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Pau Castel
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Journal Articles

Abstract 3938: A novel mouse model reveals potential therapeutic strategies for RIT1-driven lung adenocarcinomas

Alessandro Mauro Mozzarelli, Antonio Cuevas-Navarro, Anatoly Urisman, Pau Castel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3938.
https://doi.org/10.1158/1538-7445.AM2024-3938
Published: 22 March 2024
View articletitled, Abstract 3938: A novel mouse model reveals potential therapeutic strategies for RIT1-driven lung adenocarcinomas
Journal Articles

Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer

Srushti Kittane, Erik Ladewig, Taibo Li, Jillian Love, Amaia Arruabarrena-Aristorena, Xinyu Guo, Mirna Sallaku, Liliana Garcia-Martinez, Ryan Blawski, Javier Carmona Sanz, Christopher Simpkins, Wanlu Chen, Bujamin Vokshi, Peihua Zhao, Nachiket Kelkar, Laura Baldino, Ingrid Kalemi, Pau Castel, Emiliano Cocco, Lluis Morey, Charles Sawyers, Hongkai Ji, Maurizio Scaltriti, Alexis Battle, Christina Leslie, Wouter Karthaus, Eneda Toska
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1245.
https://doi.org/10.1158/1538-7445.AM2024-1245
Published: 22 March 2024
View articletitled, Abstract 1245: The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer
Journal Articles

Abstract 1452: A PIK3CA-driven mouse model of metaplastic breast carcinoma to assess potential therapeutic strategies

Paola Roa, Valentina Foglizzo, Michelle R. de Marchena, Shraddha Chandthakuri, Emiliano Cocco, Pau Castel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM2024-1452
Published: 22 March 2024
View articletitled, Abstract 1452: A PIK3CA-driven mouse model of metaplastic breast carcinoma to assess potential therapeutic strategies
Journal Articles

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Erik Ladewig, Flavia Michelini, Komal Jhaveri, Pau Castel, Javier Carmona, Lauren Fairchild, Adler G. Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina Leslie, Maurizio Scaltriti, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2269–2280.
https://doi.org/10.1158/0008-5472.CAN-22-0446
Published: 15 June 2022
View articletitled, The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Open the PDF for The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation in another window
Includes: Supplementary data
Journal Articles

Abstract NG08: Oncoprotein duality in cancer and developmental syndromes: Lessons learned from RAS GTPases

Pau Castel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG08.
https://doi.org/10.1158/1538-7445.AM2021-NG08
Published: 01 July 2021
View articletitled, Abstract NG08: Oncoprotein duality in cancer and developmental syndromes: Lessons learned from RAS GTPases
Journal Articles

Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

Yanyan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Pau Castel, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S. Reis-Filho, Pedram Razavi, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2470–2480.
https://doi.org/10.1158/0008-5472.CAN-20-3232
Published: 01 May 2021
View articletitled, Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors
Open the PDF for Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract 5520: Oncogenic RTK signaling inhibits Spred1/NF1 to sustain constitutive Ras/MAPK signaling

Evan Markegard, Ellen L. Mercado, Pau Castel, Jillian Silva, Jacqueline Galeas, Kathy Li, Anatoly Urisman, Frank McCormick
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5520.
https://doi.org/10.1158/1538-7445.AM2018-5520
Published: 01 July 2018
View articletitled, Abstract 5520: Oncogenic RTK signaling inhibits Spred1/NF1 to sustain constitutive Ras/MAPK signaling
Journal Articles

Abstract 2107: PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition

Pau Castel, Haley Ellis, Ruzica Bago, Eneda Toska, Kannan Srinivasaraghavan, F Javier Carmona, Pedram Razavi, Chandra Verma, Maura Dickler, Sarat Chandarlapaty, Edi Brogi, Dario Alessi, José Baselga, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2107.
https://doi.org/10.1158/1538-7445.AM2016-2107
Published: 15 July 2016
View articletitled, Abstract 2107: PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition
Journal Articles

Abstract 885: Epigenetic regulation of estrogen receptor transcription by the PI3K pathway in breast cancer

Eneda Toska, Hatice Osmanbeyoglu, Moshe Elkabets, Carmen Chan, Pau Castel, Maura Dickler, Scott Armstrong, Christina Leslie, Maurizio Scaltriti, Baselga José
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 885.
https://doi.org/10.1158/1538-7445.AM2016-885
Published: 15 July 2016
View articletitled, Abstract 885: Epigenetic regulation of estrogen receptor transcription by the PI3K pathway in breast cancer
Journal Articles

Abstract 2868: Mechanisms of transcriptional regulation of FOXO3 by cofactors upon PI3K/AKT/mTOR inhibition

Vasilis Hristidis, James Cownie, Ana Bosch, Joanne Soong, Pau Castel, Maurizio Scaltriti, Baselga José
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2868.
https://doi.org/10.1158/1538-7445.AM2016-2868
Published: 15 July 2016
View articletitled, Abstract 2868: Mechanisms of transcriptional regulation of FOXO3 by cofactors upon PI3K/AKT/mTOR inhibition
Journal Articles

Abstract LB-327: Loss of PTEN leads to clinical resistance to the PI3Kα inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure

Pau Castel, Dejan Juric, Helen Won, Benjamin Ainscough, Haley Ellis, Saya Ebbesen, Malachi Griffith, Obi Griffith, Iyer Gopakumar, Dennis Sgroi, Steven Isakoff, Elaine Mardis, David Solit, Scott Lowe, Cornelia Quadt, Malte Peters, Michael Berger, Maurizio Scaltriti, José Baselga
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-327.
https://doi.org/10.1158/1538-7445.AM2014-LB-327
Published: 01 October 2014
View articletitled, Abstract LB-327: Loss of PTEN leads to clinical resistance to the PI3Kα inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure
Journal Articles

Abstract NG01: Blockade of EGFR and HER3 enhances PI3K/Akt antitumor activity in triple negative breast cancer

Maurizio Scaltriti, Jessica Tao, Pau Castel, Nina Radosevic-Robin, Moshe Elkabets, Neil Auricchio, Dejan Juric, Frédérique Penault-Llorca, Jose Baselga
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): NG01.
https://doi.org/10.1158/1538-7445.AM2014-NG01
Published: 01 October 2014
View articletitled, Abstract NG01: Blockade of EGFR and HER3 enhances PI3K/Akt antitumor activity in triple negative breast cancer
Journal Articles

Abstract 4471: Combined blockade of PI3K/AKT and EGFR/HER3 enhances antitumor activity in triple negative breast cancer.

Maurizio Scaltriti, Jessica Tao, Dejan Juric, Neil Auricchio, Pau Castel, Natasha Morse, Phillip Kim, Sharat Singh, Saswati Hazra, Todd Hembrough, Jon Burrows, Jose Baselga
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4471.
https://doi.org/10.1158/1538-7445.AM2013-4471
Published: 15 April 2013
View articletitled, Abstract 4471: Combined blockade of PI3K/AKT and EGFR/HER3 enhances antitumor activity in triple negative breast cancer.