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Peter J. Brown
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Journal Articles

Abstract 6978: Discovery and characterization of BAY-805, a potent and selective DUB inhibitor of ubiquitin specific peptidase USP21

Free
Norbert Schmees, Fabian Göricke, Ulrike Scheib, Raphael Boehm, Namik Akkilic, Gerd Wohlfahrt, Kirstin Petersen, Victoria Vu, Leanna Smith, Niels Lindner, Joerg Weiske, Ulf Boemer, Krzysztof Brzezinka, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J. Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl Arrowsmith
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6978.
https://doi.org/10.1158/1538-7445.AM2025-6978
Published: 21 April 2025
View articletitled, Abstract 6978: Discovery and characterization of BAY-805, a potent and selective DUB inhibitor of ubiquitin specific peptidase USP21
Journal Articles

Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor

Free
Stefan Gradl, Holger Steuber, Jörg Weiske, Norbert Schmees, Stephan Siegel, Detlef Stoeckigt, Clara D. Christ, Fengling Li, Shawna Organ, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Steven Kennedy, Viacheslav Trush, Masoud Vedadi, Cheryl H. Arrowsmith, Peter J. Brown, Manfred Husemann, Amaury E. Fernandez-Montalvan, Volker Badock, Marcus Bauser, Andrea Haegebarth, Ingo V. Hartung, Carlo Stresemann
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2018-1646
Published: 01 July 2018
View articletitled, Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Journal Articles

Abstract 5239: Probing the cancer epigenome: empowering target validation by open innovation

Free
Ingo V. Hartung, Cheryl Arrowsmith, Volker Badock, Naomi Barak, Markus Berger, Peter J. Brown, Clara D. Christ, Erik Eggert, Ursula Egner, Oleg Fedorov, Amaury E. Fernandez-Montalvan, Matyas Gorjanacz, Andrea Haegebarth, Bernard Haendler, Roman C. Hillig, Simon H. Holton, Kilian V. Huber, Seong J. Koo, Antonius ter Laak, Susanne Mueller, Anke Mueller-Fahrnow, Cora Scholten, Stephan Siegel, Timo Stellfeld, Detlef Stoeckigt, Carlo Stresemann, Masoud Vedadi, Joerg Weiske, Hilmar Weinmann
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5239.
https://doi.org/10.1158/1538-7445.AM2017-5239
Published: 01 July 2017
View articletitled, Abstract 5239: Probing the cancer epigenome: empowering target validation by open innovation
Journal Articles

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Free
Yuting Sun, Jessica L. Bell, Daniel Carter, Samuele Gherardi, Rebecca C. Poulos, Giorgio Milazzo, Jason W.H. Wong, Rima Al-Awar, Andrew E. Tee, Pei Y. Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M. Shohet, Ygal Haupt, Johannes H. Schulte, Peter J. Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Karen L. MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M. Marshall, Antony Braithwaite, Tao Liu
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5143–5154.
https://doi.org/10.1158/0008-5472.CAN-15-0423
Published: 30 November 2015
View articletitled, WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Open the PDF for WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers

Free
Lindsey I. James, Jake I. Stuckey, Brandi M. Baughman, Michael T. Perfetti, Samantha G. Pattenden, Brad M. Dickson, Jacqueline L. Norris, Gaofeng Cui, Pavel Mader, Aiping Dong, Yunxiang Mu, Scott B. Rothbart, Brian D. Strahl, Jinrong Min, Peter J. Brown, Dmitri B. Kireev, William P. Janzen, Kevin M. McBride, Mark T. Bedford, Georges Mer, Cheryl H. Arrowsmith, Stephen V. Frye
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): SY08-03.
https://doi.org/10.1158/1538-7445.AM2015-SY08-03
Published: 01 August 2015
View articletitled, Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers
Journal Articles

Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation

Free
Elizabeth L. Zoeller, Dalia Barsyte-Lovejoy, Peter J. Brown, Dafydd R. Owen, Cheryl H. Arrowsmith, Paula M. Vertino
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2105.
https://doi.org/10.1158/1538-7445.AM2014-2105
Published: 01 October 2014
View articletitled, Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation