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Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
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Journal Articles

Abstract ND08: NXP800: A first-in-class orally active, small-molecule HSF1 pathway inhibitor

Paul Workman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): ND08.
DOI: https://doi.org/10.1158/1538-7445.AM2022-ND08
Published: 15 June 2022
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Journal Articles

Abstract 6355: A characterisation of direct and indirect transcription factor inhibition to target brachyury in chordoma

Hadley E. Sheppard, Alessandra Dall’Agnese, Woojun D. Park, M. Shamim Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Josh Sommer, Joan Levy, Tanaz Sharifnia, Mathias Wawer, Behnam Nabet, Paul A. Clemons, Stuart L. Schreiber, Paul Clarke, Rick Young, Charles Y. Lin, Paul Workman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6355.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6355
Published: 15 June 2022
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Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D'Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
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Includes: Supplementary data
Journal Articles

Abstract LB216: Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Hadley E. Sheppard, Alessandra Dall'Agnese, Woojun D. Park, Hamza Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Patricia Cogswell, Josh Sommer, Joan Levy, Tanaz Sharifnia, Mathias J. Wawer, Paul A. Clemons, Behnam Nabet, Nathanael S. Gray, Stuart L. Schreiber, Paul Workman, Richard A. Young, Charles Y. Lin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB216.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB216
Published: 01 July 2021
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Journal Articles

CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

Rebecca F. Rogers, Michael I. Walton, Daniel L. Cherry, Ian Collins, Paul A. Clarke, Michelle D. Garrett, Paul Workman
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (8): 1735–1747.
DOI: https://doi.org/10.1158/0008-5472.CAN-19-1372
Published: 15 April 2020
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Includes: Supplementary data
Journal Articles

Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

Joanna L. Holmes, Swee Y. Sharp, Steve Hobbs, Paul Workman
Journal: Cancer Research
Cancer Res (2019) 79 (1): 286.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-3577
Published: 02 January 2019
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Journal Articles

Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

Swee Y. Sharp, Kathy Boxall, Martin Rowlands, Chrisostomos Prodromou, S. Mark Roe, Alison Maloney, Marissa Powers, Paul A. Clarke, Gary Box, Sharon Sanderson, Lisa Patterson, Thomas P. Matthews, Kwai-Ming J. Cheung, Karen Ball, Angela Hayes, Florence Raynaud, Richard Marais, Laurence Pearl, Sue Eccles, Wynne Aherne, Edward McDonald, Paul Workman
Journal: Cancer Research
Cancer Res (2019) 79 (1): 287.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-3578
Published: 02 January 2019
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Journal Articles

Abstract 2896: A genome-wide CRISPR/Cas9 pooled screen identifies EML4-ALK variant-specific synthetic lethal partners of HSP90 inhibitors

Marco P. Licciardello, Paul A. Clarke, Paul Workman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2896.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2896
Published: 01 July 2018
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Journal Articles

Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin

Swee Y. Sharp, Nicola E. Chessum, John J. Caldwell, Marissa V. Powers, A Elisa Pasqua, Birgit Wilding, Ian Collins, Bugra Ozer, Martin Rowlands, Mark Stubbs, Rosemary Burke, Rob L. van Montfort, Matthew D. Cheeseman, Paul A. Clarke, Paul Workman, Keith Jones
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2976.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2976
Published: 01 July 2018
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Journal Articles

Abstract 4977: MIR1307 mediates pancreatic cancer resistance to FOLFIRINOX chemotherapy by affecting response to DNA damage

Pietro Carotenuto, Domenico Zito, Maria C. Previdi, Maya Raj, Matteo Fassan, Andrea Lampis, Francesco Scalafani, Andrea Lanese, Ian Said-Huntingford, Jens C. Hahne, Kate Young, Ruwaida Begum, Zakaria Ethiar, Andrew Wotherspoon, Naureen Starling, Anguraj Sadanandam, David Cunningham, Ian Chau, Paul Workman, Rajesh Chopra, Nicola Valeri, Chiara Braconi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4977.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4977
Published: 01 July 2018
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Journal Articles

Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen

Matthew D. Cheeseman, Nicola E. Chessum, Carl S. Rye, Elisa A. Pasqua, Michael J. Tucker, Birgit Wilding, Lindsay E. Evans, Susan Lepri, Meirion Richards, Swee Y. Sharp, Salyha Ali, Martin Rowlands, Lisa O'Fee, Asadh Miah, Angela Hayes, Alan T. Henley, Marissa Powers, Robert te Poele, Emmanuel De Billy, Loredana Pellegrino, Florence Raynaud, Rosemary Burke, Robert L. van Montfort, Suzanne A. Eccles, Keith Jones, Paul Workman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-304.
DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-304
Published: 01 July 2017
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Journal Articles

