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Journal Articles

Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang

Cancer Res canres.3230.2021.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3230

Published: 12 April 2022

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Includes: Multimedia, Supplementary data

Journal Articles

Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer

Vineet K. Gupta, Nikita S. Sharma, Brittany Durden, Vanessa T. Garrido, Kousik Kesh, Dujon Edwards, Dezhen Wang, Ciara Myer, Beatriz Mateo-Victoriano, Sai Sundeep Kollala, Yuguang Ban, Zhen Gao, Sanjoy K. Bhattacharya, Ashok Saluja, Pankaj K. Singh, Sulagna Banerjee

Cancer Res (2021) 81 (15): 4001–4013.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-2562

Published: 01 August 2021

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Includes: Supplementary data

Journal Articles

Abstract PO-023: Targeting a novel rewired pathway of nucleotide metabolism that drives chemoresistance in the most lethal molecular subtype of pancreatic cancer

Chun-Hao Pan, Yuka Otsuka, BanuPriya Sridharan, Melissa Woo, Cindy V. Leiton, Sruthi Babu, Mariana Torrente Gonçalves, Ryan R. Kawalerski, Ji Dong K. Bai, Richard A. Moffitt, Jiang Zhao, David K. Chang, Andrew V. Biankin, Tim Duong, Pankaj K. Singh, Louis Scampavia, Timothy Spicer, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos

Cancer Res (2020) 80 (22_Supplement): PO-023.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-023

Published: 13 November 2020

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Journal Articles

Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer

Chun-Hao Pan, Cindy V. Leiton, Lucia Roa-Peña, Ryan R. Kawalerski, Richard A. Moffitt, Jiang Zhao, Timothy Spicer, Peter Bailey, David K. Chang, Andrew Biankin, Tim Duong, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos

Cancer Res (2019) 79 (24_Supplement): C39.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-C39

Published: 13 December 2019

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Journal Articles

Abstract 3458: Investigation of oxidative stress-related gene signature in cancer-associated cachexia

Sumeet Jain, Surendra K. Shukla, Aneesha Dasgupta, Pankaj K. Singh

Cancer Res (2019) 79 (13_Supplement): 3458.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3458

Published: 01 July 2019

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Journal Articles

Abstract 973: The mitochondrial deoxyguanosine kinase regulates lung adenocarcinoma cancer stem-like cells through AMPK/YAP1 signaling

Shengchen Lin, Chongbiao Huang, Jianwai Sun, Xiuchao Wang, Jiaxin Kang, Matthew Taylor, Bin Fang, Pankaj K Singh, John Koomen, Jihui Hao, Shengyu Yang

Cancer Res (2019) 79 (13_Supplement): 973.

DOI: https://doi.org/10.1158/1538-7445.AM2019-973

Published: 01 July 2019

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Journal Articles

Abstract 5483: SIRT1 stabilization provides a therapeutic opportunity for reversing cachexia in pancreatic cancer

Aneesha Dasgupta, Enza Vernucci, Surendra K. Shukla, Scott E. Mulder, Ryan J. King, Jaime Abrego, Nina V. Chaika, Kyla Buettner, Pankaj K. Singh, Pankaj K. Singh

Cancer Res (2018) 78 (13_Supplement): 5483.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5483

Published: 01 July 2018

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Journal Articles

Abstract 3557: Beta-hydroxybutyrate inhibits oncogenic signaling and cellular motility in pancreatic cancer cells

Surendra K. Shukla, Nina V. Chaika, Pankaj K. Singh

Cancer Res (2018) 78 (13_Supplement): 3557.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3557

Published: 01 July 2018

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Journal Articles

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer

Saber Tadros, Surendra K. Shukla, Ryan J. King, Venugopal Gunda, Enza Vernucci, Jaime Abrego, Nina V. Chaika, Fang Yu, Audrey J. Lazenby, Lyudmyla Berim, Jean Grem, Aaron R. Sasson, Pankaj K. Singh

Cancer Res (2017) 77 (20): 5503–5517.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-3062

Published: 15 October 2017

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Includes: Supplementary data

Journal Articles

Abstract 381: Genomic alterations in mucins in cancer

Ryan J. King, Fang Yu, Pankaj K. Singh

Cancer Res (2017) 77 (13_Supplement): 381.

DOI: https://doi.org/10.1158/1538-7445.AM2017-381

Published: 01 July 2017

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Journal Articles

Abstract LB-267: Metabolic alterations in tumors cause cachexia in pancreatic cancer

Aneesha Dasgupta, Surendra K. Shukla, Venugopal Gunda, Nina V. Chaika, Pankaj K. Singh

Cancer Res (2017) 77 (13_Supplement): LB-267.

DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-267

Published: 01 July 2017

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Journal Articles

Abstract 3542: Coordination of glutamine and glucose metabolism in pancreatic cancer

Enza Vernucci, Venugopal Gunda, Surendra Shukla, Pankaj K. Singh

Cancer Res (2017) 77 (13_Supplement): 3542.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3542

Published: 01 July 2017

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Journal Articles

Abstract 459: Targeting MUC1 mediated nucleotide metabolism sensitizes pancreatic tumors to radiation therapy

VENUGOPAL GUNDA, Joshua Souchek, Jaime Abrego, Gennifer Goode, Enza Vernucci, Surendra K. Shukla, Aneesha DasGupta, Nina V. Chaika, Ryan King, Fang Yu, Tadayoshi Bessho, Chi Lin, Wang Shou, Li Sicong, Pankaj K. Singh

Cancer Res (2017) 77 (13_Supplement): 459.

