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Philipp Beckhove
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Journal Articles

Abstract 3708: OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to cell death and eradicates tumors in combination with PD-1 inhibition

Christina Hartl, Ilona-Petra Maser, Tillmann Michels, Ronny Milde, Vanessa Klein, Philipp Beckhove, Nisit Khandelwal, Hannes Loferer, Stefan Bissinger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3708.
https://doi.org/10.1158/1538-7445.AM2022-3708
Published: 15 June 2022
View article titled, Abstract 3708: OMX-0407, a highly potent SIK3 inhibitor, sensitizes tumor cells to cell death and eradicates tumors in combination with PD-1 inhibition
Journal Articles

Abstract 6698: A first-in-class SIK3 inhibitor, OMX-0370, effectively inhibits tumor growth in syngeneic tumor models, as single agent, by abolishing tumor resistance to immune-derived TNF

Tillmann Michels, Stefan Bissinger, Peter Sennhenn, Hannes Loferer, Catarina Martins Freire, Olivia Reidell, Sebastian Meier-Ewert, Apollon Papadimitriou, Philipp Beckhove, Nisit Khandelwal
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6698.
https://doi.org/10.1158/1538-7445.AM2020-6698
Published: 15 August 2020
View article titled, Abstract 6698: A first-in-class SIK3 inhibitor, OMX-0370, effectively inhibits tumor growth in syngeneic tumor models, as single agent, by abolishing tumor resistance to immune-derived TNF
Journal Articles

Abstract LB-075: Increased T cell- activation resulting from the combination of the anti-CEACAM6 function-blocking antibody BAY 1834942 with checkpoint inhibitors targeting either PD-1/PD-L1 or TIM-3

Joerg Willuda, Hans-Henning Boehm, Jessica Pinkert, Mark Trautwein, Wolf-Dietrich Doecke, Oliver von Ahsen, Karl Ziegelbauer, Rienk Offringa, Bertolt Kreft, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-075.
https://doi.org/10.1158/1538-7445.AM2019-LB-075
Published: 01 July 2019
View article titled, Abstract LB-075: Increased T cell- activation resulting from the combination of the anti-CEACAM6 function-blocking antibody BAY 1834942 with checkpoint inhibitors targeting either PD-1/PD-L1 or TIM-3
Journal Articles

Abstract 733: Modulating T cell immunity in tumors by targeting PD-L1 and neoantigens using a live attenuated oral Salmonella platform

Sébastien Wieckowski, Lilli Podola, Heiko Smetak, Anne-Lucie Nugues, Philippe Slos, Amine Adda Berkane, Ming Wei, Klaus Breiner, Albrecht Meichle, Philipp Beckhove, Marc Mansour, Heinz Lubenau
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 733.
https://doi.org/10.1158/1538-7445.AM2018-733
Published: 01 July 2018
View article titled, Abstract 733: Modulating T cell immunity in tumors by targeting PD-L1 and neoantigens using a live attenuated oral <em>Salmonella</em> platform
Journal Articles

Abstract 4558: Immunogenicity and antitumor efficacy of live attenuated Salmonella typhimurium-based oral T-cell vaccines VXM01m, VXM04m and VXM06m

Sébastien Wieckowski, Lilli Podola, Marco Springer, Iris Kobl, Zina Koob, Caroline Mignard, Amine Adda Berkane, Ming Wei, Albrecht Meichle, Klaus Breiner, Matthias Schroff, Philipp Beckhove, Heinz Lubenau
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4558.
https://doi.org/10.1158/1538-7445.AM2017-4558
Published: 01 July 2017
View article titled, Abstract 4558: Immunogenicity and antitumor efficacy of live attenuated <em>Salmonella</em> typhimurium-based oral T-cell vaccines VXM01m, VXM04m and VXM06m
Journal Articles

Abstract 2339: RNAi discovery platform to identify novel genes that prevent immune surveillance in pancreatic ductal adenocarcinoma (PDAC)

Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Nisit Khandelwal, Marco Breinig, Isabel Poschke, Valentina Volpin, Sabrina Wagner, Rienk Offringa, Michael Boutros, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2339.
https://doi.org/10.1158/1538-7445.AM2016-2339
Published: 15 July 2016
View article titled, Abstract 2339: RNAi discovery platform to identify novel genes that prevent immune surveillance in pancreatic ductal adenocarcinoma (PDAC)
Journal Articles

