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Pei-Jer Chen
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Journal Articles

Abstract CT150: Result of an open-label phase 2 trial of dual TORC1/TORC2 inhibitor onatasertib (ATG-008) in HBV+ advanced hepatocellular carcinoma (HCC) subjects who have received at least one prior line of systemic therapy (TORCH)

Shukui Qin, Xiaoyan Lin, Zhiqaing Meng, Zhenggang Ren, Yuxian Bai, Shanzhi Gu, Li Zheng, Qiu Li, Sun-Yong Oh, Yabing Guo, Yoong-Koo Kang, Wei-Yu Kao, Wei Li, Jung-Hwan Yoon, Helong Zhang, Pei-Jer Chen, Tsai-Sheng Yang, Jeong Heo, Zhendong Zheng, Hui Xie, Zhinuan Yu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT150.
https://doi.org/10.1158/1538-7445.AM2023-CT150
Published: 14 April 2023
View article titled, Abstract CT150: Result of an open-label phase 2 trial of dual TORC1/TORC2 inhibitor onatasertib (ATG-008) in HBV+ advanced hepatocellular carcinoma (HCC) subjects who have received at least one prior line of systemic therapy (TORCH)
Journal Articles

Abstract 2743: Synergistic efficacy of telomerase-specific oncolytic adenoviral therapy and histone deacetylase inhibition in human hepatocellular carcinoma

Zhong-Zhe Lin, Mickey C-T. Hu, Chiun Hsu, Yao-Ming Wu, Yen-Shen Lu, Ja-An Annie Ho, Shiou-Hwei Yeh, Pei-Jer Chen, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2743.
https://doi.org/10.1158/1538-7445.AM2023-2743
Published: 04 April 2023
View article titled, Abstract 2743: Synergistic efficacy of telomerase-specific oncolytic adenoviral therapy and histone deacetylase inhibition in human hepatocellular carcinoma
Journal Articles

Abstract 2175: Src homology region 2 domain-containing phosphatase-1 is a major target of sorafenib in hepatocellular carcinoma.

Wei-Tien Tai, Chung-Wai Shiau, Pei-Jer Chen, Ann-Lii Cheng, Kuen-Feng Chen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2175.
https://doi.org/10.1158/1538-7445.AM2013-2175
Published: 15 April 2013
View article titled, Abstract 2175: Src homology region 2 domain-containing phosphatase-1 is a major target of sorafenib in hepatocellular carcinoma.
Journal Articles

Abstract 2780: Bortezomib induces autophagy in hepatocellular carcinoma through the inhibition of CIP2A independent of proteasome inhibition.

Hui-Chuan Yu, Duen-Ren Hou, Chun-Yu Liu, Ann-Lii Cheng, Pei-Jer Chen, Kuen-Feng Chen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2780.
https://doi.org/10.1158/1538-7445.AM2012-2780
Published: 15 April 2012
View article titled, Abstract 2780: Bortezomib induces autophagy in hepatocellular carcinoma through the inhibition of CIP2A independent of proteasome inhibition.
Journal Articles

Abstract 1915: Novel sorafenib derivatives (SC-40, SC-43 and SC-60) show better anti-tumor effects than sorafenib in hepatocellular carcinoma through SHP-1/STAT3-mediated signaling pathway

Wei-Tien Tai, Chung-Wai Shiau, Ann-Lii Cheng, Pei-Jer Chen, Kuen-Feng Chen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1915.
https://doi.org/10.1158/1538-7445.AM2012-1915
Published: 15 April 2012
View article titled, Abstract 1915: Novel sorafenib derivatives (SC-40, SC-43 and SC-60) show better anti-tumor effects than sorafenib in hepatocellular carcinoma through SHP-1/STAT3-mediated signaling pathway
Journal Articles

Abstract 4516: SC-2001, a SHP-1 enhancer, induces apoptosis in hepatocellular carcinoma through SHP-1 dependent STAT3 inactivation

Kuen-Feng Chen, Jung-Chen Su, Wei-Lin Chen, Chun-Yu Liu, Ann-Lii Cheng, Pei-Jer Chen, Chung-Wai Shiau
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4516.
https://doi.org/10.1158/1538-7445.AM2011-4516
Published: 15 April 2011
View article titled, Abstract 4516: SC-2001, a SHP-1 enhancer, induces apoptosis in hepatocellular carcinoma through SHP-1 dependent STAT3 inactivation
Journal Articles

Abstract 4523: Design and synthesis of sorafenib analogues as SHP-1 activators for hepatocellular carcinoma cells

Jui-Wen Huang, Kuen-Feng Chen, Wei-Tien Tai, Wei-Lin Chen, Pei-Jer Chen, Ann-Lii Cheng, Chung-Wai Shiau
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4523.
https://doi.org/10.1158/1538-7445.AM2011-4523
Published: 15 April 2011
View article titled, Abstract 4523: Design and synthesis of sorafenib analogues as SHP-1 activators for hepatocellular carcinoma cells
Journal Articles

Abstract 355: CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells

Kuen-Feng Chen, Chun-Yu Liu, Yu-Chin Lin, Hui-Chuan Yu, Tsung-Hao Liu, Duen-Ren Hou, Pei-Jer Chen, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 355.
https://doi.org/10.1158/1538-7445.AM10-355
Published: 15 April 2010
View article titled, Abstract 355: CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
Journal Articles

Abstract 2680A: Small molecule induces apoptosis through the inhibition of signal transducers and activators of transcription 3 in hepatocellular carcinoma cells

