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Patrick C. Ma
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Journal Articles

SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma

Utsav Sen, Charles Coleman, Nishant Gandhi, Vrinda Jethalia, Deniz Demircioglu, Andrew Elliott, Ari M. Vanderwalde, Omar Hayatt, Elisa de Stanchina, Balazs Halmos, Patrick C. Ma, Mirela Berisa, Dan Hasson, Triparna Sen
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2745
Published: 08 April 2025
View articletitled, SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma
Open the PDF for SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5201: Characterization of PDLIM2 in non-small cell lung cancer

Karam Ashouri, Harris Krause, Andrew Elliott, Stephen V. Liu, Patrick C. Ma, Balazs Halmos, Zhaoxia Qu, Gutian Xiao, Ari Vanderwalde, Jorge J. Nieva
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5201.
https://doi.org/10.1158/1538-7445.AM2024-5201
Published: 22 March 2024
View articletitled, Abstract 5201: Characterization of PDLIM2 in non-small cell lung cancer
Journal Articles

Abstract 1213: Tissue-specific thresholds and microenvironment correlates of tumor mutation burden associated with immunotherapy benefit and prognosis in microsatellite stable cancers

Maishara Muquith, Magdalena Espinoza, Andrew Elliott, Joanne Xiu, Andreas Seeber, Wafik El-Deiry, Emmanuel S. Antonarakis, Stephanie Graff, Michael J. Hall, Hossein Borghaei, Dave S. Hoon, Stephen V. Liu, Patrick C. Ma, Rana R. McKay, Trisha Wise-Draper, John Marshall, George W. Sledge, David Spetzler, Hao Zhu, David Hsieh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1213.
https://doi.org/10.1158/1538-7445.AM2024-1213
Published: 22 March 2024
View articletitled, Abstract 1213: Tissue-specific thresholds and microenvironment correlates of tumor mutation burden associated with immunotherapy benefit and prognosis in microsatellite stable cancers
Journal Articles

Abstract 4119: Genomic and immune characteristics of EGFR subtypes in non-small cell lung cancer (NSCLC)

J. Nicholas Bodor, Joanne Xiu, Vinicius Ernani, Supreet Kaur, Hirva Mamdani, Pavel Brodskiy, Sai-Hong I. Ou, Patrick C. Ma, Margie L. Clapper, W. Michael Korn, Joseph Treat
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4119.
https://doi.org/10.1158/1538-7445.AM2022-4119
Published: 15 June 2022
View articletitled, Abstract 4119: Genomic and immune characteristics of EGFR subtypes in non-small cell lung cancer (NSCLC)
Journal Articles

Y Chromosome LncRNA Are Involved in Radiation Response of Male Non–Small Cell Lung Cancer Cells

Tayvia Brownmiller, Jamie A. Juric, Abby D. Ivey, Brandon M. Harvey, Emily S. Westemeier, Michael T. Winters, Alyson M. Stevens, Alana N. Stanley, Karen E. Hayes, Samuel A. Sprowls, Amanda S. Gatesman Ammer, Mackenzee Walker, Erik A. Bey, Xiaoliang Wu, Zuan-Fu Lim, Lin Zhu, Sijin Wen, Gangqing Hu, Patrick C. Ma, Ivan Martinez
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (19): 4046–4057.
https://doi.org/10.1158/0008-5472.CAN-19-4032
Published: 02 October 2020
View articletitled, Y Chromosome LncRNA Are Involved in Radiation Response of Male Non–Small Cell Lung Cancer Cells
Open the PDF for Y Chromosome LncRNA Are Involved in Radiation Response of Male Non–Small Cell Lung Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract CT113: Safety and activity of second-line durvalumab + tremelimumab in non-squamous advanced NSCLC

Jamie Chaft, Byoung Chul Cho, Myung-Ju Ahn, Sylvestre Le Moulec, Eun Kyung Cho, Vassiliki Papadimitrakopoulou, Edward Garon, Sylvia Lee, Santiago Ponce Aix, Patrick C. Ma, Gregory Otterson, Rajesh Narwal, Guozhi Gao, Jennifer McDevitt, Judson Englert, Scott Antonia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT113.
https://doi.org/10.1158/1538-7445.AM2018-CT113
Published: 01 July 2018
View articletitled, Abstract CT113: Safety and activity of second-line durvalumab + tremelimumab in non-squamous advanced NSCLC
Journal Articles

Abstract 3874: Mass spectrometry imaging determines biomarkers of early adaptive precision drug resistance in lung cancer

