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Philip W. Kantoff
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Journal Articles

Abstract A002: A reciprocal signaling crosstalk between the AR and BCl2-AKT pathways induces castration resistance in castration sensitive prostate cancer

Goutam Chakraborty, Rahim Hirani, Subhiksha Nandakumar, Nabila Zaman, Teja Muralidhar Kalidindi, Sai Harisha Rajanala, Gwo-Shu M. Lee, Konrad H. Stopsack, Naga Vara Kishore Pillarsetty, Lorelei A. Mucci, Daniel C. Danila, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A002.
https://doi.org/10.1158/1538-7445.PRCA2023-A002
Published: 02 June 2023
View article titled, Abstract A002: A reciprocal signaling crosstalk between the AR and BCl2-AKT pathways induces castration resistance in castration sensitive prostate cancer
Journal Articles

Abstract 1438: Organic anion transporter(SLCO)genotype and prostate cancer progression: Prospective cohort study and meta-analysis

Konrad H. Stopsack, Harisha Rajanala, Anna Plym, Jane B. Vaselkiv, Konstantina Matsoukas, Ericka M. Ebot, Sarah C. Markt, Kathryn L. Penney, Gwo-Shu M. Lee, Lorelei A. Mucci, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1438.
https://doi.org/10.1158/1538-7445.AM2022-1438
Published: 15 June 2022
View article titled, Abstract 1438: Organic anion transporter<em>(SLCO)</em>genotype and prostate cancer progression: Prospective cohort study and meta-analysis
Journal Articles

Abstract 2498: Identification and characterization of the PIK3R1-mutant subtype in PI3K-addicted prostate cancer

Goutam Chakraborty, Subhiksha Nandakumar, Rahim Hirani, Sai Harisha Rajanala, Bastien Nguyen, Romina Ghale, Ying Z. Mazzu, Lina E. Jehane, Gwo-Shu Mary Lee, Lorelei A. Mucci, Nikolaus Schultz, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2498.
https://doi.org/10.1158/1538-7445.AM2021-2498
Published: 01 July 2021
View article titled, Abstract 2498: Identification and characterization of the <em>PIK3R1</em>-mutant subtype in PI3K-addicted prostate cancer
Journal Articles

Abstract 893: Batch effects in tumor biomarker studies using tissue microarrays: Extent, impact, and remediation

Konrad H. Stopsack, Molin Wang, Svitlana Tyekucheva, Travis A. Gerke, J. Bailey Vaselkiv, Kathryn L. Penney, Philip W. Kantoff, Stephen P. Finn, Michelangelo Fiorentino, Massimo Loda, Giovanni Parmigiani, Lorelei A. Mucci
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 893.
https://doi.org/10.1158/1538-7445.AM2021-893
Published: 01 July 2021
View article titled, Abstract 893: Batch effects in tumor biomarker studies using tissue microarrays: Extent, impact, and remediation
Journal Articles

Abstract 863: Circadian gene expression in metastatic sites and association with survival in metastatic castration-resistant prostate cancer

Benjamin D. Booker, Konrad H. Stopsack, Travis A. Gerke, Kathryn Penny, Philip W. Kantoff, Lorelei A. Mucci, Sarah C. Markt, PCF/SU2C International Prostate Cancer Dream Team
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 863.
https://doi.org/10.1158/1538-7445.AM2021-863
Published: 01 July 2021
View article titled, Abstract 863: Circadian gene expression in metastatic sites and association with survival in metastatic castration-resistant prostate cancer
Journal Articles

Abstract 979: Bcl-2 inhibitor enhances anti-androgen therapy induced regression of castration sensitive prostate cancer

Rahim Hirani, Subhiksha Nandakumar, Teja Kalidindi, Deborah Fidele, Harisha Rajanala, Ying Mazzu, Yuki Yoshikawa, Lina Jehane, Gwo-Shu Mary Lee, Elisa de Stanchina, Adam Sowalsky, Michael J. Morris, Heiko Schoder, Naga Vara Kishore Pillarsetty, Lorelei A. Mucci, Daniel Danila, Goutam Chakraborty, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 979.
https://doi.org/10.1158/1538-7445.AM2021-979
Published: 01 July 2021
View article titled, Abstract 979: Bcl-2 inhibitor enhances anti-androgen therapy induced regression of castration sensitive prostate cancer
Journal Articles

Abstract 1308: CDK12 alterations define a distinct molecular subtype of prostate cancers with unique genomic and clinical characteristics

