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Journal Articles

Abstract 5357: Mutational landscape and tyrosine kinase inhibitor sensitivity in EGFR L833 and H835 mutated non-small cell lung cancer

Free
Nong Yang, Long Huang, Dou Ren, Fanxu Zeng, Chengchuan Jiang, Weiwei Zhang, Weifeng He, Wei Yin, Peng Huang, Hanlin Chen, Xiaoying Wu, Jiaohui Pang, Haimeng Tang, Xue Wu, Qiuxiang Ou
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5357.
https://doi.org/10.1158/1538-7445.AM2025-5357
Published: 21 April 2025
View articletitled, Abstract 5357: Mutational landscape and tyrosine kinase inhibitor sensitivity in EGFR L833 and H835 mutated non-small cell lung cancer
Journal Articles

Abstract LB162: Tinengotinib in patients with advanced solid tumors harboring actionable FGFR1-3 mutations

Free
Sarina A. Piha-Paul, Chih-Yi "Andy" Liao, Lionel Fonkoua, Amit MahipaI, Sanjay Goel, Christos Fountzilas, Lin Shen, Daneng Li, Dustin Deming, Farshid Dayyani, Weiqing Han, Zuoxing Niu, Jean Fan, Peng Peng, Hui Wang, Peng Huang, Frank Wu, Milind Javle
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB162.
https://doi.org/10.1158/1538-7445.AM2024-LB162
Published: 05 April 2024
View articletitled, Abstract LB162: Tinengotinib in patients with advanced solid tumors harboring actionable FGFR1-3 mutations
Journal Articles

Temozolomide Sensitizes ARID1A-Mutated Cancers to PARP Inhibitors

Available to Purchase
Zheng-Cheng Yu, Tianhe Li, Ellen Tully, Peng Huang, Chih-Ning Chen, Philipp Oberdoerffer, Stephanie Gaillard, Ie-Ming Shih, Tian-Li Wang
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2750–2762.
https://doi.org/10.1158/0008-5472.CAN-22-3646
Published: 15 August 2023
View articletitled, Temozolomide Sensitizes ARID1A-Mutated Cancers to PARP Inhibitors
Open the PDF for Temozolomide Sensitizes ARID1A-Mutated Cancers to PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis

Free
Yeh Wang, Peng Huang, Brant G. Wang, Tricia Murdock, Leslie Cope, Fang-Chi Hsu, Tian-Li Wang, Ie-Ming Shih
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4528–4541.
https://doi.org/10.1158/0008-5472.CAN-22-1620
Published: 16 December 2022
View articletitled, Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis
Open the PDF for Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis in another window
Includes: Supplementary data
Journal Articles

Abstract 271: Monitoring of CCR2 and CCR5 expression on circulating myeloid derived suppressor cells (MDSCs) in non-small cell lung cancer as a correlate of minimum residual disease

Free
Hamza Khan, Anas Awan, Maria Shishikura, Carley Blevins, Kristen Rodgers, Yuping Mei, Wasay Nizam, Shun Ishiyama, Yun Chen, Richard Battafarano, Errol Bush, Stephen Broderick, Stephen Yang, Hajime Orita, Peng Huang, Ada Tam, Jinny Ha, Franck Housseau, Malcolm Brock
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 271.
https://doi.org/10.1158/1538-7445.AM2022-271
Published: 15 June 2022
View articletitled, Abstract 271: Monitoring of CCR2 and CCR5 expression on circulating myeloid derived suppressor cells (MDSCs) in non-small cell lung cancer as a correlate of minimum residual disease
Journal Articles

Abstract 5804: The inhibition of PLA2G2A decreases K-ras-driven pancreatic cancer growth and migration through damaging cell membrane and mitochondria function

Free
Mingquan zhang, Peng huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5804.
https://doi.org/10.1158/1538-7445.AM2022-5804
Published: 15 June 2022
View articletitled, Abstract 5804: The inhibition of PLA2G2A decreases K-ras-driven pancreatic cancer growth and migration through damaging cell membrane and mitochondria function
Journal Articles

Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity

Available to Purchase
Feifei Xu, Zining Wang, Hongxia Zhang, Jiemin Chen, Xiaojuan Wang, Lei Cui, Chunyuan Xie, Mengyun Li, Fang Wang, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaodong Xia, Xiaojun Xia
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4514–4528.
https://doi.org/10.1158/0008-5472.CAN-20-3977
Published: 01 September 2021
View articletitled, Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity
Open the PDF for Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract 3568: Ferroptosis induced by xCT abrogation is dependent on GPX4 protein expression regulated by L-cystine/cysteine metabolism

Free
Yanyu Zhang, Peng Huang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3568.
https://doi.org/10.1158/1538-7445.AM2020-3568
Published: 15 August 2020
View articletitled, Abstract 3568: Ferroptosis induced by xCT abrogation is dependent on GPX4 protein expression regulated by L-cystine/cysteine metabolism
Journal Articles

Abstract 4299: Collagen 1 fiber content can predict for recurrence in stage 1 non-small cell lung cancer

Free
Samata Kakkad, Peng Huang, Malcom Brock, Balaji Krishnamachary, Zaver M. Bhujwalla
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4299.
https://doi.org/10.1158/1538-7445.AM2020-4299
Published: 15 August 2020
View articletitled, Abstract 4299: Collagen 1 fiber content can predict for recurrence in stage 1 non-small cell lung cancer
Journal Articles

Abstract 249: Wild-type IDH2 is a potential therapeutic target for acute myeloid leukemia