Kuen-Feng Chen, Wei-Lin Chen, Wei-Tien Tai, Ann-Lii Cheng, Pei-Jer Chen, Chung-Wai Shiau
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2680A.
https://doi.org/10.1158/1538-7445.AM10-2680A
Published: 15 April 2010
View article titled, Abstract 2680A: Small molecule induces apoptosis through the inhibition of signal transducers and activators of transcription 3 in hepatocellular carcinoma cells
Journal Articles

Abstract #4533: Bortezomib down-regulates phospho-Akt through up-regulation of protein phosphatase 2A activity in hepatocellular carcinoma cells

Kuen-Feng Chen, Hui-Chuan Yu, Yu-Lung Lee, Tsung-Hao Liu, Pei-Jer Chen, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4533.
Published: 01 May 2009
View article titled, Abstract #4533: Bortezomib down-regulates phospho-Akt through up-regulation of protein phosphatase 2A activity in hepatocellular carcinoma cells
Journal Articles

Abstract #5454: KRAS status and efficacy of first-line treatment of metastatic gastric cancer (GC) patients with cetuximab plus cisplatin and high-dose 5-fluorouracil/leucovorin

Kun-Huei Yeh, Joeu-Pei Wan, Hsun-Fang Fan, Chih-Hung Hsu, Chiun Hsu, Ching-Hung Lin, Ying-Chun Shen, Shu-Ling Wu, Pei-Jer Chen, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5454.
Published: 01 May 2009
View article titled, Abstract #5454: KRAS status and efficacy of first-line treatment of metastatic gastric cancer (GC) patients with cetuximab plus cisplatin and high-dose 5-fluorouracil/leucovorin
Journal Articles

PI-88, a novel heparanase inhibitor, as adjuvant therapy for hepatocellular carcinoma: A large randomized phase II clinical trial

Anand Gautam, Elizabeth Wilson, Pei-Jer Chen, Po-Huang Lee, Deng-Yn Lin, Cheng-Chung Wu, Long-Bin Jeng, Pin-Wen Lin, King-Tong Mok, Chun-Jen Liu, Wei-Chen Lee, Hong-Zen Yeh, Kuan-Lang Lai, Shi-Chung Chang
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2650.
Published: 01 May 2007
View article titled, PI-88, a novel heparanase inhibitor, as adjuvant therapy for hepatocellular carcinoma: A large randomized phase II clinical trial
Journal Articles

Bortezomib overcomes TRAIL resistance in hepatocellular carcinoma cells in part through the inhibition of PI3K/Akt pathway

Kuen-Feng Chen, Hui-Hua Chang, Yu-Lung Lee, Chen-Hsiang Hung, Chih-Hsuan Leu, Hui-Chen Hsu, Hsing-Pang Hsieh, Pei-Jer Chen, Ann-Lii Cheng
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1471.
Published: 01 May 2007
View article titled, Bortezomib overcomes TRAIL resistance in hepatocellular carcinoma cells in part through the inhibition of PI3K/Akt pathway
Journal Articles

Clustering of Minimal Deleted Regions Reveals Distinct Genetic Pathways of Human Hepatocellular Carcinoma

Yuh-Shan Jou, Chih-Shia Lee, Ya-Hui Chang, Chin-Fu Hsiao, Chian-Feng Chen, Chuan-Chuan Chao, Lawrence S.H. Wu, Shiou-Hwei Yeh, Ding-Shinn Chen, Pei-Jer Chen
Journal: Cancer Research
Cancer Res (2004) 64 (9): 3030–3036.
https://doi.org/10.1158/0008-5472.CAN-03-2320
Published: 03 May 2004
View article titled, Clustering of Minimal Deleted Regions Reveals Distinct Genetic Pathways of Human Hepatocellular Carcinoma
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Journal Articles

Association between hepatitis B virus genotype and hepatocellular carcinoma risk among men

Ming-Whei Yu, Pei-Jer Chen, Yun-Fan Liaw, Chih-Lin Lin, Chien-Jen Chen
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 106–107.
Published: 01 April 2004
View article titled, Association between hepatitis B virus genotype and hepatocellular carcinoma risk among men
Journal Articles

Dominance of Functional Androgen Receptor Allele with Longer CAG Repeat in Hepatitis B Virus-related Female Hepatocarcinogenesis

Shiou-Hwei Yeh, Ching-Fung Chang, Wen-Yi Shau, Ya-Wen Chen, Hey-Chi Hsu, Po-Huang Lee, Ding-Shinn Chen, Pei-Jer Chen
Journal: Cancer Research
Cancer Res (2002) 62 (15): 4346–4351.
Published: 01 August 2002
View article titled, Dominance of Functional Androgen Receptor Allele with Longer CAG Repeat in Hepatitis B Virus-related Female Hepatocarcinogenesis
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Journal Articles

Frequent Genetic Alterations at the Distal Region of Chromosome 1p in Human Hepatocellular Carcinomas

Shiou-Hwei Yeh, Pei-Jer Chen, Hui-Ling Chen, Ming-Yang Lai, Chu-Chang Wang, Ding-Shinn Chen
Journal: Cancer Research
Cancer Res (1994) 54 (15): 4188–4192.
Published: 01 August 1994
View article titled, Frequent Genetic Alterations at the Distal Region of Chromosome 1p in Human Hepatocellular Carcinomas
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Journal Articles

Splicing Mutations of the p53 Gene in Human Hepatocellular Carcinoma

Ming-Yang Lai, Hua-Chen Chang, Hsin-Pai Li, Chen-Kuo Ku, Pei-Jer Chen, Jin-Chuan Sheu, Guan-Tarng Huang, Po-Huang Lee, Ding-Shinn Chen
Journal: Cancer Research
Cancer Res (1993) 53 (7): 1653–1656.
Published: 01 April 1993
View article titled, Splicing Mutations of the <em>p53</em> Gene in Human Hepatocellular Carcinoma
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