Bastien Nguyen, Jose Mauricio Mota, Subhiksha Nandakumar, Konrad H. Stopsack, Emily Weg, Dana Rathkopf, Michael J. Morris, Howard Scher, Philip W. Kantoff, Anuradha Gopalan, Dmitriy Zamarin, David B. Solit, Nikolaus Schultz, Wassim Abida
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1308.
https://doi.org/10.1158/1538-7445.AM2020-1308
Published: 15 August 2020
View article titled, Abstract 1308: <em>CDK12</em> alterations define a distinct molecular subtype of prostate cancers with unique genomic and clinical characteristics
Journal Articles

Abstract 1650: Non-invasive imaging tool to predict BRCA2 silencing in the context of prostate cancer

Teja Kalidindi, Sang Gyu Lee, Heiko Schoder, Lina E. Jehanae, Rahim Hirani, Goutam Chakraborty, Philip W. Kantoff, Naga Vara Kishore Pillarsetty
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1650.
https://doi.org/10.1158/1538-7445.AM2020-1650
Published: 15 August 2020
View article titled, Abstract 1650: Non-invasive imaging tool to predict BRCA2 silencing in the context of prostate cancer
Journal Articles

Abstract 6219: Combined inhibition of androgen signaling and apoptosis pathways in hormone sensitive prostate cancer

Goutam Chakraborty, Rahim Hirani, Lina E. Jehane, Ying Z. Mazzu, Yuki Yoshikawa, Sai Harisha Rajanala, Gwo-Shu M. Lee, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6219.
https://doi.org/10.1158/1538-7445.AM2020-6219
Published: 15 August 2020
View article titled, Abstract 6219: Combined inhibition of androgen signaling and apoptosis pathways in hormone sensitive prostate cancer
Journal Articles

Abstract 2534: A comparative analysis of fraction genome altered vs tumor mutational count in prostate cancer

Goutam Chakraborty, Mohammad Atiq, Subhiksha Nandakumar, Ying Z. Mazzu, Joshua Armenia, Yuki Yoshikawa, Nabeela Khan, Gwo-Shu M. Lee, Lorelei Mucci, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2534.
https://doi.org/10.1158/1538-7445.AM2019-2534
Published: 01 July 2019
View article titled, Abstract 2534: A comparative analysis of fraction genome altered vs tumor mutational count in prostate cancer
Journal Articles

Abstract 4470: Aneuploidy drives lethal progression in prostate cancer

Konrad H. Stopsack, Charles A. Whittaker, Travis A. Gerke, Massimo Loda, Philip W. Kantoff, Lorelei A. Mucci, Angelika Amon
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4470.
https://doi.org/10.1158/1538-7445.AM2019-4470
Published: 01 July 2019
View article titled, Abstract 4470: Aneuploidy drives lethal progression in prostate cancer
Journal Articles

Abstract 339: Mechanisms of resistance to poly (ADP-ribose) polymerase inhibitors in prostate cancer

Mohammad Atiq, Goutam Chakraborty, Subhiksha Nandakumar, Ying Z. Mazzu, Konrad Stopsack, Yuki Yoshikawa, Nabeela Khan, Gwo-Shu Mary Lee, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 339.
https://doi.org/10.1158/1538-7445.AM2019-339
Published: 01 July 2019
View article titled, Abstract 339: Mechanisms of resistance to poly (ADP-ribose) polymerase inhibitors in prostate cancer
Journal Articles

Abstract LB-240: Immuno-genomic detection and prognostication of aggressive prostate cancer phenotypes by next-generation RNA sequencing

Amin I. Kassis, Ricardo Henao, Kirk J. Wojno, Geffrey Erickson, Harry Stylli, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-240.
https://doi.org/10.1158/1538-7445.AM2019-LB-240
Published: 01 July 2019
View article titled, Abstract LB-240: Immuno-genomic detection and prognostication of aggressive prostate cancer phenotypes by next-generation RNA sequencing
Journal Articles

Abstract B024: Family history of prostate cancer and the incidence of ERG- and PTEN-defined prostate cancer

Dana Hashim, Amparo G. Gonzalez-Feliciano, Thomas U. Ahearn, Andreas Pettersson, Lauren Barber, Claire H. Pernar, Ericka M. Ebot, Stephen Finn, Edward L. Giovannucci, Rosina T. Lis, Massimo Loda, Giovanni Parmigiani, Kathryn L. Penney, Tamara Lotan, Philip W. Kantoff, Lorelei A. Mucci, Rebecca E. Graff
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B024.
https://doi.org/10.1158/1538-7445.PRCA2017-B024
Published: 14 August 2018
View article titled, Abstract B024: Family history of prostate cancer and the incidence of ERG- and PTEN-defined prostate cancer
Journal Articles

