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Journal Articles

Abstract 276: Targeting AXL sensitizes non-small cell lung cancer to ATR inhibitors by enhancing replication stress

Kavya Ramkumar, Pan Tong, You-Hong Fan, David Peng, John V. Heymach, Don L. Gibbons, Jing Wang, Lauren A. Byers

Cancer Res (2019) 79 (13_Supplement): 276.

DOI: https://doi.org/10.1158/1538-7445.AM2019-276

Published: 01 July 2019

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Journal Articles

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

Ana Galan-Cobo, Piyada Sitthideatphaiboon, Xiao Qu, Alissa Poteete, Marlese A. Pisegna, Pan Tong, Pei-Hsuan Chen, Lindsey K. Boroughs, Mirna L.M. Rodriguez, Winter Zhang, Francesco Parlati, Jing Wang, Varsha Gandhi, Ferdinandos Skoulidis, Ralph J. DeBerardinis, John D. Minna, John V. Heymach

Cancer Res (2019) 79 (13): 3251–3267.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-3527

Published: 01 July 2019

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Includes: Supplementary data

Journal Articles

Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis

Xiang Yan, Xiaoshan Zhang, Li Wang, Ran Zhang, Xingxiang Pu, Shuhong Wu, Lei Li, Pan Tong, Jing Wang, Qing H. Meng, Vanessa B. Jensen, Luc Girard, John D. Minna, Jack A. Roth, Stephen G. Swisher, John V. Heymach, Bingliang Fang

Cancer Res (2019) 79 (1): 125–132.

DOI: https://doi.org/10.1158/0008-5472.CAN-18-1938

Published: 02 January 2019

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Includes: Supplementary data

Journal Articles

Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway

Cancer Res (2018) 78 (13_Supplement): 3413.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3413

Published: 01 July 2018

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Journal Articles

Abstract 2822: ATR inhibitors are active as single agents and in combination with PARP1 and ATM inhibitors in molecularly distinct subsets of small cell lung cancer models

Carl M. Gay, Pan Tong, Lerong Li, C. Allison Stewart, Triparna Sen, Bonnie S. Glisson, John V. Heymach, Jing Wang, Lauren Averett Byers

Cancer Res (2018) 78 (13_Supplement): 2822.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2822

Published: 01 July 2018

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Journal Articles

Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells

Vaishnavi Sambandam, Li Shen, Pan Tong, Shaohua Peng, Tuhina Mazumdar, Ratnakar Singh, Curtis R. Pickering, Jeffrey N. Myers, Jing Wang, Mitchell Frederick, Faye M. Johnson

Cancer Res (2018) 78 (13_Supplement): 2977.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2977

Published: 01 July 2018

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Journal Articles

Abstract 2408: LKB1 and KEAP1/NRF2 pathways cooperatively promote glutamine dependence and vulnerability to glutaminase inhibitors in KRAS-mutant lung adenocarcinoma

Ana Galan-Cobo, Piyada Sitthideatphaiboon, Xiao Qu, Jeffrey J. Kovacs, Alissa Poteete, Pan Tong, Sungnam Cho, Varsha V. Gandhi, Ferdinandos Skoulidis, Jing Wang, Timothy P. Heffernan, John V. Heymach

Cancer Res (2018) 78 (13_Supplement): 2408.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2408

Published: 01 July 2018

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Journal Articles

Abstract 1960: T790M-independent EGFR TKI resistance is associated with a broad multi-drug resistant phenotype but selective vulnerabilities to spindle assembly complex (SAC) and CDK inhibitors

Monique B. Nilsson, Jacqueline Robichaux, Huiying Sun, Pan Tong, Lixia Diao, Mia Hofstad, YouHong Fan, Jing Wang, John Heymach

Cancer Res (2018) 78 (13_Supplement): 1960.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1960

Published: 01 July 2018

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Journal Articles

Abstract 5147: Lactate transporters are a potential therapeutic target for LKB1-deficient lung cancers

Irene Guijarro, Alissa Poteete, Pan Tong, Jing Wang, John Heymach

Cancer Res (2018) 78 (13_Supplement): 5147.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5147

Published: 01 July 2018

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Journal Articles

Abstract 990: Single-cell profiling of small cell lung cancer circulating tumor cell-derived xenograft models reveals intratumoral heterogeneity among mediators of chemoresistance

Cancer Res (2018) 78 (13_Supplement): 990.

DOI: https://doi.org/10.1158/1538-7445.AM2018-990

Published: 01 July 2018

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Journal Articles

Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

Tuhina Mazumdar, Nene N. Kalu, Shaohua Peng, Pan Tong, Li Shen, Jing Wang, Jeffrey N. Myers, Curtis R. Pickering, David Brunell, Clifford C. Stephan, Faye M. Johnson

Cancer Res (2018) 78 (13_Supplement): 4646.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4646

Published: 01 July 2018

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Journal Articles

HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Cancer Res (2017) 77 (19): 5313–5326.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-0986

Published: 01 October 2017

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Includes: Supplementary data

Journal Articles

CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib

Triparna Sen, Pan Tong, C. Allison Stewart, Sandra Cristea, Aly Valliani, David S. Shames, Abena B. Redwood, You Hong Fan, Lerong Li, Bonnie S. Glisson, John D. Minna, Julien Sage, Don L. Gibbons, Helen Piwnica-Worms, John V. Heymach, Jing Wang, Lauren Averett Byers

Cancer Res (2017) 77 (14): 3870–3884.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-3409

Published: 13 July 2017

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Includes: Supplementary data

