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Patrizia Mancuso
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Journal Articles

Abstract 1712: A single-cell RNA atlas of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo- and immunotherapies

Laura Carpen, Paolo Falvo, Stefania Orecchioni, Giulia Mitola, Roman Hillje, Saveria Mazzara, Patrizia Mancuso, Stefano Pileri, Alessandro Raveane, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1712.
https://doi.org/10.1158/1538-7445.AM2022-1712
Published: 15 June 2022
View article titled, Abstract 1712: A single-cell RNA atlas of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo- and immunotherapies
Journal Articles

Abstract 1653: A single-cell atlas of the effect of chemotherapeutics over intratumoral immune cells reveals that combining an alkylating agent and a vinca alkaloid can activate antigen presenting cells and increase tcf1+ stem-like CD8+ T-cells, thus improving anti-PD-1 efficacy in triple negative breast cancer and lymphoma

Paolo Falvo, Stefania Orecchioni, Roman Hillje, Alessandro Raveane, Giulia Mitola, Patrizia Mancuso, Chiara Camisaschi, Lucilla Luzi, PierGiuseppe Pelicci, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1653.
https://doi.org/10.1158/1538-7445.AM2021-1653
Published: 01 July 2021
View article titled, Abstract 1653: A single-cell atlas of the effect of chemotherapeutics over intratumoral immune cells reveals that combining an alkylating agent and a vinca alkaloid can activate antigen presenting cells and increase tcf1+ stem-like CD8+ T-cells, thus improving anti-PD-1 efficacy in triple negative breast cancer and lymphoma
Journal Articles

Cyclophosphamide and Vinorelbine Activate Stem-Like CD8+ T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer

Paolo Falvo, Stefania Orecchioni, Roman Hillje, Alessandro Raveane, Patrizia Mancuso, Chiara Camisaschi, Lucilla Luzi, PierGiuseppe Pelicci, Francesco Bertolini
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (3): 685–697.
https://doi.org/10.1158/0008-5472.CAN-20-1818
Published: 01 February 2021
View article titled, Cyclophosphamide and Vinorelbine Activate Stem-Like CD8<sup>+</sup> T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Open the PDF for Cyclophosphamide and Vinorelbine Activate Stem-Like CD8<sup>+</sup> T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 900: Intermittent cyclophosphamide and vinorelbine reshape the immune cell environment, induce T cell clonal replacement and increase the efficacy of PD-1 inhibition in models of triple negative breast cancer

Paolo Falvo, Stefania Orecchioni, Roman Hillje, Alessandro Raveane, Patrizia Mancuso, Chiara Camisaschi, Lucilla Luzi, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 900.
https://doi.org/10.1158/1538-7445.AM2020-900
Published: 15 August 2020
View article titled, Abstract 900: Intermittent cyclophosphamide and vinorelbine reshape the immune cell environment, induce T cell clonal replacement and increase the efficacy of PD-1 inhibition in models of triple negative breast cancer
Journal Articles

Abstract 3948: The sequential administration of vinca alkaloids and intermittent cyclophosphamide primes antigen-presenting and NK cells and significantly improves in vivo efficacy of anti-PD-L1 in triple-negative breast cancer models

Stefania Orecchioni, Loredana Vecchi, Paolo Falvo, Lucilla Luzi, Patrizia Mancuso, Chiara Camisaschi, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3948.
https://doi.org/10.1158/1538-7445.AM2019-3948
Published: 01 July 2019
View article titled, Abstract 3948: The sequential administration of vinca alkaloids and intermittent cyclophosphamide primes antigen-presenting and NK cells and significantly improves in vivo efficacy of anti-PD-L1 in triple-negative breast cancer models
Journal Articles

Abstract 18: MMP9 inhibition in mouse models of breast cancer: Therapeutic synergy with vinorelbine-based chemotherapy

Francesca Reggiani, Loredana Vecchi, Valentina Labanca, Patrizia Mancuso, Amanda Mikels-Vigdal, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 18.
https://doi.org/10.1158/1538-7445.AM2018-18
Published: 01 July 2018
View article titled, Abstract 18: MMP9 inhibition in mouse models of breast cancer: Therapeutic synergy with vinorelbine-based chemotherapy
Journal Articles

