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Journal Articles

Abstract LB091: T cell targeted lentiviral gene delivery using the PACK-IT Platform generates CAR-T cells with superior potency compared to conventional lentivirus and enables in vivo generation of CD19-CAR T cells capable of controlling leukemia in preclinical models

Kylie A. Burdsall, Peng Xu, Daniela Castro-Martinez, Louai Labanieh, Katie Ho, Quanming Shi, Bingfei Yu, Elena Sotillo, Howard Y. Chang, Crystal L. Mackall

Cancer Res (2025) 85 (8_Supplement_2): LB091.

https://doi.org/10.1158/1538-7445.AM2025-LB091

Published: 25 April 2025

View articletitled, Abstract LB091: T cell targeted lentiviral gene delivery using the PACK-IT Platform generates CAR-T cells with superior potency compared to conventional lentivirus and enables in vivo generation of CD19-CAR T cells capable of controlling leukemia in preclinical models

Journal Articles

Abstract LB047: Resolving tumor heterogeneity by uncovering novel genomic and transcriptomic events with a new scaled and automated workflow

Cancer Res (2025) 85 (8_Supplement_2): LB047.

https://doi.org/10.1158/1538-7445.AM2025-LB047

Published: 25 April 2025

View articletitled, Abstract LB047: Resolving tumor heterogeneity by uncovering novel genomic and transcriptomic events with a new scaled and automated workflow

Journal Articles

Abstract 3940: Development of immunocomplex pediatric tumor organoids for onco-immunotherapy research

Naiara Martinez Velez, Roel Polak, William Wang, Maria Fernanda Henao Echeverri, Diane Cruz Manjarrez, Moksha Desai, Yiyun Cheng, Peng Xu, Cara Coleen Rada, Bita Sahaf, Hiroyuki Yoda, William Weiss, Elena Sotillo, Calvin J. Kuo, Crystal L. Mackall

Cancer Res (2025) 85 (8_Supplement_1): 3940.

https://doi.org/10.1158/1538-7445.AM2025-3940

Published: 21 April 2025

View articletitled, Abstract 3940: Development of immunocomplex pediatric tumor organoids for onco-immunotherapy research

Journal Articles

Abstract 6116: Generation of multi-specific CAR T cells using a novel single-marker selection platform to target medulloblastoma heterogeneity

Diren Usta, Yushen Feng, Yiyun Chen, Louai Labanieh, Nikoo Jafari, Peng Xu, Sabine Heitzeneder, Elena Sotillo, Crystal Mackall

Cancer Res (2025) 85 (8_Supplement_1): 6116.

https://doi.org/10.1158/1538-7445.AM2025-6116

Published: 21 April 2025

View articletitled, Abstract 6116: Generation of multi-specific CAR T cells using a novel single-marker selection platform to target medulloblastoma heterogeneity

Journal Articles

Abstract 3765: Combined silencing of MED12 and activation of IL2 by epigenetic editing enhances CAR T antitumor potency

Frank Lin, Sean Yamada-Hunter, Alexandra Croft, Nicole DeNamur, Emi Tokuda, Molly Libbrecht, Nathaniel Chartrand, Yiyun Chen, Peng Xu, Akiko Seki, Erica Li, Jason Dean, Katie Freitas, Lucas Thompson, Blythe Sather, Crystal Mackall, Elena Sotillo

Cancer Res (2025) 85 (8_Supplement_1): 3765.

https://doi.org/10.1158/1538-7445.AM2025-3765

Published: 21 April 2025

View articletitled, Abstract 3765: Combined silencing of MED12 and activation of IL2 by epigenetic editing enhances CAR T antitumor potency

Journal Articles

Abstract 6398: Harnessing the conditional proteolytic activity of ADAM17 to generate autonomous regulatory mechanisms in CAR T cells

Jeremy R. Bjelajac, Adria Canellas Socias, Jennifer Hamad, Preeti Nehra, Meena B. Malipatlolla, Peng Xu, Sean Alexander Yamada-Hunter, Louai Labanieh, Elena Sotillo, Crystal L. Mackall

Cancer Res (2025) 85 (8_Supplement_1): 6398.

https://doi.org/10.1158/1538-7445.AM2025-6398

Published: 21 April 2025

View articletitled, Abstract 6398: Harnessing the conditional proteolytic activity of ADAM17 to generate autonomous regulatory mechanisms in CAR T cells

Journal Articles

Abstract PO5-06-12: Genetic screen identifies epigenetic drivers of breast cancer brain metastasis

Jocelyn Chen, Wesley Cai, Peng Xu, Don Nguyen, Qin Yan

Cancer Res (2024) 84 (9_Supplement): PO5-06-12.

https://doi.org/10.1158/1538-7445.SABCS23-PO5-06-12

Published: 02 May 2024

View articletitled, Abstract PO5-06-12: Genetic screen identifies epigenetic drivers of breast cancer brain metastasis

Journal Articles

Abstract 316: A novel, high-throughput full-length scRNA-seq workflow for improved biomarker discovery