Journal Articles

Abstract 3816: Mutations of the lim protein ajuba mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell cycle inhibitors

Ming Zhang, Singh Ratnakar, Shaohua Peng, Mazumdar Tuhina, Shen Li, Pan Tong, Curtis Pickering, Jeffrey N. Myers, Jing Wang, Faye M. Johnson

Cancer Res (2017) 77 (13_Supplement): 3816.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3816

Published: 01 July 2017

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Journal Articles

Abstract 4095: c-Met activation mediates resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer

Ratnakar Singh, Li Shen, Pan Tong, Jing Wang, Faye M. Johnson

Cancer Res (2017) 77 (13_Supplement): 4095.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4095

Published: 01 July 2017

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Journal Articles

Abstract 1560: Differential sensitivity analysis for resistant malignancies (DISARM), a novel approach for drug screen analysis, identifies common candidate drugs across platinum-resistant cancer types

Carl M. Gay, Pan Tong, Robert J. Cardnell, Xiao Su, Nene N. Kalu, Upasana Banerjee, Rasha O. Bara, Faye M. Johnson, John V. Heymach, Jing Wang, Lauren A. Byers

Cancer Res (2017) 77 (13_Supplement): 1560.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1560

Published: 01 July 2017

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Journal Articles

Abstract 627: NLRC5 co-mutations are associated with impaired antigen presentation and immune exclusion in KRAS-mutant lung adenocarcinoma

Ferdinandos Skoulidis, Taghreed Hirz, Xiang Dong Lee, Jaime Rodriguez Canales, Edwin R. Parra, Pan Tong, Carmen Behrens, Vassiliki A. Papadimitrakopoulou, Jing Wang, Ignacio Wistuba, John V. Heymach

Cancer Res (2017) 77 (13_Supplement): 627.

DOI: https://doi.org/10.1158/1538-7445.AM2017-627

Published: 01 July 2017

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Journal Articles

Abstract 2992: Identification of NOTCH1 inactivating mutation as a therapeutic vulnerability to PI3K/mTOR pathway inhibition in head and neck squamous cell carcinoma (HNSCC)

Vaishnavi Sambandam, Li Shen, Pan Tong, Tuhina Mazumdar, Curtis Pickering, Jeffrey N. Myers, Jing Wang, Mitchell Frederick, Faye M. Johnson

Cancer Res (2017) 77 (13_Supplement): 2992.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2992

Published: 01 July 2017

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Journal Articles

Abstract 298: WEE1 inhibitor activity correlates to AXL/mTOR expression and exhibits synergy with temozolomide (TMZ) in small cell lung cancer (SCLC)

Triparna Sen, Pan Tong, Lixia Diao, You Hong-Fan, C. Allison Stewart, John V. Heymach, Jing Wang, Lauren A. Byers

Cancer Res (2017) 77 (13_Supplement): 298.

DOI: https://doi.org/10.1158/1538-7445.AM2017-298

Published: 01 July 2017

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Journal Articles

Abstract 3272: LKB1 loss is associated with resistance to VEGF inhibitors in non-small cell lung cancer (NSCLC)

Irene Guijarro, Alissa Poteete, Chao Yang, Emily Roarty, Monique Nilsson, Huiying Sun, Pan Tong, Edward Chang, Jaime Rodriguez-Canales, Barbara Mino, Edwin Parra, Ignacio Wistuba, Jing Wang, Timothy Heffernan, John V. Heymach

Cancer Res (2016) 76 (14_Supplement): 3272.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3272

Published: 15 July 2016

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NARROW

Abstract 276: Targeting AXL sensitizes non-small cell lung cancer to ATR inhibitors by enhancing replication stress

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis

Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway

Abstract 2822: ATR inhibitors are active as single agents and in combination with PARP1 and ATM inhibitors in molecularly distinct subsets of small cell lung cancer models

Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells

Abstract 2408: LKB1 and KEAP1/NRF2 pathways cooperatively promote glutamine dependence and vulnerability to glutaminase inhibitors in KRAS-mutant lung adenocarcinoma

Abstract 1960: T790M-independent EGFR TKI resistance is associated with a broad multi-drug resistant phenotype but selective vulnerabilities to spindle assembly complex (SAC) and CDK inhibitors

Abstract 5147: Lactate transporters are a potential therapeutic target for LKB1-deficient lung cancers

Abstract 990: Single-cell profiling of small cell lung cancer circulating tumor cell-derived xenograft models reveals intratumoral heterogeneity among mediators of chemoresistance

Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib

Abstract 3816: Mutations of the lim protein ajuba mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell cycle inhibitors

Abstract 4095: c-Met activation mediates resistance to polo-like kinase 1 inhibitor-induced apoptosis in non-small cell lung cancer

Abstract 1560: Differential sensitivity analysis for resistant malignancies (DISARM), a novel approach for drug screen analysis, identifies common candidate drugs across platinum-resistant cancer types

Abstract 627: NLRC5 co-mutations are associated with impaired antigen presentation and immune exclusion in KRAS-mutant lung adenocarcinoma

Abstract 2992: Identification of NOTCH1 inactivating mutation as a therapeutic vulnerability to PI3K/mTOR pathway inhibition in head and neck squamous cell carcinoma (HNSCC)

Abstract 298: WEE1 inhibitor activity correlates to AXL/mTOR expression and exhibits synergy with temozolomide (TMZ) in small cell lung cancer (SCLC)

Abstract 3272: LKB1 loss is associated with resistance to VEGF inhibitors in non-small cell lung cancer (NSCLC)

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