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Journal Articles

Abstract 4284: Enhancing subclonal reconstruction algorithm for resolving complex tumor phylogenies from multi-sample tumor DNA sequencing

Helena Winata, Daniel Knight, Juber A. Patel, Nicholas K. Wang, Pier Selenica, Stefan E. Eng, Caroline Kostrzewa, Jaron Arbet, Yingjie Zhu, Ronglai Shen, Jorge Reis-Filho, Pedram Razafi, Paul C. Boutros
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4284.
https://doi.org/10.1158/1538-7445.AM2023-4284
Published: 04 April 2023
View article titled, Abstract 4284: Enhancing subclonal reconstruction algorithm for resolving complex tumor phylogenies from multi-sample tumor DNA sequencing
Journal Articles

Abstract 3375: Ultrasensitive ctDNA minimal residual disease monitoring in early NSCLC with PhasED-Seq

James M. Isbell, Bob T. Li, Pedram Razavi, Jorge Reis-Filo, Si-Yang Liu, Pier Selenica, Prasad Adusumilli, Matthew Bott, David R. Jones, Valerie W. Rusch, Smita Sihag, Darren J. Buonocore, Justin Jee, Emily Lebow, Daniel Gomez, Andreas Rimner, Fernando C. Santini, Charles M. Rudin, Jordan E. Eichholz, Andres Martinez, Daphne Alerte, Gregory J. Hogan, Andre Schultz, Ronald P. Schuyler, Alanna Roff, Dustin Hite, Jacob J. Chabon, David M. Kurtz, Ash A. Alizadeh, Maximilian Diehn
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3375.
https://doi.org/10.1158/1538-7445.AM2023-3375
Published: 04 April 2023
View article titled, Abstract 3375: Ultrasensitive ctDNA minimal residual disease monitoring in early NSCLC with PhasED-Seq
Journal Articles

Abstract 5469: Characterization of CCNE1 amplifications and associated genomic features in ovarian and uterine cancers

Sunantha Sethuraman, Dominik Glodzik, Pier Selenica, Adrienne Johnson, Jorge S. Reis-Filho, Artur Veloso, Ian M. Silverman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5469.
https://doi.org/10.1158/1538-7445.AM2023-5469
Published: 04 April 2023
View article titled, Abstract 5469: Characterization of <em>CCNE1</em> amplifications and associated genomic features in ovarian and uterine cancers
Journal Articles

Abstract P4-08-12: Clinical and Genomic Landscape of Breast Cancers Carrying CCNE1 Amplification

Antonio Marra, Pier Selenica, Yingjie Zhu, Pedram Razavi, Anton Safonov, Emanuela Ferraro, Sarat Chandarlapaty, Jorge Reis-Filho
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-12.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-12
Published: 01 March 2023
View article titled, Abstract P4-08-12: Clinical and Genomic Landscape of Breast Cancers Carrying CCNE1 Amplification
Journal Articles

Abstract P1-13-17: Hyperactivation of the EGFR pathway is associated with resistance to tucatinib in HER2-positive breast cancer models

Fu-Tien Liao, Tia Gordon, Chia Chia Liu, Pier Selenica, Yingjie Zhu, Juber Patel, Sarmistha Nanda, Lanfang Qin, Xiaoyong Fu, Andrea Gazzo, Antonio Marra, Juan Blanco-Heredia, Britta Weigelt, Jorge Reis-Filho, C. Kent Osborne, Mothaffar Rimawi, Rachel Schiff, Jamunarani Veeraraghavan
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-13-17.
https://doi.org/10.1158/1538-7445.SABCS22-P1-13-17
Published: 01 March 2023
View article titled, Abstract P1-13-17: Hyperactivation of the EGFR pathway is associated with resistance to tucatinib in HER2-positive breast cancer models
Journal Articles

Abstract P2-23-15: Histologic, immunohistochemical and genomic comparison between classic Invasive lobular carcinomas and lobular-like invasive ductal carcinomas

Edaise M. da Silva, Thais Basili, Jing Yu, Juan Blanco-Heredia, Pier Selenica, Qiqi Ye, Arnaud da Cruz Paula, Higinio Dopeso, Antonio Marra, Steffi Oesterreich, Jorge Reis-Filho, Rohit Bhargava
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P2-23-15.
https://doi.org/10.1158/1538-7445.SABCS22-P2-23-15
Published: 01 March 2023
View article titled, Abstract P2-23-15: Histologic, immunohistochemical and genomic comparison between classic Invasive lobular carcinomas and lobular-like invasive ductal carcinomas
Journal Articles

Abstract HER2-07: HER2-07 Genomic Characterization of Primary and Metastatic HER2-low Breast Cancers

Antonio Marra, Anton Safonov, Joshua Drago, Emanuela Ferraro, Pier Selenica, Andrea Gazzo, Giuseppe Curigliano, Shanu Modi, Pedram Razavi, Jorge Reis-Filho, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): HER2-07.
https://doi.org/10.1158/1538-7445.SABCS22-HER2-07
Published: 01 March 2023
View article titled, Abstract HER2-07: HER2-07 Genomic Characterization of Primary and Metastatic HER2-low Breast Cancers
Journal Articles

