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Journal Articles

Chromatin Remodelers Are Regulators of the Tumor Immune Microenvironment

Apoorvi Chaudhri, Gregory Lizee, Patrick Hwu, Kunal Rai
Journal: Cancer Research
Cancer Res (2024) 84 (7): 965–976.
https://doi.org/10.1158/0008-5472.CAN-23-2244
Published: 01 April 2024
View article titled, Chromatin Remodelers Are Regulators of the Tumor Immune Microenvironment
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Includes: Supplementary data
Journal Articles

Abstract 3886: Analysis of clonal heterogeneity within paired primary and metastatic tumor samples of patients with solid tumors and implications for neoantigen-based personalized cancer vaccines

Alyssa Obermayer, Timothy Shaw, Darwin Chang, Joshua Davis, Jamie K. Teer, Xiaoqing Yu, Xuefeng Wang, Dale Hedges, Aik Choon Tan, Robert Rounbehler, Abdul Rafeh Naqash, Margaret Gatti-Mays, Aakrosh Ratan, Martin McCarter, Howard Colman, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, William Dalton, George Weiner, Jose Conejo-Garcia, Paulo C. Rodriguez, Bodour Salhia, Ahmad A. Tarhini
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3886.
https://doi.org/10.1158/1538-7445.AM2024-3886
Published: 22 March 2024
View article titled, Abstract 3886: Analysis of clonal heterogeneity within paired primary and metastatic tumor samples of patients with solid tumors and implications for neoantigen-based personalized cancer vaccines
Journal Articles

Abstract 3605: Phase II study of pembrolizumab in conjunction with lymphodepletion, TIL ACT, and high- or low-dose IL-2 in patients with metastatic melanoma

Merve Hasanov, Simin Kiany, Marie-Andrée Forget, Roland L. Bassett, Michael A. Davies, Adi Diab, Jeffrey E. Gershenwald, Isabella C. Glitza, Jeffrey E. Lee, Anthony Lucci, Jennifer L. McQuade, Sapna P. Patel, Merrick I. Ross, Hussein A. Tawbi, Jennifer Wargo, Michael K. Wong, Chantale Bernatchez, Patrick Hwu, Cara Haymaker, Rodabe N. Amaria
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3605.
https://doi.org/10.1158/1538-7445.AM2024-3605
Published: 22 March 2024
View article titled, Abstract 3605: Phase II study of pembrolizumab in conjunction with lymphodepletion, TIL ACT, and high- or low-dose IL-2 in patients with metastatic melanoma
Journal Articles

Abstract 71: Differential infiltration of key immune cell populations across malignancies varying by immunogenic potential and likelihood of response to immunotherapy

Ahmad A. Tarhini, Islam Eljilany, Sam Coleman, Dale J. Hedges, Martin McCarter, John Carpten, Howard Colman, Abdul Rafeh Naqash, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, William S. Dalton, George J. Weiner, Aik Choon Tan, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 71.
https://doi.org/10.1158/1538-7445.AM2024-71
Published: 22 March 2024
View article titled, Abstract 71: Differential infiltration of key immune cell populations across malignancies varying by immunogenic potential and likelihood of response to immunotherapy
Journal Articles

Abstract 6425: Functional roles of enhancers in immune microenvironment & immunotherapy response

Kunal Rai, Mayinuer Maitituoheti, Alvin Shi, Ming Tang, Li-Lun Ho, Firas Youssef Kreidieh, Christopher Terranova, Kyriakitsa Galani, Emily Z. Keung, Caitlin A. Creasy, Manrong Wu, Jiajia Chen, Nana Chen, Anand K. Singh, Apoorvi Chaudhri, Nazanin E. Anvar, Giuseppe Tarrantino, Jiekun Yang, Sharmistha Sarkar, Shan Jiang, Jared Malke, Lauren Haydu, Elizabeth Burton, Michael A. Davies, Jeffrey E. Gershenwald, Patrick Hwu, Alexander Lazar, Jaime H. Cheah, Christian K. Soule, Stuart S. Levine, Chantale Bernatchez, Srinivas V. Saladi, David Liu, Hussein Tawbi, Jennifer Wargo, Genevieve M. Boland, Manolis Kellis
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6425.
https://doi.org/10.1158/1538-7445.AM2023-6425
Published: 04 April 2023
View article titled, Abstract 6425: Functional roles of enhancers in immune microenvironment & immunotherapy response
Journal Articles