Abstract 1283: In situ activity of tumor specific CTL is a prognostic factor in colorectal cancer

Slava Stamova, Christoph Reissfelder, Christina Gossmann, Marion Braun, Andreas Bonertz, Ute Walliczek, Moritz Koch, Axel Benner, Dirk Jäger, Niels Halama, Khashayarsha Khazaie, Jürgen Weitz, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1283.
https://doi.org/10.1158/1538-7445.AM2015-1283
Published: 01 August 2015
View article titled, Abstract 1283: In situ activity of tumor specific CTL is a prognostic factor in colorectal cancer
Journal Articles

Abstract 245: Identification of novel immune checkpoints as potential therapeutic targets in pancreatic ductal adenocarcinoma (PDAC) using RNAi screening

Antonio Sorrentino, Tillmann Michels, Ayse Nur Menevse, Nisit Khandelwal, Marco Breinig, Isabel Poschke, Rienk Offringa, Michael Boutros, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 245.
https://doi.org/10.1158/1538-7445.AM2015-245
Published: 01 August 2015
View article titled, Abstract 245: Identification of novel immune checkpoints as potential therapeutic targets in pancreatic ductal adenocarcinoma (PDAC) using RNAi screening
Journal Articles

Abstract 254: TiMi1 is a novel immune-checkpoint in solid tumors identified via a tumor-infiltrating lymphocyte (TIL)-based RNAi screening

Tillmann Michels, Christina A. Hartl, Nisit Khandelwal, Marco Breinig, Antonio Sorrentino, Christina Mäder, Ludmila Umansky, Isabel Poschke, Rienk Offringa, Michael Boutros, Galit Eisenberg, Michal Lotem, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 254.
https://doi.org/10.1158/1538-7445.AM2015-254
Published: 01 August 2015
View article titled, Abstract 254: TiMi1 is a novel immune-checkpoint in solid tumors identified via a tumor-infiltrating lymphocyte (TIL)-based RNAi screening
Journal Articles

Abstract 4076: Characterizing tumor-specific memory stem like T cells in blood and bone marrow of breast cancer patients

Mudita Pincha, Paranchai Boonsawat, Christoph Domschke, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4076.
https://doi.org/10.1158/1538-7445.AM2014-4076
Published: 01 October 2014
View article titled, Abstract 4076: Characterizing tumor-specific memory stem like T cells in blood and bone marrow of breast cancer patients
Journal Articles

Abstract 2896: Identification of novel tumor associated antigens in colorectal cancer

Slava Stamova, Christoph Schlude, Saskia Rösch, Christel Herold-Mende, Taronish D. Dubash, Claudia R. Ball, Hanno Glimm, Martin A. Schneider, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2896.
https://doi.org/10.1158/1538-7445.AM2014-2896
Published: 01 October 2014
View article titled, Abstract 2896: Identification of novel tumor associated antigens in colorectal cancer
Journal Articles

Abstract 2803: Preclinical models for the development of HER2-specific T-cell therapy

Christiane Kreutzer, Heinke Conrad, Peter Meyerhuber, Wolfgang Uckert, Philipp Beckhove, Helga Bernhard
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2803.
https://doi.org/10.1158/1538-7445.AM2014-2803
Published: 01 October 2014
View article titled, Abstract 2803: Preclinical models for the development of HER2-specific T-cell therapy
Journal Articles

Abstract A97: A high-throughput RNAi screen unravels new immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes.

Nisit Khandelwal, Marco Breinig, Tobias Speck, Heinke Conrad, Ludmila Umansky, Michael Boutros, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): A97.
https://doi.org/10.1158/1538-7445.TUMIMM2012-A97
Published: 02 April 2014
View article titled, Abstract A97: A high-throughput RNAi screen unravels new immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes.
Journal Articles

Abstract 1261: T cell responses against mutations in oncoproteins/tumor suppressor proteins and their induction by vaccination with long peptides.

