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Journal Articles

Abstract 3081: The multiciliated transcription factor FOXJ1 modulates microtubule dynamics and mediates taxane resistance in prostate cancer

Ada Gjyrezi, Fang Xie, Daniel E. Fein, Maryam Labaf, Larysa Poluben, Olga Voznesensky, Aniket Gad, Eva Corey, Rupal S. Bhatt, Steven Balk, Paraskevi Giannakakou

Cancer Res (2025) 85 (8_Supplement_1): 3081.

https://doi.org/10.1158/1538-7445.AM2025-3081

Published: 21 April 2025

View articletitled, Abstract 3081: The multiciliated transcription factor FOXJ1 modulates microtubule dynamics and mediates taxane resistance in prostate cancer

Journal Articles

Abstract 1645: Developing first-in-class AR-V7/AR-fl molecular glue degrader to revolutionize prostate cancer therapeutics

CheukMan Cherie Au, Michelle Naidoo, Catrina Estrella, Prerna Vatsa, Ying Wang, Zhao Wang, David M. Nanus, Urko del Castillo, Paraskevi Giannakakou

Cancer Res (2025) 85 (8_Supplement_1): 1645.

https://doi.org/10.1158/1538-7445.AM2025-1645

Published: 21 April 2025

View articletitled, Abstract 1645: Developing first-in-class AR-V7/AR-fl molecular glue degrader to revolutionize prostate cancer therapeutics

Journal Articles

Abstract 1231: First-in-class AR-V7/AR-fl small molecule molecular glue degrader for prostate cancer treatment

CheukMan C. Au, Catrina Estrella, Prerna Vatsa, Michelle Naidoo, Michael Miller, Peter T. Meinke, David M. Nanus, Paraskevi Giannakakou

Cancer Res (2024) 84 (6_Supplement): 1231.

https://doi.org/10.1158/1538-7445.AM2024-1231

Published: 22 March 2024

View articletitled, Abstract 1231: First-in-class AR-V7/AR-fl small molecule molecular glue degrader for prostate cancer treatment

Journal Articles

Abstract 1404: Blood-based transcriptomics provides novel insights into Sjögren's syndrome-associated lymphomagenesis

Ada Gjyrezi, Charalampos Skarlis, Paul Zumbo, Doron Betel, Ioanna E. Stergiou, Michael Voulgarelis, Clio P. Mavragani, Paraskevi Giannakakou

Cancer Res (2024) 84 (6_Supplement): 1404.

https://doi.org/10.1158/1538-7445.AM2024-1404

Published: 22 March 2024

View articletitled, Abstract 1404: Blood-based transcriptomics provides novel insights into Sjögren's syndrome-associated lymphomagenesis

Journal Articles

Abstract 6271: Novel insights into androgen receptor-variant 7 subnuclear localization and function in castration resistant prostate cancer

Michelle K. Naidoo, Paraskevi Giannakakou

Cancer Res (2024) 84 (6_Supplement): 6271.

https://doi.org/10.1158/1538-7445.AM2024-6271

Published: 22 March 2024

View articletitled, Abstract 6271: Novel insights into androgen receptor-variant 7 subnuclear localization and function in castration resistant prostate cancer

Journal Articles

Abstract 2009: Novel clinically relevant CLIP-170 variants display an extended conformation microtubule-lattice bound conformation associated with taxane resistance

Urko del Castillo, Kiran Kumari Sahu, William G. Stone, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2024) 84 (6_Supplement): 2009.

https://doi.org/10.1158/1538-7445.AM2024-2009

Published: 22 March 2024

View articletitled, Abstract 2009: Novel clinically relevant CLIP-170 variants display an extended conformation microtubule-lattice bound conformation associated with taxane resistance

Journal Articles

Abstract 1742: Cediranib reverses taxane resistance in CLIP-170S expressing gastric cancer

William G. Stone, Urko del Castillo, Prashant V. Thakkar, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2023) 83 (7_Supplement): 1742.

https://doi.org/10.1158/1538-7445.AM2023-1742

Published: 04 April 2023

View articletitled, Abstract 1742: Cediranib reverses taxane resistance in CLIP-170S expressing gastric cancer

Journal Articles

Abstract 1264: CTC-based biomarker analysis and correlation with clinical response to PSMA-TRT in mCRPC

Giuseppe Galletti, Prerna Vatsa, Joseph R. Osborne, Neil H. Bander, David M. Nanus, Scott T. Tagawa, Paraskevi Giannakakou

Cancer Res (2022) 82 (12_Supplement): 1264.

