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Journal Articles

Abstract 2795: Safety profile and therapeutic potential in breast cancer of STX140, an original tubulin binding agent

Florence Meyer-Losic, Ann Fiore, Mark Carlson, Jeffrey Lauer, Pierre Roubert, Sonia Bernetière, Charleen Oligo, Laurent Vignaux, Hervé Gaudry, Paul A. Foster, Simon P. Newman, Atul Purohit, Matthew P. Leese, Philip G. Kasprzyk

Cancer Res (2012) 72 (8_Supplement): 2795.

https://doi.org/10.1158/1538-7445.AM2012-2795

Published: 15 April 2012

View article titled, Abstract 2795: Safety profile and therapeutic potential in breast cancer of STX140, an original tubulin binding agent

Journal Articles

Abstract 756: Optimization of tetrahydroisoquinoline-based microtubule disruptors as anticancer agents

Mathew P. Leese, Fabrice L. Jourdan, Eric Ferrandis, Sandra Regis-Lydi, Philip G. Kasprzyk, Ann Fiore, Simon P. Newman, Chloe Stengel, Michael J. Reed, Atul Purohit, Barry VL Potter

Cancer Res (2010) 70 (8_Supplement): 756.

https://doi.org/10.1158/1538-7445.AM10-756

Published: 15 April 2010

View article titled, Abstract 756: Optimization of tetrahydroisoquinoline-based microtubule disruptors as anticancer agents

Journal Articles

Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex

Cancer Res (2006) 66 (18): 9227–9234.

https://doi.org/10.1158/0008-5472.CAN-05-4205

Published: 18 September 2006

View article titled, Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex

Journal Articles

2-Substituted estradiol sulfamates: D-ring SAR and anti-tumor activity

Mathew P. Leese, Fabrice L. Jourdan, Philip G. Kasprzyk, Simon P. Newman, Atul Purohit, Michael J. Reed, Barry V L Potter

Cancer Res (2006) 66 (8_Supplement): 263.

Published: 15 April 2006

View article titled, 2-Substituted estradiol sulfamates: D-ring SAR and anti-tumor activity

Journal Articles

2-Methoxyestradiol-3,17-O,O-bis-sulfamate binds to the colchicine site of tubulin and down-regulates survivin, inhibits the anti-apoptotic protein Bcl-2 and down-regulates the pro-angiogenic transcription factor HIF-1 alpha

Joanna M. Day, Simon P. Newman, Yaik T. Ho, Bindumalini Raobaikady, Sarah Tagg, Mathew P. Leese, Philip G. Kasprzyk, Barry V L Potter, Michael J. Reed, Atul Purohit

Cancer Res (2006) 66 (8_Supplement): 117.

Published: 15 April 2006

View article titled, 2-Methoxyestradiol-3,17-O,O-bis-sulfamate binds to the colchicine site of tubulin and down-regulates survivin, inhibits the anti-apoptotic protein Bcl-2 and down-regulates the pro-angiogenic transcription factor HIF-1 alpha

Journal Articles

The role of 17β-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.

Simon P. Newman, Christopher R. Ireson, Helena J. Tutill, Joanna M. Day, Michael F. Parsons, Philip G. Kasprzyk, Barry V. Potter, Michael J. Reed, Atul Purohit

Cancer Res (2006) 66 (8_Supplement): 1275.

Published: 15 April 2006

View article titled, The role of 17β-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.

Journal Articles

The novel inhibitor of heterotrimer G-protein signaling, BIM-46174, enhances the anticancer activity of cisplatin in human NSCLC lung tumor xenografts

Gregoire Prevost, Marie-Odile Lonchampt, Susan Holbeck, S. Attoub, Daniel W. Zaharevitz, Michael C. Alley, John J. Wright, Marie-Christine Brezak, Helene Couloumb, Ann Savola, Marion Huchet, Sophie Chaumeron, Q.-D. Nguyen, P. Forgez, Eric Ferrandis, Pierre Roubert, Christian Gespach, Philip G. Kasprzyk

Cancer Res (2005) 65 (9_Supplement): 158.

Published: 01 May 2005

View article titled, The novel inhibitor of heterotrimer G-protein signaling, BIM-46174, enhances the anticancer activity of cisplatin in human NSCLC lung tumor xenografts

Journal Articles

Targeted diflomotecan- and camptothecin-containing somatostatin analogs specifically inhibit the growth of SCLCs rich in somatostatin receptors

Philip G. Kasprzyk, Ann Savola, Mark Carlson, Yeelana Shen, Jundong Zhang, Jeanne M. Comstock, Xiaojun Zou, John E. Taylor, Mark Telliot, Caroline Touvay, Jesse Dong

Cancer Res (2005) 65 (9_Supplement): 133.

