeng Liu, Chi Wang, Heidi L. Weiss, Chunming Liu, Eun Y. Lee, B. Mark Evers
Journal: Cancer Research
Cancer Res (2018) 78 (12): 3163–3175.
https://doi.org/10.1158/0008-5472.CAN-17-3107
Published: 14 June 2018
View articletitled, Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth
Open the PDF for Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth in another window
Journal Articles

Abstract 201: Targeting colorectal cancer lung metastasis microenvironment with PI3K inhibitors and chemotherapy

Piotr Rychahou, Younsoo Bae, Derek A. Reichel, Yekaterina Zaytseva, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 201.
https://doi.org/10.1158/1538-7445.AM2017-201
Published: 01 July 2017
View articletitled, Abstract 201: Targeting colorectal cancer lung metastasis microenvironment with PI3K inhibitors and chemotherapy
Journal Articles

Abstract 1222: Fluorinated N, N-diarylureas treatment as effective strategy to target colorectal cancer stem cells

Piotr Rychahou, Dasha Kenlan, Vitaliy M. Sviripa, David S. Watt, B. Mark Evers
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1222.
https://doi.org/10.1158/1538-7445.AM2016-1222
Published: 15 July 2016
View articletitled, Abstract 1222: Fluorinated N, N-diarylureas treatment as effective strategy to target colorectal cancer stem cells
Journal Articles

Abstract 390: Colorectal cancer pulmonary metastasis treatment with lung-selective delivery of PAN-class I PI3K inhibitors

Piotr Rychahou, Younsoo Bae, Yekaterina Zaytseva, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 390.
https://doi.org/10.1158/1538-7445.AM2016-390
Published: 15 July 2016
View articletitled, Abstract 390: Colorectal cancer pulmonary metastasis treatment with lung-selective delivery of PAN-class I PI3K inhibitors
Journal Articles

Abstract 1009: Tumor-specific expression of fatty acid synthase promotes angiogenesis in colorectal cancer

Yekaterina Y. Zaytseva, Victoria Elliott, Piotr Rychahou, William Mustain, Ji Tae Kim, Joseph Valentino, Tianyan Gao, Kathleen O'Connor, Janna Neltner, Heidi Weiss, B. Mark Evers
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1009.
https://doi.org/10.1158/1538-7445.AM2014-1009
Published: 01 October 2014
View articletitled, Abstract 1009: Tumor-specific expression of fatty acid synthase promotes angiogenesis in colorectal cancer
Journal Articles

Abstract LB-21: Regulation of Bmi1 by β-catenin and KLF4 and its implication in colon cancer

Tianxin Yu, Xi Chen, Wen Zhang, Deannon Colon, Jiandang Shi, Dana Napier, Piotr Rychahou, Wang Lu, Eun Y. Lee, Heidi Weiss, B. Mark Evers, Chunming Liu
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-21.
https://doi.org/10.1158/1538-7445.AM2012-LB-21
Published: 15 April 2012
View articletitled, Abstract LB-21: Regulation of Bmi1 by β-catenin and KLF4 and its implication in colon cancer