Abstract 1017: Vinorelbine, cyclophosphamide, and 5-FU effects on the circulating and intratumoral landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma

Stefania Orecchioni, Giovanna Talarico, Valentina Labanca, Patrizia Mancuso, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1017.
https://doi.org/10.1158/1538-7445.AM2018-1017
Published: 01 July 2018
View article titled, Abstract 1017: Vinorelbine, cyclophosphamide, and 5-FU effects on the circulating and intratumoral landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma
Journal Articles

Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression

Francesca Reggiani, Valentina Labanca, Patrizia Mancuso, Cristina Rabascio, Giovanna Talarico, Stefania Orecchioni, Andrea Manconi, Francesco Bertolini
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (18): 5169–5182.
https://doi.org/10.1158/0008-5472.CAN-17-0914
Published: 14 September 2017
View article titled, Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression
Open the PDF for Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 5919: Identification of a novel molecular interaction, targeted by Metformin, between breast cancer and white adipose tissue progenitors

Francesca Reggiani, Valentina Labanca, Patrizia Mancuso, Andrea Manconi, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5919.
https://doi.org/10.1158/1538-7445.AM2017-5919
Published: 01 July 2017
View article titled, Abstract 5919: Identification of a novel molecular interaction, targeted by Metformin, between breast cancer and white adipose tissue progenitors
Journal Articles

Abstract 2620: Selecting the right chemotherapy partner for checkpoint inhibitors: an in vivo comparison of different drugs and dosages

Stefania Orecchioni, Giovanna Talarico, Valentina Labanca, Patrizia Mancuso, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2620.
https://doi.org/10.1158/1538-7445.AM2017-2620
Published: 01 July 2017
View article titled, Abstract 2620: Selecting the right chemotherapy partner for checkpoint inhibitors: an <em>in vivo</em> comparison of different drugs and dosages
Journal Articles

Abstract 2635: Baseline myeloid-derived suppressor cell and eosinophil cell counts predict clinical efficacy in patients with non-small cell lung cancer (NSCLC) treated with nivolumab in second line

Patrizia Mancuso, Antonio Passaro, Valentina Labanca, Sara Gandini, Gianluca Spitaleri, Elena Guerini, Massimo Barberis, Cristina Noberasco, Ester del Signore, Alessia Pochesci, Chiara Catania, Filippo De Marinis, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2635.
https://doi.org/10.1158/1538-7445.AM2017-2635
Published: 01 July 2017
View article titled, Abstract 2635: Baseline myeloid-derived suppressor cell and eosinophil cell counts predict clinical efficacy in patients with non-small cell lung cancer (NSCLC) treated with nivolumab in second line
Journal Articles

Abstract 3374: GM-CSF and MMP9 are key regulators of the effect of adipose progenitor cells over breast cancer onset and metastatic progression in obesity

Francesca Reggiani, Valentina Labanca, Giovanna Talarico, Stefania Orecchioni, Patrizia Mancuso, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3374.
https://doi.org/10.1158/1538-7445.AM2016-3374
Published: 15 July 2016
View article titled, Abstract 3374: GM-CSF and MMP9 are key regulators of the effect of adipose progenitor cells over breast cancer onset and metastatic progression in obesity
Journal Articles

Abstract 4003: Metformin reduces intratumoral CD8+PD-1+ and Treg lymphocytes in orthotopic models of breast cancer and lymphoma, and has paradoxic effects on anti-PD-L1 treatment

Stefania Orecchioni, Giovanna Talarico, Patrizia Mancuso, Valentina Labanca, Francesca Reggiani, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4003.
https://doi.org/10.1158/1538-7445.AM2016-4003
Published: 15 July 2016
View article titled, Abstract 4003: Metformin reduces intratumoral CD8+PD-1+ and Treg lymphocytes in orthotopic models of breast cancer and lymphoma, and has paradoxic effects on anti-PD-L1 treatment
Journal Articles

Abstract 5214: Synergistic activity of aspirin, atenolol and metformin in the inhibition of angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

