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Philippe Guillaume
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Journal Articles

Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells

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Michael Hebeisen, Julien Schmidt, Philippe Guillaume, Petra Baumgaertner, Daniel E. Speiser, Immanuel Luescher, Nathalie Rufer
Journal: Cancer Research
Cancer Res (2015) 75 (10): 1983–1991.
https://doi.org/10.1158/0008-5472.CAN-14-3516
Published: 13 May 2015
View articletitled, Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells
Open the PDF for Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells in another window
Includes: Supplementary data
Journal Articles

PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines

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Julien Fourcade, Zhaojun Sun, Ornella Pagliano, Joe-Marc Chauvin, Cindy Sander, Bratislav Janjic, Ahmad A. Tarhini, Hussein A. Tawbi, John M. Kirkwood, Stergios Moschos, Hong Wang, Philippe Guillaume, Immanuel F. Luescher, Arthur Krieg, Ana C. Anderson, Vijay K. Kuchroo, Hassane M. Zarour
Journal: Cancer Research
Cancer Res (2014) 74 (4): 1045–1055.
https://doi.org/10.1158/0008-5472.CAN-13-2908
Published: 16 February 2014
View articletitled, PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines
Open the PDF for PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines in another window
Includes: Supplementary data
Journal Articles

Abstract 5407: The upregulation of BTLA and PD-1 defines a novel subset of dysfunctional tumor antigen-specific CD8+ T cells

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Julien Fourcade, Zhaojun Sun, Ornella Pagliano, Philippe Guillaume, Immanuel F. Luescher, Cindy Sander, John M. Kirkwood, Daniel Olive, Vijay Kuchroo, Hassane M. Zarour
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2012-5407
Published: 15 April 2012
View articletitled, Abstract 5407: The upregulation of BTLA and PD-1 defines a novel subset of dysfunctional tumor antigen-specific CD8+ T cells
Journal Articles

CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1

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Julien Fourcade, Zhaojun Sun, Ornella Pagliano, Philippe Guillaume, Immanuel F. Luescher, Cindy Sander, John M. Kirkwood, Daniel Olive, Vijay Kuchroo, Hassane M. Zarour
Journal: Cancer Research
Cancer Res (2012) 72 (4): 887–896.
https://doi.org/10.1158/0008-5472.CAN-11-2637
Published: 14 February 2012
View articletitled, CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
Open the PDF for CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1 in another window
Includes: Supplementary data
Journal Articles

Abstract 3657: Upregulation of PD-1 and Tim-3 expression on tumor antigen-specific CD4+ T cells is associated with reversible T cell dysfunction in patients with advanced melanoma

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Julien Fourcade, Zhaojun Sun, Philippe Guillaume, Immanuel F. Luescher, Cindy Sander, John M. Kirkwood, Vijay Kuchroo, Hassane M. Zarour
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3657.
https://doi.org/10.1158/1538-7445.AM2011-3657
Published: 15 April 2011
View articletitled, Abstract 3657: Upregulation of PD-1 and Tim-3 expression on tumor antigen-specific CD4+ T cells is associated with reversible T cell dysfunction in patients with advanced melanoma
Journal Articles

Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

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Alfred Zippelius, Pascal Batard, Verena Rubio-Godoy, Gilles Bioley, Danielle Liénard, Ferdy Lejeune, Donata Rimoldi, Philippe Guillaume, Norbert Meidenbauer, Andreas Mackensen, Nathalie Rufer, Norbert Lubenow, Daniel Speiser, Jean-Charles Cerottini, Pedro Romero, Mikaël J. Pittet
Journal: Cancer Research
Cancer Res (2004) 64 (8): 2865–2873.
https://doi.org/10.1158/0008-5472.CAN-03-3066
Published: 15 April 2004
View articletitled, Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance
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Journal Articles

Tumor-reactive, SSX-2-specific CD8+ T Cells Are Selectively Expanded during Immune Responses to Antigen-expressing Tumors in Melanoma Patients

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Maha Ayyoub, Donata Rimoldi, Philippe Guillaume, Pedro Romero, Jean-Charles Cerottini, Danila Valmori, Daniel Speiser
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5601–5606.
Published: 18 September 2003
View articletitled, Tumor-reactive, SSX-2-specific CD8+ T Cells Are Selectively Expanded during Immune Responses to Antigen-expressing Tumors in Melanoma Patients
Open the PDF for Tumor-reactive, SSX-2-specific CD8+ T Cells Are Selectively Expanded during Immune Responses to Antigen-expressing Tumors in Melanoma Patients in another window
Journal Articles

