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Patrick M. O’Connor
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Journal Articles

A p21Waf1/Cip1 Carboxyl-terminal Peptide Exhibited Cyclin-dependent Kinase-inhibitory Activity and Cytotoxicity When Introduced into Human Cells

Masato Mutoh, Feng-Di T. Lung, Ya-Qiu Long, Peter P. Roller, Robert S. Sikorski, Patrick M. O’Connor
Journal: Cancer Research
Cancer Res (1999) 59 (14): 3480–3488.
Published: 15 July 1999
View articletitled, A p21Waf1/Cip1 Carboxyl-terminal Peptide Exhibited Cyclin-dependent Kinase-inhibitory Activity and Cytotoxicity When Introduced into Human Cells
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Journal Articles

Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents

Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy G. Myers, Saijun Fan, Masato Mutoh, Dominic A. Scudiero, Ann Monks, Edward A. Sausville, John N. Weinstein, Stephen Friend, Albert J. Fornace, Jr., Kurt W. Kohn
Journal: Cancer Research
Cancer Res (1997) 57 (19): 4285–4300.
Published: 01 October 1997
View articletitled, Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents
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Journal Articles

Abrogation of an S-Phase Checkpoint and Potentiation of Camptothecin Cytotoxicity by 7-Hydroxystaurosporine (UCN-01) in Human Cancer Cell Lines, Possibly Influenced by p53 Function

Rong-Guang Shao, Chun-Xia Cao, Tsunehiro Shimizu, Patrick M. O'Connor, Kurt W. Kohn, Yves Pommier
Journal: Cancer Research
Cancer Res (1997) 57 (18): 4029–4035.
Published: 01 September 1997
View articletitled, Abrogation of an S-Phase Checkpoint and Potentiation of Camptothecin Cytotoxicity by 7-Hydroxystaurosporine (UCN-01) in Human Cancer Cell Lines, Possibly Influenced by p53 Function
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Journal Articles

Correlations between S and G2 Arrest and the Cytotoxicity of Camptothecin in Human Colon Carcinoma Cells

François Goldwasser, Tsunehiro Shimizu, Joany Jackman, Yuko Hoki, Patrick M. O'Connor, Kurt W. Kohn, Yves Pommier
Journal: Cancer Research
Cancer Res (1996) 56 (19): 4430–4437.
Published: 01 October 1996
View articletitled, Correlations between S and G2 Arrest and the Cytotoxicity of Camptothecin in Human Colon Carcinoma Cells
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Journal Articles

An Abnormality in the p53 Pathway following γ-Irradiation in Many Wild-Type p53 Human Melanoma Lines

Insoo Bae, Martin L. Smith, M. Saeed Sheikh, Qimin Zhan, Dominic A. Scudiero, Stephen H. Friend, Patrick M. O'Connor, Albert J. Fornace, Jr.
Journal: Cancer Research
Cancer Res (1996) 56 (4): 840–847.
Published: 01 February 1996
View articletitled, An Abnormality in the p53 Pathway following γ-Irradiation in Many Wild-Type p53 Human Melanoma Lines
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Journal Articles

Relationships between G1 Arrest and Stability of the p53 and p21Cip1/Waf1 Proteins following γ-Irradiation of Human Lymphoma Cells

Insoo Bae, Saijun Fan, Kishor Bhatia, Kurt W. Kohn, Albert J. Fornace, Jr., Patrick M. O'Connor
Journal: Cancer Research
Cancer Res (1995) 55 (11): 2387–2393.
Published: 01 June 1995
View articletitled, Relationships between G1 Arrest and Stability of the p53 and p21Cip1/Waf1 Proteins following γ-Irradiation of Human Lymphoma Cells
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Journal Articles

Disruption of p53 Function Sensitizes Breast Cancer MCF-7 Cells to Cisplatin and Pentoxifylline

