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Peter Wipf
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Journal Articles

Abstract 5500: A PTP4A3 inhibitor reduces ovarian cancer dissemination and alters STAT3 and ERK activation

John S. Lazo, Kelly N. Isbell, Danielle C. Llaneza, Ettore J. Rastelli, Charles N. Landen, Peter Wipf, Elizabeth R. Sharlow
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5500.
https://doi.org/10.1158/1538-7445.AM2022-5500
Published: 15 June 2022
View article titled, Abstract 5500: A PTP4A3 inhibitor reduces ovarian cancer dissemination and alters STAT3 and ERK activation
Journal Articles

Abstract 1460: The design and biological characterization of PTP4A-targeted chemodegraders

Duncan J. Hart, Ettore J. Rastelli, Anna J. Mendelson, Christopher T. Letai, John Robert Cornelison, Elizabeth R. Sharlow, Peter Wipf, John S. Lazo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1460.
https://doi.org/10.1158/1538-7445.AM2021-1460
Published: 01 July 2021
View article titled, Abstract 1460: The design and biological characterization of PTP4A-targeted chemodegraders
Journal Articles

Abstract 1459: PTP4A3 phosphatase is a novel drug target for epithelial ovarian cancer

John Robert Cornelison, Ettore J. Rastelli, Duncan J. Hart, Anna J. Mendelson, Elizabeth R. Sharlow, Peter Wipf, John S. Lazo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1459.
https://doi.org/10.1158/1538-7445.AM2021-1459
Published: 01 July 2021
View article titled, Abstract 1459: PTP4A3 phosphatase is a novel drug target for epithelial ovarian cancer
Journal Articles

Abstract 2365: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

Kelley E. McQueeney, Joseph M. Salamoun, Jennifer Ahn, Paula Pekic, Isabella K. Blanco, Heather Struckman, Elizabeth R. Sharlow, Peter Wipf, John S. Lazo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2365.
https://doi.org/10.1158/1538-7445.AM2018-2365
Published: 01 July 2018
View article titled, Abstract 2365: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion
Journal Articles

Abstract 3210: Targeting PTP4A3 phosphatase in ovarian cancer with the potent noncompetitive inhibitor JMS-631-053

John S. Lazo, Paula Pekic, Alex Cheung, Kelley McQueeney, Joseph Salamoun, Peter Wipf, Charles N. Landen, Elizabeth R. Sharlow
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3210.
https://doi.org/10.1158/1538-7445.AM2017-3210
Published: 01 July 2017
View article titled, Abstract 3210: Targeting PTP4A3 phosphatase in ovarian cancer with the potent noncompetitive inhibitor JMS-631-053
Journal Articles

Abstract 1220: Coordinated chemical-genetics approach identifies PTP4A3-mediated regulation of colon cancer cell migration and extracellular matrix interactions

Kelley E. McQueeney, Joseph M. Salamoun, Isabella K. Blanco, Paula Pekic, Jennifer Ahn, Elizabeth R. Sharlow, Peter Wipf, John S. Lazo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1220.
https://doi.org/10.1158/1538-7445.AM2017-1220
Published: 01 July 2017
View article titled, Abstract 1220: Coordinated chemical-genetics approach identifies PTP4A3-mediated regulation of colon cancer cell migration and extracellular matrix interactions
Journal Articles

Abstract 202: Depletion of PTP4A3 phosphatase disrupts colorectal cancer cell adhesion and extracellular matrix interactions

Kelley E. McQueeney, Paula Pekic, Joseph M. Salamoun, Jennifer Ahn, Elizabeth R. Sharlow, Peter Wipf, John S. Lazo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 202.
https://doi.org/10.1158/1538-7445.AM2016-202
Published: 15 July 2016
View article titled, Abstract 202: Depletion of PTP4A3 phosphatase disrupts colorectal cancer cell adhesion and extracellular matrix interactions
Journal Articles

Abstract 3340: Intraoral administration of mitochondrial targeted GS-nitroxide (JP4-039) radioprotects the oral mucosa but not orthotopic tumors in Fancd2-/- mice

Michael W. Epperly, Ashwin Shinde, Hebist Berhane, Byung Han Rhieu, Ronny Kalash, Karen Xu, Darcy Franicola, Xichen Zhang, Tracy Dixon, Donna Shields, Hong Wang, Peter Wipf, Kalindi Parmar, Eva Guinan, Valerian Kagan, Yulia Tyurina, Robert L. Ferris, Song Li, Joel S. Greenberger
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3340.
https://doi.org/10.1158/1538-7445.AM2015-3340
Published: 01 August 2015
View article titled, Abstract 3340: Intraoral administration of mitochondrial targeted GS-nitroxide (JP4-039) radioprotects the oral mucosa but not orthotopic tumors in Fancd2-/- mice
Journal Articles

Abstract 5344: Novel thioxodihydroquinazolinone small molecules for combination with platinum drugs to reverse platinum resistance through inducing mitochondrial apoptosis independent of Bax and Bak

Wei Qian, Joseph Salamoun, Jingnan Wang, Vera Roginskaya, Bennett Van Houten, Peter Wipf
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5344.
https://doi.org/10.1158/1538-7445.AM2015-5344
Published: 01 August 2015
View article titled, Abstract 5344: Novel thioxodihydroquinazolinone small molecules for combination with platinum drugs to reverse platinum resistance through inducing mitochondrial apoptosis independent of Bax and Bak
Journal Articles

Abstract 228: Withaferin A downregulates tubulins and covalently binds β-tubulin at cysteine-303 in human breast cancer cells

Shivendra V. Singh, Marie Lue Antony, Joomin Lee, Eun-Ryeong Hahm, Su-Hyeong Kim, Guillermo Romero, Adam I. Marcus, Zhen Yang, Vandana Kumari, Xinhua Ji, Courtney L. Vowell, Peter Wipf, Guy T. Uechi, Nathan A. Yates
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 228.
https://doi.org/10.1158/1538-7445.AM2014-228
Published: 01 October 2014
View article titled, Abstract 228: Withaferin A downregulates tubulins and covalently binds β-tubulin at cysteine-303 in human breast cancer cells
Journal Articles

Abstract 70: GS nitroxide (JP4-039) induces radiation resistance of conditional MnSOD tet/tet murine bone marrow stromal cells.

Ronny Kalash, Frank Houghton, Hebist Berhane, Peter Wipf, Donna Shields, Michael W. Epperly, Richard Chaillet, Shaonan Cao, Xichen Zhang, Joel S. Greenberger
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 70.
https://doi.org/10.1158/1538-7445.AM2013-70
Published: 15 April 2013
View article titled, Abstract 70: GS nitroxide (JP4-039) induces radiation resistance of conditional MnSOD tet/tet murine bone marrow stromal cells.
Journal Articles

Abstract 2182: Novel ATP-competitive protein kinase D inhibitors: in vitro characterization and SAR analysis.

Manuj Tandon, James Johnson, Elisa Farber, Evan Carder, Peter Wipf, Qiming J. Wang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2182.
https://doi.org/10.1158/1538-7445.AM2013-2182
Published: 15 April 2013
View article titled, Abstract 2182: Novel ATP-competitive protein kinase D inhibitors: in vitro characterization and SAR analysis.
Journal Articles

Abstract 1475: Localization of mitochondrial targeted GS-nitroxide JP4-039 BODIPY FL conjugate during radioprotection and mitigation in vivo

Julie P. Goff, Erin Skoda, Song Li, Xiang Gao, Michael W. Epperly, Darcy Franicola, Frank Houghton, Peter Wipf, Joel S. Greenberger
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1475.
https://doi.org/10.1158/1538-7445.AM2012-1475
Published: 15 April 2012
View article titled, Abstract 1475: Localization of mitochondrial targeted GS-nitroxide JP4-039 BODIPY FL conjugate during radioprotection and mitigation <em>in vivo</em>
Journal Articles