Abstract 129: Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19

Paul A. Clarke, Maria-Jesus Ortiz-Ruiz, Robert Te Poele, Olajumoke Adeniji-Popoola, Gary Box, Christina Esdar, Kenneth Ewan, Sharon Gowan, Alexis De Haven Brandon, Phllip Hewitt, Wolfgang Kaufmann, Aurelie Mallinger, Florence Raynaud, Felix Rohdich, Kai Schiemann, Stephanie Simon, Richard Schneider, Melanie Valenti, Julian Blagg, Trevor Dale, Suzanne Eccles, Paul Workman, Dirk Wienke Dirk Wienke
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 129.
DOI: https://doi.org/10.1158/1538-7445.AM2017-129
Published: 01 July 2017
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Journal Articles

Abstract 293: Screening the druggable genome for synthetic lethal interactions with the CHK1 inhibitor PNT737

Rebecca Rogers, Mike I. Walton, Paul Clarke, Ian Collins, Michelle D. Garrett, Paul Workman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 293.
DOI: https://doi.org/10.1158/1538-7445.AM2017-293
Published: 01 July 2017
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Journal Articles

Abstract 1069: MiR-21 may serve as a predictive biomarker of response in the assessment of efficacy of HSP-90 inhibition in gastrointestinal (GI) cancers

Andrea Lampis, Luciano Cascione, Rosemary Burke, Paul Clarke, Michele Simbolo, Aldo Scarpa, Else Bosma, Sijia Yu, Rebecca Cole, Mark Stubbs, Swee Sharp, Rob Van Montfort, Jens C. Hahne, Matteo Fassan, Paul Workman, Nicola Valeri, Chiara Braconi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1069.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1069
Published: 15 July 2016
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Journal Articles

Abstract 2998: Molecular and cellular effects of individual and combinatorial silencing of HSP90 paralogs

Marissa V. Powers, Robert H. Te Poele, Ravindhi L. Murphy, Emmanuel de Billy, Paul A. Clarke, Paul Workman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2998.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2998
Published: 15 July 2016
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Journal Articles

Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential

Paul Clarke, Christina Esdar, Aurelie Mallinger, Kai Schiemann, Dennis Waalboer, Simon Crumpler, Christian Rink, Frank Stieber, Michel Calderini, Olajumoke Adeniji-Popoola, Maria-Jesus Ortiz-Ruiz, Rahul S. Samant, Paul Czodrowski, Djordje Musil, Daniel Schwarz, Klaus Schneider, Michael Busch, Mark Stubbs, Rosemary Burke, Robert TePoele, Sharon Gowan, Felix Rohdich, Florence Raynaud, Richard Schneider, Oliver Poeschke, Andree Blaukat, Klaus Urbahns, Paul Workman, Wolfgang Kaufmann, Stephanie Simon, Suzanne A. Eccles, Trevor Dale, Dirk Wienke, Julian Blagg
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3025.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3025
Published: 15 July 2016
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Journal Articles

Abstract 3869: Phosphoproteomic-based identification of CDK8/CDK19 substrates in colorectal cancer

Olajumoke O. Popoola, Rahul Samant, Maria-Jesus Ortiz-Ruiz, Aurelie Mallinger, Will Court, Steve Hobbs, Robert Te-Poele, Mark Stubbs, Rosemary Burke, Christina Esdar, Kai Schiemann, Dirk Wienke, Sue Eccles, Julian Blagg, Paul Workman, Paul Clarke
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3869.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3869
Published: 15 July 2016
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Journal Articles

Abstract 4355: Elucidation of the different roles of CDK8 and CDK19 in colorectal cancer (CRC) using CRISPR gene editing technology

Maria J. Ortiz Ruiz, Olajumoke Popoola, Aurelie Mallinger, Sharon Gowan, Will Court, Gary Box, Melanie Valenti, Alexis De Haven Brandon, Robert Te-Poele, Paul Workman, Kai Schiemann, Cristina Esdar, Dirk Wienke, Julian Blagg, Paul Clarke, Suzanne A. Eccles
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4355.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4355
Published: 15 July 2016
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Journal Articles

Abstract 4383: SOCRATES: integrating ex vivo and in silico analysis to identify optimal drug combinations for patients

Elizabeth A. Coker, Adam Stewart, Anna Minchom, Mary O’Brien, Timothy Yap, Paul Workman, Udai Banerji, Bissan Al-Lazikani
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4383.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4383
Published: 15 July 2016
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