Abstract 1692: Single-cell DNA sequencing from frozen endometrial tumors to address clonal evolution of somatic mutations

Arnaud Da Cruz Paula, Yingjie Zhu, Shirin Issa Bhaloo, Fresia Pareja, Timothy Hoang, Pier Selenica, Etta Hanlon, Thais Basili, Higinio Dopeso, Nadeem Abu-Rustum, Jorge Sergio Reis-Filho, Britta Weigelt
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1692.
https://doi.org/10.1158/1538-7445.AM2022-1692
Published: 15 June 2022
View article titled, Abstract 1692: Single-cell DNA sequencing from frozen endometrial tumors to address clonal evolution of somatic mutations
Journal Articles

Abstract LB517A: The role of EGFR in resistance to tucatinib and its therapeutic implications

Jamunarani Veeraraghavan, Fu-Tien Liao, Tia Gordon, Pier Selenica, Sarmistha Nanda, Lanfang Qin, Yingjie Zhu, Juber A. Patel, Andrea Gazzo, Fabio Stossi, Michael A. Mancini, Carolina Gutierrez, Britta Weigelt, Jorge S. Reis-Filho, C. Kent Osborne, Mothaffar F. Rimawi, Rachel Schiff
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB517A.
https://doi.org/10.1158/1538-7445.AM2022-LB517A
Published: 15 June 2022
View article titled, Abstract LB517A: The role of EGFR in resistance to tucatinib and its therapeutic implications
Journal Articles

Abstract PD11-01: An artificial intelligence-based predictor of CDH1 biallelic mutations and invasive lobular carcinoma

Jorge S Reis-Filho, Fresia Pareja, Fatemeh Derakhshan, David N Brown, Jillian Sue, Pier Selenica, Yi Kan Wang, Arnaud Da Cruz Paula, Monami Banerjee, Zahra Ebrahimzadeh, Manuel Isava, Matthew Lee, Ran Godrich, Adam Casson, Ruben Padron, George Shaikovski, Alexander van Eck, Antonio Marra, Higinio Dopeso, Hannah Y Wen, Edi Brogi, Matthew G Hanna, Chris Kanan, Jeremy D Kunz, Felipe C Geyer, Carla Leibowitz, David Klimstra, Leo Grady, Thomas J Fuchs
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD11-01.
https://doi.org/10.1158/1538-7445.SABCS21-PD11-01
Published: 15 February 2022
View article titled, Abstract PD11-01: An artificial intelligence-based predictor of CDH1 biallelic mutations and invasive lobular carcinoma
Journal Articles

Abstract PD1-06: Apobec mutagenesis is a pervasive feature of poor prognosis breast cancer associating with ESR1 wild type, endocrine resistant disease

Antonio Marra, Andrea Gazzo, Pier Selenica, Xin Pei, Avantika Gupta, Fresia Pareja, Giuseppe Curigliano, Reuben Harris, Nadeem Riaz, Jorge S. Reis-Filho, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-06.
https://doi.org/10.1158/1538-7445.SABCS21-PD1-06
Published: 15 February 2022
View article titled, Abstract PD1-06: Apobec mutagenesis is a pervasive feature of poor prognosis breast cancer associating with <em>ESR1</em> wild type, endocrine resistant disease
Journal Articles

Abstract PD8-06: Acquired resistance to tucatinib is associated with EGFR amplification in HER2+ breast cancer (BC) models and can be overcome by a more complete blockade of HER receptor layer

Jamunarani Veeraraghavan, Sreyashree Bose, Ragini Mistry, Pier Selenica, Sarmistha Nanda, Lanfang Qin, Andrea Gazzo, Yingjie Zhu, Michael A Mancini, Fabio Stossi, Britta Weigelt, Jorge S Reis-Filho, C. Kent Osborne, Mothaffar F Rimawi, Rachel Schiff
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD8-06.
https://doi.org/10.1158/1538-7445.SABCS21-PD8-06
Published: 15 February 2022
View article titled, Abstract PD8-06: Acquired resistance to tucatinib is associated with EGFR amplification in HER2+ breast cancer (BC) models and can be overcome by a more complete blockade of HER receptor layer
Journal Articles

Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance

Anton Safonov, Chai Bandlamudi, Paulino Tallón de Lara, Emanuela Ferraro, Fatemeh Derakhshan, Marie Will, Mark Donoghue, Pier Selenica, Joshua Drago, Ezra Rosen, Carlos dos Anjos, Elaine Walsh, Elizabeth A Comen, Mehnaj Ahmed, Barbara Acevedo, Ahmet Zehir, Michael F Berger, David Solit, Larry Norton, Ronglai Shen, Zsofia Stadler, Simon Powell, Jorge S Reis-Filho, Sarat Chandarlapaty, Mark Robson, Pedram Razavi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS4-08.
https://doi.org/10.1158/1538-7445.SABCS21-GS4-08
Published: 15 February 2022
View article titled, Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance
Journal Articles

Abstract PD14-03: Genetic and epigenetic basis of invasive lobular carcinomas lacking CDH1-alterations

