1-15 of 15
Paul T. Spellman
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 3882: Patterns of genomic patient-model conservation and evolution in the Human Cancer Models Initiative (HCMI) next-generation cancer model resource

Free
Andrew W. McPherson, Seongmin Choi, William F. Hooper, Jennifer M. Shelton, Timothy R. Chu, Dina ElHarouni, Mushriq Al-Jazrawe, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Moony Tseng, Hayley E. Francies, Priya Sridevi, Rachana Agarwal, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, James M. Clinton, The HCMI Network, Peter W. Laird, Calvin J. Kuo, Olivier Elemento, David L. Spector, Andrew D. Cherniack, Kyle Ellrott, Martin L. Ferguson, Rameen Beroukhim, Katherine A. Hoadley, Nicolas Robine, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis Staudt, Jesse Boehm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3882.
https://doi.org/10.1158/1538-7445.AM2025-3882
Published: 21 April 2025
View articletitled, Abstract 3882: Patterns of genomic patient-model conservation and evolution in the Human Cancer Models Initiative (HCMI) next-generation cancer model resource
Journal Articles

Abstract 6358: Single cell transcriptional dynamics in the HCMI cancer model collection

Free
Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Moony Tseng, Hayley E. Francies, Priya Sridevi, Rachana Agarwal, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, James M. Clinton, The HCMI Network, Peter W. Laird, Calvin J. Kuo, Olivier Elemento, David L. Spector, Andrew D. Cherniack, Kyle Elrott, Martin L. Ferguson, Rameen Beroukhim, Katherine A. Hoadley, Nicolas Robine, Andrew McPherson, Matthew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis M. Staudt, Jesse Boehm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6358.
https://doi.org/10.1158/1538-7445.AM2025-6358
Published: 21 April 2025
View articletitled, Abstract 6358: Single cell transcriptional dynamics in the HCMI cancer model collection
Journal Articles

Abstract 1165: The landscape of molecular targets across 665 next-generation cancer models in the human cancer models initiative identifies opportunities for improved therapy and overcoming resistance

Free
Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Moony Tseng, Hayley E. Francies, Priya Sridevi, Rachana Agarwal, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, James M. Clinton, William F. Hooper, Jennifer M. Shelton, Timothy R. Chu, The HCMI Network, Peter W. Laird, Calvin J. Kuo, Olivier Elemento, David L. Spector, Andrew D. Cherniack, Kyle Ellrott, Martin L. Ferguson, Rameen Beroukhim, Katherine A. Hoadley, Nicolas Robine, Andrew McPherson, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis M. Staudt, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1165.
https://doi.org/10.1158/1538-7445.AM2025-1165
Published: 21 April 2025
View articletitled, Abstract 1165: The landscape of molecular targets across 665 next-generation cancer models in the human cancer models initiative identifies opportunities for improved therapy and overcoming resistance
Journal Articles

Abstract 4005: Integrative clinical and molecular characterization of an international community resource of organoid models of human cancer

Free
Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E. Francies, Priya Sridevi, Rachana Agarwal, Cindy W. Kyi, Julyann Perez-Mayoral, Megan Stine, Eva Tonsing-Carter, James M. Clinton, The Human Cancer Models Initiative Network, Peter W. Laird, Calvin J. Kuo, Olivier Elemento, David L. Spector, Andrew D. Cherniack, Kyle Ellrott, Martin L. Ferguson, Rameen Beroukhim, Katherine A. Hoadley, Nicolas Robine, Andrew McPherson, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith Ligon, Daniela S. Gerhard, Louis M. Staudt, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4005.
https://doi.org/10.1158/1538-7445.AM2025-4005
Published: 21 April 2025
View articletitled, Abstract 4005: Integrative clinical and molecular characterization of an international community resource of organoid models of human cancer
Journal Articles

Abstract 6608: Integrating HCMI models and tumors with CCLE and TCGA: Advancing cancer modeling and precision oncology