https://doi.org/10.1158/1538-7445.AM2022-1264

Published: 15 June 2022

View articletitled, Abstract 1264: CTC-based biomarker analysis and correlation with clinical response to PSMA-TRT in mCRPC

Journal Articles

Abstract 3946: Development of selective small molecule AR-V7 inhibitors for prostate cancer treatment

CheukMan Cherie Au, Seaho Kim, Prerna Vatsa, Mohd Azrin Bin Jamalruddin, Michael Miller, Peter T. Meinke, Paraskevi Giannakakou

Cancer Res (2022) 82 (12_Supplement): 3946.

https://doi.org/10.1158/1538-7445.AM2022-3946

Published: 15 June 2022

View articletitled, Abstract 3946: Development of selective small molecule AR-V7 inhibitors for prostate cancer treatment

Journal Articles

Abstract 2623: Variants of CLIP-170 associated with taxane resistance in tumors

Prashant V. Thakkar, Katsuhiro Kita, Urko del Castillo, William G. Stone, Giuseppe Galletti, Neel Madhukar, Elena Vila Navarro, Elena Barasoain, Holly V. Goodson, Dan Sackett, José Fernando Díaz, Yao Lu, Arindam RoyChoudhury, Henrik Molina, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2022) 82 (12_Supplement): 2623.

https://doi.org/10.1158/1538-7445.AM2022-2623

Published: 15 June 2022

View articletitled, Abstract 2623: Variants of CLIP-170 associated with taxane resistance in tumors

Journal Articles

Abstract 646: Liquid biopsy transcriptomics identify pathways associated with poor outcomes and immune phenotypes in men with mCRPC

Cancer Res (2022) 82 (12_Supplement): 646.

https://doi.org/10.1158/1538-7445.AM2022-646

Published: 15 June 2022

View articletitled, Abstract 646: Liquid biopsy transcriptomics identify pathways associated with poor outcomes and immune phenotypes in men with mCRPC

Journal Articles

Abstract 2011: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer

Sandipto Sarkar, Prashant K. Thakkar, Heinz Lenz, Peter Enzinger, Andrew H. Ko, Allyson J. Ocean, Yao Lu, Chao Zhang, Bhavneet Bhinder, Olga Plotnikova, Nikita Kotlov, Feliz Frenkel, Aleksander Bagaev, Olivier Elemento, Doron Betel, Paraskevi Giannakakou, Meredith E. Pittman, Manish A. Shah

Cancer Res (2020) 80 (16_Supplement): 2011.

https://doi.org/10.1158/1538-7445.AM2020-2011

Published: 15 August 2020

View articletitled, Abstract 2011: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer

Journal Articles

Abstract 641: Systems biology identifies Gleevec as a specific inhibitor of CLIP-170S, a novel +TIP isoform, which causes taxane resistance in cancer cells and patients by obstructing the Microtubule pore

Prashant V. Thakkar, Katsuhiro Kita, Giuseppe Galletti, Neel Madhukar, Elena Vila Navarro, Kyle Cleveland, Isabel Barasoain, Holly V. Goodson, Dan Sackett, Jose Fernando Diaz, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2020) 80 (16_Supplement): 641.

https://doi.org/10.1158/1538-7445.AM2020-641

Published: 15 August 2020

View articletitled, Abstract 641: Systems biology identifies Gleevec as a specific inhibitor of CLIP-170S, a novel +TIP isoform, which causes taxane resistance in cancer cells and patients by obstructing the Microtubule pore

Journal Articles

Abstract 3196: Analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRLX301, a nanoparticle of docetaxel

Eiman Mukhtar, Daniel Worroll, Giuseppe Galletti, Shelly Schuster, Sarina A. Piha-Paul, Paraskevi Giannakakou

Cancer Res (2020) 80 (16_Supplement): 3196.

https://doi.org/10.1158/1538-7445.AM2020-3196

Published: 15 August 2020

View articletitled, Abstract 3196: Analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRLX301, a nanoparticle of docetaxel

Journal Articles

Abstract 1017: Novel inhibitors of AR-v7 nuclear import: new therapeutic opportunities for CRPC

Seaho Kim, Mohd Azrin Jamalruddin, Eiman Mukhtar, Michael Miller, Leigh Baxt, Stacia Kargman, Andrew Stamford, Peter Meinke, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 1017.

https://doi.org/10.1158/1538-7445.AM2019-1017

Published: 01 July 2019

View articletitled, Abstract 1017: Novel inhibitors of AR-v7 nuclear import: new therapeutic opportunities for CRPC

Journal Articles

Abstract 3817: Systems biology identifies that Gleevec reverses taxane resistance in solid tumors by selective inhibition of a novel +Tip microtubule-binding variant