Free
Peiting Zeng, Peng Huang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 249.
https://doi.org/10.1158/1538-7445.AM2020-249
Published: 15 August 2020
View articletitled, Abstract 249: Wild-type IDH2 is a potential therapeutic target for acute myeloid leukemia
Journal Articles

Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Free
Junchen Liu, Guo Chen, Zezhen Liu, Shaoyou Liu, Zhiduan Cai, Pan You, Yuepeng Ke, Li Lai, Yun Huang, Hongchang Gao, Liangcai Zhao, Helene Pelicano, Peng Huang, Wallace L. McKeehan, Chin-Lee Wu, Cong Wang, Weide Zhong, Fen Wang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (16): 4459–4470.
https://doi.org/10.1158/0008-5472.CAN-17-3226
Published: 14 August 2018
View articletitled, Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer
Open the PDF for Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism

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Yan Li, Shuhai Lin, Lei Li, Zhi Tang, Yumin Hu, Xiaojiao Ban, Tingting Zeng, Ying Zhou, Yinghui Zhu, Song Gao, Wen Deng, Xiaoshi Zhang, Dan Xie, Yunfei Yuan, Peng Huang, Jinjun Li, Zongwei Cai, Xin-Yuan Guan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (16): 4471–4481.
https://doi.org/10.1158/0008-5472.CAN-17-2172
Published: 14 August 2018
View articletitled, PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism
Open the PDF for PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism in another window
Includes: Supplementary data
Journal Articles

Abstract 3691: Collagen 1 fiber content may predict for recurrence in non-small cell lung cancer

Free
Samata Kakkad, Peng Huang, Malcolm Brock, Balaji Krishnamachary, Zaver M. Bhujwalla
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3691.
https://doi.org/10.1158/1538-7445.AM2018-3691
Published: 01 July 2018
View articletitled, Abstract 3691: Collagen 1 fiber content may predict for recurrence in non-small cell lung cancer
Journal Articles

Abstract 2037: Oral nitroxoline in combination with intravesical bacille calmette-guerin (BCG) shows synergistic antitumor efficacy in mouse bladder cancer orthotopic xenograft

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Qiang Li, Kevin Pan, Xiezhao Li, Naijin Xu, Peng Huang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2037.
https://doi.org/10.1158/1538-7445.AM2017-2037
Published: 01 July 2017
View articletitled, Abstract 2037: Oral nitroxoline in combination with intravesical bacille calmette-guerin (BCG) shows synergistic antitumor efficacy in mouse bladder cancer orthotopic xenograft
Journal Articles

Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Free
Helene Pelicano, Li Feng, William G. Wierda, Michael J. Keating, Peng Huang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4408.
https://doi.org/10.1158/1538-7445.AM2017-4408
Published: 01 July 2017
View articletitled, Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity
Journal Articles

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents

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Warren Fiskus, Veena Coothankandaswamy, Jianguang Chen, Hongwei Ma, Kyungsoo Ha, Dyana T. Saenz, Stephanie S. Krieger, Christopher P. Mill, Baohua Sun, Peng Huang, Jeffrey S. Mumm, Ari M. Melnick, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5467–5478.
https://doi.org/10.1158/0008-5472.CAN-16-0126
Published: 15 September 2016
View articletitled, SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents
Open the PDF for SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents in another window
Includes: Supplementary data
Journal Articles

Abstract 1248: Ibrutinib inhibits platelet aggregation through inhibition of mitochondrial respiratory chain function and suppression of Syk activation

Free
Jie Huang, Helen Pelicano, Feng Li, Michael J. Keating, Peng Huang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1248.
https://doi.org/10.1158/1538-7445.AM2016-1248
Published: 15 July 2016
View articletitled, Abstract 1248: Ibrutinib inhibits platelet aggregation through inhibition of mitochondrial respiratory chain function and suppression of Syk activation
Journal Articles

Abstract 3073: Targeting chronic lymphocytic leukemia by interfering glutathione synthesis using a novel therapeutic enzyme cyst(e)inase (AEB3103)

Free
Jinyun Liu, Li Feng, Everett M. Stone, Joseph Tyler, Scott W. Rowlinson, Michael J. Keating, Peng Huang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3073.
https://doi.org/10.1158/1538-7445.AM2016-3073
Published: 15 July 2016
View articletitled, Abstract 3073: Targeting chronic lymphocytic leukemia by interfering glutathione synthesis using a novel therapeutic enzyme cyst(e)inase (AEB3103)
Journal Articles

Abstract 4455: DNA methylation as biomarkers to predict early recurrence of T1-2N0 lung cancer

Free
Chen Chen, Andrew Yang, Devlin Danielle, Kristen Rodgers, Peng Huang, Zhihao Lu, Candace Griffin, Beverly Lee, Richard Battafarano, Fenglei Yu, Tza-Huei Wang, Stephen Baylin, James Herman, Alicia Hulbert, Malcolm Brock
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4455.
https://doi.org/10.1158/1538-7445.AM2016-4455
Published: 15 July 2016
View articletitled, Abstract 4455: DNA methylation as biomarkers to predict early recurrence of T1-2N0 lung cancer
Journal Articles

Abstract A105: Mechanisms of overcoming intrinsic resistance to gemcitabine in pancreatic ductal adenocarcinoma through redox modulation

Free
Huaiqiang Ju, Takshi Gocho, Mitzi Aguilar, Zhuo-Nan Zhuang, Jie Fu, Min Wu, Katsuhiko Yanaga, Peng Huang, Paul Chiao
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A105.
https://doi.org/10.1158/1538-7445.PANCA2014-A105
Published: 30 June 2015
View articletitled, Abstract A105: Mechanisms of overcoming intrinsic resistance to gemcitabine in pancreatic ductal adenocarcinoma through redox modulation