Free
Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Moony Tseng, Hayley E. Francies, Priya Sridevi, Rachana Agarwal, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, James M. Clinton, The HCMI Network, Peter W. Laird, Calvin J. Kuo, Olivier Elemento, David L. Spector, Andrew D. Cherniack, Kyle Ellrott, Martin L. Ferguson, Rameen Beroukhim, Katherine A. Hoadley, Nicolas Robine, Andrew McPherson, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis M. Staudt, Jesse S. Boehm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6608.
https://doi.org/10.1158/1538-7445.AM2025-6608
Published: 21 April 2025
View articletitled, Abstract 6608: Integrating HCMI models and tumors with CCLE and TCGA: Advancing cancer modeling and precision oncology
Journal Articles

Abstract B025: Integrative clinical and molecular analysis of 665 next-generation in vitro cancer models generated by the the Human Cancer Models Initiative (HCMI) for advancing precision medicine and functional drug discovery

Free
Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A Misek, Heeju Noh, Luca Zanella, Moony Tseng, Hayley E Francies, Priya Sridevi, Rachana Agarwal, Cindy W Kyi, Julyann Perez-Mayoral, Megan J Stine, Eva Tonsing-Carter, James M Clinton, The HCMI Network, Peter W Laird, Calvin J Kuo, Olivier Elemento, David L Spector, Andrew D Cherniack, Kyle Ellrott, Martin L Ferguson, Rameen Beroukhim, Katherine A Hoadley, Nicolas Robine, Mathew Garnett, Andrea Califano, Paul T Spellman, David A Tuveson, Keith L Ligon, Daniela S Gerhard, Louis M Staudt, Jesse Boehm
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): B025.
https://doi.org/10.1158/1538-7445.GENFUNC25-B025
Published: 11 March 2025
View articletitled, Abstract B025: Integrative clinical and molecular analysis of 665 next-generation in vitro cancer models generated by the the Human Cancer Models Initiative (HCMI) for advancing precision medicine and functional drug discovery
Journal Articles

Abstract A061: A novel genetically engineered mouse model of Myc-driven pancreatic cancer recapitulates phenotypic heterogeneity, metastasis, and therapy resistance seen in clinical populations

Free
Isabel A. English, Patrick J. Worth, Kevin A. MacPherson, Michael B. Heskett, Vidhi Shah, Jackie L. Phipps, Courtney Betts, Shamilene Sivagnanam, Carl Pelz, Amy S. Farrell, Brittany L. Allen-Petersen, Meghan M. Joly, Motoyuki Tsuda, Colin J. Daniel, Jenny Eng, Xiaoyan Wang, Ashley L. Kiemen, Laura D. Wood, Terry K. Morgan, Mary C. Thoma, Jennifer M. Chu, Paul T. Spellman, Lisa M. Coussens, Ellen M. Langer, Rosalie C. Sears
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A061.
https://doi.org/10.1158/1538-7445.PANCA2023-A061
Published: 16 January 2024
View articletitled, Abstract A061: A novel genetically engineered mouse model of Myc-driven pancreatic cancer recapitulates phenotypic heterogeneity, metastasis, and therapy resistance seen in clinical populations
Journal Articles

Abstract LB178: Cell free RNA for prediction of PDAC in de novo symptomatic patients presenting for EUS-FNA

Free
Travis Moore, Elias Spiliotopolous, Rowan Callahan, Ward Kirschbaum, Hyun Ji Kim, Dove Keith, Aaron Grossberg, Paul T. Spellman, Gordon Mills, Rosalie C. Sears, Terry Morgan, Thuy Ngo
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB178.
https://doi.org/10.1158/1538-7445.AM2023-LB178
Published: 14 April 2023
View articletitled, Abstract LB178: Cell free RNA for prediction of PDAC in de novo symptomatic patients presenting for EUS-FNA
Journal Articles

Abstract 999: Epigenetic loss of heterogeneity from low to high grade localized prostate tumors

Free
Ece Sebnem Eksi, Zeynep Sayar, Alex Chitsazan, George T. Thomas, Andrew Adey, Paul T. Spellman, Ryan Kopp
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 999.
https://doi.org/10.1158/1538-7445.AM2022-999
Published: 15 June 2022
View articletitled, Abstract 999: Epigenetic loss of heterogeneity from low to high grade localized prostate tumors
Journal Articles