Jasmin Quandt, Christoph Schlude, Michael Bartoschek, Angel Cid-Arregui, Philipp Beckhove, Frank Momburg
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1261.
https://doi.org/10.1158/1538-7445.AM2013-1261
Published: 15 April 2013
View article titled, Abstract 1261: T cell responses against mutations in oncoproteins/tumor suppressor proteins and their induction by vaccination with long peptides.
Journal Articles

Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy

Niels Halama, Sara Michel, Matthias Kloor, Inka Zoernig, Axel Benner, Anna Spille, Thora Pommerencke, Doeberitz Magnus von Knebel, Gunnar Folprecht, Birgit Luber, Nadine Feyen, Uwe M. Martens, Philipp Beckhove, Sacha Gnjatic, Peter Schirmacher, Esther Herpel, Juergen Weitz, Niels Grabe, Dirk Jaeger
Journal: Cancer Research
Cancer Res (2011) 71 (17): 5670–5677.
https://doi.org/10.1158/0008-5472.CAN-11-0268
Published: 30 August 2011
View article titled, Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
Open the PDF for Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 2396: IMA950: A novel multi-peptide cancer vaccine for treatment of glioblastoma

Oliver Schoor, Norbert Hilf, Valérie Dutoit, Toni Weinschenk, Steffen Walter, Peter Lewandrowski, Sylvia Flohr, Claudia Trautwein, Cécile Gouttefangeas, Stefan Stevanović, Hans-Georg Rammensee, Philipp Beckhove, Christel Herold-Mende, Pierre-Yves Dietrich, Harpreet Singh
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2396.
https://doi.org/10.1158/1538-7445.AM10-2396
Published: 15 April 2010
View article titled, Abstract 2396: IMA950: A novel multi-peptide cancer vaccine for treatment of glioblastoma
Journal Articles

Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Christoph Domschke, Florian Schuetz, Yingzi Ge, Tobias Seibel, Christine Falk, Benedikt Brors, Israel Vlodavsky, Nora Sommerfeldt, Hans-Peter Sinn, Marie-Christine Kühnle, Andreas Schneeweiss, Alexander Scharf, Christof Sohn, Volker Schirrmacher, Gerhard Moldenhauer, Frank Momburg, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2009) 69 (21): 8420–8428.
https://doi.org/10.1158/0008-5472.CAN-09-1627
Published: 28 October 2009
View article titled, Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis
Open the PDF for Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis in another window
Includes: Supplementary data
Journal Articles

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

Elias Gounaris, Nichole R. Blatner, Kristen Dennis, Fay Magnusson, Michael F. Gurish, Terry B. Strom, Philipp Beckhove, Fotini Gounari, Khashayarsha Khazaie
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5490–5497.
https://doi.org/10.1158/0008-5472.CAN-09-0304
Published: 01 July 2009
View article titled, T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis
Open the PDF for T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis in another window
Includes: Supplementary data
Journal Articles

The Shaping of a Polyvalent and Highly Individual T-Cell Repertoire in the Bone Marrow of Breast Cancer Patients

Nora Sommerfeldt, Florian Schütz, Christoph Sohn, Joanna Förster, Volker Schirrmacher, Philipp Beckhove
Journal: Cancer Research
Cancer Res (2006) 66 (16): 8258–8265.
https://doi.org/10.1158/0008-5472.CAN-05-4201
Published: 15 August 2006
View article titled, The Shaping of a Polyvalent and Highly Individual T-Cell Repertoire in the Bone Marrow of Breast Cancer Patients
Open the PDF for The Shaping of a Polyvalent and Highly Individual T-Cell Repertoire in the Bone Marrow of Breast Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Heparanase: A New Metastasis-Associated Antigen Recognized in Breast Cancer Patients by Spontaneously Induced Memory T Lymphocytes

Nora Sommerfeldt, Philipp Beckhove, Yingzi Ge, Florian Schütz, Carmen Choi, Mariana Bucur, Christoph Domschke, Christof Sohn, Andreas Schneeweis, Joachim Rom, Dirk Pollmann, Dagmar Leucht, Israel Vlodavsky, Volker Schirrmacher
Journal: Cancer Research
Cancer Res (2006) 66 (15): 7716–7723.
https://doi.org/10.1158/0008-5472.CAN-05-2363
Published: 02 August 2006
View article titled, Heparanase: A New Metastasis-Associated Antigen Recognized in Breast Cancer Patients by Spontaneously Induced Memory T Lymphocytes
Open the PDF for Heparanase: A New Metastasis-Associated Antigen Recognized in Breast Cancer Patients by Spontaneously Induced Memory T Lymphocytes in another window