DOI: https://doi.org/10.1158/1538-7445.AM2017-459

Published: 01 July 2017

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Journal Articles

Abstract 10: Silibinin exhibits anti-cachectic and anti-cancerous property by modulating metabolic properties of pancreatic cancer cells

Surendra K. Shukla, Aneesha Dasgupta, Kamiya Mehla, Venugopal Gunda, Enza Vernucci, Joshua Soucheck, Gennifer Goode, Ryan King, Anusha Mishra, Ibha Rai, Sangeetha Natrajan, Nina Chaika, Fang Yu, Pankaj K. Singh

Cancer Res (2016) 76 (14_Supplement): 10.

DOI: https://doi.org/10.1158/1538-7445.AM2016-10

Published: 15 July 2016

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Journal Articles

Abstract 1059: Pancreatic cancer cells acclimatize to low pH by increasing glutamine metabolism

Jaime Abrego, Venugopal Gunda, Pankaj K. Singh, Gennifer Goode

Cancer Res (2016) 76 (14_Supplement): 1059.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1059

Published: 15 July 2016

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Journal Articles

Abstract 3029: Dual targeting of ARK5 and CDK4 pathways with ON 123300 as a therapeutic strategy for colorectal carcinoma

Saikrishna A. Divakar, M.V. Ramana Reddy, Stephen C. Cosenza, Stacey J. Baker, Vinee Purohit, Venugopal Gunda, Pankaj K. Singh, E. Premkumar Reddy

Cancer Res (2016) 76 (14_Supplement): 3029.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3029

Published: 15 July 2016

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Journal Articles

Abstract 3310: Targeting MUC1-mediated metabolism sensitizes pancreatic cancer cells to radiation therapy

Venugopal Gunda, Jaime Abrego, Surendra K. Shukla, Nina V. Chaika, Fang Yu, Tadayoshi Bessho, Chi Lin, Pankaj K. Singh

Cancer Res (2015) 75 (15_Supplement): 3310.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3310

Published: 01 August 2015

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Journal Articles

Abstract 348: Amino acid-based prodrugs of gemcitabine - a therapeutic option to overcome chemoresistance in pancreatic cancer

Yangzom D. Bhutia, Ellappan Babu, Pankaj K. Singh, Vadivel Ganapathy

Cancer Res (2015) 75 (15_Supplement): 348.

DOI: https://doi.org/10.1158/1538-7445.AM2015-348

Published: 01 August 2015

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Journal Articles

Abstract 3376: Targeting metabolic flux of tumor cells to prevent pancreatic cancer associated cachexia

Surendra K. Shukla, Pankaj K. Singh

Cancer Res (2014) 74 (19_Supplement): 3376.

DOI: https://doi.org/10.1158/1538-7445.AM2014-3376

Published: 01 October 2014

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Journal Articles

Abstract 5391: MUC1 and HIF-1α signaling interactions modulate glucose flux in pancreatic cancer.

Vinee Purohit, Nina V. Chaika, Teklab Gebregiworgis, Prakash Radhakrishnan, Bo Zhang, Kamiya Mehla, Fang Yu, Keith R. Johnson, Robert Powers, Michael A. Hollingsworth, Pankaj K. Singh

Cancer Res (2013) 73 (8_Supplement): 5391.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5391

Published: 15 April 2013

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NARROW

Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer

Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer

Abstract PO-023: Targeting a novel rewired pathway of nucleotide metabolism that drives chemoresistance in the most lethal molecular subtype of pancreatic cancer

Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer

Abstract 3458: Investigation of oxidative stress-related gene signature in cancer-associated cachexia

Abstract 973: The mitochondrial deoxyguanosine kinase regulates lung adenocarcinoma cancer stem-like cells through AMPK/YAP1 signaling

Abstract 5483: SIRT1 stabilization provides a therapeutic opportunity for reversing cachexia in pancreatic cancer

Abstract 3557: Beta-hydroxybutyrate inhibits oncogenic signaling and cellular motility in pancreatic cancer cells

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer

Abstract 381: Genomic alterations in mucins in cancer

Abstract LB-267: Metabolic alterations in tumors cause cachexia in pancreatic cancer

Abstract 3542: Coordination of glutamine and glucose metabolism in pancreatic cancer

Abstract 459: Targeting MUC1 mediated nucleotide metabolism sensitizes pancreatic tumors to radiation therapy

Abstract 10: Silibinin exhibits anti-cachectic and anti-cancerous property by modulating metabolic properties of pancreatic cancer cells

Abstract 1059: Pancreatic cancer cells acclimatize to low pH by increasing glutamine metabolism

Abstract 3029: Dual targeting of ARK5 and CDK4 pathways with ON 123300 as a therapeutic strategy for colorectal carcinoma

Abstract 3310: Targeting MUC1-mediated metabolism sensitizes pancreatic cancer cells to radiation therapy

Abstract 348: Amino acid-based prodrugs of gemcitabine - a therapeutic option to overcome chemoresistance in pancreatic cancer

Abstract 3376: Targeting metabolic flux of tumor cells to prevent pancreatic cancer associated cachexia

Abstract 5391: MUC1 and HIF-1α signaling interactions modulate glucose flux in pancreatic cancer.

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