Abstract 1836: Combining a novel retinoic acid receptor-γ agonist with immune checkpoint blockade represses lung cancer growth in vivo

Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Zibo Chen, Mi Shi, Vidyasagar Vuligonda, Martin Sanders, Serguei Kozlov, King Chan, Amir Horowitz, Mary Carrington, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1836.
https://doi.org/10.1158/1538-7445.AM2023-1836
Published: 04 April 2023
View article titled, Abstract 1836: Combining a novel retinoic acid receptor-γ agonist with immune checkpoint blockade represses lung cancer growth <em>in vivo</em>
Journal Articles

Abstract 5704: An integrated immune signature predictive of adjuvant immunotherapeutic benefits for high-risk melanoma

Alyssa N. Obermayer, Timothy I. Shaw, Sandra J. Lee, F. Stephen Hodi, William A. LaFramboise, Walter Storkus, Arivarasan D. Karunamurthy, Patrick Hwu, Howard Streicher, Dung-Tsa Chen, John M. Kirkwood, Ahmad A. Tarhini
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5704.
https://doi.org/10.1158/1538-7445.AM2023-5704
Published: 04 April 2023
View article titled, Abstract 5704: An integrated immune signature predictive of adjuvant immunotherapeutic benefits for high-risk melanoma
Journal Articles

Abstract 5703: The immune cell state atlas analysis predicts therapeutic benefits with immune checkpoint inhibitors

Tingyi Li, Vineeth Sukrithan, Aakrosh Ratan, Martin McCarter, John Carpten, Howard Colman, Alexandra P. Ikeguchi, Igor Puzanov, Susanne Arnold, Michelle Churchman, Patrick Hwu, Paulo C. Rodriguez, William S. Dalton, George J. Weiner, Ahmad Tarhini, Xuefeng Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5703.
https://doi.org/10.1158/1538-7445.AM2023-5703
Published: 04 April 2023
View article titled, Abstract 5703: The immune cell state atlas analysis predicts therapeutic benefits with immune checkpoint inhibitors
Journal Articles

Abstract CT039: Intratumoral CD40 agonist sotigalimab with pembrolizumab induces broad innate and adaptive immune activation in local and distant tumors in metastatic melanoma

Salah-Eddine Bentebibel, Daniel Johnson, Rodabe Amariae, Daniel McGrail, Srisuda Lecagoonporn, Cara Haymaker, Dzifa Duose, Khalida Wani, Houssein Safa, Isabella Claudia Glitza, Sapna Pradyuman Patel, Michael K. Wong, Hussein Tawbi, Jared Burks, Xiaodong Yang, Patrick Hwu, Cassian Yee, Michael A. Davies, Ravi Murthy, Chantale Bernatchez, Suhendan Ekmekcioglu, Adi Diab, Gregory Lizée
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT039.
https://doi.org/10.1158/1538-7445.AM2022-CT039
Published: 15 June 2022
View article titled, Abstract CT039: Intratumoral CD40 agonist sotigalimab with pembrolizumab induces broad innate and adaptive immune activation in local and distant tumors in metastatic melanoma
Journal Articles

Abstract 5545: Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Yifan Zhou, Yusra B. Medik, Bhakti Patel, Daniel B. Zamler, Sijie Chen, Thomas Chapman, Sarah Schneider, Rachel L. Babcock, Taylor T. Chrisikos, Laura M. Kahn, Allison M. Dyevoich, Elizabeth M. Park, Alexandria P. Cogdill, Daniel H. Johnson, Sarah B. Johnson, Khalida M. Wani, Debora A. Ledesma, Courtney W. Hudgens, Jingjing Wang, Md Abdul Wadud Khan, Aron Y. Joon, Weiyi Peng, Haiyan S. Li, Reetakshi Arora, Ximing Tang, Maria Gabriela Raso, Xuegong Zhang, Wai Chin Foo, Michael T. Tetzlaff, Gretchen E. Diehl, Karen Clise-Dwyer, Elizabeth M. Whitley, Matthew M. Gubin, James P. Allison, Patrick Hwu, Nadim J. Ajami, Adi Diab, Jennifer A. Wargo, Stephanie S. Watowich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5545.
https://doi.org/10.1158/1538-7445.AM2022-5545
Published: 15 June 2022
View article titled, Abstract 5545: Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration
Journal Articles

