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Piergiorgio Pettazzoni
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Journal Articles

Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase

Shota Kikuchi, Piergiorgio Pettazzoni, Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons, Chu-Chiao Wu, Melissa A. Hoffman, Aaron N. Snead, Xiaodan Song, Thomas Glaza, Jason C. Green, Donald C. Rogness, Betty Lam, Maria E. Rodriguez-Aguirre, David R. Woody, Christie L. Eissler, Socorro Rodiles, Seth M. Negron, Steffen M. Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N. Williams, Martha K. Pastuszka, John J. Sigler, Markus G. Rudolph, Moritz Classen, Doris Brugger, Christopher Claiborne, Jean-Marc Plancher, Isabel Cuartas, Joan Seoane, Laurence E. Burgess, Robert T. Abraham, David S. Weinstein, Gabriel M. Simon, Matthew P. Patricelli, Todd M. Kinsella
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND11.
https://doi.org/10.1158/1538-7445.AM2024-ND11
Published: 05 April 2024
View article titled, Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase
Journal Articles

Activity and Resistance of a Brain-Permeable Paradox Breaker BRAF Inhibitor in Melanoma Brain Metastasis

Ester Bonfill-Teixidor, Raffaella Iurlaro, Cornelia Handl, Jürgen Wichmann, Alexandra Arias, Isabel Cuartas, Jasmin Emmenegger, Andrea Romagnani, Luca Mangano, Thomas Lorber, Marco Berrera, Christina Godfried Sie, Fabian Köchl, Jan Eckmann, Romi Feddersen, Martin Kornacker, Gabriel Schnetzler, Marta Cicuendez, Esteban Cordero, Thomaz E. Topczewski, Abel Ferres-Pijoan, Josep González, Francisco Martínez-Ricarte, Eva Muñoz-Couselo, Josep Tabernero, James R. Bischoff, Piergiorgio Pettazzoni, Joan Seoane
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2552–2564.
https://doi.org/10.1158/0008-5472.CAN-21-4152
Published: 18 July 2022
View article titled, Activity and Resistance of a Brain-Permeable Paradox Breaker BRAF Inhibitor in Melanoma Brain Metastasis
Open the PDF for Activity and Resistance of a Brain-Permeable Paradox Breaker BRAF Inhibitor in Melanoma Brain Metastasis in another window
Includes: Supplementary data
Journal Articles

EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming

Remi Adelaiye-Ogala, Justin Budka, Nur P. Damayanti, Justine Arrington, Mary Ferris, Chuan-Chih Hsu, Sreenivasulu Chintala, Ashley Orillion, Kiersten Marie Miles, Li Shen, May Elbanna, Eric Ciamporcero, Sreevani Arisa, Piergiorgio Pettazzoni, Giulio F. Draetta, Mukund Seshadri, Bradley Hancock, Milan Radovich, Janaiah Kota, Michael Buck, Heike Keilhack, Brian P. McCarthy, Scott A. Persohn, Paul R. Territo, Yong Zang, Joseph Irudayaraj, W. Andy Tao, Peter Hollenhorst, Roberto Pili
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6651–6666.
https://doi.org/10.1158/0008-5472.CAN-17-0899
Published: 30 November 2017
View article titled, EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming
Open the PDF for EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming in another window
Includes: Supplementary data
Journal Articles

Abstract 4170: Targeting androgen receptor overcomes resistance to tyrosine kinase inhibitors in advanced clear cell renal cell carcinoma

Remi M. Adelaiye-Ogala, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Ben Elzey, Nur Damayanti, Kiersten M. Miles, Chinghai Kao, Piergiorgio Pettazzoni, Giulio F. Draetta, Roberto Pili
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4170.
https://doi.org/10.1158/1538-7445.AM2017-4170
Published: 01 July 2017
View article titled, Abstract 4170: Targeting androgen receptor overcomes resistance to tyrosine kinase inhibitors in advanced clear cell renal cell carcinoma
Journal Articles

Abstract 2126: Androgen receptor expression is associated with sunitinib resistance in renal cell carcinoma models

