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Abstract 646: Liquid biopsy transcriptomics identify pathways associated with poor outcomes and immune phenotypes in men with mCRPC

Cancer Res (2022) 82 (12_Supplement): 646.

DOI: https://doi.org/10.1158/1538-7445.AM2022-646

Published: 15 June 2022

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Journal Articles

Abstract 2623: Variants of CLIP-170 associated with taxane resistance in tumors

Prashant V. Thakkar, Katsuhiro Kita, Urko del Castillo, William G. Stone, Giuseppe Galletti, Neel Madhukar, Elena Vila Navarro, Elena Barasoain, Holly V. Goodson, Dan Sackett, José Fernando Díaz, Yao Lu, Arindam RoyChoudhury, Henrik Molina, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2022) 82 (12_Supplement): 2623.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2623

Published: 15 June 2022

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Abstract 3946: Development of selective small molecule AR-V7 inhibitors for prostate cancer treatment

CheukMan Cherie Au, Seaho Kim, Prerna Vatsa, Mohd Azrin Bin Jamalruddin, Michael Miller, Peter T. Meinke, Paraskevi Giannakakou

Cancer Res (2022) 82 (12_Supplement): 3946.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3946

Published: 15 June 2022

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Abstract 1264: CTC-based biomarker analysis and correlation with clinical response to PSMA-TRT in mCRPC

Giuseppe Galletti, Prerna Vatsa, Joseph R. Osborne, Neil H. Bander, David M. Nanus, Scott T. Tagawa, Paraskevi Giannakakou

Cancer Res (2022) 82 (12_Supplement): 1264.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1264

Published: 15 June 2022

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Journal Articles

Abstract 3196: Analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRLX301, a nanoparticle of docetaxel

Eiman Mukhtar, Daniel Worroll, Giuseppe Galletti, Shelly Schuster, Sarina A. Piha-Paul, Paraskevi Giannakakou

Cancer Res (2020) 80 (16_Supplement): 3196.

DOI: https://doi.org/10.1158/1538-7445.AM2020-3196

Published: 15 August 2020

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Abstract 641: Systems biology identifies Gleevec as a specific inhibitor of CLIP-170S, a novel +TIP isoform, which causes taxane resistance in cancer cells and patients by obstructing the Microtubule pore

Prashant V. Thakkar, Katsuhiro Kita, Giuseppe Galletti, Neel Madhukar, Elena Vila Navarro, Kyle Cleveland, Isabel Barasoain, Holly V. Goodson, Dan Sackett, Jose Fernando Diaz, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2020) 80 (16_Supplement): 641.

DOI: https://doi.org/10.1158/1538-7445.AM2020-641

Published: 15 August 2020

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Journal Articles

Abstract 2011: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer

Sandipto Sarkar, Prashant K. Thakkar, Heinz Lenz, Peter Enzinger, Andrew H. Ko, Allyson J. Ocean, Yao Lu, Chao Zhang, Bhavneet Bhinder, Olga Plotnikova, Nikita Kotlov, Feliz Frenkel, Aleksander Bagaev, Olivier Elemento, Doron Betel, Paraskevi Giannakakou, Meredith E. Pittman, Manish A. Shah

Cancer Res (2020) 80 (16_Supplement): 2011.

DOI: https://doi.org/10.1158/1538-7445.AM2020-2011

Published: 15 August 2020

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Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)

Ana Molina, Paul Christos, Amy Hackett, Luke Nordquist, Edward Gelmann, Mark Stein, Cora Sternberg, Himisha Beltran, Lauren Gracey, Giuseppe Galletti, Paraskevi Giannakakou, David M. Nanus, Scott T. Tagawa

Cancer Res (2019) 79 (13_Supplement): CT097.

DOI: https://doi.org/10.1158/1538-7445.AM2019-CT097

Published: 01 July 2019

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Abstract 454: Transferrin receptor identifies a novel circulating tumor cell population in patients with pancreatic cancer with a unique metastasis-associated molecular signature

Ahmed Halima, Jiaren Zhang, Giuseppe Galletti, Allyson J. Ocean, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 454.

DOI: https://doi.org/10.1158/1538-7445.AM2019-454

Published: 01 July 2019

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Abstract 1017: Novel inhibitors of AR-v7 nuclear import: new therapeutic opportunities for CRPC

Seaho Kim, Mohd Azrin Jamalruddin, Eiman Mukhtar, Michael Miller, Leigh Baxt, Stacia Kargman, Andrew Stamford, Peter Meinke, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 1017.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1017

Published: 01 July 2019

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Abstract 3817: Systems biology identifies that Gleevec reverses taxane resistance in solid tumors by selective inhibition of a novel +Tip microtubule-binding variant

Prashant V. Thakkar, Katsuhiro Kita, Giuseppe Galletti, Neel S. Madhukar, Kyle Cleveland, Isabel Barasoain, Jose Fernando Diaz, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 3817.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3817

Published: 01 July 2019

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Journal Articles

Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants

Ada Gjyrezi, Giuseppe Galletti, Jiaren Zhang, Rohan Bareja, Ahmed Halima, Daniel Worroll, David Nanus, Scott Tagawa, Himisha Beltran, Paraskevi Giannakakou

Cancer Res (2019) 79 (13_Supplement): 451.