Peng Xu, Joseph Liu, Yana Ryan, Kazuo Tori, Xuan Li, Hima Anbunathan, Mike Covington, Tomoya Uchiyama, Mohammad Fallahi, Xuan Qu, Xiaoyun Xing, Ting Wang, Bryan Bell, Shuwen Chen, Yue Yun, Andrew Farmer

Cancer Res (2024) 84 (6_Supplement): 316.

https://doi.org/10.1158/1538-7445.AM2024-316

Published: 22 March 2024

View articletitled, Abstract 316: A novel, high-throughput full-length scRNA-seq workflow for improved biomarker discovery

Journal Articles

Body Weight Correlates with Molecular Variances in Patients with Cancer

Fengyuan Huang, Peng Xu, Zongliang Yue, Yuwei Song, Kaili Hu, Xinyang Zhao, Min Gao, Zechen Chong

Cancer Res (2024) 84 (5): 757–770.

https://doi.org/10.1158/0008-5472.CAN-23-1463

Published: 04 March 2024

View articletitled, Body Weight Correlates with Molecular Variances in Patients with Cancer

Includes: Supplementary data

Journal Articles

Abstract 6540: Multiscale protein networks: de novo aberrant protein interactions and oncogenic regulators in seven cancer types

Won Min Song, Abdulkadir Elmas, Richard Farias, Peng Xu, Xianxiao Zhou, Benjamin Hopkins, Kuan-lin Huang, Bin Zhang

Cancer Res (2023) 83 (7_Supplement): 6540.

https://doi.org/10.1158/1538-7445.AM2023-6540

Published: 04 April 2023

View articletitled, Abstract 6540: Multiscale protein networks: de novo aberrant protein interactions and oncogenic regulators in seven cancer types

Journal Articles

Abstract 1158: Inosine endows CAR T cells with features of increased stemness and anti-tumor potency

Cancer Res (2023) 83 (7_Supplement): 1158.

https://doi.org/10.1158/1538-7445.AM2023-1158

Published: 04 April 2023

View articletitled, Abstract 1158: Inosine endows CAR T cells with features of increased stemness and anti-tumor potency

Journal Articles

Abstract 5741: Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy

Sean A. Yamada-Hunter, Johanna Theruvath, Molly T. Radosevich, Brianna J. McIntosh, Katherine A. Freitas, Naiara Martinez-Velez, Elena Sotillo, Amaury Leruste, Peng Xu, Moksha H. Desai, Bita Sahaf, Allison Banuelos, Savannah L. Wasserman, Irving L. Weissman, Jennifer R. Cochran, Crystal L. Mackall

Cancer Res (2023) 83 (7_Supplement): 5741.

https://doi.org/10.1158/1538-7445.AM2023-5741

Published: 04 April 2023

View articletitled, Abstract 5741: Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy

Journal Articles

Abstract 2822: Enhanced effector activity of mediator CDK8 kinase module deficient CAR-T Cells

Katherine A. Freitas, Julia A. Belk, Elena Sotillo, Bence Daniel, Katalin Sandor, Dorota Klysz, Vandon T. Duong, Peng Xu, Meena Malipatlolla, Evan W. Weber, Robbie G. Majzner, Howard Y. Chang, Ansuman T. Satpathy, Crystal Mackall

Cancer Res (2022) 82 (12_Supplement): 2822.

https://doi.org/10.1158/1538-7445.AM2022-2822

Published: 15 June 2022

View articletitled, Abstract 2822: Enhanced effector activity of mediator CDK8 kinase module deficient CAR-T Cells

Journal Articles

Abstract 2101: RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4⁺ T cell-dependent anti-tumor immunity

Zhuo Zhang, Lin Luo, Chuan Xing, Yu Chen, Peng Xu, Mao Li, Ling Zeng, Chao Li, Sadashib Ghosh, Deborah Della Manna, Tim Townes, William J. Britt, Narendra Wajapeyee, Barry P. Sleckman, Zechen Chong, Jianmei Wu Leavenworth, Eddy Yang

Cancer Res (2022) 82 (12_Supplement): 2101.

https://doi.org/10.1158/1538-7445.AM2022-2101

Published: 15 June 2022

View articletitled, Abstract 2101: RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T cell-dependent anti-tumor immunity

Journal Articles

Abstract 1362: Metabolic engineering of CAR-T cells overcomes suppressive adenosine signaling and enhances functionality

Dorota Klysz, Meena Malipatlolla, Katherine Freitas, Malek Bashti, Louai Labanieh, Peng Xu, Cecilia Ramello, Amaury Lerust, Hyatt Balke Want, Kaithlen Zen Pacheco, Evan W. Weber, Shabnum Patel, Steven Feldman, Elena Sotillo, Crystal L. Mackall

Cancer Res (2022) 82 (12_Supplement): 1362.

https://doi.org/10.1158/1538-7445.AM2022-1362

Published: 15 June 2022

View articletitled, Abstract 1362: Metabolic engineering of CAR-T cells overcomes suppressive adenosine signaling and enhances functionality