Abstract 1450: Intratumoral CYP27A1 expression in relation to cholesterol synthesis and vitamin D signaling and its association with lethal prostate cancer

Nabeela A. Khan, Konrad H. Stopsack, Emma H. Allott, Travis A. Gerke, Edward L. Giovannucci, Lorelei A. Mucci, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1450.
https://doi.org/10.1158/1538-7445.AM2018-1450
Published: 01 July 2018
View article titled, Abstract 1450: Intratumoral <em>CYP27A1</em> expression in relation to cholesterol synthesis and vitamin D signaling and its association with lethal prostate cancer
Journal Articles

Abstract LB-275: Targeting poor-prognosis subtypes of prostate cancer by inhibition of DNA repair gene ribonucleotide reductase small subunit M2

Ying Z. Mazzu, Joshua Armenia, Goutam Chakraborty, Yuki Yoshikawa, Travis A. Gerke, Si Ana A. Coggins, Xintao Qiu, Mohammad Atiq, Konrad H. Stopsack, Gwo-Shu Mary Lee, Henry W. Long, Baek Kim, Matthew L. Freedman, Mark M. Pomerantz, Lorelei A. Mucci, Philip W. Kantoff
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-275.
https://doi.org/10.1158/1538-7445.AM2018-LB-275
Published: 01 July 2018
View article titled, Abstract LB-275: Targeting poor-prognosis subtypes of prostate cancer by inhibition of DNA repair gene ribonucleotide reductase small subunit M2
Journal Articles

Abstract LB-212: IMAAGEN study biomarker analysis in patients with long term response to abiraterone acetate with prednisone for non-metastatic castrate resistant prostate cancer

Olesya Chornoguz, Dong Shen, Gurpreet Kapoor, Weimin Li, Jennifer Phillips, Charles J. Ryan, E David Crawford, Neal D. Shore, Willie Underwood, Mary-Ellen Taplin, Philip W. Kantoff, Tracy McGowan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-212.
https://doi.org/10.1158/1538-7445.AM2018-LB-212
Published: 01 July 2018
View article titled, Abstract LB-212: IMAAGEN study biomarker analysis in patients with long term response to abiraterone acetate with prednisone for non-metastatic castrate resistant prostate cancer
Journal Articles

Abstract 3566: The long tail of significantly mutated genes in prostate cancer

Joshua Armenia, Stephanie Mullane, Jianjiong Gao, Debyani Chakravarty, Ritika Kundra, Franklin Huang, Celine Han, Dan Robinson, Levi A. Garraway, Peter Nelson, Mark Rubin, Mary-Ellen Taplin, Wassim Abida, Charles L. Sawyers, Arul M. Chinnaiyan, Philip W. Kantoff, Johann S. Bono, Nikolaus Schultz, Eliezer M. Van Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3566.
https://doi.org/10.1158/1538-7445.AM2017-3566
Published: 01 July 2017
View article titled, Abstract 3566: The long tail of significantly mutated genes in prostate cancer
Journal Articles

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6

Atish D. Choudhury, Anna C. Schinzel, Maura B. Cotter, Rosina T. Lis, Katherine Labella, Ying Jie Lock, Francesca Izzo, Isil Guney, Michaela Bowden, Yvonne Y. Li, Jinal Patel, Emily Hartman, Steven A. Carr, Monica Schenone, Jacob D. Jaffe, Philip W. Kantoff, Peter S. Hammerman, William C. Hahn
Journal: Cancer Research
Cancer Res (2017) 77 (3): 753–765.
https://doi.org/10.1158/0008-5472.CAN-16-0455
Published: 31 January 2017
View article titled, Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6
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Includes: Supplementary data
Journal Articles

Abstract 2674: High fat diet accelerates MYC-driven prostate cancer through metabolic and epigenomic rewiring

David P. Labbe’, Giorgia Zadra, Meng Yang, Charles Y. Lin, Jaime M. Reyes, Stefano Cacciatore, Ericka M. Ebot, Maura B. Cotter, Amanda L. Creech, Jacob D. Jaffe, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Jorge E. Chavarro, Massimo Loda, Myles Brown
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2674.
https://doi.org/10.1158/1538-7445.AM2016-2674
Published: 15 July 2016
View article titled, Abstract 2674: High fat diet accelerates MYC-driven prostate cancer through metabolic and epigenomic rewiring