Giovanna Talarico, Francesca Reggiani, Stefania Orecchioni, Patrizia Mancuso, Angelica Calleri, Giuliana Gregato, Valentina Labanca, Douglas M. Noonan, Katiuscia Dallaglio, Adriana Albini, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5214.
https://doi.org/10.1158/1538-7445.AM2015-5214
Published: 01 August 2015
View article titled, Abstract 5214: Synergistic activity of aspirin, atenolol and metformin in the inhibition of angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells
Journal Articles

Abstract 5212: GM-CSF and MMP9, targets of metformin, are crucial mediators of the tumor-promoting role of adipose tissue cells in breast cancer

Francesca Reggiani, Patrizia Mancuso, Cristina Rabascio, Stefania Orecchioni, Giovanna Talarico, Cinzia Massaro, Valentina Labanca, Angelica Calleri, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5212.
https://doi.org/10.1158/1538-7445.AM2015-5212
Published: 01 August 2015
View article titled, Abstract 5212: GM-CSF and MMP9, targets of metformin, are crucial mediators of the tumor-promoting role of adipose tissue cells in breast cancer
Journal Articles

Abstract 1011: Metformin inhibits angiogenesis, local and metastatic growth of triple-negative breast cancer by targeting two classes of adipose tissue progenitors

Stefania Orecchioni, Giuliana Gregato, Francesca Reggiani, Patrizia Mancuso, Angelica Calleri, Giovanna Talarico, Valentina Labanca, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1011.
https://doi.org/10.1158/1538-7445.AM2014-1011
Published: 01 October 2014
View article titled, Abstract 1011: Metformin inhibits angiogenesis, local and metastatic growth of triple-negative breast cancer by targeting two classes of adipose tissue progenitors
Journal Articles

Complementary Populations of Human Adipose CD34+ Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer

Stefania Orecchioni, Giuliana Gregato, Ines Martin-Padura, Francesca Reggiani, Paola Braidotti, Patrizia Mancuso, Angelica Calleri, Jessica Quarna, Paola Marighetti, Chiara Aldeni, Giancarlo Pruneri, Stefano Martella, Andrea Manconi, Jean-Yves Petit, Mario Rietjens, Francesco Bertolini
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (19): 5880–5891.
https://doi.org/10.1158/0008-5472.CAN-13-0821
Published: 01 October 2013
View article titled, Complementary Populations of Human Adipose CD34<sup>+</sup> Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer
Open the PDF for Complementary Populations of Human Adipose CD34<sup>+</sup> Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2311: Two complementary populations of human adipose tissue CD34+ progenitors promote breast cancer angiogenesis, growth, and metastases.

Stefania Orecchioni, Giuliana Gregato, Ines Martin-Padura, Patrizia Mancuso, Angelica Calleri, Chiara Corsini, Stefano Martella, Jean-Yves Petit, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2311.
https://doi.org/10.1158/1538-7445.AM2013-2311
Published: 15 April 2013
View article titled, Abstract 2311: Two complementary populations of human adipose tissue CD34+ progenitors promote breast cancer angiogenesis, growth, and metastases.
Journal Articles

Abstract 1019: CD34+ progenitors resident in the human white adipose tissue promote tumor angiogenesis, growth and metastases in orthotopic models of breast cancer

Ines Martin-Padura, Giuliana Gregato, Paola Marighetti, Patrizia Mancuso, Angelica Calleri, Chiara Corsini, Visnu Lohririwat, Jean-Yves Petit, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1019.
https://doi.org/10.1158/1538-7445.AM2012-1019
Published: 15 April 2012
View article titled, Abstract 1019: CD34+ progenitors resident in the human white adipose tissue promote tumor angiogenesis, growth and metastases in orthotopic models of breast cancer
Journal Articles

Abstract 1383: High levels of CD109+ circulating endothelial cells and progenitors as marker of response to bevacizumab and irinotecan in high grade gliomas

Lucia Cuppini, Serena Pellegatta, Angelica Calleri, Maria Grazia Bruzzone, Elena Prodi, Elena Anghileri, Patrizia Mancuso, Francesco Bertolini, Gaetano Finocchiaro, Marica Eoli
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1383.
https://doi.org/10.1158/1538-7445.AM2012-1383
Published: 15 April 2012
View article titled, Abstract 1383: High levels of CD109+ circulating endothelial cells and progenitors as marker of response to bevacizumab and irinotecan in high grade gliomas