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Panagis Filippakopoulos
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Journal Articles

Abstract 5779: Enhancing selectivity and overcoming tissue-specific toxicity in drug discovery: A novel BET inhibitor with targeted delivery for prostate cancer treatment

Free
Cong Tang, Rui Traquete, Elizabeth Henderson, João Conde, Sara Picaud, Panagis Filippakopoulos, Gonçalo Bernardes
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5779.
https://doi.org/10.1158/1538-7445.AM2024-5779
Published: 22 March 2024
View articletitled, Abstract 5779: Enhancing selectivity and overcoming tissue-specific toxicity in drug discovery: A novel BET inhibitor with targeted delivery for prostate cancer treatment
Journal Articles

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Free
Sarah Picaud, Oleg Fedorov, Angeliki Thanasopoulou, Katharina Leonards, Katherine Jones, Julia Meier, Heidi Olzscha, Octovia Monteiro, Sarah Martin, Martin Philpott, Anthony Tumber, Panagis Filippakopoulos, Clarence Yapp, Christopher Wells, Ka Hing Che, Andrew Bannister, Samuel Robson, Umesh Kumar, Nigel Parr, Kevin Lee, Dave Lugo, Philip Jeffrey, Simon Taylor, Matteo L. Vecellio, Chas Bountra, Paul E. Brennan, Alison O'Mahony, Sharlene Velichko, Susanne Müller, Duncan Hay, Danette L. Daniels, Marjeta Urh, Nicholas B. La Thangue, Tony Kouzarides, Rab Prinjha, Jürg Schwaller, Stefan Knapp
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (23): 5106–5119.
https://doi.org/10.1158/0008-5472.CAN-15-0236
Published: 30 November 2015
View articletitled, Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Open the PDF for Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract IA19: Regulation of signaling interactomes in cancer

Free
Jean-Philippe Lambert, Yiwang Zhou, Amber Couzens, Chih-Chiang Tsou, Sarah Picaud, Gordana Ivosev, Stephen Tate, Alexey Nesvizhskii, Panagis Filippakopoulos, Anne-Claude Gingras
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): IA19.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-IA19
Published: 15 November 2015
View articletitled, Abstract IA19: Regulation of signaling interactomes in cancer
Journal Articles

Abstract 5387: Dual kinase/bromodomain inhibitors for rationally designed polypharmacology

Free
Elizabeth R. Quinn, Pietro Ciceri, Susanne Müller-Knapp, Alison O'Mahony, Oleg Fedorov, Panagis Filippakopoulos, Jeremy P. Hunt, Elisabeth A. Lasater, Gabriel Pallares, Sarah Picaud, Christopher Wells, Lisa M. Wodicka, Neil P. Shah, Stefan Knapp, Daniel K. Treiber
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5387.
https://doi.org/10.1158/1538-7445.AM2014-5387
Published: 01 October 2014
View articletitled, Abstract 5387: Dual kinase/bromodomain inhibitors for rationally designed polypharmacology
Journal Articles

PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains

Free
Sarah Picaud, David Da Costa, Angeliki Thanasopoulou, Panagis Filippakopoulos, Paul V. Fish, Martin Philpott, Oleg Fedorov, Paul Brennan, Mark E. Bunnage, Dafydd R. Owen, James E. Bradner, Philippe Taniere, Brendan O'Sullivan, Susanne Müller, Juerg Schwaller, Tatjana Stankovic, Stefan Knapp
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (11): 3336–3346.
https://doi.org/10.1158/0008-5472.CAN-12-3292
Published: 30 May 2013
View articletitled, PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains
Open the PDF for PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains in another window
Includes: Supplementary data
Journal Articles

Abstract 2318: BET bromodomain inhibitors for cancer therapy

Free
Jun Qi, Panagis Filippakopoulos, Michael McKeown, Katharin L. Shaw, William B. Smith, Christopher A. French, Andrew L. Kung, Stefan Knapp, James E. Bradner
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2318.
https://doi.org/10.1158/1538-7445.AM2011-2318
Published: 15 April 2011
View articletitled, Abstract 2318: BET bromodomain inhibitors for cancer therapy
Journal Articles

Abstract 3683: Small molecule inhibitors of the Fes non-receptor tyrosine kinase

Free
Sabine Hellwig, Jianming Zhang, Panagis Filippakopoulos, Eidarus Salah, Stefan Knapp, Nathanael S. Gray, Thomas E. Smithgall
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3683.
https://doi.org/10.1158/1538-7445.AM10-3683
Published: 15 April 2010
View articletitled, Abstract 3683: Small molecule inhibitors of the Fes non-receptor tyrosine kinase
Journal Articles

Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity

Free
Vanda Pogacic, Alex N. Bullock, Oleg Fedorov, Panagis Filippakopoulos, Christelle Gasser, Andrea Biondi, Sandrine Meyer-Monard, Stefan Knapp, Juerg Schwaller
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6916–6924.
https://doi.org/10.1158/0008-5472.CAN-07-0320
Published: 17 July 2007
View articletitled, Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Open the PDF for Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity in another window
Includes: Supplementary data