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Paolo M. Comoglio
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Journal Articles

Abstract 2358: miRNA-483-3p overexpression unleashes invasiveness of metastatic colorectal cancer by NDRG1 targeting and upregulation of the HER3-AKT axis

Ermes Candiello, Gigliola Reato, Federica Verginelli, Antonio D'Ambrosio, Gennaro Gambardella, Raffaella Albano, Paolo Luraghi, Paolo M. Comoglio, Andrea Bertotti, Livio Trusolino, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2358.
https://doi.org/10.1158/1538-7445.AM2021-2358
Published: 01 July 2021
View articletitled, Abstract 2358: miRNA-483-3p overexpression unleashes invasiveness of metastatic colorectal cancer by NDRG1 targeting and upregulation of the HER3-AKT axis
Journal Articles

Abstract 942: ErbB3 overexpression unleashed by miR-205 epigenetic silencing is a therapeutic target in glioblastoma

Francesca De Bacco, Francesca Orzan, Jessica Erriquez, Elena Casanova, Ludovic Barault, Raffaella Albano, Antonio D'Ambrosio, Viola Bigatto, Gigliola Reato, Monica Patané, Bianca Pollo, Geoffrey Kuesters, Carmine Dell'Aglio, Laura Casorzo, Serena Pellegatta, Gaetano Finocchiaro, Paolo M. Comoglio, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 942.
https://doi.org/10.1158/1538-7445.AM2021-942
Published: 01 July 2021
View articletitled, Abstract 942: ErbB3 overexpression unleashed by miR-205 epigenetic silencing is a therapeutic target in glioblastoma
Journal Articles

Abstract 2871: Hypermetastatic stem-like cells from 'cancer of unknown primary' (CUP) model multi-organ dissemination and unveil liability to MEK inhibition

Federica Verginelli, Alberto Pisacane, Gennaro Gambardella, Antonio D'Ambrosio, Ermes Candiello, Marco Ferrio, Mara Panero, Laura Casorzo, Silvia Benvenuti, Eliano Cascardi, Rebecca Senetta, Elena Geuna, Andrea Ballabio, Filippo Montemurro, Anna Sapino, Paolo M. Comoglio, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2871.
https://doi.org/10.1158/1538-7445.AM2021-2871
Published: 01 July 2021
View articletitled, Abstract 2871: Hypermetastatic stem-like cells from 'cancer of unknown primary' (CUP) model multi-organ dissemination and unveil liability to MEK inhibition
Journal Articles

Abstract 1387: MET inhibition radiosensitizes KRAS-mutant rectal cancer

Antonio D'Ambrosio, Federica Verginelli, Francesca Orzan, Raffaella Albano, Elena Casanova, Paolo Luraghi, Francesca De Bacco, Andrea Bertotti, Livio Trusolino, Rebecca Senetta, Anna Sapino, Elena Del Mastro, Marco Gatti, Paolo M. Comoglio, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1387.
https://doi.org/10.1158/1538-7445.AM2021-1387
Published: 01 July 2021
View articletitled, Abstract 1387: MET inhibition radiosensitizes KRAS-mutant rectal cancer
Journal Articles

Abstract 828: Targeting the MET oncogene by concomitant inhibition of receptor and ligand by an antibody-‘decoy' strategy

Cristina Basilico, Chiara Modica, Federica Maione, Elisa Vigna, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 828.
https://doi.org/10.1158/1538-7445.AM2018-828
Published: 01 July 2018
View articletitled, Abstract 828: Targeting the MET oncogene by concomitant inhibition of receptor and ligand by an antibody-‘decoy' strategy
Journal Articles

Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody

Emanuela Pupo, Nadia Ducano, Barbara Lupo, Elisa Vigna, Daniele Avanzato, Timothy Perera, Livio Trusolino, Letizia Lanzetti, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2016) 76 (17): 5019–5029.
https://doi.org/10.1158/0008-5472.CAN-15-3107
Published: 31 August 2016
View articletitled, Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody
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Includes: Supplementary data
Journal Articles

Abstract 622: Gastric cancer in the age of targeted agents: identification and validation of novel therapeutic strategies through the generation of a patient-derived xenografts platform

Silvia Menegon, Maria Apicella, Cristina Migliore, Tania Capeloa, Marilisa Cargnelutti, Maurizio Degiuli, Anna Sapino, Paola Cassoni, Michele De Simone, Paolo M. Comoglio, Silvia Marsoni, Simona Corso, Silvia Giordano
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 622.
https://doi.org/10.1158/1538-7445.AM2016-622
Published: 15 July 2016
View articletitled, Abstract 622: Gastric cancer in the age of targeted agents: identification and validation of novel therapeutic strategies through the generation of a patient-derived xenografts platform
Journal Articles

Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs

Selma Pennacchietti, Manuela Cazzanti, Andrea Bertotti, William M. Rideout, III, May Han, Jeno Gyuris, Timothy Perera, Paolo M. Comoglio, Livio Trusolino, Paolo Michieli
Journal: Cancer Research
Cancer Res (2014) 74 (22): 6598–6609.
https://doi.org/10.1158/0008-5472.CAN-14-0761
Published: 13 November 2014
View articletitled, Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs
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Includes: Supplementary data
Journal Articles

MET-Mediated Resistance to EGFR Inhibitors: An Old Liaison Rooted in Colorectal Cancer Stem Cells

Carla Boccaccio, Paolo Luraghi, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2014) 74 (14): 3647–3651.
https://doi.org/10.1158/0008-5472.CAN-14-1088
Published: 14 July 2014
View articletitled, MET-Mediated Resistance to EGFR Inhibitors: An Old Liaison Rooted in Colorectal Cancer Stem Cells
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Journal Articles

MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors

Paolo Luraghi, Gigliola Reato, Elia Cipriano, Francesco Sassi, Francesca Orzan, Viola Bigatto, Francesca De Bacco, Elena Menietti, May Han, William M. Rideout, III, Timothy Perera, Andrea Bertotti, Livio Trusolino, Paolo M. Comoglio, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2014) 74 (6): 1857–1869.
https://doi.org/10.1158/0008-5472.CAN-13-2340-T
Published: 13 March 2014
View articletitled, MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors
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Includes: Supplementary data
Journal Articles

The MET Oncogene in Glioblastoma Stem Cells: Implications as a Diagnostic Marker and a Therapeutic Target

Carla Boccaccio, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2013) 73 (11): 3193–3199.
https://doi.org/10.1158/0008-5472.CAN-12-4039
Published: 30 May 2013
View articletitled, The MET Oncogene in Glioblastoma Stem Cells: Implications as a Diagnostic Marker and a Therapeutic Target
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Journal Articles

The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Francesca De Bacco, Elena Casanova, Enzo Medico, Serena Pellegatta, Francesca Orzan, Raffaella Albano, Paolo Luraghi, Gigliola Reato, Antonio D'Ambrosio, Paola Porrati, Monica Patanè, Emanuela Maderna, Bianca Pollo, Paolo M. Comoglio, Gaetano Finocchiaro, Carla Boccaccio
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4537–4550.
https://doi.org/10.1158/0008-5472.CAN-11-3490
Published: 30 August 2012
View articletitled, The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype
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Includes: Supplementary data
Journal Articles

Abstract 631: Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody

Giovanni Pacchiana, Cristina Chiriaco, Maria C. Stella, Fiorella Petronzelli, Rita De Santis, Maria Galluzzo, Paolo Carminati, Paolo M. Comoglio, Paolo Michieli, Elisa Vigna
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 631.
https://doi.org/10.1158/1538-7445.AM2011-631
Published: 15 April 2011
View articletitled, Abstract 631: Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody
Journal Articles

Abstract 3272: A Met receptor docking site peptide fused to cell-penetrating sequences acts as a powerful inhibitor of angiogenesis and vascular tumour growth

Anna Rita Cantelmo, Rosaria Cammarota, Douglas M. Noonan, Chiara Focaccetti, Paolo M. Comoglio, Andrea Graziani, Maria Prat, Adriana Albini
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3272.
https://doi.org/10.1158/1538-7445.AM2011-3272
Published: 15 April 2011
View articletitled, Abstract 3272: A Met receptor docking site peptide fused to cell-penetrating sequences acts as a powerful inhibitor of angiogenesis and vascular tumour growth
Journal Articles

Abstract 633: Target therapy of glioblastoma by gene transfer of a monovalent antibody against the MET oncogene

Giovanni Pacchiana, Cristina Chiriaco, Lara Fontani, Paolo M. Comoglio, Elisa Vigna
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 633.
https://doi.org/10.1158/1538-7445.AM2011-633
Published: 15 April 2011
View articletitled, Abstract 633: Target therapy of glioblastoma by gene transfer of a monovalent antibody against the MET oncogene
Journal Articles

Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis

Alessandra Gentile, Luca Lazzari, Silvia Benvenuti, Livio Trusolino, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3132–3141.
https://doi.org/10.1158/0008-5472.CAN-10-2662
Published: 13 April 2011
View articletitled, Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis
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Includes: Supplementary data
Journal Articles

Ron Kinase Transphosphorylation Sustains MET Oncogene Addiction

Silvia Benvenuti, Luca Lazzari, Addolorata Arnesano, Giulia Li Chiavi, Alessandra Gentile, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1945–1955.
https://doi.org/10.1158/0008-5472.CAN-10-2100
Published: 01 March 2011
View articletitled, Ron Kinase Transphosphorylation Sustains MET Oncogene Addiction
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Includes: Supplementary data
Journal Articles

Abstract 3398: Double-faced Sema3E-PlexinD1 signaling inhibits tumor growth but promotes metastatic spreading

Andrea Casazza, Lorena Capparuccia, Veronica Finisguerra, Massimiliano Mazzone, Paolo M. Comoglio, Luca Tamagnone
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3398.
https://doi.org/10.1158/1538-7445.AM10-3398
Published: 15 April 2010
View articletitled, Abstract 3398: Double-faced Sema3E-PlexinD1 signaling inhibits tumor growth but promotes metastatic spreading
Journal Articles

MicroRNAs Impair MET-Mediated Invasive Growth

Cristina Migliore, Annalisa Petrelli, Elena Ghiso, Simona Corso, Lorena Capparuccia, Adriana Eramo, Paolo M. Comoglio, Silvia Giordano
Journal: Cancer Research
Cancer Res (2008) 68 (24): 10128–10136.
https://doi.org/10.1158/0008-5472.CAN-08-2148
Published: 15 December 2008
View articletitled, MicroRNAs Impair MET-Mediated Invasive Growth
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Includes: Supplementary data
Journal Articles

“Active” Cancer Immunotherapy by Anti-Met Antibody Gene Transfer

Elisa Vigna, Giovanni Pacchiana, Massimiliano Mazzone, Cristina Chiriaco, Lara Fontani, Cristina Basilico, Selma Pennacchietti, Paolo M. Comoglio
Journal: Cancer Research
Cancer Res (2008) 68 (22): 9176–9183.
https://doi.org/10.1158/0008-5472.CAN-08-1688
Published: 14 November 2008
View articletitled, “Active” Cancer Immunotherapy by Anti-Met Antibody Gene Transfer
Open the PDF for “Active” Cancer Immunotherapy by Anti-Met Antibody Gene Transfer in another window
Includes: Supplementary data