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Paul Nghiem
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Journal Articles

Abstract 2052: LAMP1 targeting of the large T antigen of Merkel cell polyomavirus elicits potent CD4+ T cell responses, tumor inhibition, and provides rationale for first-in-human trial

Claire Buchta Rosean, Mohan Karkada, David M. Koelle, Paul Nghiem, Teri Heiland
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2052.
https://doi.org/10.1158/1538-7445.AM2022-2052
Published: 15 June 2022
View article titled, Abstract 2052: LAMP1 targeting of the large T antigen of Merkel cell polyomavirus elicits potent CD4<sup>+</sup> T cell responses, tumor inhibition, and provides rationale for first-in-human trial
Journal Articles

Abstract 4476: PD-1 and TIGIT co-expression identifies a circulating CD8 T cell population predictive of response to anti-PD-1 therapy in melanoma and Merkel-cell carcinoma patients

Sylvain Simon, Valentin Voillet, Virginie Vignard, Zhong Wu, Camille Dabrowski, Nicolas Jouand, Tiffany Beauvais, Amir Khammari, Cecile Braudeau, Regis Josien, Olivier Adotevi, Caroline Laheurte, Francçois Aubin, Charles Nardin, Samuel Rulli, Raphaël Gottardo, Nirasha Ramchurren, Cheever Martin, Steven P. Fling, Candice D. Church, Paul Nghiem, Brigitte Dreno, Stanley R. Riddell, Nathalie Labarriere
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4476.
https://doi.org/10.1158/1538-7445.AM2020-4476
Published: 15 August 2020
View article titled, Abstract 4476: PD-1 and TIGIT co-expression identifies a circulating CD8 T cell population predictive of response to anti-PD-1 therapy in melanoma and Merkel-cell carcinoma patients
Journal Articles

Abstract 4585: LAMP1 targeting of the large T antigen of Merkel cell polyomavirus elicits potent CD4+ T cell responses and prevents tumor growth

Claire Buchta Rosean, Pratima Sinha, David M. Koelle, Paul Nghiem, Teri Heiland
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4585.
https://doi.org/10.1158/1538-7445.AM2020-4585
Published: 15 August 2020
View article titled, Abstract 4585: LAMP1 targeting of the large T antigen of Merkel cell polyomavirus elicits potent CD4+ T cell responses and prevents tumor growth
Journal Articles

Abstract 2962: Targeting BCL2 as a therapeutic strategy in neuroendocrine prostate cancer

Alexandra N. Corella, Jared M. Lucas, Arja Kaipainen, Ilsa M. Coleman, Colm Morrissey, Eva Corey, Paul Nghiem, David MacPherson, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2962.
https://doi.org/10.1158/1538-7445.AM2019-2962
Published: 01 July 2019
View article titled, Abstract 2962: Targeting BCL2 as a therapeutic strategy in neuroendocrine prostate cancer
Journal Articles

Abstract 3567: Novel approaches to high-affinity TCR isolation for clinical translation enabled by single cell RNA sequencing

Megan S. McAfee, Kelly Paulson, Thomas Schmitt, Natalie Miller, Daniel Hunter, Jason Bielas, David Koelle, Valentin Voillet, Raphael Gottardo, Phillip Greenberg, Paul Nghiem, Aude Chapuis
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3567.
https://doi.org/10.1158/1538-7445.AM2018-3567
Published: 01 July 2018
View article titled, Abstract 3567: Novel approaches to high-affinity TCR isolation for clinical translation enabled by single cell RNA sequencing
Journal Articles

Abstract 2518: Folate hydrolase-1 is a novel target for J591-brachytherapy in Merkel cell carcinoma

Barbara Meier, Marigdalia K. Ramirez-Fort, Kristina Lachance, Candice D. Church, Sean S. Mahase, Joseph M. Jenrette, Christopher S. Lange, Lars E. French, Paul Nghiem, Neil H. Bander
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2518.
https://doi.org/10.1158/1538-7445.AM2018-2518
Published: 01 July 2018
View article titled, Abstract 2518: Folate hydrolase-1 is a novel target for J591-brachytherapy in Merkel cell carcinoma
Journal Articles

Abstract CT074: Non-comparative, open-label, multiple cohort, phase 1/2 study to evaluate nivolumab (NIVO) in patients with virus-associated tumors (CheckMate 358): Efficacy and safety in Merkel cell carcinoma (MCC)

Suzanne L. Topalian, Shailender Bhatia, Antoine Hollebecque, Ahmad Awada, Jan Paul De Boer, Ragini R. Kudchadkar, Anthony Goncalves, Jean-Pierre Delord, Uwe M. Martens, Jose Maria Lopez Picazo, Ana Oaknin, William C. Spanos, Raid Aljumaily, William H. Sharfman, Shangbang Rao, Ibrahima Soumaoro, Alexander Cao, Paul Nghiem, Dirk Schadendorf
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT074.
https://doi.org/10.1158/1538-7445.AM2017-CT074
Published: 01 July 2017
View article titled, Abstract CT074: Non-comparative, open-label, multiple cohort, phase 1/2 study to evaluate nivolumab (NIVO) in patients with virus-associated tumors (CheckMate 358): Efficacy and safety in Merkel cell carcinoma (MCC)
Journal Articles

Abstract CT079: Durable responses to avelumab (anti-PD-L1) in patients with Merkel cell carcinoma progressed after chemotherapy: 1-year efficacy update