Abstract 218: The evolutionary history of 2,658 cancers

Free
Clemency Jolly, Moritz Gerstung, Ignaty Leshchiner, Stefan C. Dentro, Santiago Gonzalez, Thomas J. Mitchell, Yulia Rubanova, Pavana Anur, Daniel Rosebrock, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vásquez-García, Kerstin Haase, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, Nilgun Donmez, Dimitri G. Livitz, Mark Cmero, Jonas Demeulemeester, Steve Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, Matthias Schlesner, Paul C. Boutros, David D. Bowtell, Hongtu Zhu, Gad Getz, Marcin Imielinski, Rameen Beroukhim, S Cenk Sahinalp, Yuan Ji, Martin Peifer, Florian Markowetz, Ville Mustonen, Ke Juan, Wenyi Wang, Quaid D. Morris, Paul T. Spellman, David C. Wedge, Peter Van Loo, PCAWG Evolution and Heterogeneity Working Group
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 218.
https://doi.org/10.1158/1538-7445.AM2018-218
Published: 01 July 2018
View articletitled, Abstract 218: The evolutionary history of 2,658 cancers
Journal Articles

Abstract 5238: Acquired therapeutic resistance is mediated by deregulation of multiple pathways.

Free
Laura M. Heiser, Chad A. Shaw, Nicholas J. Wang, Catie Grasso, Pavana Anur, Sam Ng, Theodore Goldstein, Paul T. Spellman, Joshua Stuart, Kent Osborne, Joe Gray, Rachel Schiff
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5238.
https://doi.org/10.1158/1538-7445.AM2013-5238
Published: 15 April 2013
View articletitled, Abstract 5238: Acquired therapeutic resistance is mediated by deregulation of multiple pathways.
Journal Articles

Abstract 639: Inhibition of HER2 signaling using targeted therapeutics in breast cancer cell lines

Free
James Korkola, Nora Bayani, Brian Cooper, Laura M. Heiser, Paul T. Spellman, Heidi S. Feiler, Richard Wooster, Joe W. Gray
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 639.
https://doi.org/10.1158/1538-7445.AM2011-639
Published: 15 April 2011
View articletitled, Abstract 639: Inhibition of HER2 signaling using targeted therapeutics in breast cancer cell lines
Journal Articles

Abstract LB-24: Molecular subtypes of pancreatic adenocarcinoma with different biological characteristics and therapeutical responses

Free
Anguraj Sadanandam, Eric A. Collisson, Peter Olson, William J. Gibb, Morgan Truitt, Adam Olshen, Margaret A. Tempero, Paul T. Spellman, Douglas Hanahan, Joe W. Gray
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-24.
https://doi.org/10.1158/1538-7445.AM2011-LB-24
Published: 15 April 2011
View articletitled, Abstract LB-24: Molecular subtypes of pancreatic adenocarcinoma with different biological characteristics and therapeutical responses
Journal Articles

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Free
Olga K. Mirzoeva, Debopriya Das, Laura M. Heiser, Sanchita Bhattacharya, Doris Siwak, Rina Gendelman, Nora Bayani, Nicholas J. Wang, Richard M. Neve, Yinghui Guan, Zhi Hu, Zachary Knight, Heidi S. Feiler, Philippe Gascard, Bahram Parvin, Paul T. Spellman, Kevan M. Shokat, Andrew J. Wyrobek, Mina J. Bissell, Frank McCormick, Wen-Lin Kuo, Gordon B. Mills, Joe W. Gray, W. Michael Korn
Journal: Cancer Research
Cancer Res (2009) 69 (2): 565–572.
https://doi.org/10.1158/0008-5472.CAN-08-3389
Published: 15 January 2009
View articletitled, Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition
Open the PDF for Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Utilization of SNP copy number analysis to identify allele specific copy number alterations in breast and ovarian cancer.

Free
Nicholas J. Wang, Dione K. Bailey, Wen-Lin Kuo, Koei Chin, Paul T. Spellman, Joe W. Gray
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1339–1340.
Published: 15 April 2006
View articletitled, Utilization of SNP copy number analysis to identify allele specific copy number alterations in breast and ovarian cancer.