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Peter D. Aplan
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Journal Articles

Abstract 6940: Ptpn1 deficiency collaborates with a NUP98::HOXD13 fusion gene to generate B cell precursor acute lymphoblastic leukemia

Free
Nupur Nigam, Toshihiro Matsukawa, Ryan Bertoli, Michel L. Tremblay, Mianmian Yin, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6940.
https://doi.org/10.1158/1538-7445.AM2025-6940
Published: 21 April 2025
View articletitled, Abstract 6940: Ptpn1 deficiency collaborates with a NUP98::HOXD13 fusion gene to generate B cell precursor acute lymphoblastic leukemia
Journal Articles

The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development

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Ryan M. Bertoli, Yang Jo Chung, Michael J. Difilippantonio, Anthony Wokasch, Madison R.B. Marasco, Haley Klimaszewski, Susannah Gammell, Yuelin J. Zhu, Robert L. Walker, Dengchao Cao, Ajay Khanna, Matthew J. Walter, James H. Doroshow, Paul S. Meltzer, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2518–2532.
https://doi.org/10.1158/0008-5472.CAN-23-2785
Published: 01 August 2024
View articletitled, The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development
Open the PDF for The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development in another window
Includes: Supplementary data
Journal Articles

Abstract 624: Ptpn1 deficiency collaborates with a NUP98::HOXD13 fusion gene to generate B cell precursor acute lymphoblastic leukemia

Free
Nupur Nigam, Toshihiro Matsukawa, Ryan Bertoli, Michel L. Tremblay, Mianmian Yin, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 624.
https://doi.org/10.1158/1538-7445.AM2024-624
Published: 22 March 2024
View articletitled, Abstract 624: Ptpn1 deficiency collaborates with a NUP98::HOXD13 fusion gene to generate B cell precursor acute lymphoblastic leukemia
Journal Articles

Abstract 1484: 5-Aza-4'-thio-2'-deoxycytidine induces C to G transversions in a specific trinucleotide context and leads to acute lymphoid leukemia

Free
Ryan Matthew Bertoli, Yang Jo Chung, Michael Difilippantonio, Anthony Wokasch, Madison R. Marasco, Haley Klimaszewski, Susannah Garber, Yuelin Jack Zhu, Robert L. Walker, Dengchao Cao, James Doroshow, Paul Meltzer, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1484.
https://doi.org/10.1158/1538-7445.AM2024-1484
Published: 22 March 2024
View articletitled, Abstract 1484: 5-Aza-4'-thio-2'-deoxycytidine induces C to G transversions in a specific trinucleotide context and leads to acute lymphoid leukemia
Journal Articles

Abstract 3664: Mechanism for bone marrow failure differs between acute myeloid and lymphoid leukemia

Free
Ryan Matthew Bertoli, Peter D. Aplan, Yang Jo Chung
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3664.
https://doi.org/10.1158/1538-7445.AM2023-3664
Published: 04 April 2023
View articletitled, Abstract 3664: Mechanism for bone marrow failure differs between acute myeloid and lymphoid leukemia
Journal Articles

Abstract 5026: Protein tyrosine phosphatase Ptpn1 knockout in mouse models drives B-cell hematological malignancies

Free
Toshihiro Matsukawa, Nupur Nigam, Ryan Bertoli, Michel L. Tremblay, Mianmian Yin, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5026.
https://doi.org/10.1158/1538-7445.AM2023-5026
Published: 04 April 2023
View articletitled, Abstract 5026: Protein tyrosine phosphatase Ptpn1 knockout in mouse models drives B-cell hematological malignancies
Journal Articles

Abstract 2641: Examining the potential therapeutic efficacy of the CDK inhibitor alvocidib in a pre-clinical model of myelodysplastic syndrome

Free
Ryan M. Bertoli, Yang Jo Chung, Jason M. Foulks, Anthony S. Wokasch, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2641.
https://doi.org/10.1158/1538-7445.AM2022-2641
Published: 15 June 2022
View articletitled, Abstract 2641: Examining the potential therapeutic efficacy of the CDK inhibitor alvocidib in a pre-clinical model of myelodysplastic syndrome
Journal Articles

Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

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Liat Goldberg, Vijay Negi, Yang Jo Chung, Masahiro Onozawa, Yuelin J. Zhu, Robert L. Walker, Rachel Pierce, Daxesh P. Patel, Kristopher W. Krausz, Frank J. Gonzalez, Margaret A. Goodell, Benjamin A.T. Rodriguez, Paul S. Meltzer, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5033–5046.
https://doi.org/10.1158/0008-5472.CAN-21-1027
Published: 01 October 2021
View articletitled, Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL
Open the PDF for Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL in another window
Includes: Supplementary data
Journal Articles

Abstract 3362: Mice with a “deletor” phenotype allow high resolution detection of lymphoid leukemia tumor suppressor genes

Free
Mianmian Yin, Timour Baslan, Amy Freeland, Steven C. Pruitt, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3362.
https://doi.org/10.1158/1538-7445.AM2018-3362
Published: 01 July 2018
View articletitled, Abstract 3362: Mice with a “deletor” phenotype allow high resolution detection of lymphoid leukemia tumor suppressor genes
Journal Articles

Abstract 2643: Thymic precursor cells generate acute myeloid leukemia in NP23-NHD13 double transgenic mice

Free
Subhadip Kundu, Eun Sil Park, Yang Jo Chung, Trevor Stephen Barlowe, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2643.
https://doi.org/10.1158/1538-7445.AM2017-2643
Published: 01 July 2017
View articletitled, Abstract 2643: Thymic precursor cells generate acute myeloid leukemia in NP23-NHD13 double transgenic mice
Journal Articles

Abstract 3851: NUP98-PHF23 (NP23) binds H3K4me3 and causes a wide spectrum of leukemias, including AML, T-ALL, and pre-B1 ALL.

