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Peter J. Houghton
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Journal Articles

Abstract 1090: GPC2 directed CAR T cells are efficacious against fusion-positive and fusion-negative rhabdomyosarcomas

Rawan Shraim, Patrick M. Schuerch, Anna Maria Giudice, Karina L. Conkrite, Amber K. Weiner, Alexander B. Radaoui, Brian Mooney, Raushan T. Kurmasheva, Peter J. Houghton, Gregg B. Morin, Yael B. Mosse, Poul H. Sorensen, Benjamin A. Garcia, Ahmet Sacan, John M. Maris, Kristopher R. Bosse, Sharon J. Diskin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1090.
https://doi.org/10.1158/1538-7445.AM2024-1090
Published: 22 March 2024
View article titled, Abstract 1090: GPC2 directed CAR T cells are efficacious against fusion-positive and fusion-negative rhabdomyosarcomas
Journal Articles

Abstract LB267: Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Panneerselvam Jayabal, Xiuye Ma, Kathryn M. Bondra, Yidong Chen, Peter J. Houghton, Yuzuru Shiio
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB267.
https://doi.org/10.1158/1538-7445.AM2023-LB267
Published: 14 April 2023
View article titled, Abstract LB267: Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma
Journal Articles

Abstract 1680: Characterization of sensitivity to single agents and combination treatments (VAC and VI) and development of acquired resistance in childhood rhabdomyosarcoma xenograft models

Samson Ghilu, Peter J. Houghton, Siyuan Zheng, Raushan T. Kurmasheva
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1680.
https://doi.org/10.1158/1538-7445.AM2023-1680
Published: 04 April 2023
View article titled, Abstract 1680: Characterization of sensitivity to single agents and combination treatments (VAC and VI) and development of acquired resistance in childhood rhabdomyosarcoma xenograft models
Journal Articles

Abstract 3572: Genomic profiling of subcutaneous patient derived xenograft models of solid childhood cancer

Funan He, Abhik M. Bandyopadhyay, Laura Klesse, Anna Rogojina, Erin Butler, Taylor Hartshorne, Trevor Holland, Luz Perez Prado, Anne-Marie Langevan, Allison C. Grimes, Chatchawin Assanasen, Zhao Lai, Yi Zou, Dias Kurmashev, Lin Xu, Yang Xie, Yidong Chen, Xiaojing Wang, Gail E. Tomlinson, Stephen X. Skapek, Raushan T. Kurmasheva, Peter J. Houghton, Siyuan Zheng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3572.
https://doi.org/10.1158/1538-7445.AM2023-3572
Published: 04 April 2023
View article titled, Abstract 3572: Genomic profiling of subcutaneous patient derived xenograft models of solid childhood cancer
Journal Articles

Abstract 1086: PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma

Vanessa Del Pozo, Andrew J. Robles, Shaun Fontaine, Qianqian Liu, Joel E. Michalek, Peter J. Houghton, Raushan Kurmasheva
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1086.
https://doi.org/10.1158/1538-7445.AM2022-1086
Published: 15 June 2022
View article titled, Abstract 1086: PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
Journal Articles

SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton, Myron S. Ignatius
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5451–5463.
https://doi.org/10.1158/0008-5472.CAN-20-4191
Published: 01 November 2021
View article titled, SNAI2-Mediated Repression of <em>BIM</em> Protects Rhabdomyosarcoma from Ionizing Radiation
Open the PDF for SNAI2-Mediated Repression of <em>BIM</em> Protects Rhabdomyosarcoma from Ionizing Radiation in another window
Includes: Supplementary data
Journal Articles

Abstract LB252: Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium osteosarcoma in vivo models

Douglas Harrison, Jonathan Gill, Pooja Hingorani, Michael Roth, Wendong Zhang, Beverly Teicher, Eric J. Earley, Stephen W. Erickson, Gregory Gatto, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Edward A. Kolb, Richard Gorlick
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB252.
https://doi.org/10.1158/1538-7445.AM2021-LB252
Published: 01 July 2021
View article titled, Abstract LB252: Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium osteosarcoma <em>in vivo</em> models
Journal Articles

Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)

Richard B. Lock, Kathryn Evans, Narimanne El-Zein, Brian J. Lannutti, Katti A. Jessen, Eric J. Earley, Stephen W. Erickson, Malcolm A. Smith, Raushan Kurmasheva, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3038.
https://doi.org/10.1158/1538-7445.AM2021-3038
Published: 01 July 2021
View article titled, Abstract 3038: Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC)
Journal Articles

A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan T. Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J. Peer, Ryan Nguyen, William D. Figg, Sr., Denis R. Beckford-Vera, Daniel V. Santi
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1076–1086.
https://doi.org/10.1158/0008-5472.CAN-20-1741
Published: 15 February 2021
View article titled, A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models
Open the PDF for A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models in another window
Includes: Supplementary data
Journal Articles

Abstract LB-060: A very long-acting poly(ADP-ribose) polymerase inhibitor

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan Kurmasheva, Morgan Diolati, Alan Ashworth, Daniel V. Santi
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-060.
https://doi.org/10.1158/1538-7445.AM2020-LB-060
Published: 15 August 2020
View article titled, Abstract LB-060: A very long-acting poly(ADP-ribose) polymerase inhibitor
Journal Articles

Abstract 2755: Defining the properties of the OS-33 osteosarcoma cell line and the effects of mTORC1 inhibition by rapamycin treatment

Ashley VanCleave, Mykayla Palmer, Fang Fang, Haydee M. Torres, Alan Ross, Patricia Crotwell Lieferman, Yohannes Tecleab, Peter J. Houghton, Jianning Tao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2755.
https://doi.org/10.1158/1538-7445.AM2020-2755
Published: 15 August 2020
View article titled, Abstract 2755: Defining the properties of the OS-33 osteosarcoma cell line and the effects of mTORC1 inhibition by rapamycin treatment
Journal Articles

