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Pankaj K. Singh
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Journal Articles

Abstract 6764: Lipophagy-dependent fatty acid oxidation is a metabolic vulnerability for KRAS signaling inhibition in pancreatic cancer

Junzhang Zhao, Ravi Thakur, Dezhen Wang, Tuo Hu, Chunbo He, Surendra K. Shukla, Kirsten L. Bryant, Kamiya Mehla, Channing J. Der, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6764.
https://doi.org/10.1158/1538-7445.AM2025-6764
Published: 21 April 2025
View articletitled, Abstract 6764: Lipophagy-dependent fatty acid oxidation is a metabolic vulnerability for KRAS signaling inhibition in pancreatic cancer
Journal Articles

Abstract 4164: Targeting glycogen metabolism as a potential therapy for Ewing sarcoma

Yueying Liu, Pankaj K. Singh, Lyndsay E. Young, Harrison A. Clarke, Tara R. Hawkinson, Meagan L. McCall, Elias Sayour, Craig W. Vander Kooi, Li Chen, Ramon C. Sun, Matthew S. Gentry
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4164.
https://doi.org/10.1158/1538-7445.AM2025-4164
Published: 21 April 2025
View articletitled, Abstract 4164: Targeting glycogen metabolism as a potential therapy for Ewing sarcoma
Journal Articles

Abstract C034: MUC1 positive extracellular vesicles play an important role on gemcitabine resistance in PDAC

Ying Huang, Dezhen Wang, Chunbo He, Bo Tu, Kamiya Mehla, Pankaj K. Singh, Michael A. Hollingsworth
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C034.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C034
Published: 15 September 2024
View articletitled, Abstract C034: MUC1 positive extracellular vesicles play an important role on gemcitabine resistance in PDAC
Journal Articles

Abstract C031: Keratin 17 promotes pancreatic cancer chemoresistance through mitochondrial translocation and stabilization of dihydroorotate dehydrogenase (DHODH)

Yinghuan Lyu, Monisankar Ghosh, Chun-Hao Pan, Shayan Sarkar, Girish H Rajacharya, Bo Chen, Natalia Marchenko, Pankaj K Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C031.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C031
Published: 15 September 2024
View articletitled, Abstract C031: Keratin 17 promotes pancreatic cancer chemoresistance through mitochondrial translocation and stabilization of dihydroorotate dehydrogenase (DHODH)
Journal Articles

Abstract C106: IMPACT restrains immuno-metabolic GCN1 signaling to govern pancreatic cancer metastasis

Surajit Sinha, Abir Panda, Zeribe Nwosu, Rodrigo Neves Das, Xu Ke, Elke van Beek, Alexander J. Rossi, Reed I. Ayabe, James McDonald, Michael M. Wach, Samantha Ruff, Priyanka P. Desai, David Sun, Martha E. Teke, Emily A. Verbus, Areeba Saif, Shreya Gupta, Tahsin Khan, Leila Sarvestani, Carrie E. Ryan, Jacob Lambdin, Kirsten Remmert, Emily Smith, Kenneth Luberice, Stephie Lux, Imani A. Alexander, Tracey Pu, Allen Luna, Sarfraz R. Akmal, Shahyan Rehman, Ashley Rainey, Hanna Hong, Yuri Lin, Samantha Sevilla, Gasmi Billel, Sivasish Sindiri, Todd Prickett, King Chan, Eileen Li, Xiaolin Wu, Nicholas D. Klemen, Giorgio Trinchieri, Costas A. Lyssiotis, Jeremy Davis, Pankaj K. Singh, Steven A. Rosenberg, Michael B. Yaffe, Filippo Giancotti, Ethan M. Shevach, Jonathan M. Hernandez
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C106.
https://doi.org/10.1158/1538-7445.PANCA2023-C106
Published: 16 January 2024
View articletitled, Abstract C106: IMPACT restrains immuno-metabolic GCN1 signaling to govern pancreatic cancer metastasis
Journal Articles

Abstract B085: K17-induced pyrimidine biosynthesis drives chemoresistance in PDAC