Remi M. Adelaiye-Ogala, Sreenivasulu Chintala, Ashley Orillion, Piergiorgio Pettazzoni, May Elbanna, Bennett Elzey, Kiersten Marie Miles, Chinghai Kao, Giulio F. Draetta, Roberto Pili
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2126.
https://doi.org/10.1158/1538-7445.AM2016-2126
Published: 15 July 2016
View article titled, Abstract 2126: Androgen receptor expression is associated with sunitinib resistance in renal cell carcinoma models
Journal Articles

Abstract 976: Metabolic eradication of treatment resistant cancer stem cells in pancreatic tumors: A clonal tracking-based platform for identifying the best personalized treatment

Denise Corti, Alessandro Carugo, Seth Sahil, Matteo Marchesini, Piergiorgio Pettazzoni, Luigi Nezi, Tessa Green, Joseph R Marszalek, Maria Emilia Di Francesco, Timothy P Heffernan, Giulio F Draetta, Andrea Viale
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 976.
https://doi.org/10.1158/1538-7445.AM2015-976
Published: 01 August 2015
View article titled, Abstract 976: Metabolic eradication of treatment resistant cancer stem cells in pancreatic tumors: A clonal tracking-based platform for identifying the best personalized treatment
Journal Articles

Abstract A87: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function

Andrea Viale, Piergiorgio Pettazzoni, Costas Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani, Timothy Heffernan, Alec Kimmelman, Huamin Wang, Jason Fleming, Lewis Cantley, Ronald DePinho, Giulio Draetta
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A87.
https://doi.org/10.1158/1538-7445.PANCA2014-A87
Published: 30 June 2015
View article titled, Abstract A87: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function
Journal Articles

Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function

Andrea Viale, Piergiorgio Pettazzoni, Costas Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani, Timothy Heffernan, Alec Kimmelman, Huamin Wang, Jason Fleming, Lewis Cantley, Ronald DePinho, Giulio Draetta
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): PR13.
https://doi.org/10.1158/1538-7445.PANCA2014-PR13
Published: 30 June 2015
View article titled, Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function
Journal Articles

Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Avnish Kapoor, Wantong Yao, Haoqiang Ying, Sujun Hua, Alison Liewen, Anguraj Sadanandam, Ramsey Al-Khalil, Andrea Viale, Piergiorgio Pettazzoni, Nora Sanchez, Alexei Protopopov, Jianhua Zhang, Timothy Heffernan, Randy L. Johnson, Lynda Chin, Y. Alan Wang, Giulio Draetta, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A94.
https://doi.org/10.1158/1538-7445.PANCA2014-A94
Published: 30 June 2015
View article titled, Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
Journal Articles

Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer

Piergiorgio Pettazzoni, Andrea Viale, Parantu Shah, Alessandro Carugo, Haoqiang Ying, Huamin Wang, Giannicola Genovese, Sahil Seth, Rosalba Minelli, Tessa Green, Emmet Huang-Hobbs, Denise Corti, Nora Sanchez, Luigi Nezi, Matteo Marchesini, Avnish Kapoor, Wantong Yao, Maria E. Di Francesco, Alessia Petrocchi, Angela K. Deem, Kenneth Scott, Simona Colla, Gordon B. Mills, Jason B. Fleming, Timothy P. Heffernan, Philip Jones, Carlo Toniatti, Ronald A. DePinho, Giulio F. Draetta
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (6): 1091–1101.
https://doi.org/10.1158/0008-5472.CAN-14-1854
Published: 12 March 2015
View article titled, Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
Open the PDF for Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4431: Antitumor activity of nanosponge-encapsulated camptotechin in human prostate tumors

Rosalba Minelli, Roberta Cavalli, Roberto Fantozzi, Chiara Dianzani, Piergiorgio Pettazzoni, Leigh Ellis, Li Shen, Roberto Pili
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4431.
https://doi.org/10.1158/1538-7445.AM2011-4431
Published: 15 April 2011
View article titled, Abstract 4431: Antitumor activity of nanosponge-encapsulated camptotechin in human prostate tumors