DOI: https://doi.org/10.1158/1538-7445.AM2019-451

Published: 01 July 2019

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Abstract 2736: A digital droplet PCR assay for the quantitation of androgen receptor and splice variant expression in CTCs from metastatic castration resistant prostate cancer patients

Ada Gjyrezi, Giuseppe Galletti, Areti Strati, Seaho Kim, Evi Lianidou, David M. Nanus, Jun Luo, Emmanuel Antonarakis, Scott T. Tagawa, Andrew Armstrong, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 2736.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2736

Published: 01 July 2017

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Abstract 1590: High intranuclear mobility of AR-v7 reveals distinct mode of transcriptional activity in prostate cancer with important therapeutic implications

Seaho Kim, Mohd Azrin Jamalruddin, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 1590.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1590

Published: 01 July 2017

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Journal Articles

Abstract 1713: Transferrin receptor 1 (TfR) as marker for circulating tumor cells (CTCs) identification in NSCLC

Giuseppe Galletti, Galatea Kallergi, Ashish Saxena, Despoina Aggouraki, Christos Stournaras, Vassilis Georgoulias, Timothy E. McGraw, Nasser Altorki, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 1713.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1713

Published: 01 July 2017

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Journal Articles

Abstract 4169: A novel, short isoform of the +Tip microtubule binding protein CLIP170 confers taxane resistance in gastric cancer

Prashant V. Thakkar, Katsuhiro Kita, Giuseppe Galletti, Kyle Cleveland, Isabel Barasoain, Jose Fernando Diaz, Manish A. Shah, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 4169.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4169

Published: 01 July 2017

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Journal Articles

Abstract 4646: A novel truncated variant of the hematopoietic Hβ-1 tubulin isotype with implications for stem cell biology

Yang Bai, Paul Basciano, Xi Li, Jason Matakas, Silvana Di Giandomenico, Siddhartha Sen, Todd Evans, Joseph Scandura, Monica Guzman, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 4646.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4646

Published: 01 July 2017

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Journal Articles

Abstract 5634: Characterization of molecular mechanisms of cytoplasmic trafficking and nuclear translocation of AR splice variants ARv7

Eiman Mukhtar, Seaho Kim, Paraskevi Giannakakou

Cancer Res (2017) 77 (13_Supplement): 5634.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5634

Published: 01 July 2017

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Journal Articles

Abstract LB-106: Using a data-driven Bayesian approach to predict the targets of orphan small molecules and ways to overcome drug resistance

Neel S. Madhukar, Prashant Khade, Linda Huang, Kaitlyn Gayvert, Giuseppe Galletti, Paraskevi Giannakakou, Olivier Elemento

Cancer Res (2016) 76 (14_Supplement): LB-106.

DOI: https://doi.org/10.1158/1538-7445.AM2016-LB-106

Published: 15 July 2016

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Journal Articles

Abstract 2125: ERG and AR-v7 involvement in taxane resistance of metastatic castration-resistant prostate cancers

Adeline Berger, Seaho Kim, Ada Gjyrezi, Giuseppe Galletti, Andrea Sboner, Mark A. Rubin, Scott Tagawa, Paraskevi Giannakakou, David S. rickman

Cancer Res (2016) 76 (14_Supplement): 2125.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2125

Published: 15 July 2016

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2 3 4 5

NARROW

Abstract 646: Liquid biopsy transcriptomics identify pathways associated with poor outcomes and immune phenotypes in men with mCRPC

Abstract 2623: Variants of CLIP-170 associated with taxane resistance in tumors

Abstract 3946: Development of selective small molecule AR-V7 inhibitors for prostate cancer treatment

Abstract 1264: CTC-based biomarker analysis and correlation with clinical response to PSMA-TRT in mCRPC

Abstract 3196: Analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRLX301, a nanoparticle of docetaxel

Abstract 641: Systems biology identifies Gleevec as a specific inhibitor of CLIP-170S, a novel +TIP isoform, which causes taxane resistance in cancer cells and patients by obstructing the Microtubule pore

Abstract 2011: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer

Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)

Abstract 454: Transferrin receptor identifies a novel circulating tumor cell population in patients with pancreatic cancer with a unique metastasis-associated molecular signature

Abstract 1017: Novel inhibitors of AR-v7 nuclear import: new therapeutic opportunities for CRPC

Abstract 3817: Systems biology identifies that Gleevec reverses taxane resistance in solid tumors by selective inhibition of a novel +Tip microtubule-binding variant

Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants

Abstract 2736: A digital droplet PCR assay for the quantitation of androgen receptor and splice variant expression in CTCs from metastatic castration resistant prostate cancer patients

Abstract 1590: High intranuclear mobility of AR-v7 reveals distinct mode of transcriptional activity in prostate cancer with important therapeutic implications

Abstract 1713: Transferrin receptor 1 (TfR) as marker for circulating tumor cells (CTCs) identification in NSCLC

Abstract 4169: A novel, short isoform of the +Tip microtubule binding protein CLIP170 confers taxane resistance in gastric cancer

Abstract 4646: A novel truncated variant of the hematopoietic Hβ-1 tubulin isotype with implications for stem cell biology

Abstract 5634: Characterization of molecular mechanisms of cytoplasmic trafficking and nuclear translocation of AR splice variants ARv7

Abstract LB-106: Using a data-driven Bayesian approach to predict the targets of orphan small molecules and ways to overcome drug resistance

Abstract 2125: ERG and AR-v7 involvement in taxane resistance of metastatic castration-resistant prostate cancers

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