Published: 01 May 2005

View article titled, Targeted diflomotecan- and camptothecin-containing somatostatin analogs specifically inhibit the growth of SCLCs rich in somatostatin receptors

Journal Articles

BN80927: A Novel Homocamptothecin That Inhibits Proliferation of Human Tumor Cells in Vitro and in Vivo

Danièle Demarquay, Marion Huchet, Helène Coulomb, Laurence Lesueur-Ginot, Olivier Lavergne, José Camara, Philip G. Kasprzyk, Grégoire Prévost, Dennis C. H. Bigg

Cancer Res (2004) 64 (14): 4942–4949.

https://doi.org/10.1158/0008-5472.CAN-03-3872

Published: 15 July 2004

View article titled, BN80927: <subtitle>A Novel Homocamptothecin That Inhibits Proliferation of Human Tumor Cells in Vitro and in Vivo </subtitle>

Journal Articles

A Novel Synthetic Inhibitor of CDC25 Phosphatases: BN82002

Marie-Christine Brezak, Muriel Quaranta, Odile Mondésert, Marie-Odile Galcera, Olivier Lavergne, Frédéric Alby, Martine Cazales, Véronique Baldin, Christophe Thurieau, Jeremiath Harnett, Christophe Lanco, Philip G. Kasprzyk, Gregoire P. Prevost, Bernard Ducommun

Cancer Res (2004) 64 (9): 3320–3325.

https://doi.org/10.1158/0008-5472.CAN-03-3984

Published: 03 May 2004

View article titled, A Novel Synthetic Inhibitor of CDC25 Phosphatases: <subtitle>BN82002</subtitle>

Journal Articles

Homocamptothecin, an E-Ring Modified Camptothecin with Enhanced Lactone Stability, Retains Topoisomerase I-targeted Activity andAntitumor Properties

Laurence Lesueur-Ginot, Danièle Demarquay, Robert Kiss, Philip G. Kasprzyk, Laurent Dassonneville, Christian Bailly, José Camara, Olivier Lavergne, Dennis C. H. Bigg

Cancer Res (1999) 59 (12): 2939–2943.

Published: 15 June 1999

View article titled, Homocamptothecin, an E-Ring Modified Camptothecin with Enhanced Lactone Stability, Retains Topoisomerase I-targeted Activity andAntitumor Properties

Journal Articles

Therapy of an Animal Model of Human Gastric Cancer Using a Combination of Anti-erbB-2 Monoclonal Antibodies

Philip G. Kasprzyk, Sun Uk Song, Pier Paolo Di Fiore, C. Richter King

Cancer Res (1992) 52 (10): 2771–2776.

Published: 01 May 1992

View article titled, Therapy of an Animal Model of Human Gastric Cancer Using a Combination of Anti-erbB-2 Monoclonal Antibodies

NARROW

Abstract 2795: Safety profile and therapeutic potential in breast cancer of STX140, an original tubulin binding agent

Abstract 756: Optimization of tetrahydroisoquinoline-based microtubule disruptors as anticancer agents

Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex

2-Substituted estradiol sulfamates: D-ring SAR and anti-tumor activity

2-Methoxyestradiol-3,17-O,O-bis-sulfamate binds to the colchicine site of tubulin and down-regulates survivin, inhibits the anti-apoptotic protein Bcl-2 and down-regulates the pro-angiogenic transcription factor HIF-1 alpha

The role of 17β-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.

The novel inhibitor of heterotrimer G-protein signaling, BIM-46174, enhances the anticancer activity of cisplatin in human NSCLC lung tumor xenografts

Targeted diflomotecan- and camptothecin-containing somatostatin analogs specifically inhibit the growth of SCLCs rich in somatostatin receptors

BN80927: A Novel Homocamptothecin That Inhibits Proliferation of Human Tumor Cells in Vitro and in Vivo

A Novel Synthetic Inhibitor of CDC25 Phosphatases: BN82002

Homocamptothecin, an E-Ring Modified Camptothecin with Enhanced Lactone Stability, Retains Topoisomerase I-targeted Activity andAntitumor Properties

Therapy of an Animal Model of Human Gastric Cancer Using a Combination of Anti-erbB-2 Monoclonal Antibodies

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