Howard L. Kaufman, Jeffery S. Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P. D’Angelo, Kent C. Shih, Celeste Lebbé, Michele Milella, Isaac Brownell, Karl D. Lewis, Jochen H. Lorch, Anja von Heydebreck, Lisa Mahnke, Paul Nghiem
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT079.
https://doi.org/10.1158/1538-7445.AM2017-CT079
Published: 01 July 2017
View article titled, Abstract CT079: Durable responses to avelumab (anti-PD-L1) in patients with Merkel cell carcinoma progressed after chemotherapy: 1-year efficacy update
Journal Articles

Abstract CT096: Clinical activity, immune and viral correlates of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma

Paul Nghiem, Shailender Bhatia, Evan Lipson, Ragini Kudchadkar, Natalie Miller, Adil Daud, Steven Fling, Philip Friedlander, Harriet Kluger, Holbrook Kohrt, Lisa Lundgren, Kim Margolin, Thomas Olencki, Sunil Reddy, Erica Shantha, William Sharfman, Elad Sharon, Michi Shinohara, John Thompson, Jennifer Yearley, Suzanne Topalian, Martin Cheever
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT096.
https://doi.org/10.1158/1538-7445.AM2016-CT096
Published: 15 July 2016
View article titled, Abstract CT096: Clinical activity, immune and viral correlates of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma
Journal Articles

Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity

Masaoki Kawasumi, James E. Bradner, Nicola Tolliday, Renee Thibodeau, Heather Sloan, Kay M. Brummond, Paul Nghiem
Journal: Cancer Research
Cancer Res (2014) 74 (24): 7534–7545.
https://doi.org/10.1158/0008-5472.CAN-14-2650
Published: 14 December 2014
View article titled, Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity
Open the PDF for Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity in another window
Includes: Supplementary data
Journal Articles

Abstract IA17: Merkel cell carcinoma therapy with viral oncoprotein-specific T cells in combination with immunostimulatory adjuvants.

Olga Afanasiev, Aude Chapuis, Jayasri Iyer, Kotaro Nagase, Kelly Paulson, Aaron Seo, Ivy Lai, Ilana Roberts, Erik Farrar, Joo Ha Hwang, Upendra Parvathaneni, David Koelle, Cassian Yee, Paul Nghiem
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): IA17.
https://doi.org/10.1158/1538-7445.TUMIMM2012-IA17
Published: 02 April 2014
View article titled, Abstract IA17: Merkel cell carcinoma therapy with viral oncoprotein-specific T cells in combination with immunostimulatory adjuvants.
Journal Articles

Abstract 569: Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice.

Jamie J. Bernard, You-Rong Lou, Sarah Peng, Tao Li, Paul Nghiem, Allan H. Conney, Yao-Ping Lu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 569.
https://doi.org/10.1158/1538-7445.AM2013-569
Published: 15 April 2013
View article titled, Abstract 569: Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice.
Journal Articles

Abstract LB-430: Anti-polyomavirus CTL targeting Merkel cell carcinoma combined with MHC class I upregulation induces tumor regression

Aude G. Chapuis, Olga Afanasiev, jayasri Iyer, Upendra Parvathaneni, Joo Ha Hwang, Ivy Lai, Ilana Roberts, Erik Farrar, David Koelle, Paul Nghiem, Cassian Yee
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-430.
https://doi.org/10.1158/1538-7445.AM2012-LB-430
Published: 15 April 2012
View article titled, Abstract LB-430: Anti-polyomavirus CTL targeting Merkel cell carcinoma combined with MHC class I upregulation induces tumor regression
Journal Articles

Abstract 1815: Stimulation of apoptosis by caffeine or exercise is associated with an increase in thymine dimer formation in the epidermis of UVB-treated SKH-1 mice

Yao-ping Lu, You-rong Lou, Qingyun Peng, Tao Li, Sherry Zhou, Paul Nghiem, Allan H. Conney
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1815.
https://doi.org/10.1158/1538-7445.AM2011-1815
Published: 15 April 2011
View article titled, Abstract 1815: Stimulation of apoptosis by caffeine or exercise is associated with an increase in thymine dimer formation in the epidermis of UVB-treated SKH-1 mice
Journal Articles

Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients

Kelly G. Paulson, Joseph J. Carter, Lisa G. Johnson, Kevin W. Cahill, Jayasri G. Iyer, David Schrama, Juergen C. Becker, Margaret M. Madeleine, Paul Nghiem, Denise A. Galloway
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8388–8397.
https://doi.org/10.1158/0008-5472.CAN-10-2128
Published: 31 October 2010
View article titled, Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients
Open the PDF for Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients in another window
Includes: Supplementary data
Journal Articles

Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice

Yao-Ping Lu, You-Rong Lou, Qing-Yun Peng, Jian-Guo Xie, Paul Nghiem, Allan H. Conney
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2523–2529.
https://doi.org/10.1158/0008-5472.CAN-07-5955
Published: 01 April 2008
View article titled, Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice
Open the PDF for Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice in another window
Journal Articles

Effect of oral or topical administration of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated SKH-1 mice

Yao-ping Lu, You Rong Lou, Qing Yun Peng, Jian Guo Xie, Paul Nghiem, Allan Conney
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3451.
Published: 01 May 2007
View article titled, Effect of oral or topical administration of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated SKH-1 mice