Free
Sheryl M. Gough, Fan Lee, Yang Jo Chung, Robert L. Walker, Fan Yang, Jack Zhu, Yi Ning, Paul S. Meltzer, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3851.
https://doi.org/10.1158/1538-7445.AM2013-3851
Published: 15 April 2013
View articletitled, Abstract 3851: NUP98-PHF23 (NP23) binds H3K4me3 and causes a wide spectrum of leukemias, including AML, T-ALL, and pre-B1 ALL.
Journal Articles

Abstract 2603: Inhibition of Notch and mTOR by nelfinavir as a novel approach for T cell acute lymphoblastic leukemia (T-ALL)

Free
Yoon Soo Chang, Leah M. Meza, Masahiro Onozawa, Joell J. Gills, Peter D. Aplan, Phillip A. Dennis
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2603.
https://doi.org/10.1158/1538-7445.AM2011-2603
Published: 15 April 2011
View articletitled, Abstract 2603: Inhibition of Notch and mTOR by nelfinavir as a novel approach for T cell acute lymphoblastic leukemia (T-ALL)
Journal Articles

Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological Aspects

Free
David P. Harper, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2008) 68 (24): 10024–10027.
https://doi.org/10.1158/0008-5472.CAN-08-2208
Published: 15 December 2008
View articletitled, Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological Aspects
Open the PDF for Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological Aspects in another window
Journal Articles

Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice

Free
David Caudell, Zhenhua Zhang, Yang Jo Chung, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2007) 67 (17): 8022–8031.
https://doi.org/10.1158/0008-5472.CAN-06-3749
Published: 05 September 2007
View articletitled, Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice
Open the PDF for Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice in another window
Includes: Supplementary data
Journal Articles

Retroviral Insertional Mutagenesis Identifies Genes that Collaborate with NUP98-HOXD13 during Leukemic Transformation

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Christopher Slape, Helge Hartung, Ying-Wei Lin, Juraj Bies, Linda Wolff, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2007) 67 (11): 5148–5155.
https://doi.org/10.1158/0008-5472.CAN-07-0075
Published: 01 June 2007
View articletitled, Retroviral Insertional Mutagenesis Identifies Genes that Collaborate with NUP98-HOXD13 during Leukemic Transformation
Open the PDF for Retroviral Insertional Mutagenesis Identifies Genes that Collaborate with NUP98-HOXD13 during Leukemic Transformation in another window
Includes: Supplementary data
Journal Articles

Notch1 mutations are acquired in murine models of precursor T-cell lymphoblastic leukemia/lymphoma

Free
Ying-Wei Lin, Rebecca A. Nichols, John J. Letterio, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 346.
Published: 15 April 2006
View articletitled, Notch1 mutations are acquired in murine models of precursor T-cell lymphoblastic leukemia/lymphoma
Journal Articles

Generation of immortal, IL3-dependent cell lines from embryonic stem (ES) cells expressing a NUP98-HOXD13 fusion gene

Free
Christopher I. Slape, Lino Tessarollo, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 61.
Published: 15 April 2006
View articletitled, Generation of immortal, IL3-dependent cell lines from embryonic stem (ES) cells expressing a NUP98-HOXD13 fusion gene
Journal Articles

OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1

Free
Ying-Wei Lin, Ramona Deveney, Mary Barbara, Norman N. Iscove, Stephen D. Nimer, Christopher Slape, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2005) 65 (16): 7151–7158.
https://doi.org/10.1158/0008-5472.CAN-05-1400
Published: 15 August 2005
View articletitled, OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1
Open the PDF for OLIG2 (BHLHB1), a bHLH Transcription Factor, Contributes to Leukemogenesis in Concert with LMO1 in another window
Includes: Supplementary data
Journal Articles

NUP98-HOXD13 transgenic mice develop a severe myelodysplastic syndrome that progresses to acute leukemia

Free
Christopher Slape, Ying-Wei Lin, Zhenhua Zhang, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 243.
Published: 01 May 2005
View articletitled, NUP98-HOXD13 transgenic mice develop a severe myelodysplastic syndrome that progresses to acute leukemia
Journal Articles

The transcription factor, BHLHB1 (OLIG 2) induces precursor T cell lymphoblastic lymphoma/leukemia in concert with LMO1 in transgenic mice

Free
Ying-Wei Lin, Ramona Deveney, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 243.
Published: 01 May 2005
View articletitled, The transcription factor, BHLHB1 (OLIG 2) induces precursor T cell lymphoblastic lymphoma/leukemia in concert with LMO1 in transgenic mice