Abstract 2502: Swallowed small molecule GS-nitroxide, JP-4-039, protects the irradiated esophagus

Michael W. Epperly, Joel S. Greenberger, Hyun Kim, Mark Bernard, Tracy Dixon, Darcy Franicola, Peter Wipf, Song Li, Xiang Gao, Valerian Kagan, Andrew Amoscato, Hongmei Shen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2502.
https://doi.org/10.1158/1538-7445.AM2011-2502
Published: 15 April 2011
View article titled, Abstract 2502: Swallowed small molecule GS-nitroxide, JP-4-039, protects the irradiated esophagus
Journal Articles

Abstract 1404: Mitochondrial-targeted nitroxide JP4-039 ameliorates irradiation-induced delay in bone wound healing and inhibits orthotopic tumor growth

Jean-Claude Rwigema, Abhay Gokhale, Michael Epperly, Julie Glowackie, Hong Wang, Tracy Dixon, Ken Patrene, Peter Wipf, Joel S. Greenberger
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1404.
https://doi.org/10.1158/1538-7445.AM10-1404
Published: 15 April 2010
View article titled, Abstract 1404: Mitochondrial-targeted nitroxide JP4-039 ameliorates irradiation-induced delay in bone wound healing and inhibits orthotopic tumor growth
Journal Articles

Abstract 2532: In vitro cytotoxicity, and pharmacokinetics, tissue distribution, and metabolism of the protein kinase D inhibitors, kb-NB142-70 and kb-NB184-43, in mice bearing human cancer xenografts

Guo Jianxia, Robert A. Parise, Jan H. Beumer, Dana M. Clausen, Merrill J. Egorin, John S. Lazo, Peter Wipf, Q. Jane Wang, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2532.
https://doi.org/10.1158/1538-7445.AM10-2532
Published: 15 April 2010
View article titled, Abstract 2532: <em>In vitro</em> cytotoxicity, and pharmacokinetics, tissue distribution, and metabolism of the protein kinase D inhibitors, kb-NB142-70 and kb-NB184-43, in mice bearing human cancer xenografts
Journal Articles

Abstract #3988: The mitochondrial targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair

Malolan Rajagopalan, Kanika Gupta, Michael Epperly, Darcy Franicola, Xichen Zhang, Hong Wang, Valarian Kagan, Peter Wipf, Joel Greenberger
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3988.
Published: 01 May 2009
View article titled, Abstract #3988: The mitochondrial targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair
Journal Articles

Abstract #4774: Discovery of a potent and selective small molecule inhibitor of PKD functionality

Q. Wang, Elizabeth Sharlow, Karthik Giridhar, Courtney LaValle, Jun Chen, Stephanie Leimgruber, Rebecca Barrett, Karla Bravo-Altamirano, Peter Wipf, John Lazo
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4774.
Published: 01 May 2009
View article titled, Abstract #4774: Discovery of a potent and selective small molecule inhibitor of PKD functionality
Journal Articles

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Nathan T. Ihle, Robert Lemos, Jr., Peter Wipf, Adly Yacoub, Clint Mitchell, Doris Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick, Garth Powis
Journal: Cancer Research
Cancer Res (2009) 69 (1): 143–150.
https://doi.org/10.1158/0008-5472.CAN-07-6656
Published: 31 December 2008
View article titled, Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance
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Journal Articles

Synthetic lethal screening predicts novel mechanism for synergism of PI3K inhibitors and microtubule perturbing agents for tumor cell death

Peter McDonald, Celeste Reese, Ian Pollack, Peter Wipf, John Lazo
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1540.
Published: 01 May 2008
View article titled, Synthetic lethal screening predicts novel mechanism for synergism of PI3K inhibitors and microtubule perturbing agents for tumor cell death