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Journal Articles

Abstract 3368: Combination of a chk1/2 dual inhibitor (prexasertib) and gemcitabine reveals a novel intrinsic synergy mechanism in head and neck squamous cell carcinoma

Vinayak C. Palve, Hannah L. Walker-Mimms, Ritu Chaudhary, Victoria Izumi, Neelkamal Chaudhary, Bin Fang, John Koomen, Jose Alejandro Guevara, Paulo C. Rodriguez, Christine H. Chung, Derek R. Duckett

Cancer Res (2024) 84 (6_Supplement): 3368.

https://doi.org/10.1158/1538-7445.AM2024-3368

Published: 22 March 2024

View article titled, Abstract 3368: Combination of a chk1/2 dual inhibitor (prexasertib) and gemcitabine reveals a novel intrinsic synergy mechanism in head and neck squamous cell carcinoma

Journal Articles

Abstract 3886: Analysis of clonal heterogeneity within paired primary and metastatic tumor samples of patients with solid tumors and implications for neoantigen-based personalized cancer vaccines

Cancer Res (2024) 84 (6_Supplement): 3886.

https://doi.org/10.1158/1538-7445.AM2024-3886

Published: 22 March 2024

View article titled, Abstract 3886: Analysis of clonal heterogeneity within paired primary and metastatic tumor samples of patients with solid tumors and implications for neoantigen-based personalized cancer vaccines

Journal Articles

Abstract 71: Differential infiltration of key immune cell populations across malignancies varying by immunogenic potential and likelihood of response to immunotherapy

Ahmad A. Tarhini, Islam Eljilany, Sam Coleman, Dale J. Hedges, Martin McCarter, John Carpten, Howard Colman, Abdul Rafeh Naqash, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, William S. Dalton, George J. Weiner, Aik Choon Tan, Jose R. Conejo-Garcia, Paulo C. Rodriguez

Cancer Res (2024) 84 (6_Supplement): 71.

https://doi.org/10.1158/1538-7445.AM2024-71

Published: 22 March 2024

View article titled, Abstract 71: Differential infiltration of key immune cell populations across malignancies varying by immunogenic potential and likelihood of response to immunotherapy

Journal Articles

Abstract 5703: The immune cell state atlas analysis predicts therapeutic benefits with immune checkpoint inhibitors

Tingyi Li, Vineeth Sukrithan, Aakrosh Ratan, Martin McCarter, John Carpten, Howard Colman, Alexandra P. Ikeguchi, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, Paulo C. Rodriguez, William S. Dalton, George J. Weiner, Ahmad Tarhini, Xuefeng Wang

Cancer Res (2023) 83 (7_Supplement): 5703.

https://doi.org/10.1158/1538-7445.AM2023-5703

Published: 04 April 2023

View article titled, Abstract 5703: The immune cell state atlas analysis predicts therapeutic benefits with immune checkpoint inhibitors

Journal Articles

Abstract 5109: The anti-PD1+anti-LAG3 and anti-CTLA4+anti-PD1 combinations have non-overlapping mechanisms of action in melanoma cranial and extra cranial metastases

Manali S. Phadke, Jiannong Li, Jessica Mandula, Ann Chen, Paulo C. Rodriguez, Keiran S. M. Smalley

Cancer Res (2023) 83 (7_Supplement): 5109.

https://doi.org/10.1158/1538-7445.AM2023-5109

Published: 04 April 2023

View article titled, Abstract 5109: The anti-PD1+anti-LAG3 and anti-CTLA4+anti-PD1 combinations have non-overlapping mechanisms of action in melanoma cranial and extra cranial metastases

Journal Articles

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Cancer Res (2022) 82 (10): 1969–1990.

https://doi.org/10.1158/0008-5472.CAN-21-3155

Published: 16 May 2022

View article titled, Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Includes: Supplementary data

Journal Articles

IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer

Cancer Res (2022) 82 (5): 859–871.

https://doi.org/10.1158/0008-5472.CAN-21-2376

Published: 03 March 2022

View article titled, IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer

Includes: Supplementary data

Journal Articles

Abstract 4517: Targeting Notch1 via adenosine A2A receptor to modulate tumor immunity