Circulating Tumor-reactive CD8+ T Cells in Melanoma Patients Contain a CD45RA+CCR7− Effector Subset Exerting ex Vivo Tumor-specific Cytolytic Activity

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Danila Valmori, Carmen Scheibenbogen, Valerie Dutoit, Dirk Nagorsen, Anne Marie Asemissen, Verena Rubio-Godoy, Donata Rimoldi, Philippe Guillaume, Pedro Romero, Dirk Schadendorf, Martin Lipp, Pierre-Yves Dietrich, Eckhard Thiel, Jean-Charles Cerottini, Danielle Liénard, Ulrich Keilholz
Journal: Cancer Research
Cancer Res (2002) 62 (6): 1743–1750.
Published: 15 March 2002
View articletitled, Circulating Tumor-reactive CD8+ T Cells in Melanoma Patients Contain a CD45RA+CCR7− Effector Subset Exerting ex Vivo Tumor-specific Cytolytic Activity
Open the PDF for Circulating Tumor-reactive CD8+ T Cells in Melanoma Patients Contain a CD45RA+CCR7− Effector Subset Exerting ex Vivo Tumor-specific Cytolytic Activity in another window
Journal Articles

Heterogeneous T-Cell Response to MAGE-A10254–262: High Avidity-specific Cytolytic T Lymphocytes Show Superior Antitumor Activity

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Valérie Dutoit, Verena Rubio-Godoy, Pierre-Yves Dietrich, Anne-Lise Quiqueres, Valérie Schnuriger, Donata Rimoldi, Danielle Liénard, Daniel Speiser, Philippe Guillaume, Pascal Batard, Jean-Charles Cerottini, Pedro Romero, Danila Valmori
Journal: Cancer Research
Cancer Res (2001) 61 (15): 5850–5856.
Published: 01 August 2001
View articletitled, Heterogeneous T-Cell Response to MAGE-A10254–262: High Avidity-specific Cytolytic T Lymphocytes Show Superior Antitumor Activity
Open the PDF for Heterogeneous T-Cell Response to MAGE-A10254–262: High Avidity-specific Cytolytic T Lymphocytes Show Superior Antitumor Activity in another window
Journal Articles

Combinatorial Peptide Libraries as an Alternative Approach to the Identification of Ligands for Tumor-reactive Cytolytic T Lymphocytes

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Clemencia Pinilla, Verena Rubio-Godoy, Valerie Dutoit, Philippe Guillaume, Richard Simon, Yindong Zhao, Richard A. Houghten, Jean-Charles Cerottini, Pedro Romero, Danila Valmori
Journal: Cancer Research
Cancer Res (2001) 61 (13): 5153–5160.
Published: 01 July 2001
View articletitled, Combinatorial Peptide Libraries as an Alternative Approach to the Identification of Ligands for Tumor-reactive Cytolytic T Lymphocytes
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Journal Articles

Melanoma Patients Respond to a Cytotoxic T Lymphocyte-defined Self-Peptide with Diverse and Nonoverlapping T-Cell Receptor Repertoires

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Pierre-Yves Dietrich, Paul R. Walker, Anne-Lise Quiquerez, Gaelle Perrin, Valerie Dutoit, Danielle Liénard, Philippe Guillaume, Jean-Charles Cerottini, Pedro Romero, Danila Valmori
Journal: Cancer Research
Cancer Res (2001) 61 (5): 2047–2054.
Published: 01 March 2001
View articletitled, Melanoma Patients Respond to a Cytotoxic T Lymphocyte-defined Self-Peptide with Diverse and Nonoverlapping T-Cell Receptor Repertoires
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Journal Articles

Frequent Cytolytic T-Cell Responses to Peptide MAGE-A10254–262 in Melanoma

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Danila Valmori, Valérie Dutoit, Verena Rubio-Godoy, Céline Chambaz, Danielle Liénard, Philippe Guillaume, Pedro Romero, Jean-Charles Cerottini, Donata Rimoldi
Journal: Cancer Research
Cancer Res (2001) 61 (2): 509–512.
Published: 01 January 2001
View articletitled, Frequent Cytolytic T-Cell Responses to Peptide MAGE-A10254–262 in Melanoma
Open the PDF for Frequent Cytolytic T-Cell Responses to Peptide MAGE-A10254–262 in Melanoma in another window