Journal Articles

Abstract 1548: Potent activity of CAR T cells targeting the oncofetal protein GPC2 engineered to recognize low antigen density in neuroblastoma

Cancer Res (2021) 81 (13_Supplement): 1548.

https://doi.org/10.1158/1538-7445.AM2021-1548

Published: 01 July 2021

View articletitled, Abstract 1548: Potent activity of CAR T cells targeting the oncofetal protein GPC2 engineered to recognize low antigen density in neuroblastoma

Journal Articles

Abstract A09: Glypican-2 targeted CAR T cells designed to effectively eradicate endogenous site density solid tumors in the absence of toxicity

Sabine Heitzeneder, Kristopher R. Bosse, Zhongyu Zhu, Robbie G. Majzner, Johanna Theruvath, Peng Xu, Shaurya Dhingra, Hima Anbunathan, Anya Alag, Dimiter S. Dimitrov, John M. Maris, Crystal L. Mackall

Cancer Res (2020) 80 (14_Supplement): A09.

https://doi.org/10.1158/1538-7445.PEDCA19-A09

Published: 15 July 2020

View articletitled, Abstract A09: Glypican-2 targeted CAR T cells designed to effectively eradicate endogenous site density solid tumors in the absence of toxicity

Journal Articles

Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker

Shihua Dong, Wei Li, Lin Wang, Jie Hu, Yuanlin Song, Baolong Zhang, Xiaoguang Ren, Shimeng Ji, Jin Li, Peng Xu, Ying Liang, Gang Chen, Jia-Tao Lou, Wenqiang Yu

Cancer Res (2019) 79 (24): 6101–6112.

https://doi.org/10.1158/0008-5472.CAN-19-1019

Published: 13 December 2019

View articletitled, Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker

Includes: Supplementary data

Journal Articles

Abstract LB-112: Engineering AP1 to combat CAR T cell exhaustion

Rachel C. Lynn, Evan W. Weber, David Gennert, Elena Sotillo, Robert Jones, Peng Xu, Ansuman Satpathy, Howard Y. Chang, Crystal L. Mackall

Cancer Res (2018) 78 (13_Supplement): LB-112.

https://doi.org/10.1158/1538-7445.AM2018-LB-112

Published: 01 July 2018

View articletitled, Abstract LB-112: Engineering AP1 to combat CAR T cell exhaustion

Journal Articles

Abstract LB-111: Precise regulation of CAR signaling prevents and reverses CAR T cell exhaustion

Evan W. Weber, Rachel C. Lynn, Meena Malipatlolla, Elena Sotillo, Peng Xu, Crystal L. Mackall

Cancer Res (2018) 78 (13_Supplement): LB-111.

https://doi.org/10.1158/1538-7445.AM2018-LB-111

Published: 01 July 2018

View articletitled, Abstract LB-111: Precise regulation of CAR signaling prevents and reverses CAR T cell exhaustion

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Abstract LB091: T cell targeted lentiviral gene delivery using the PACK-IT Platform generates CAR-T cells with superior potency compared to conventional lentivirus and enables in vivo generation of CD19-CAR T cells capable of controlling leukemia in preclinical models

Abstract LB047: Resolving tumor heterogeneity by uncovering novel genomic and transcriptomic events with a new scaled and automated workflow

Abstract 3940: Development of immunocomplex pediatric tumor organoids for onco-immunotherapy research

Abstract 6116: Generation of multi-specific CAR T cells using a novel single-marker selection platform to target medulloblastoma heterogeneity

Abstract 3765: Combined silencing of MED12 and activation of IL2 by epigenetic editing enhances CAR T antitumor potency

Abstract 6398: Harnessing the conditional proteolytic activity of ADAM17 to generate autonomous regulatory mechanisms in CAR T cells

Abstract PO5-06-12: Genetic screen identifies epigenetic drivers of breast cancer brain metastasis

Abstract 316: A novel, high-throughput full-length scRNA-seq workflow for improved biomarker discovery

Body Weight Correlates with Molecular Variances in Patients with Cancer

Abstract 6540: Multiscale protein networks: de novo aberrant protein interactions and oncogenic regulators in seven cancer types

Abstract 1158: Inosine endows CAR T cells with features of increased stemness and anti-tumor potency

Abstract 5741: Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy

Abstract 2822: Enhanced effector activity of mediator CDK8 kinase module deficient CAR-T Cells

Abstract 2101: RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4⁺ T cell-dependent anti-tumor immunity

Abstract 1362: Metabolic engineering of CAR-T cells overcomes suppressive adenosine signaling and enhances functionality

Abstract 1548: Potent activity of CAR T cells targeting the oncofetal protein GPC2 engineered to recognize low antigen density in neuroblastoma

Abstract A09: Glypican-2 targeted CAR T cells designed to effectively eradicate endogenous site density solid tumors in the absence of toxicity

Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker

Abstract LB-112: Engineering AP1 to combat CAR T cell exhaustion

Abstract LB-111: Precise regulation of CAR signaling prevents and reverses CAR T cell exhaustion

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