Giulia Monticone, Fokhrul M. Hossain, Deniz A. Ucar, Samarpan Majumder, Claudia Sorrentino, Paulo C. Rodriguez, Rosa A. Sierra, Antonio Pannuti, Stephen Hatfield, Barbara A. Osborne, Lisa M. Minter, Silvana Morello, Lucio Miele

Cancer Res (2020) 80 (16_Supplement): 4517.

https://doi.org/10.1158/1538-7445.AM2020-4517

Published: 15 August 2020

View article titled, Abstract 4517: Targeting Notch1 via adenosine A2A receptor to modulate tumor immunity

Journal Articles

AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells

Jimena Trillo-Tinoco, Rosa A. Sierra, Eslam Mohamed, Yu Cao, Álvaro de Mingo-Pulido, Danielle L. Gilvary, Carmen M. Anadon, Tara Lee Costich, Sheng Wei, Elsa R. Flores, Brian Ruffell, José R. Conejo-Garcia, Paulo C. Rodriguez

Cancer Res (2019) 79 (19): 5034–5047.

https://doi.org/10.1158/0008-5472.CAN-19-0880

Published: 01 October 2019

View article titled, AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells

Includes: Supplementary data

Journal Articles

Abstract 4717: MAP kinase inhibition induces metabolic reprogramming in T-cells leading to induction of stem cell memory CD8 cells that enhance potency of adoptive cell therapy and anti-OX40 antibody

Vivek Verma, Shamim Ahmad, Peng Zeng, Mikayel Mkrtichyan, Simon T. Barry, Paul D. Smith, Paulo C. Rodriguez, John E. Janik, Seema Gupta, Samir N. Khleif

Cancer Res (2018) 78 (13_Supplement): 4717.

https://doi.org/10.1158/1538-7445.AM2018-4717

Published: 01 July 2018

View article titled, Abstract 4717: MAP kinase inhibition induces metabolic reprogramming in T-cells leading to induction of stem cell memory CD8 cells that enhance potency of adoptive cell therapy and anti-OX40 antibody

Journal Articles

Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance

Rosa A. Sierra, Jimena Trillo-Tinoco, Eslam Mohamed, Lolie Yu, Bhagelu R. Achyut, Ali Arbab, Jennifer W. Bradford, Barbara A. Osborne, Lucio Miele, Paulo C. Rodriguez

Cancer Res (2017) 77 (20): 5628–5638.

https://doi.org/10.1158/0008-5472.CAN-17-0357

Published: 15 October 2017

View article titled, Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance

Includes: Supplementary data

Journal Articles

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

Rasha Abu Eid, Shamim Ahmad, Yuan Lin, Mason Webb, Zuzana Berrong, Rajeev Shrimali, Takumi Kumai, Sudha Ananth, Paulo C. Rodriguez, Esteban Celis, John Janik, Mikayel Mkrtichyan, Samir N. Khleif

Cancer Res (2017) 77 (15): 4135–4145.

https://doi.org/10.1158/0008-5472.CAN-16-1925

Published: 01 August 2017

View article titled, Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

Includes: Supplementary data

Journal Articles

Abstract 5807: Disseminated tumor cell clearance by the immune system

Raziye Piranlioglu, Eun Mi Lee, Maria Ouzunova, Ali S. Arbab, Paulo C. Rodriguez, Asm L. Iskander, Hasan Korkaya

Cancer Res (2017) 77 (13_Supplement): 5807.

https://doi.org/10.1158/1538-7445.AM2017-5807

Published: 01 July 2017

View article titled, Abstract 5807: Disseminated tumor cell clearance by the immune system

Journal Articles

Differential PI3Kδ Signaling in CD4⁺ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy

Shamim Ahmad, Rasha Abu-Eid, Rajeev Shrimali, Mason Webb, Vivek Verma, Atbin Doroodchi, Zuzana Berrong, Raed Samara, Paulo C. Rodriguez, Mikayel Mkrtichyan, Samir N. Khleif

Cancer Res (2017) 77 (8): 1892–1904.

https://doi.org/10.1158/0008-5472.CAN-16-1839

Published: 13 April 2017

View article titled, Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy

Includes: Supplementary data

Journal Articles

Abstract LB-077: T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

Patrick Raber, Rosa A. Sierra, Shuzhong Zhang, Paul Thevenot, Paulo C. Rodriguez

Cancer Res (2016) 76 (14_Supplement): LB-077.