Prashant V. Thakkar, Katsuhiro Kita, Giuseppe Galletti, Neel S. Madhukar, Kyle Cleveland, Isabel Barasoain, Jose Fernando Diaz, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 3817.

https://doi.org/10.1158/1538-7445.AM2019-3817

Published: 01 July 2019

View articletitled, Abstract 3817: Systems biology identifies that Gleevec reverses taxane resistance in solid tumors by selective inhibition of a novel +Tip microtubule-binding variant

Journal Articles

Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)

Ana Molina, Paul Christos, Amy Hackett, Luke Nordquist, Edward Gelmann, Mark Stein, Cora Sternberg, Himisha Beltran, Lauren Gracey, Giuseppe Galletti, Paraskevi Giannakakou, David M. Nanus, Scott T. Tagawa

Cancer Res (2019) 79 (13_Supplement): CT097.

https://doi.org/10.1158/1538-7445.AM2019-CT097

Published: 01 July 2019

View articletitled, Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)

Journal Articles

Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants

Ada Gjyrezi, Giuseppe Galletti, Jiaren Zhang, Rohan Bareja, Ahmed Halima, Daniel Worroll, David Nanus, Scott Tagawa, Himisha Beltran, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 451.

https://doi.org/10.1158/1538-7445.AM2019-451

Published: 01 July 2019

View articletitled, Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants

Journal Articles

Abstract 454: Transferrin receptor identifies a novel circulating tumor cell population in patients with pancreatic cancer with a unique metastasis-associated molecular signature

Ahmed Halima, Jiaren Zhang, Giuseppe Galletti, Allyson J. Ocean, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 454.

https://doi.org/10.1158/1538-7445.AM2019-454

Published: 01 July 2019

View articletitled, Abstract 454: Transferrin receptor identifies a novel circulating tumor cell population in patients with pancreatic cancer with a unique metastasis-associated molecular signature

Journal Articles

Abstract 4646: A novel truncated variant of the hematopoietic Hβ-1 tubulin isotype with implications for stem cell biology

Yang Bai, Paul Basciano, Xi Li, Jason Matakas, Silvana Di Giandomenico, Siddhartha Sen, Todd Evans, Joseph Scandura, Monica Guzman, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 4646.

https://doi.org/10.1158/1538-7445.AM2017-4646

Published: 01 July 2017

View articletitled, Abstract 4646: A novel truncated variant of the hematopoietic Hβ-1 tubulin isotype with implications for stem cell biology

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Abstract 3081: The multiciliated transcription factor FOXJ1 modulates microtubule dynamics and mediates taxane resistance in prostate cancer

Abstract 1645: Developing first-in-class AR-V7/AR-fl molecular glue degrader to revolutionize prostate cancer therapeutics

Abstract 1231: First-in-class AR-V7/AR-fl small molecule molecular glue degrader for prostate cancer treatment

Abstract 1404: Blood-based transcriptomics provides novel insights into Sjögren's syndrome-associated lymphomagenesis

Abstract 6271: Novel insights into androgen receptor-variant 7 subnuclear localization and function in castration resistant prostate cancer

Abstract 2009: Novel clinically relevant CLIP-170 variants display an extended conformation microtubule-lattice bound conformation associated with taxane resistance

Abstract 1742: Cediranib reverses taxane resistance in CLIP-170S expressing gastric cancer

Abstract 1264: CTC-based biomarker analysis and correlation with clinical response to PSMA-TRT in mCRPC

Abstract 3946: Development of selective small molecule AR-V7 inhibitors for prostate cancer treatment

Abstract 2623: Variants of CLIP-170 associated with taxane resistance in tumors

Abstract 646: Liquid biopsy transcriptomics identify pathways associated with poor outcomes and immune phenotypes in men with mCRPC

Abstract 2011: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer

Abstract 641: Systems biology identifies Gleevec as a specific inhibitor of CLIP-170S, a novel +TIP isoform, which causes taxane resistance in cancer cells and patients by obstructing the Microtubule pore

Abstract 3196: Analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRLX301, a nanoparticle of docetaxel

Abstract 1017: Novel inhibitors of AR-v7 nuclear import: new therapeutic opportunities for CRPC

Abstract 3817: Systems biology identifies that Gleevec reverses taxane resistance in solid tumors by selective inhibition of a novel +Tip microtubule-binding variant

Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)

Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants

Abstract 454: Transferrin receptor identifies a novel circulating tumor cell population in patients with pancreatic cancer with a unique metastasis-associated molecular signature

Abstract 4646: A novel truncated variant of the hematopoietic Hβ-1 tubulin isotype with implications for stem cell biology

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