Saijun Fan, Martin L. Smith, Dennis J. Rivert, II, Diane Duba, Qimin Zhan, Kurt W. Kohn, Albert J. Fornace, Jr., Patrick M. O'Connor
Journal: Cancer Research
Cancer Res (1995) 55 (8): 1649–1654.
Published: 01 April 1995
View articletitled, Disruption of p53 Function Sensitizes Breast Cancer MCF-7 Cells to Cisplatin and Pentoxifylline
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Journal Articles

A Mutant p21 Cyclin-dependent Kinase Inhibitor Isolated from a Burkitt's Lymphoma

Kishor Bhatia, Saijun Fan, Gordon Spangler, Michael Weintraub, Patrick M. O'Connor, Jean-Gabriel Judde, Ian Magrath
Journal: Cancer Research
Cancer Res (1995) 55 (7): 1431–1435.
Published: 01 April 1995
View articletitled, A Mutant p21 Cyclin-dependent Kinase Inhibitor Isolated from a Burkitt's Lymphoma
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Journal Articles

Unscheduled Activation of Cyclin B1/Cdc2 Kinase in Human Promyelocytic Leukemia Cell Line HL60 Cells Undergoing Apoptosis Induced by DNA Damage

Tsunehiro Shimizu, Patrick M. O'Connor, Kurt W. Kohn, Yves Pommier
Journal: Cancer Research
Cancer Res (1995) 55 (2): 228–231.
Published: 01 January 1995
View articletitled, Unscheduled Activation of Cyclin B1/Cdc2 Kinase in Human Promyelocytic Leukemia Cell Line HL60 Cells Undergoing Apoptosis Induced by DNA Damage
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Journal Articles

p53 Gene Mutations Are Associated with Decreased Sensitivity of Human Lymphoma Cells to DNA Damaging Agents

Saijun Fan, Wafik S. El-Deiry, Insoo Bae, Jim Freeman, Daniel Jondle, Kishor Bhatia, Albert J. Fornace, Jr., Ian Magrath, Kurt W. Kohn, Patrick M. O'Connor
Journal: Cancer Research
Cancer Res (1994) 54 (22): 5824–5830.
Published: 01 November 1994
View articletitled, p53 Gene Mutations Are Associated with Decreased Sensitivity of Human Lymphoma Cells to DNA Damaging Agents
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Journal Articles

WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis

Wafik S. El-Deiry, J. Wade Harper, Patrick M. O'Connor, Victor E. Velculescu, Christine E. Canman, Joany Jackman, Jennifer A. Pietenpol, Marilee Burrell, David E. Hill, Yisong Wang, Klas G. Wiman, W. Edward Mercer, Michael B. Kastan, Kurt W. Kohn, Stephen J. Elledge, Kenneth W. Kinzler, Bert Vogelstein
Journal: Cancer Research
Cancer Res (1994) 54 (5): 1169–1174.
Published: 01 March 1994
View articletitled, WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis
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Journal Articles

Role of the p53 Tumor Suppressor Gene in Cell Cycle Arrest and Radiosensitivity of Burkitt's Lymphoma Cell Lines

Patrick M. O'Connor, Joany Jackman, Daniel Jondle, Kishor Bhatia, Ian Magrath, Kurt W. Kohn
Journal: Cancer Research
Cancer Res (1993) 53 (20): 4776–4780.
Published: 01 October 1993
View articletitled, Role of the p53 Tumor Suppressor Gene in Cell Cycle Arrest and Radiosensitivity of Burkitt's Lymphoma Cell Lines
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Journal Articles

Relationship between DNA Cross-Links, Cell Cycle, and Apoptosis in Burkitt's Lymphoma Cell Lines Differing in Sensitivity to Nitrogen Mustard

Patrick M. O'Connor, Karsten Wassermann, Monica Sarang, Ian Magrath, Vilhelm A. Bohr, Kurt W. Kohn
Journal: Cancer Research
Cancer Res (1991) 51 (24): 6550–6557.
Published: 01 December 1991
View articletitled, Relationship between DNA Cross-Links, Cell Cycle, and Apoptosis in Burkitt's Lymphoma Cell Lines Differing in Sensitivity to Nitrogen Mustard
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