Erin H. Seeley, Pamela S. Cantrell, Callee M. Walsh, Sijin Wen, Satoshi Komo, Xiaoliang Wu, Wei Zhang, Patrick C. Ma
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3874.
https://doi.org/10.1158/1538-7445.AM2016-3874
Published: 15 July 2016
View articletitled, Abstract 3874: Mass spectrometry imaging determines biomarkers of early adaptive precision drug resistance in lung cancer
Journal Articles

Abstract 3718: Adaptive drug escape of EML4-ALK lung cancer against targeted ALK inhibitor involving TGFβ2-mitochondrial priming

Lihong Yin, Wei Zhang, Ivy Shi, Yan Feng, Rakesh Bagai, Daniel Lindner, Patrick C. Ma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3718.
https://doi.org/10.1158/1538-7445.AM2014-3718
Published: 01 October 2014
View articletitled, Abstract 3718: Adaptive drug escape of EML4-ALK lung cancer against targeted ALK inhibitor involving TGFβ2-mitochondrial priming
Journal Articles

Abstract 1835: Transcriptome and metabolome reprogramming in EGFR-mutant NSCLC early adaptive drug-escape against erlotinib

Patrick C. Ma, Praveena S. Thiagarajan, Patrick Leahy, Rakesh Bagai, Ivy Shi, Wei Zhang, Yan Feng, Martina L. Veigl, Daniel Lindner, David Danielpour, Lihong Yin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1835.
https://doi.org/10.1158/1538-7445.AM2014-1835
Published: 01 October 2014
View articletitled, Abstract 1835: Transcriptome and metabolome reprogramming in EGFR-mutant NSCLC early adaptive drug-escape against erlotinib
Journal Articles

Abstract 4466: Integrative study of dysregulated genes in translocated ALK-positive non-small cell lung cancer and personalized targeted therapy resistance.

Ivy Shi, Lihong Yin, Patrick C. Ma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4466.
https://doi.org/10.1158/1538-7445.AM2013-4466
Published: 15 April 2013
View articletitled, Abstract 4466: Integrative study of dysregulated genes in translocated ALK-positive non-small cell lung cancer and personalized targeted therapy resistance.
Journal Articles

Abstract 4455: Studies of early adaptive resistance in mutant-EGFR and EML4-ALK addicted non-small cell lung cancer in escape against small molecule inhibitors.

Lihong Yin, Ivy Shi, Wei Zhang, Rakesh Bagai, Yan Feng, Patrick C. Ma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4455.
https://doi.org/10.1158/1538-7445.AM2013-4455
Published: 15 April 2013
View articletitled, Abstract 4455: Studies of early adaptive resistance in mutant-EGFR and EML4-ALK addicted non-small cell lung cancer in escape against small molecule inhibitors.
Journal Articles

MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents

Weiwen Fan, Zhe Tang, Lihong Yin, Bei Morrison, Said Hafez-Khayyata, Pingfu Fu, Honglian Huang, Rakesh Bagai, Shan Jiang, Adam Kresak, Scott Howell, Amit Vasanji, Chris A. Flask, Balazs Halmos, Henry Koon, Patrick C. Ma
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4494–4505.
https://doi.org/10.1158/0008-5472.CAN-10-2668
Published: 30 June 2011
View articletitled, MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Open the PDF for MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 836: In vivo PET imaging of MET receptor in human cancer using [11C]SU11274

Patrick C. Ma, Chunying Wu, Zhe Tang, Weiwen Fan, Wenxia Zhu, Changning Wang, Edurado Somoza, Norbert Owino, Ruoshi Li, Yanming Wang
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 836.
https://doi.org/10.1158/1538-7445.AM10-836
Published: 15 April 2010
View articletitled, Abstract 836: In vivo PET imaging of MET receptor in human cancer using [11C]SU11274
Journal Articles

Abstract LB-307: Overexpression of AXL as a novel acquired resistance mechanism in EGFR-mutated non-small cell lung cancer cells

Zhenfeng Zhang, Thomas LaFramboise, Mohamed Abdel-Rahman, Alan D. Levine, Patrick C. Ma, Balazs Halmos
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-307.
https://doi.org/10.1158/1538-7445.AM10-LB-307
Published: 15 April 2010
View articletitled, Abstract LB-307: Overexpression of AXL as a novel acquired resistance mechanism in EGFR-mutated non-small cell lung cancer cells
Journal Articles

Resistance to an Irreversible Epidermal Growth Factor Receptor (EGFR) Inhibitor in EGFR-Mutant Lung Cancer Reveals Novel Treatment Strategies

