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Philip M. Potter
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Journal Articles

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

P. Jake Slavish, Liying Chi, Mi-Kyung Yun, Lyudmila Tsurkan, Nancy E. Martinez, Barbara Jonchere, Sergio C. Chai, Michele Connelly, M. Brett Waddell, Sourav Das, Geoffrey Neale, Zhenmei Li, William R. Shadrick, Rachelle R. Olsen, Kevin W. Freeman, Jonathan A. Low, Jeanine E. Price, Brandon M. Young, Nagakumar Bharatham, Vincent A. Boyd, Jun Yang, Richard E. Lee, Marie Morfouace, Martine F. Roussel, Taosheng Chen, Daniel Savic, R. Kiplin Guy, Stephen W. White, Anang A. Shelat, Philip M. Potter
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3507–3518.
https://doi.org/10.1158/0008-5472.CAN-19-3934
Published: 02 September 2020
View articletitled, Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
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Includes: Supplementary data
Journal Articles

Abstract 731: Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Scott Newman, Liying Fan, Allison Pribnow, Antonina Silkov, Stephen V. Rice, Seungjae Lee, Ying Shao, Bridget Shaner, Heather Mulder, Joy Nakitandwe, Sheila Shurtleff, Elizabeth Azzato, Gang Wu, Xin Zhou, Raymond Barnhill, John Easton, Kim E. Nichols, David W. Ellison, Downing R. James, Alberto Pappo, Philip M. Potter, Jinghui Zhang, Armita Bahrami
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 731.
https://doi.org/10.1158/1538-7445.AM2019-731
Published: 01 July 2019
View articletitled, Abstract 731: Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas
Journal Articles

Abstract 5794: Targeting the BD2 BET bromodomain to inhibit proliferation of pancreatic ductal adenocarcinoma cells

Aubrey Lynn Miller, Peter J. Slavish, Brandon M. Young, Philip M. Potter, Anang A. Shelat, Karina J. Yoon
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5794.
https://doi.org/10.1158/1538-7445.AM2018-5794
Published: 01 July 2018
View articletitled, Abstract 5794: Targeting the BD2 BET bromodomain to inhibit proliferation of pancreatic ductal adenocarcinoma cells
Journal Articles

Abstract 3109: ALK as a valid therapeutic target for the treatment of rhabdomyosarcoma

Monika Wierdl, Lyudmila Tsurkan, Viktor Tollemar, Lying Chi, Elizabeth Stewart, Michael A. Dyer, Philip M. Potter
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3109.
https://doi.org/10.1158/1538-7445.AM2014-3109
Published: 01 October 2014
View articletitled, Abstract 3109: ALK as a valid therapeutic target for the treatment of rhabdomyosarcoma
Journal Articles

Abstract 1125: Spliceosome-targeted antitumor drug discovery.

Timothy A. Graubert, Sharyn Baker, Philip M. Potter, Manorama Tripathi, Matthew Walter, Gustavo Palacios, Thomas R. Webb
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1125.
https://doi.org/10.1158/1538-7445.AM2013-1125
Published: 15 April 2013
View articletitled, Abstract 1125: Spliceosome-targeted antitumor drug discovery.
Journal Articles

Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma

Mary K. Danks, K. Jin Yoon, Rebecca A. Bush, Joanna S. Remack, Monika Wierdl, Lyudmila Tsurkan, Seung U. Kim, Elizabeth Garcia, Marianne Z. Metz, Joseph Najbauer, Philip M. Potter, Karen S. Aboody
Journal: Cancer Research
Cancer Res (2007) 67 (1): 22–25.
https://doi.org/10.1158/0008-5472.CAN-06-3607
Published: 08 January 2007
View articletitled, Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma
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Journal Articles

Analysis of the human intestinal carboxylesterase and development of specific inhibitors to ameliorate the delayed diarrhea associated with CPT-ll administration.

Michael J. Hatfield, Lyudmila Tsurkan, Janice L. Hyatt, Carol C. Edwards, Monika Wierdl, Philip M. Potter
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1299.
Published: 15 April 2006
View articletitled, Analysis of the human intestinal carboxylesterase and development of specific inhibitors to ameliorate the delayed diarrhea associated with CPT-ll administration.
Journal Articles

Synthesis of novel benzils and benzoins as selective inhibitors of mammalian carboxylesterases designed to ameliorate the delayed diarrhea associated with CPT-11 treatment.