https://doi.org/10.1158/1538-7445.AM2016-LB-077

Published: 15 July 2016

View article titled, Abstract LB-077: T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

Journal Articles

l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Matthew Fletcher, Maria E. Ramirez, Rosa A. Sierra, Patrick Raber, Paul Thevenot, Amir A. Al-Khami, Dulfary Sanchez-Pino, Claudia Hernandez, Dorota D. Wyczechowska, Augusto C. Ochoa, Paulo C. Rodriguez

Cancer Res (2015) 75 (2): 275–283.

https://doi.org/10.1158/0008-5472.CAN-14-1491

Published: 14 January 2015

View article titled, <sc>l</sc>-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Includes: Supplementary data

Journal Articles

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8⁺ T Cell Function via l-Arginine Metabolism

Lyse A. Norian, Paulo C. Rodriguez, Leigh A. O'Mara, Jovanny Zabaleta, Augusto C. Ochoa, Marina Cella, Paul M. Allen

Cancer Res (2009) 69 (7): 3086–3094.

https://doi.org/10.1158/0008-5472.CAN-08-2826

Published: 01 April 2009

View article titled, Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via <sc>l</sc>-Arginine Metabolism

Includes: Supplementary data

Journal Articles

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

Paulo C. Rodriguez, Marc S. Ernstoff, Claudia Hernandez, Michael Atkins, Jovanny Zabaleta, Rosa Sierra, Augusto C. Ochoa

Cancer Res (2009) 69 (4): 1553–1560.

https://doi.org/10.1158/0008-5472.CAN-08-1921

Published: 12 February 2009

View article titled, Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

Includes: Supplementary data

Journal Articles

Suppressor myeloid cells in Renal Cell Carcinoma patients block T cell function and CD3 ζ chain expression

Arnold H. Zea, Paulo C. Rodriguez, Michael B. Atkins, Claudia Hernandez, Sabina Signoretti, Jovanny Zabaleta, David McDermott, David Quiceno, Amanda Youmans, Anne O’Niell, Meredith Regan, James Mier, Augusto C. Ochoa

Cancer Res (2005) 65 (9_Supplement): 569.

Published: 01 May 2005

View article titled, Suppressor myeloid cells in Renal Cell Carcinoma patients block T cell function and CD3 ζ chain expression

Journal Articles

Prostanoids from tumor cells induce Arginase I in tumor associated suppressor myeloid cells, that block T cell function

Paulo C. Rodriguez, David Quiceno, Jovanny Zabaleta, Juan B. Ochoa, Augusto C. Ochoa

Cancer Res (2005) 65 (9_Supplement): 1255.

Published: 01 May 2005

View article titled, Prostanoids from tumor cells induce Arginase I in tumor associated suppressor myeloid cells, that block T cell function

NARROW

Abstract 3368: Combination of a chk1/2 dual inhibitor (prexasertib) and gemcitabine reveals a novel intrinsic synergy mechanism in head and neck squamous cell carcinoma

Abstract 3886: Analysis of clonal heterogeneity within paired primary and metastatic tumor samples of patients with solid tumors and implications for neoantigen-based personalized cancer vaccines

Abstract 71: Differential infiltration of key immune cell populations across malignancies varying by immunogenic potential and likelihood of response to immunotherapy

Abstract 5703: The immune cell state atlas analysis predicts therapeutic benefits with immune checkpoint inhibitors

Abstract 5109: The anti-PD1+anti-LAG3 and anti-CTLA4+anti-PD1 combinations have non-overlapping mechanisms of action in melanoma cranial and extra cranial metastases

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer

Abstract 4517: Targeting Notch1 via adenosine A2A receptor to modulate tumor immunity

AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells

Abstract 4717: MAP kinase inhibition induces metabolic reprogramming in T-cells leading to induction of stem cell memory CD8 cells that enhance potency of adoptive cell therapy and anti-OX40 antibody

Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

Abstract 5807: Disseminated tumor cell clearance by the immune system

Differential PI3Kδ Signaling in CD4⁺ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy

Abstract LB-077: T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8⁺ T Cell Function via l-Arginine Metabolism

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

Suppressor myeloid cells in Renal Cell Carcinoma patients block T cell function and CD3 ζ chain expression

Prostanoids from tumor cells induce Arginase I in tumor associated suppressor myeloid cells, that block T cell function

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