Zhiwei Yu, Titus J. Boggon, Susumu Kobayashi, Cheng Jin, Patrick C. Ma, Afshin Dowlati, Jeffrey A. Kern, Daniel G. Tenen, Balázs Halmos
Journal: Cancer Research
Cancer Res (2007) 67 (21): 10417–10427.
https://doi.org/10.1158/0008-5472.CAN-07-1248
Published: 01 November 2007
View articletitled, Resistance to an Irreversible Epidermal Growth Factor Receptor (EGFR) Inhibitor in EGFR-Mutant Lung Cancer Reveals Novel Treatment Strategies
Open the PDF for Resistance to an Irreversible Epidermal Growth Factor Receptor (EGFR) Inhibitor in EGFR-Mutant Lung Cancer Reveals Novel Treatment Strategies in another window
Includes: Supplementary data
Journal Articles

Mutation of c-Met RTK: A novel molecular therapeutic target for the treatment of mesothelioma

Ramasamy Jagadeeswaran, Patrick C. Ma, Tanguy Y. Seiwert, Sujatha Jagadeeswaran, Osvaldo Zumba, Vidya Nallasura, Salman Ahmed, Robert A. Kratzke, Gavin J. Gordon, David J. Sugarbaker, Raphael Bueno, Varalakshmi Janamanchi, Vytas P. Bindokas, Hedy L. Kindler, Ravi Salgia
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 713.
Published: 15 April 2006
View articletitled, Mutation of c-Met RTK: A novel molecular therapeutic target for the treatment of mesothelioma
Journal Articles

EGFR mutation and striking response to gefitinib in a patient with leptomeningeal carcinomatosis and erlotinib-refractory adenocarcinoma lung cancer

Nicholas W. Choong, Sascha Dietrich, Tanguy Y. Seiwert, Maria S. Tretiakova, Vidya Nallasura, Gareth C. Davies, Stanley Lipkowitz, Aliya N. Husain, Ravi Salgia, Patrick C. Ma
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 949.
Published: 15 April 2006
View articletitled, EGFR mutation and striking response to gefitinib in a patient with leptomeningeal carcinomatosis and erlotinib-refractory adenocarcinoma lung cancer
Journal Articles

Functional Analysis of c-Met/Hepatocyte Growth Factor Pathway in Malignant Pleural Mesothelioma

Ramasamy Jagadeeswaran, Patrick C. Ma, Tanguy Y. Seiwert, Sujatha Jagadeeswaran, Osvaldo Zumba, Vidya Nallasura, Salman Ahmed, Rosangela Filiberti, Michela Paganuzzi, Riccardo Puntoni, Robert A. Kratzke, Gavin J. Gordon, David J. Sugarbaker, Raphael Bueno, Varalakshmi Janamanchi, Vytas P. Bindokas, Hedy L. Kindler, Ravi Salgia
Journal: Cancer Research
Cancer Res (2006) 66 (1): 352–361.
https://doi.org/10.1158/0008-5472.CAN-04-4567
Published: 05 January 2006
View articletitled, Functional Analysis of c-Met/Hepatocyte Growth Factor Pathway in Malignant Pleural Mesothelioma
Open the PDF for Functional Analysis of c-Met/Hepatocyte Growth Factor Pathway in Malignant Pleural Mesothelioma in another window
Journal Articles

Role of c-Met and its mutated variants as therapeutic target using the small molecule inhibitor SU11274 and siRNA in non-small cell lung cancer

Patrick C. Ma, Ramasamy Jagadeeswaran, Sascha Dietrich, Simha Jagadeesh, Maria S. Tretiakova, Vidya Nallasura, Edward A. Fox, Alan Lader, William Richards, David Sugarbaker, Aliya N. Husain, James G. Christensen, Ravi Salgia
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 134–135.
Published: 01 May 2005
View articletitled, Role of c-Met and its mutated variants as therapeutic target using the small molecule inhibitor SU11274 and siRNA in non-small cell lung cancer
Journal Articles

Heat shock protein (HSP) overexpression in lung cancer and potential as a therapeutic target

Tanguy Y. Seiwert, Maria Tretiakova, Patrick C. Ma, Md Abdul Khaleque, Aliya N. Husain, Andras Ladanyi, Lan Bo Chen, Ajit Bharti, Ravi Salgia
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 559–560.
Published: 01 May 2005
View articletitled, Heat shock protein (HSP) overexpression in lung cancer and potential as a therapeutic target