Latorya D. Hicks, Janice L. Hyatt, Randy M. Wadkins, Carol C. Edwards, Lyudmila Tsurkan, Monika Weirdl, Philip M. Potter
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1300.
Published: 15 April 2006
View articletitled, Synthesis of novel benzils and benzoins as selective inhibitors of mammalian carboxylesterases designed to ameliorate the delayed diarrhea associated with CPT-11 treatment.
Journal Articles

Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, CYP2B1 and Secreted Human Intestinal Carboxylesterase, in Combination with Cyclophosphamide and Irinotecan

Edyta Tyminski, Stanley LeRoy, Kinya Terada, Dianne M. Finkelstein, Janice L. Hyatt, Mary K. Danks, Philip M. Potter, Yoshinaga Saeki, E. Antonio Chiocca
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6850–6857.
https://doi.org/10.1158/0008-5472.CAN-05-0154
Published: 01 August 2005
View articletitled, Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, CYP2B1 and Secreted Human Intestinal Carboxylesterase, in Combination with Cyclophosphamide and Irinotecan
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Journal Articles

Development of an etoposide prodrug that is selectively activated by rabbit carboxylesterase, for combination with irinotecan, in enzyme-prodrug activation approaches to therapy

K. Jin Yoon, Joanna S. Remack, Jianjun Qi, Richard E. Lee, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 330.
Published: 01 May 2005
View articletitled, Development of an etoposide prodrug that is selectively activated by rabbit carboxylesterase, for combination with irinotecan, in enzyme-prodrug activation approaches to therapy
Journal Articles

Human neural progenitor cells (NPCs) as delivery vectors for therapeutic transgenes: NPC-directed enzyme prodrug therapy (NDEPT)

Karen S. Aboody, Rebecca A. Bush, Elizabeth Garcia, Marianne Metz, Doris A. Phelps, Joanna Remack, Monika Wierdl, K. Jin Yoon, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 796.
Published: 01 May 2005
View articletitled, Human neural progenitor cells (NPCs) as delivery vectors for therapeutic transgenes: NPC-directed enzyme prodrug therapy (NDEPT)
Journal Articles

Identification of novel selective inhibitors of human intestinal carboxylesterase: Synthesis, QSAR analysis, mechanism of action and biological activity.

Randy M. Wadkins, Janice L. Hyatt, Kyoung Jin P. Yoon, Christopher L. Morton, Richard E. Lee, Komath Damodaran, Paul Beroza, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 462.
Published: 01 April 2004
View articletitled, Identification of novel selective inhibitors of human intestinal carboxylesterase: Synthesis, QSAR analysis, mechanism of action and biological activity.
Journal Articles

VDEPT using a rabbit liver carboxylesterase and CPT-11.

Christopher L. Morton, Monika Wierdl, Peter J. Houghton, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 871.
Published: 01 April 2004
View articletitled, VDEPT using a rabbit liver carboxylesterase and CPT-11.
Journal Articles

Development of a viral-directed, combination prodrug-enzyme therapy (VDEPT) for the treatment of solid tumors

Kyoung J. Yoon, Joanna S. Remack, Kristopher G. Virga, Richard E. Lee, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 151.
Published: 01 April 2004
View articletitled, Development of a viral-directed, combination prodrug-enzyme therapy (VDEPT) for the treatment of solid tumors
Journal Articles

A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38

Hilde Stubdal, Noah Perin, Marilyn Lemmon, Patricia Holman, Maxine Bauzon, Philip M. Potter, Mary K. Danks, Ali Fattaey, Thomas Dubensky, Leisa Johnson
Journal: Cancer Research
Cancer Res (2003) 63 (20): 6900–6908.
Published: 28 October 2003
View articletitled, A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38
Open the PDF for A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38 in another window
Journal Articles

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

Lars M. Wagner, Sylvie M. Guichard, Rebecca A. Burger, Christopher L. Morton, Charles M. Straign, Richard A. Ashmun, Linda C. Harris, Peter J. Houghton, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2002) 62 (17): 5001–5007.
Published: 01 September 2002
View articletitled, Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients
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Journal Articles

Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase

Monika Wierdl, Christopher L. Morton, James K. Weeks, Mary K. Danks, Linda C. Harris, Philip M. Potter
Journal: Cancer Research
Cancer Res (2001) 61 (13): 5078–5082.
Published: 01 July 2001
View articletitled, Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase
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Journal Articles

A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

Mandy M. Meck, Monika Wierdl, Lars M. Wagner, Rebecca A. Burger, Sylvie M. Guichard, Erik. J. Krull, Linda C. Harris, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2001) 61 (13): 5083–5089.
Published: 01 July 2001
View articletitled, A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11
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Journal Articles

Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression

Rekha V. Iyengar, Cynthia A. Pawlik, Erik J. Krull, Doris A. Phelps, Rebecca A. Burger, Linda C. Harris, Philip M. Potter, Mary K. Danks
Journal: Cancer Research
Cancer Res (2001) 61 (7): 3045–3052.
Published: 01 April 2001
View articletitled, Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression
Open the PDF for Use of a Modified Ornithine Decarboxylase Promoter to Achieve Efficient c-MYC- or N-MYC-regulated Protein Expression in another window
Journal Articles

Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase

Ruchi Khanna, Christopher L. Morton, Mary K. Danks, Philip M. Potter
Journal: Cancer Research
Cancer Res (2000) 60 (17): 4725–4728.
Published: 01 September 2000
View articletitled, Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase
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