Yinghuan Lyu, Kenneth Shroyer, Chun-Hao Pan, Robert Tseng, Md Afjalus Siraj, Girish Halemirle Rajacharya, Bo Chen, Katie L Donnelly, Michael Horowitz, Carlos Mauricio Mejia Arbelaez, Sumedha Chowdhury, Lyanne Oblein, Natalia Marchenko, Luisa Escobar-Hoyos, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B085.
https://doi.org/10.1158/1538-7445.PANCA2023-B085
Published: 16 January 2024
View articletitled, Abstract B085: K17-induced pyrimidine biosynthesis drives chemoresistance in PDAC
Journal Articles

LXR Signaling-Mediated Cholesterol Metabolism Reprogramming Regulates Cancer Cell Metastasis

Pankaj K. Singh, Kamiya Mehla
Journal: Cancer Research
Cancer Res (2023) 83 (11): 1759–1761.
https://doi.org/10.1158/0008-5472.CAN-23-0624
Published: 02 June 2023
View articletitled, LXR Signaling-Mediated Cholesterol Metabolism Reprogramming Regulates Cancer Cell Metastasis
Open the PDF for LXR Signaling-Mediated Cholesterol Metabolism Reprogramming Regulates Cancer Cell Metastasis in another window
Journal Articles

Abstract 2025: Phosphoproteomic profiling following MAP3K1 kinase inhibition identifies NPM1 as a novel substrate

Lidia Boghean, Sarbjit Singh, Kiran Mangalaparthi, Surendra K. Shukla, Smitha Kizhake, Amritha Kizhake, Donn Wishka, Jayapal Reddy Mallareddy, Joel Morris, Paul Grothaus, Pankaj K. Singh, Akhilesh Pandey, Amarnath Natarajan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2025.
https://doi.org/10.1158/1538-7445.AM2023-2025
Published: 04 April 2023
View articletitled, Abstract 2025: Phosphoproteomic profiling following MAP3K1 kinase inhibition identifies NPM1 as a novel substrate
Journal Articles

Abstract B006: Targeting keratin 17-mediated metabolic reprogramming of de novo pyrimidine biosynthesis as a novel strategy to overcome chemoresistance in pancreatic cancer

Chun-Hao Pan, Robert Tseng, Michael Horowitz, Md Afjalus Sira, Bo Chen, Katie L. Donnelly, Cindy V. Leiton, Natalia Marchenko, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B006.
https://doi.org/10.1158/1538-7445.PANCA22-B006
Published: 15 November 2022
View articletitled, Abstract B006: Targeting keratin 17-mediated metabolic reprogramming of de novo pyrimidine biosynthesis as a novel strategy to overcome chemoresistance in pancreatic cancer
Journal Articles

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2254–2268.
https://doi.org/10.1158/0008-5472.CAN-21-3230
Published: 15 June 2022
View articletitled, Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
Open the PDF for Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer

Vineet K. Gupta, Nikita S. Sharma, Brittany Durden, Vanessa T. Garrido, Kousik Kesh, Dujon Edwards, Dezhen Wang, Ciara Myer, Beatriz Mateo-Victoriano, Sai Sundeep Kollala, Yuguang Ban, Zhen Gao, Sanjoy K. Bhattacharya, Ashok Saluja, Pankaj K. Singh, Sulagna Banerjee
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4001–4013.
https://doi.org/10.1158/0008-5472.CAN-20-2562
Published: 01 August 2021
View articletitled, Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer
Open the PDF for Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO-023: Targeting a novel rewired pathway of nucleotide metabolism that drives chemoresistance in the most lethal molecular subtype of pancreatic cancer

Chun-Hao Pan, Yuka Otsuka, BanuPriya Sridharan, Melissa Woo, Cindy V. Leiton, Sruthi Babu, Mariana Torrente Gonçalves, Ryan R. Kawalerski, Ji Dong K. Bai, Richard A. Moffitt, Jiang Zhao, David K. Chang, Andrew V. Biankin, Tim Duong, Pankaj K. Singh, Louis Scampavia, Timothy Spicer, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-023.
https://doi.org/10.1158/1538-7445.PANCA20-PO-023
Published: 13 November 2020
View articletitled, Abstract PO-023: Targeting a novel rewired pathway of nucleotide metabolism that drives chemoresistance in the most lethal molecular subtype of pancreatic cancer
Journal Articles

Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer

Chun-Hao Pan, Cindy V. Leiton, Lucia Roa-Peña, Ryan R. Kawalerski, Richard A. Moffitt, Jiang Zhao, Timothy Spicer, Peter Bailey, David K. Chang, Andrew Biankin, Tim Duong, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C39.
https://doi.org/10.1158/1538-7445.PANCA19-C39
Published: 13 December 2019
View articletitled, Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer
Journal Articles

Abstract 973: The mitochondrial deoxyguanosine kinase regulates lung adenocarcinoma cancer stem-like cells through AMPK/YAP1 signaling

Shengchen Lin, Chongbiao Huang, Jianwai Sun, Xiuchao Wang, Jiaxin Kang, Matthew Taylor, Bin Fang, Pankaj K Singh, John Koomen, Jihui Hao, Shengyu Yang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 973.
https://doi.org/10.1158/1538-7445.AM2019-973
Published: 01 July 2019
View articletitled, Abstract 973: The mitochondrial deoxyguanosine kinase regulates lung adenocarcinoma cancer stem-like cells through AMPK/YAP1 signaling
Journal Articles

Abstract 3458: Investigation of oxidative stress-related gene signature in cancer-associated cachexia

Sumeet Jain, Surendra K. Shukla, Aneesha Dasgupta, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3458.
https://doi.org/10.1158/1538-7445.AM2019-3458
Published: 01 July 2019
View articletitled, Abstract 3458: Investigation of oxidative stress-related gene signature in cancer-associated cachexia
Journal Articles

Abstract 5483: SIRT1 stabilization provides a therapeutic opportunity for reversing cachexia in pancreatic cancer

Aneesha Dasgupta, Enza Vernucci, Surendra K. Shukla, Scott E. Mulder, Ryan J. King, Jaime Abrego, Nina V. Chaika, Kyla Buettner, Pankaj K. Singh, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5483.
https://doi.org/10.1158/1538-7445.AM2018-5483
Published: 01 July 2018
View articletitled, Abstract 5483: SIRT1 stabilization provides a therapeutic opportunity for reversing cachexia in pancreatic cancer
Journal Articles

Abstract 3557: Beta-hydroxybutyrate inhibits oncogenic signaling and cellular motility in pancreatic cancer cells

Surendra K. Shukla, Nina V. Chaika, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3557.
https://doi.org/10.1158/1538-7445.AM2018-3557
Published: 01 July 2018
View articletitled, Abstract 3557: Beta-hydroxybutyrate inhibits oncogenic signaling and cellular motility in pancreatic cancer cells
Journal Articles

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer

Saber Tadros, Surendra K. Shukla, Ryan J. King, Venugopal Gunda, Enza Vernucci, Jaime Abrego, Nina V. Chaika, Fang Yu, Audrey J. Lazenby, Lyudmyla Berim, Jean Grem, Aaron R. Sasson, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2017) 77 (20): 5503–5517.
https://doi.org/10.1158/0008-5472.CAN-16-3062
Published: 15 October 2017
View articletitled, De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Open the PDF for De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-267: Metabolic alterations in tumors cause cachexia in pancreatic cancer

Aneesha Dasgupta, Surendra K. Shukla, Venugopal Gunda, Nina V. Chaika, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-267.
https://doi.org/10.1158/1538-7445.AM2017-LB-267
Published: 01 July 2017
View articletitled, Abstract LB-267: Metabolic alterations in tumors cause cachexia in pancreatic cancer
Journal Articles

Abstract 381: Genomic alterations in mucins in cancer

Ryan J. King, Fang Yu, Pankaj K. Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 381.
https://doi.org/10.1158/1538-7445.AM2017-381
Published: 01 July 2017
View articletitled, Abstract 381: Genomic alterations in mucins in cancer