Abstract A54: Parallel targeting of RAF/MEK/ERK pathway in RAS-mutant embryonal rhabdomyosarcoma

Angelina V. Vaseva, Abhik Bandyopadhyay, Vanessa Del Pozo, Craig M. Goodwin, Prson Gautam, Krister Wennerberg, Kris C. Wood, Yidong Chen, Channing J. Der, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A54.
https://doi.org/10.1158/1538-7445.PEDCA19-A54
Published: 15 July 2020
View article titled, Abstract A54: Parallel targeting of RAF/MEK/ERK pathway in RAS-mutant embryonal rhabdomyosarcoma
Journal Articles

Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts

Eric Earley, Richard Gorlick, Peter J. Houghton, John M. Maris, Xiao-Nan Li, Richard B. Lock, Beverly Teicher, Malcolm A. Smith, Stephen W. Erickson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-321.
https://doi.org/10.1158/1538-7445.AM2019-LB-321
Published: 01 July 2019
View article titled, Abstract LB-321: Re-evaluating sample sizes in preclinical testing of patient-derived xenografts
Journal Articles

Abstract 2141: Mechanistic studies of altertoxin II: A fungal metabolite with selective activity against Ewing sarcoma

Andrew J. Robles, Wentao Dai, Robert H. Cichewicz, Susan L. Mooberry, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2141.
https://doi.org/10.1158/1538-7445.AM2019-2141
Published: 01 July 2019
View article titled, Abstract 2141: Mechanistic studies of altertoxin II: A fungal metabolite with selective activity against Ewing sarcoma
Journal Articles

Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts

Beverly A. Teicher, Richard B. Lock, Kathryn Evans, Peter J. Houghton, Raushan T. Kurmasheva, Richard Gorlicki, Steve Erickson, Donn Wishka, Joel Morris, Michael Difilippantonio, Jerry E. Collins, Malcolm A. Smith, James H. Doroshow
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3839.
https://doi.org/10.1158/1538-7445.AM2019-3839
Published: 01 July 2019
View article titled, Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts
Journal Articles

Abstract 3835: In vivo evaluation of the Menin inhibitor VTP-50469 against Ewing sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC)

Peter J. Houghton, Raushan Kurmasheva, Gerard M. McGeehan, Steve W. Erickson, Beverly Teicher, Malcolm Smith
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3835.
https://doi.org/10.1158/1538-7445.AM2019-3835
Published: 01 July 2019
View article titled, Abstract 3835: In vivo evaluation of the Menin inhibitor VTP-50469 against Ewing sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC)
Journal Articles

Abstract 3848: In vivo evaluation of the LSD1 inhibitor SP-2577 against Ewing sarcoma and rhabdomyosarcoma preclinincal models: A report from the Pediatric Preclinical Testing Consortium (PPTC)

Peter J. Houghton, Steve W. Erickson, Beverly Teicher, Malcolm A. Smith, Ruolan Han, Raushan Kurmasheva
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3848.
https://doi.org/10.1158/1538-7445.AM2019-3848
Published: 01 July 2019
View article titled, Abstract 3848: <em>In vivo</em> evaluation of the LSD1 inhibitor SP-2577 against Ewing sarcoma and rhabdomyosarcoma preclinincal models: A report from the Pediatric Preclinical Testing Consortium (PPTC)
Journal Articles

Abstract B09: IL6 and CXCL8 mediate redundant tumor-host signaling pathways that facilitate osteosarcoma lung metastasis

Ryan D. Roberts, Hakan Cam, Amy C. Gross, Sarah Winget, Doris Phelps, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): B09.
https://doi.org/10.1158/1538-7445.PEDCA17-B09
Published: 01 October 2018
View article titled, Abstract B09: IL6 and CXCL8 mediate redundant tumor-host signaling pathways that facilitate osteosarcoma lung metastasis
Journal Articles

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Terrence F. Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A. Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A. Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H. Brush, Annette T. Byrne, Carlos Caldas, Amanda L. Christie, Dominic A. Clark, Heidi Dowst, Jonathan R. Dry, James H. Doroshow, Olivier Duchamp, Yvonne A. Evrard, Stephane Ferretti, Kristopher K. Frese, Neal C. Goodwin, Danielle Greenawalt, Melissa A. Haendel, Els Hermans, Peter J. Houghton, Jos Jonkers, Kristel Kemper, Tin O. Khor, Michael T. Lewis, K.C. Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B. Neuhauser, James M. Olson, Daniel S. Peeper, Oscar M. Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J. Wechsler-Reya, David M. Weinstock, Alana Welm, S. John Weroha, Frédéric Amant, Stefan M. Pfister, Marcel Kool, Helen Parkinson, Atul J. Butte, Carol J. Bult
Journal: Cancer Research
Cancer Res (2017) 77 (21): e62–e66.
https://doi.org/10.1158/0008-5472.CAN-17-0582
Published: 01 November 2017
View article titled, PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
Open the PDF for PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 4458: Regulation of MYC protein stability by mutant KRAS in pancreatic ductal adenocarcinoma

Angelina V. Vaseva, Devon R. Blake, Salma H. Azam, Karim T. Gilbert, Chad V. Pecot, Kenneth H. Pearce, Laura E. Herring, Lee M. Graves, Peter J. Houghton, Channing J. Der
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4458.
https://doi.org/10.1158/1538-7445.AM2017-4458
Published: 01 July 2017
View article titled, Abstract 4458: Regulation of MYC protein stability by mutant KRAS in pancreatic ductal adenocarcinoma