Abstract 3183: Adrenergic signaling augments cytotoxic T-cell anti-tumor function in p53-deficient head and neck cancer

Deborah Silverman, Sara Leahey, Shamima Akhter, Tongxin Xie, Yunfei Wang, Elien Doordjuin, George Calin, Jeffrey Myers, Patrick Hwu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3183.
https://doi.org/10.1158/1538-7445.AM2021-3183
Published: 01 July 2021
View article titled, Abstract 3183: Adrenergic signaling augments cytotoxic T-cell anti-tumor function in p53-deficient head and neck cancer
Journal Articles

Abstract 1599: SMARCA4 regulates tumor resistance to anti-tumor immune response

Apoorvi Chaudhri, Yunfei Wang, Leilei Shi, Kunal Rai, Patrick Hwu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1599.
https://doi.org/10.1158/1538-7445.AM2021-1599
Published: 01 July 2021
View article titled, Abstract 1599: SMARCA4 regulates tumor resistance to anti-tumor immune response
Journal Articles

Abstract 1575: The landscape of tumor intrinsic immune regulators revealed by genome-wide CRISPR immune screen integrated with comprehensive clinical data analysis

Jiakai Hou, Yunfei Wang, Leilei Shi, Yuan Chen, Chunyu Xu, Arash Saeedi, Ke Pan, Ritu Bohat, Nicholas A. Egan, Jodi A. McKenzie, Rina M. Mbofung, Leila J. Williams, Zhenghuang Yang, Ming Sun, Xiaofang Liang, Jordi Rodon Ahnert, Navin Varadarajan, Cassian Yee, Yiwen Chen, Patrick Hwu, Weiyi Peng
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1575.
https://doi.org/10.1158/1538-7445.AM2021-1575
Published: 01 July 2021
View article titled, Abstract 1575: The landscape of tumor intrinsic immune regulators revealed by genome-wide CRISPR immune screen integrated with comprehensive clinical data analysis
Journal Articles

Abstract A09: Characteristics of uveal melanoma patients with central nervous system metastases

Sapna P. Patel, Patrick Hwu, Michael Davies, Michael Wong, Hussein Tawbi, Rodabe Amaria, Adi Diab, Dan Gombos, Isabella C. Glitza
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): A09.
https://doi.org/10.1158/1538-7445.MEL2019-A09
Published: 02 October 2020
View article titled, Abstract A09: Characteristics of uveal melanoma patients with central nervous system metastases
Journal Articles

Abstract PR03: Nongenomic BAP1 aberrancy drives highly aggressive cutaneous melanoma phenotype

Haifeng Zhu, Junna Oba, Xiaoxing Yu, Caitlin A. Creasy, Marie-Andrée Forget, Fernando Carapeto, Cara L. Haymaker, Chang-Jiun Wu, Tatiana V. Karpinets, Wei-Lien Wang, Michael T. Tetzlaff, Alexander J. Lazar, Gordon B. Mills, Amanda R. Moore, Yu Chen, Jianhua Zhang, Jeffrey E. Gershenwald, Jennifer A. Wargo, Chantale Bernatchez, Patrick Hwu, P. Andrew Futreal, Scott E. Woodman
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR03.
https://doi.org/10.1158/1538-7445.MEL2019-PR03
Published: 02 October 2020
View article titled, Abstract PR03: Nongenomic BAP1 aberrancy drives highly aggressive cutaneous melanoma phenotype
Journal Articles

Abstract PR15: CD74 regulated inflammatory pattern is associated with TIL growth and favorable response to adoptive immunotherapy