Fatemeh Derakhshan, Higinio Dopeso, Arnaud Da Cruz Paula, Pier Selenica, Antonio Marra, Edaise M da Silva, Andrea Gazzo, Shirin Issa Bhaloo, Dara S Ross, Anne Grabenstetter, Sarat Chandarlapaty, Pedram Razavi, Hannah Y. Wen, Hong Zhang, Edi Brogi, Britta Weigelt, Fresia Pareja, Jorge S. Reis-Filho
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD14-03.
https://doi.org/10.1158/1538-7445.SABCS21-PD14-03
Published: 15 February 2022
View article titled, Abstract PD14-03: Genetic and epigenetic basis of invasive lobular carcinomas lacking <em>CDH1</em>-alterations
Journal Articles

Abstract P4-01-01: Resistance to next generation tyrosine kinase inhibitors (TKIs) in HER2-positive breast cancer (BC): Role of HER and PIK3CA mutations and development of new treatment strategies and study models

Sreyashree Bose, Ragini Mistry, Chia Chia Liu, Sarmistha Nanda, Lanfang Qin, Pier Selenica, Andrea Gazzo, Yingjie Zhu, Michael A. Mancini, Fabio Stossi, Irmina Diala, Lisa D. Eli, Britta Weigelt, Jorge S. Reis-Filho, Mothaffar F. Rimawi, C. Kent Osborne, Rachel Schiff, Jamunarani Veeraraghavan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-01-01.
https://doi.org/10.1158/1538-7445.SABCS21-P4-01-01
Published: 15 February 2022
View article titled, Abstract P4-01-01: Resistance to next generation tyrosine kinase inhibitors (TKIs) in HER2-positive breast cancer (BC): Role of <em>HER</em> and <em>PIK3CA</em> mutations and development of new treatment strategies and study models
Journal Articles

Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

Yanyan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Pau Castel, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S. Reis-Filho, Pedram Razavi, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2470–2480.
https://doi.org/10.1158/0008-5472.CAN-20-3232
Published: 01 May 2021
View article titled, Genomic Alterations in <em>PIK3CA</em>-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors
Open the PDF for Genomic Alterations in <em>PIK3CA</em>-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract LB-335: Loss of function of the BRCA1-PALB2-BRCA2 axis accelerates p53-associated tumorigenesis

Yanying Huo, Amar Mahdi, Pier Selenica, Jorge S S. Reis-Filho, Britta Weigelt, Bing Xia
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-335.
https://doi.org/10.1158/1538-7445.AM2020-LB-335
Published: 15 August 2020
View article titled, Abstract LB-335: Loss of function of the BRCA1-PALB2-BRCA2 axis accelerates p53-associated tumorigenesis
Journal Articles

Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer

Amaia Arruabarrena-Aristorena, Jesper LV Maag, Srushti Kittane, Yanyan Cai, Jane Park, Pedram Razavi, Lorenzo Ferrando, Pier Selenica, Wouter R. Karthaus, Srinivasaraghavan Kannan, Emiliano Cocco, Sik Y. Ho, Daisylyn Senna Tan, Mirna Sallaku, Charles L. Sawyers, Jorge S. Reis-Fihlo, Chandra S. Verma, Ralf Jauch, Richard Koche, José Baselga, Eneda Toska, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3439.
https://doi.org/10.1158/1538-7445.AM2020-3439
Published: 15 August 2020
View article titled, Abstract 3439: FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer
Journal Articles

Abstract GS2-01: High levels of interferon-response gene signatures are associated with de novo and acquired resistance to CDK4/6 inhibitors in ER+ breast cancer

Carmine De Angelis, Xiaoyong Fu, Maria Letizia Cataldo, Agostina Nardone, Valerie M. Jansen, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Vidyalakshmi Sethunath, Resel Pereira, Matteo Benelli, Ilenia Migliaccio, Luca Malorni, Joshua Donaldson, Pier Selenica, David N. Brown, Britta Weigelt, Jorge S. Reis-Filho, Ben H. Park, Sara A. Hurvitz, Dennis J. Slamon, Mothaffar F. Rimawi, Rinath Jeselsohn, Kent Osborne, Rachel Schiff
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): GS2-01.
https://doi.org/10.1158/1538-7445.SABCS19-GS2-01
Published: 15 February 2020
View article titled, Abstract GS2-01: High levels of interferon-response gene signatures are associated with <em>de novo</em> and acquired resistance to CDK4/6 inhibitors in ER+ breast cancer
Journal Articles

Abstract PD8-06: The genomic landscape of metastatic special histologic types of breast cancer

Fresia Pareja, Simon SK Lee, Francisco Beca, Lorenzo Ferrando, Pier Selenica, David N Brown, Hannah Y Wen, Hong Zhang, Edi Brogi, Pedram Razavi, Sarat Chandarlapaty, Britta Weigelt, Jorge S Reis-Filho
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD8-06.
https://doi.org/10.1158/1538-7445.SABCS19-PD8-06
Published: 15 February 2020
View article titled, Abstract PD8-06: The genomic landscape of metastatic special histologic types of breast cancer