Dai-Ogata, Caitlin A. Creasy, Sun-Hee Kim, Jason Roszik, Patrick Hwu, Elizabeth A. Grimm, Chantale Bernatchez, Suhendan Ekmekcioglu
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR15.
https://doi.org/10.1158/1538-7445.MEL2019-PR15
Published: 02 October 2020
View article titled, Abstract PR15: CD74 regulated inflammatory pattern is associated with TIL growth and favorable response to adoptive immunotherapy
Journal Articles

Abstract A13: Clinical characteristics of responders to nivolumab plus ipilimumab (Nivo/Ipi) in metastatic uveal melanoma

Michael Paul Shephard, Maura Glover, Gener Balmes, Suzanne Cain, Anna Vardeleon, Rosalind Mouton, Liberty Posada, Rinata Simien, Patrick Hwu, Michael Davies, Cassian Yee, Michael Wong, Hussein Tawbi, Scott Woodman, Rodabe Amaria, Adi Diab, Isabella Glitza, Wen-Jen Hwu, Sapna Patel
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): A13.
https://doi.org/10.1158/1538-7445.MEL2019-A13
Published: 02 October 2020
View article titled, Abstract A13: Clinical characteristics of responders to nivolumab plus ipilimumab (Nivo/Ipi) in metastatic uveal melanoma
Journal Articles

Abstract 941: B cells are required to generate optimal antitumor immunity in response to PD-1 blockade treatment

Shubhra Singh, Karishma Bavisi, Jason Roszik, Adi Diab, Richard E. Davis, Patrick Hwu, Willem W. Overwijk, Manisha Singh
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 941.
https://doi.org/10.1158/1538-7445.AM2019-941
Published: 01 July 2019
View article titled, Abstract 941: B cells are required to generate optimal antitumor immunity in response to PD-1 blockade treatment
Journal Articles

Abstract 1493: Therapeutic efficacy and tolerability of combined immune checkpoint blockade in metastatic melanoma patients is influenced by the gut microbiome

Vancheswaran Gopalakrishnan, Miles Andrews, Wei-Shen Chen, Christine Spencer, Luis Vence, Alexandre Reuben, Zachary A. Cooper, Peter A. Prieto, Michael T. Tetzlaff, MA Abdul Wadud Khan, Alexander Lazar, Courtney W. Hudgens, Lauren E. Haydu, Hussein A. Tawbi, Patrick Hwu, Wen-Jen Hwu, Rodabe N. Amaria, Elizabeth M. Burton, Scottt E. Woodman, Adi Diab, Sapna P. Patel, Isabella C. Glitza, Jianhua Zhang, Joseph Petrosino, Robert R. Jenq, Michael A. Davies, Jeffrey E. Gershenwald, Padmanee Sharma, James P. Allison, Andrew Futreal, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1493.
https://doi.org/10.1158/1538-7445.AM2019-1493
Published: 01 July 2019
View article titled, Abstract 1493: Therapeutic efficacy and tolerability of combined immune checkpoint blockade in metastatic melanoma patients is influenced by the gut microbiome
Journal Articles

Abstract 3776: Spatially resolved immunogenomic analyses reveal diverse sub tumoral microenvironments in the context of melanoma immunotherapy

Akash Mitra, Miles C. Andrews, Whijae Roh, Mariana P. de Macedo, Alexandre Reuben, Fernando Carapeto, Feng Wang, Sangeetha M. Reddy, Khalida Wani, Christine Spencer, John Miller, Aislyn Schalck, Latasha D. Little, Donald A. Sakellariou-Thompson, Curtis Gumbs, Wen-Jen Hwu, Chantale Bernatchez, Jianhua Zhang, Patrick Hwu, Nicholas Navin, Padmanee Sharma, James P. Allison, Jennifer Wargo, Alexander J. Lazar, Philip A. Futreal
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3776.
https://doi.org/10.1158/1538-7445.AM2019-3776
Published: 01 July 2019
View article titled, Abstract 3776: Spatially resolved immunogenomic analyses reveal diverse sub tumoral microenvironments in the context of melanoma immunotherapy